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Article ; Online: Development of a social skills training programme to target social isolation using virtual reality technology in primary mental health care.

Ose, Solveig Osborg / Thaulow, Kristin / Færevik, Hilde / Hoffmann, Per Lund / Lestander, Hedvig / Stiles, Tore / Lindgren, Martin

Journal of rehabilitation and assistive technologies engineering

2023 Volume 10, Page(s) 20556683231187545

Abstract: Introduction: People with severe mental illness often have a small or no network of friends and limited contact with their family and live social isolated lives. We developed a social skills training programme to be administered by public mental health ... ...

Abstract	Introduction: People with severe mental illness often have a small or no network of friends and limited contact with their family and live social isolated lives. We developed a social skills training programme to be administered by public mental health professionals in helping those with mental illness to overcome their social isolation. Methods: The programme was developed over 3 years in close collaboration among psychologists, service users, municipal mental health professionals, mental health service researchers and a local firm providing virtual reality (VR) training. We started with the simplest available equipment, that is, a cardboard headset combined with a smartphone, then we used Oculus Quest and now Oculus Quest 2. Results: The resulting programme is comprised of eight steps from: 1) identify service user's primary and secondary goals to 8) three-month follow-up. Conclusion: Several factors made adoption and implementation of VR technology possible in a relatively short timeframe: namely, the municipality and service users were involved from the beginning of the development process, efforts were made to introduce VR to mental health professionals and allow them to reflect on its usability, solutions were low-tech and low cost, and the long-term research collaboration was established without municipal financial obligations.
Language	English
Publishing date	2023-07-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2819384-2
ISSN	2055-6683 ; 2055-6683
ISSN (online)	2055-6683
ISSN	2055-6683
DOI	10.1177/20556683231187545
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Article ; Online: Genetic associations of cardiovascular risk genes in European patients with coronary artery spasm.

Tremmel, Roman / Martínez Pereyra, Valeria / Broders, Incifer / Schaeffeler, Elke / Hoffmann, Per / Nöthen, Markus M / Bekeredjian, Raffi / Sechtem, Udo / Schwab, Matthias / Ong, Peter

Clinical research in cardiology : official journal of the German Cardiac Society

2024

Abstract: Background: Coronary artery spasm (CAS) is a frequent finding in patients presenting with angina pectoris. Although the pathogenesis of CAS is incompletely understood, previous studies suggested a genetic contribution. Our study aimed to elucidate ... ...

Abstract	Background: Coronary artery spasm (CAS) is a frequent finding in patients presenting with angina pectoris. Although the pathogenesis of CAS is incompletely understood, previous studies suggested a genetic contribution. Our study aimed to elucidate genetic variants in a cohort of European patients with angina and unobstructed coronary arteries who underwent acetylcholine (ACh) provocation testing. Methods: A candidate association analysis of 208 genes previously associated with cardiovascular conditions was performed using genotyped and imputed variants in patients grouped in epicardial (focal, diffuse) CAS (n = 119) and microvascular CAS (n = 87). Patients with a negative ACh test result (n = 45) served as controls. Results: We found no association below the genome-wide significance threshold of p < 5 × 10 Conclusions: In summary, we suggest EDN1 as potential genetic risk loci for patients with diffuse epicardial CAS, and European ancestry. Plasma ET-1 levels may serve as a potential cardiac marker.
Language	English
Publishing date	2024-04-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2213295-8
ISSN	1861-0692 ; 1861-0684
ISSN (online)	1861-0692
ISSN	1861-0684
DOI	10.1007/s00392-024-02446-x
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Book: Conservation of archaeological ships and boats

Hoffmann, Per

personal experiences

2013

Author's details	Per Hoffmann
Keywords	Historic preservation ; Ships, Ancient ; Ships, Medieval ; Ships, Wooden ; Underwater archaeology ; Wood/Preservation
Language	English
Size	XV, 173 S., zahlr. Ill.
Publisher	Archetype
Publishing place	London
Document type	Book
Note	Literaturverz. S. [164] - 167
ISBN	9781904982821 ; 1904982824
Database	Johann Heinrich von Thünen-Institut, Federal Research Institute for Rural Areas, Forestry and Fisheries

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Article ; Online: Differential DNA methylation and mRNA transcription in gingival tissues in periodontal health and disease.

