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  1. Book: Infectious disease and parasites

    Hofman, Paul

    (Encyclopedia of pathology)

    2016  

    Author's details Paul Hofman editor
    Series title Encyclopedia of pathology
    Keywords Adenovirus ; Human Immunodeficiency Virus ; Malaria ; Toxoplasmosis ; Viral Infections
    Language English
    Size xix, 343 Seiten, Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT019027151
    ISBN 978-3-319-30008-5 ; 9783319300092 ; 3-319-30008-3 ; 3319300091
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2016 A 1649 available for loan (reading room) Lesesaal EG

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  2. Article: Matched tissue and liquid biopsies for advanced non-small cell lung cancer patients A potentially indispensable complementary approach.

    Hofman, Paul

    Translational oncology

    2023  Volume 35, Page(s) 101735

    Abstract: The introduction of liquid biopsies (LB) has brought forth a number of therapeutic opportunities into the domain of thoracic oncology. Many of which have been adopted for care of patients presenting with advanced non-squamous non-small cell lung cancer ( ... ...

    Abstract The introduction of liquid biopsies (LB) has brought forth a number of therapeutic opportunities into the domain of thoracic oncology. Many of which have been adopted for care of patients presenting with advanced non-squamous non-small cell lung cancer (aNS-NSCLC). For example, one of the most frequent indications to perform a LB in these patients, at least in Europe, is for patients treated with tyrosine kinase inhibitors (TKIs) targeting EGFR and ALK genomic alterations when the tumor progresses. A tissue biopsy (TB) must then be taken, ideally from a site of a tumor that progresses, in particular if the LB does not permit detection of a mechanism of resistance to TKI. A LB from a patient with aNS-NSCLC is recommended before first-line therapy if no tissue and/or cytological material is accessible or if the extracted nucleic acid is insufficient in amount and/or of poor quality. At present a LB and a TB are rarely performed simultaneously before treatment and/or on tumor progression. This complementary/matched testing approach is still controversial but needs to be better evaluated to determine the true benefit to care of patients. This review provides an update on the complementarity of the LB and TB method for care of patients presenting with aNS-NSCLC.
    Language English
    Publishing date 2023-07-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2443840-6
    ISSN 1936-5233
    ISSN 1936-5233
    DOI 10.1016/j.tranon.2023.101735
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: Towards New Promising Discoveries for Lung Cancer Patients: A Selection of Papers from the First Joint Meeting on Lung Cancer of the FHU OncoAge (Nice, France) and the MD Anderson Cancer Center (Houston, TX, USA)

    Calin, George / Hofman, Paul / Mani, Sendurai

    2019  

    Abstract: This Special Issue of Cancers (Basel) is mainly dedicated to selecting papers from the talks given during the first Joint Meeting on Lung Cancer (JMLC) between the MD Anderson Cancer Center (Houston, Texas USA) and the Hospital University Federation (HUF) ...

    Abstract This Special Issue of Cancers (Basel) is mainly dedicated to selecting papers from the talks given during the first Joint Meeting on Lung Cancer (JMLC) between the MD Anderson Cancer Center (Houston, Texas USA) and the Hospital University Federation (HUF) OncoAge (University Côte d'Azur, Nice, France) (Nice, September 2018). The central theme of JMLC is to discuss new advances and exchange ideas regarding lung cancer. Notably, the talks covered different topics on new therapeutic strategies (targeted therapy and immuno-oncology), molecular and cellular biology, biomarkers, and the epidemiology of lung cancer. Special attention was also given to lung cancer in elderly patients. The articles published in this Special Issue covered subjects such as the assessment of new biomarkers and new approaches for the early detection of lung cancer, epidemiological data, and emphasized a place for the newly characterized cellular pathways in lung cancer, which opens room for therapeutic perspectives for lung cancer patients
    Keywords Medicine (General) ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens
    Size 1 electronic resource (230 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online
    Note eng ; Open Access
    HBZ-ID HT020323970
    ISBN 9783039214518 ; 9783039214525 ; 3039214519 ; 3039214527
    DOI 10.3390/books978-3-03921-452-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article: Next-Generation Sequencing with Liquid Biopsies from Treatment-Naïve Non-Small Cell Lung Carcinoma Patients.

    Hofman, Paul

    Cancers

    2021  Volume 13, Issue 9

    Abstract: Recently, the liquid biopsy (LB), a non-invasive and easy to repeat approach, has started to compete with the tissue biopsy (TB) for detection of targets for administration of therapeutic strategies for patients with advanced stages of lung cancer at ... ...

    Abstract Recently, the liquid biopsy (LB), a non-invasive and easy to repeat approach, has started to compete with the tissue biopsy (TB) for detection of targets for administration of therapeutic strategies for patients with advanced stages of lung cancer at tumor progression. A LB at diagnosis of late stage non-small cell lung carcinoma (NSCLC) is also being performed. It may be asked if a LB can be complementary (according to the clinical presentation or systematics) or even an alternative to a TB for treatment-naïve advanced NSCLC patients. Nucleic acid analysis with a TB by next-generation sequencing (NGS) is gradually replacing targeted sequencing methods for assessment of genomic alterations in lung cancer patients with tumor progression, but also at baseline. However, LB is still not often used in daily practice for NGS. This review addresses different aspects relating to the use of LB for NGS at diagnosis in advanced NSCLC, including its advantages and limitations.
    Language English
    Publishing date 2021-04-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13092049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Gestion des échantillons dans les laboratoires de pathologie et les biobanques au cours de la pandémie liée à la Covid-19.

    Hofman, Paul

    Revue francophone des laboratoires : RFL

    2021  Volume 2021, Issue 528, Page(s) 36–42

    Abstract: The Covid-19 pandemic dramatically disrupted the functionning and the organization of hospitals, notably the clinical departments and the biology laboratories. Moreover, this pandemic led to sudden impact in the management of tissue and cytological ... ...

    Title translation Management of samples in pathology laboratories and biobanks during the Covid-19 pandemic.
    Abstract The Covid-19 pandemic dramatically disrupted the functionning and the organization of hospitals, notably the clinical departments and the biology laboratories. Moreover, this pandemic led to sudden impact in the management of tissue and cytological samples by pathology laboratories and biobanks. The consequences concerned the urgent mandatory setting up of sanitary measures adapted to these laboratories. Another consequence was to note a strong decrease of the different activities in pathology laboratories and biobanks. So, in this context, the health workers in pathology laboratories and biobanks had to organize their laboratories according to the international guidelines for sanitary measures, aiming to keep going to take care of clinical and molecular diagnoses too. This review adresses the main consequences induced by the Covid-19 pandemic in pathology laboratories and in biobanks and some of the different actions took by these laboratories in order to maintain their activity during this crisis period.
    Language French
    Publishing date 2021-01-07
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 2222772-6
    ISSN 1773-0368 ; 1773-035X
    ISSN (online) 1773-0368
    ISSN 1773-035X
    DOI 10.1016/S1773-035X(20)30392-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: EGFR

    Hofman, Paul

    Cells

    2021  Volume 10, Issue 8

    Abstract: The recent emergence of novel neoadjuvant and/or adjuvant therapies for early stage (I-IIIA) non-small cell lung carcinoma (NSCLC), mainly tyrosine kinase inhibitors (TKIs) ... ...

    Abstract The recent emergence of novel neoadjuvant and/or adjuvant therapies for early stage (I-IIIA) non-small cell lung carcinoma (NSCLC), mainly tyrosine kinase inhibitors (TKIs) targeting
    MeSH term(s) Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/pathology ; ErbB Receptors/metabolism ; Humans ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Mutation/genetics ; Pathologists/standards
    Chemical Substances ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2021-08-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10082157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Detecting Resistance to Therapeutic ALK Inhibitors in Tumor Tissue and Liquid Biopsy Markers: An Update to a Clinical Routine Practice.

    Hofman, Paul

    Cells

    2021  Volume 10, Issue 1

    Abstract: The survival of most patients with advanced stage non-small cell lung cancer is prolonged by several months when they are treated with first- and next-generation inhibitors ... ...

    Abstract The survival of most patients with advanced stage non-small cell lung cancer is prolonged by several months when they are treated with first- and next-generation inhibitors targeting
    MeSH term(s) Anaplastic Lymphoma Kinase/antagonists & inhibitors ; Anaplastic Lymphoma Kinase/genetics ; Antineoplastic Agents/pharmacology ; Binding Sites ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/enzymology ; Carcinoma, Non-Small-Cell Lung/pathology ; Disease Progression ; Drug Resistance, Neoplasm ; Epithelial-Mesenchymal Transition ; Gene Rearrangement ; Genomics ; Humans ; Liquid Biopsy ; Lung Neoplasms/drug therapy ; Lung Neoplasms/enzymology ; Lung Neoplasms/pathology ; Mutation ; Neoplastic Cells, Circulating/metabolism ; Protein Kinase Inhibitors/pharmacology ; Receptor Protein-Tyrosine Kinases/genetics
    Chemical Substances Antineoplastic Agents ; Protein Kinase Inhibitors ; ALK protein, human (EC 2.7.10.1) ; Anaplastic Lymphoma Kinase (EC 2.7.10.1) ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1)
    Language English
    Publishing date 2021-01-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10010168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The power of immunotherapy plus platinum-based chemotherapy for locally advanced or early stage non-small cell lung cancer.