Kim, Hyunjin / Momen-Heravi, Fatemeh / Chen, Steven / Hoffmann, Per / Kebschull, Moritz / Papapanou, Panos N

Journal of clinical periodontology

2021 Volume 48, Issue 9, Page(s) 1152–1164

Abstract: Aim: We investigated differential DNA methylation in gingival tissues in periodontal health, gingivitis, and periodontitis, and its association with differential mRNA expression.: Materials and methods: Gingival tissues were harvested from ... ...

Abstract	Aim: We investigated differential DNA methylation in gingival tissues in periodontal health, gingivitis, and periodontitis, and its association with differential mRNA expression. Materials and methods: Gingival tissues were harvested from individuals and sites with clinically healthy and intact periodontium, gingivitis, and periodontitis. Samples were processed for differential DNA methylation and mRNA expression using the IlluminaEPIC (850 K) and the IlluminaHiSeq2000 platforms, respectively. Across the three phenotypes, we identified differentially methylated CpG sites and regions, differentially expressed genes (DEGs), and genes with concomitant differential methylation at their promoters and expression were identified. The findings were validated using our earlier databases using HG-U133Plus2.0Affymetrix microarrays and Illumina (450 K) methylation arrays. Results: We observed 43,631 differentially methylated positions (DMPs) between periodontitis and health, and 536 DMPs between gingivitis and health (FDR < 0.05). On the mRNA level, statistically significant DEGs were observed only between periodontitis and health (n = 126). Twelve DEGs between periodontitis and health (DCC, KCNA3, KCNA2, RIMS2, HOXB7, PNOC, IRX1, JSRP1, TBX1, OPCML, CECR1, SCN4B) were also differentially methylated between the two phenotypes. Spearman correlations between methylation and expression in the EPIC/mRNAseq dataset were largely replicated in the 450 K/Affymetrix datasets. Conclusions: Concomitant study of DNA methylation and gene expression patterns may identify genes whose expression is epigenetically regulated in periodontitis.
MeSH term(s)	Cell Adhesion Molecules ; DNA Methylation/genetics ; GPI-Linked Proteins ; Gingivitis/genetics ; Homeodomain Proteins ; Humans ; Periodontitis/genetics ; Periodontium ; RNA, Messenger/genetics ; Transcription Factors
Chemical Substances	Cell Adhesion Molecules ; GPI-Linked Proteins ; HOXB7 protein, human ; Homeodomain Proteins ; IRX1 protein, human ; OPCML protein, human ; RNA, Messenger ; Transcription Factors
Language	English
Publishing date	2021-07-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	188647-2
ISSN	1600-051X ; 0303-6979
ISSN (online)	1600-051X
ISSN	0303-6979
DOI	10.1111/jcpe.13504
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Article: Epigenome-Wide Analysis of DNA Methylation in Parkinson's Disease Cortex.

Kaut, Oliver / Schmitt, Ina / Stahl, Fabian / Fröhlich, Holger / Hoffmann, Per / Gonzalez, Frank J / Wüllner, Ullrich

Life (Basel, Switzerland)

2022 Volume 12, Issue 4

Abstract: Background: Epigenetic factors including DNA methylation contribute to specific patterns of gene expression. Gene−environment interactions can change the methylation status in the brain, and accumulation of these epigenetic changes over a lifespan may be ...