    Hofman, Paul

    Annals of translational medicine

    2020  Volume 8, Issue 5, Page(s) 151

    Language English
    Publishing date 2020-04-03
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2020.01.91
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: New insights into the interaction of the immune system with non-small cell lung carcinomas.

    Hofman, Paul

    Translational lung cancer research

    2020  Volume 9, Issue 5, Page(s) 2199–2213

    Abstract: The basis of current and future lung cancer immunotherapy depends mainly on our knowledge of the molecular mechanisms of interactions between cancer and immune cells (ICs), as well as on interactions occurring between the different populations of intra- ... ...

    Abstract The basis of current and future lung cancer immunotherapy depends mainly on our knowledge of the molecular mechanisms of interactions between cancer and immune cells (ICs), as well as on interactions occurring between the different populations of intra-tumor ICs. These interactions are very complex, as virtually all immune cell types, including macrophages, neutrophils, mast cells, natural killer (NK) cells, dendritic cells and T and B lymphocytes can infiltrate lung cancer tissues at the same time. Moreover these interactions lead to progressive emergence of an imbalance in ICs. Initially ICs have an anti-tumor effect but then induce immune tolerance and eventually tumor progression and dissemination. All the cells of innate and adaptive intra-tumor immunity engage in this progressive phenotypic switch. A majority of non-small cell lung carcinoma (NSCLC) patients do not benefit from the expected positive responses associated with current immunotherapy. Thus, there is urgent need to better understand the different roles of the associated cancer ICs. This review summarizes some of the new insights into this domain, with particular focus on: the myeloid cell population associated with tumors, the tertiary lymphoid structures (TLSs), the role of the P2 purinergic receptors (P2R) and ATP, and the new concept of the "liquid microenvironment" implying blood circulating ICs.
    Language English
    Publishing date 2020-11-18
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2754335-3
    ISSN 2226-4477 ; 2218-6751
    ISSN (online) 2226-4477
    ISSN 2218-6751
    DOI 10.21037/tlcr-20-178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Challenges and issues surrounding the use for translational research of human samples obtained during the COVID-19 pandemic from lung cancer patients.

    Hofman, Paul

    Translational lung cancer research

    2020  Volume 9, Issue 4, Page(s) 1543–1553

    Abstract: In only a few weeks after the eruption of the pandemic caused by syndrome coronavirus 2 (SARS-CoV-2), the number of associated research projects worldwide increased dramatically. The continual and almost daily improvement in the information associated ... ...

    Abstract In only a few weeks after the eruption of the pandemic caused by syndrome coronavirus 2 (SARS-CoV-2), the number of associated research projects worldwide increased dramatically. The continual and almost daily improvement in the information associated with this viral infection has been spectacular, notably in the areas of epidemiology, pathophysiology and therapy. This knowledge but also the many uncertainties concerning coronavirus disease 2019 (COVID-19), in particular with respect to the level of contagiousness of different samples sent to pathology and biology laboratories, rapidly effected the collection for translational research projects, notably of samples from patients with thoracic cancers. However, it is still difficult to evaluate the current and the near impact of the COVID-19 pandemic on this domain. It is essential in this context to be reminded of good practice for the management of biological samples for research, notably concerning the biosafety and security procedures. Moreover, new recommendations concerning the traceability and use of human lung cancer samples from tissue and different biofluids may rapidly be issued in the near future. This review aims to discuss the new challenges and constraints encountered by pathologists, biobankers and researchers within the framework of collection and the use of samples from patients with lung cancer for research while taking into account the COVID-19 pandemic.
    Keywords covid19
    Language English
    Publishing date 2020-09-11
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2754335-3
    ISSN 2226-4477 ; 2218-6751
    ISSN (online) 2226-4477
    ISSN 2218-6751
    DOI 10.21037/tlcr-20-594
    Database MEDical Literature Analysis and Retrieval System OnLINE

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