Abstract	Background: Epigenetic factors including DNA methylation contribute to specific patterns of gene expression. Gene−environment interactions can change the methylation status in the brain, and accumulation of these epigenetic changes over a lifespan may be co-responsible for a neurodegenerative disease like Parkinson’s disease, which that is characterised by a late onset in life. Aims: To determine epigenetic modifications in the brains of Parkinson’s disease patients. Patients and Methods: DNA methylation patterns were compared in the cortex tissue of 14 male PD patients and 10 male healthy individuals using the Illumina Methylation 450 K chip. Subsequently, DNA methylation of candidate genes was evaluated using bisulphite pyrosequencing, and DNA methylation of cytochrome P450 2E1 (CYP2E1) was characterized in DNA from blood mononuclear cells (259 PD patients and 182 healthy controls) and skin fibroblasts (10 PD patients and 5 healthy controls). Protein levels of CYP2E1 were analysed using Western blot in human cortex and knock-out mice brain samples. Results: We found 35 hypomethylated and 22 hypermethylated genes with a methylation M-value difference >0.5. Decreased methylation of cytochrome P450 2E1 (CYP2E1) was associated with increased protein levels in PD brains, but in peripheral tissues, i.e., in blood cells and skin fibroblasts, DNA methylation of CYP2E1 was unchanged. In CYP2E1 knock-out mice brain alpha-synuclein (SNCA) protein levels were down-regulated compared to wild-type mice, whereas treatment with trichloroethylene (TCE) up-regulated CYP2E1 protein in a dose-dependent manner in cultured cells. We further identified an interconnected group of genes associated with oxidative stress, such as Methionine sulfoxide reductase A (MSRA) and tumour protein 73 (TP73) in the brain, which again were not paralleled in other tissues and appeared to indicate brain-specific changes. Conclusions: Our study revealed surprisingly few dysmethylated genes in a brain region less affected in PD. We confirmed hypomethylation of CYP2E1.
Language	English
Publishing date	2022-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life12040502
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Article: Desaturase Activity and the Risk of Type 2 Diabetes and Coronary Artery Disease: A Mendelian Randomization Study

Jäger, Susanne / Cuadrat, Rafael / Hoffmann, Per / Wittenbecher, Clemens / Schulze, Matthias B

Nutrients. 2020 July 28, v. 12, no. 8

2020

Abstract: Estimated Δ5-desaturase (D5D) and Δ6-desaturase (D6D) are key enzymes in metabolism of polyunsaturated fatty acids (PUFA) and have been associated with cardiometabolic risk; however, causality needs to be clarified. We applied two-sample Mendelian ... ...

Abstract	Estimated Δ5-desaturase (D5D) and Δ6-desaturase (D6D) are key enzymes in metabolism of polyunsaturated fatty acids (PUFA) and have been associated with cardiometabolic risk; however, causality needs to be clarified. We applied two-sample Mendelian randomization (MR) approach using a representative sub-cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)–Potsdam Study and public data from DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) and Coronary ARtery DIsease Genome wide Replication and Meta-analysis (CARDIoGRAM) genome-wide association studies (GWAS). Furthermore, we addressed confounding by linkage disequilibrium (LD) as all instruments from FADS1 (encoding D5D) are in LD with FADS2 (encoding D6D) variants. Our univariable MRs revealed risk-increasing total effects of both, D6D and D5D on type 2 diabetes (T2DM) risk; and risk-increasing total effect of D6D on risk of coronary artery disease (CAD). The multivariable MR approach could not unambiguously allocate a direct causal effect to either of the individual desaturases. Our results suggest that D6D is causally linked to cardiometabolic risk, which is likely due to downstream production of fatty acids and products resulting from high D6D activity. For D5D, we found indication for causal effects on T2DM and CAD, which could, however, still be confounded by LD.
Keywords	coronary artery disease ; genome ; linkage disequilibrium ; meta-analysis ; metabolism ; noninsulin-dependent diabetes mellitus ; nutrition ; prospective studies ; risk
Language	English
Dates of publication	2020-0728
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-light
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu12082261
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Article ; Online: Desaturase Activity and the Risk of Type 2 Diabetes and Coronary Artery Disease: A Mendelian Randomization Study.

Jäger, Susanne / Cuadrat, Rafael / Hoffmann, Per / Wittenbecher, Clemens / Schulze, Matthias B

Nutrients

2020 Volume 12, Issue 8

Abstract	Estimated Δ5-desaturase (D5D) and Δ6-desaturase (D6D) are key enzymes in metabolism of polyunsaturated fatty acids (PUFA) and have been associated with cardiometabolic risk; however, causality needs to be clarified. We applied two-sample Mendelian randomization (MR) approach using a representative sub-cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study and public data from DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) and Coronary ARtery DIsease Genome wide Replication and Meta-analysis (CARDIoGRAM) genome-wide association studies (GWAS). Furthermore, we addressed confounding by linkage disequilibrium (LD) as all instruments from
MeSH term(s)	Adult ; Aged ; Cardiometabolic Risk Factors ; Coronary Artery Disease/genetics ; Delta-5 Fatty Acid Desaturase ; Diabetes Mellitus, Type 2/genetics ; Fatty Acid Desaturases/genetics ; Fatty Acids, Unsaturated/metabolism ; Female ; Genetic Predisposition to Disease/genetics ; Genome-Wide Association Study ; Humans ; Linkage Disequilibrium ; Linoleoyl-CoA Desaturase/genetics ; Male ; Mendelian Randomization Analysis ; Meta-Analysis as Topic ; Middle Aged ; Prospective Studies
Chemical Substances	Delta-5 Fatty Acid Desaturase ; Fatty Acids, Unsaturated ; Fatty Acid Desaturases (EC 1.14.19.-) ; FADS1 protein, human (EC 1.14.19.3) ; Linoleoyl-CoA Desaturase (EC 1.14.19.3)
Language	English
Publishing date	2020-07-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu12082261
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Article ; Online: Generation of induced pluripotent stem cells from two ADHD patients and two healthy controls.

Yde Ohki, Cristine Marie / Walter, Natalie Monet / Rickli, Michelle / Van Puyenbroeck, Pakita / Döring, Christian / Hoffmann, Per / Herms, Stefan / Maria Werling, Anna / Walitza, Susanne / Grünblatt, Edna

Stem cell research

2023 Volume 69, Page(s) 103084

Abstract: Attention-deficit hyperactivity disorder is a neurodevelopmental disorder which prevalence has been increasing in the past decades, affecting more than 5% of children, adolescents worldwide. Regarding etiology, polygenic, environmental factors contribute ...

Abstract	Attention-deficit hyperactivity disorder is a neurodevelopmental disorder which prevalence has been increasing in the past decades, affecting more than 5% of children, adolescents worldwide. Regarding etiology, polygenic, environmental factors contribute to the occurrence of ADHD even though molecular mechanisms are not known. Understanding the pathophysiology in patient-specific cells is crucial for the discovery of potential predictive markers, the establishment of new therapeutic targets. In this study, we generated further lines from ADHD patients, healthy controls using Sendai virus transduction, which may help on the study of ADHD at the molecular, cellular levels.
MeSH term(s)	Child ; Adolescent ; Humans ; Attention Deficit Disorder with Hyperactivity ; Induced Pluripotent Stem Cells ; Neurodevelopmental Disorders
Language	English
Publishing date	2023-03-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2393143-7
ISSN	1876-7753 ; 1873-5061
ISSN (online)	1876-7753
ISSN	1873-5061
DOI	10.1016/j.scr.2023.103084
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Article ; Online: IFN-γ secretion of PBMC from non-drug-allergic control persons: Considerations for the validity of a positive lymphocyte transformation test.

Glässner, Andreas / Wurpts, Gerda / Röseler, Stefanie / Yazdi, Amir S / Krämer, Christine / Fatangare, Amol / Sickmann, Albert / Hoffmann, Per / Nöthen, Markus / Sachs, Bernhardt

Journal of immunological methods

2023 Volume 519, Page(s) 113515

Abstract: Background: The lymphocyte transformation test (LTT) is used for the in vitro detection of a drug sensitization in assumed drug allergic patients. It is based on the detection of antigen (drug)-specific activation of T cells indicated by e.g. ... ...

Abstract	Background: The lymphocyte transformation test (LTT) is used for the in vitro detection of a drug sensitization in assumed drug allergic patients. It is based on the detection of antigen (drug)-specific activation of T cells indicated by e.g. proliferation or cytokine secretion. However, occasional stimulatory effects of the drug unrelated to specific drug-allergic mechanisms can only be detected if a larger number of non-drug allergic control persons are tested with this specific drug. In this respect, the overall specificity of the LTT with ELISA read-out is summarized in several review articles, but the impact of a specific drug on the specificity has not yet been analyzed in a larger set of control persons. Objective: Do amoxicillin, cefuroxime and clindamycin induce an interferon (IFN)-y or interleukin (IL)-5 secretion of PBMC from control persons using the LTT with ELISA read-out? Methods: We performed LTTs with amoxicillin, cefuroxime and clindamycin and determined drug-specific IFN-γ and IL-5 secretion measured by ELISA read-out. We included PBMC from 60 non-drug allergic control persons, who were unexposed to the tested drug at the time of blood donation. Results: PBMC from 12 out of 23 control persons tested with amoxicillin gave a positive stimulation index (SI > 3.0) for IFN-γ resulting in a specificity of 47.8%. The corresponding specificity was 75% for cefuroxime (5/20 if SI > 3.0) and 58.8% for clindamycin (7/17, if SI > 2.0), respectively. In a next step, we calculated the Δ IFN-γ concentration by subtracting the background IFN-γ concentration in the unstimulated sample from the stimulated sample. After stimulation with amoxicillin, a mean concentration of 21.0 pg/mL IFN-γ was secreted. The less outlier prone median concentration was 7.4 pg/mL and much higher than for cefuroxime (1.7 pg/mL) and clindamycin (1.0 pg/mL). Remarkably, IL-5 concentrations were below the detection limit (< 1 pg/mL) for all drugs in all control persons who responded to TT. Conclusion: Consideration of these observations may be helpful since a positive LTT result in a control patient may challenge the validity of a positive LTT result in the same experiment for a patient with assumed drug allergy.
MeSH term(s)	Humans ; Interleukin-5 ; Leukocytes, Mononuclear ; Lymphocyte Activation ; Cefuroxime/pharmacology ; Clindamycin/pharmacology ; Interleukin-4 ; Interferon-gamma ; Amoxicillin
Chemical Substances	Interleukin-5 ; Cefuroxime (O1R9FJ93ED) ; Clindamycin (3U02EL437C) ; Interleukin-4 (207137-56-2) ; Interferon-gamma (82115-62-6) ; Amoxicillin (804826J2HU)
Language	English
Publishing date	2023-06-16
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120142-6
ISSN	1872-7905 ; 0022-1759
ISSN (online)	1872-7905
ISSN	0022-1759
DOI	10.1016/j.jim.2023.113515
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Article ; Online: Relationships between neurotransmitter receptor densities and expression levels of their corresponding genes in the human hippocampus.

Zhao, Ling / Mühleisen, Thomas W / Pelzer, Dominique I / Burger, Bettina / Beins, Eva C / Forstner, Andreas J / Herms, Stefan / Hoffmann, Per / Amunts, Katrin / Palomero-Gallagher, Nicola / Cichon, Sven

NeuroImage

2023 Volume 273, Page(s) 120095

Abstract: Neurotransmitter receptors are key molecules in signal transmission, their alterations are associated with brain dysfunction. Relationships between receptors and their corresponding genes are poorly understood, especially in humans. We combined in vitro ... ...

Abstract	Neurotransmitter receptors are key molecules in signal transmission, their alterations are associated with brain dysfunction. Relationships between receptors and their corresponding genes are poorly understood, especially in humans. We combined in vitro receptor autoradiography and RNA sequencing to quantify, in the same tissue samples (7 subjects), the densities of 14 receptors and expression levels of their corresponding 43 genes in the Cornu Ammonis (CA) and dentate gyrus (DG) of human hippocampus. Significant differences in receptor densities between both structures were found only for metabotropic receptors, whereas significant differences in RNA expression levels mostly pertained ionotropic receptors. Receptor fingerprints of CA and DG differ in shapes but have similar sizes; the opposite holds true for their "RNA fingerprints", which represent the expression levels of multiple genes in a single area. In addition, the correlation coefficients between receptor densities and corresponding gene expression levels vary widely and the mean correlation strength was weak-to-moderate. Our results suggest that receptor densities are not only controlled by corresponding RNA expression levels, but also by multiple regionally specific post-translational factors.
MeSH term(s)	Humans ; Hippocampus/physiology ; Receptors, Neurotransmitter/genetics ; Receptors, Neurotransmitter/metabolism ; RNA/metabolism ; Autoradiography
Chemical Substances	Receptors, Neurotransmitter ; RNA (63231-63-0)
Language	English
Publishing date	2023-04-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2023.120095
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