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  1. Book ; Thesis: Implementierung von Biomarkern und genomischen Signaturen zur Bestimmung des frühen Therapieansprechens und zur verbesserten Therapieentscheidung beim frühen Hormonrezeptor-positiven, HER2-negativen Mammakarzinom

    Hofmann, Daniel

    die ADAPT Studie als Vorreiter

    2014  

    Author's details vorgelegt von Daniel Hofmann
    Language German ; English
    Size VIII Bl., 72 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Köln, Univ., Diss., 2014
    Note Enth. Sonderabdr. aus Zeitschr. in engl. Sprache
    HBZ-ID HT018557102
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 D 187 order for loan Magazin

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  2. Book: Gentechnologie

    Hofmann, Daniel

    (NZZ-Fokus ; 3)

    1997  

    Institution Neue Zürcher Zeitung AG
    Author's details Neue Zürcher Zeitung. [Verantwortl. für dieses Dossier: Daniel Hofmann ...]
    Series title NZZ-Fokus ; 3
    Collection
    Keywords Ethics, Medical ; Genetic Engineering
    Language German
    Size 94 S.
    Publishing place Zürich
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT008723088
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1998 A 5206 order for loan Magazin

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  3. Article: Use of the Gene Expression Test Prosigna

    Ziegler, Cordula / Sotlar, Karl / Hofmann, Daniel Maria / Kolben, Thomas / Harbeck, Nadia / Wuerstlein, Rachel

    Breast care (Basel, Switzerland)

    2023  Volume 19, Issue 1, Page(s) 34–42

    Abstract: Introduction: In hormone receptor-positive (ER+/PR+) and human epidermal growth factor receptor 2-negative (HER2-) early-stage breast cancer (EBC), gene expression tests such as the Prosigna are increasingly used since classic clinicopathological ... ...

    Abstract Introduction: In hormone receptor-positive (ER+/PR+) and human epidermal growth factor receptor 2-negative (HER2-) early-stage breast cancer (EBC), gene expression tests such as the Prosigna are increasingly used since classic clinicopathological parameters and the proliferation factor Ki-67 often do not allow a definite therapy decision regarding an adjuvant chemotherapy. While the Prosigna test has been validated for postmenopausal patients, few data are available regarding its use in premenopausal patients. The present study compared the Prosigna test with the Ki-67 index in premenopausal patients.
    Materials and methods: Premenopausal patients with HR+ HER2-, pN0-1, G1-2 EBC were retrospectively enrolled (
    Results: According to Ki-67, patients were in the low (LR)-, intermediate (IR)-, and high-risk (HR) groups in 40%, 36%, and 24% of the cases. The Prosigna gene signature assay assessed the risk of recurrence as LR for 45% of the patients, IR for 35%, and HR for 20%. The most frequent intrinsic subtypes were luminal A in 73% and luminal B in 24% of the patients. A moderate correlation was found between Prosigna and Ki-67 scores with a Pearson correlation coefficient of 0.51. In the overall cohort, 47% of the Ki-67-based therapy decision would correspond to those based on the Prosigna score. After exclusion of IR patients, matching of low/low or high/high results was observed in 57% of the cases.
    Conclusion: According to the present study, there is only limited concordance regarding the risk group stratification between Ki-67 and Prosigna-based risk assessment. The relevance and frequency of premenopausal breast cancer emphasizes the need for further evaluation of gene expression analyses in this setting and the correlation with classic clinicopathological parameters regarding therapy decision-making.
    Language English
    Publishing date 2023-10-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2202236-3
    ISSN 1661-3805 ; 1661-3791
    ISSN (online) 1661-3805
    ISSN 1661-3791
    DOI 10.1159/000534634
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6620: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Book: Einsatz drahtloser Kommunikationstechnologie zur wirtschaftlichen Zustandsüberwachung von Schiffsgetrieben

    Hofmann, Daniel

    Verbundprojekt: DriveCoM ; Abschlussbericht ; Berichtszeitraum: 01. April 2013 bis 31. März 2015

    2015  

    Title variant Abschlussbericht DriveCoM - SEnergy
    Author's details Autor: Daniel Hofmann
    Language German
    Size 48 S., Ill., graph. Darst.
    Publisher Hahn-Schickard-Gesellschaft für angewandte Forschung e.V
    Publishing place Villingen-Schweningen
    Document type Book
    Note Förderkennzeichen BMWi 03SX350C. - Verbund-Nr. 01102945. - Literaturverz. Bl. 48
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  5. Article ; Online: Still Standing Inside: A Local Idiom Related to Trauma among Namibian Speakers of Khoekhoegowab.

    Claudius, Milena / Shino, Elizabeth N / Job, Sylvanus / Hofmann, Daniel / Thalmayer, Amber Gayle

    International journal of environmental research and public health

    2022  Volume 19, Issue 21

    Abstract: Euro-centric psychiatric conceptualizations often ignore the interplay of local with universal factors in psychological suffering. Emic, locally focused perspectives can enrich etic knowledge to provide culturally sensitive care and to better elucidate ... ...

    Abstract Euro-centric psychiatric conceptualizations often ignore the interplay of local with universal factors in psychological suffering. Emic, locally focused perspectives can enrich etic knowledge to provide culturally sensitive care and to better elucidate the role of culture in mental illness. This study explored the idiom
    MeSH term(s) Humans ; Mental Disorders ; Anxiety ; Blacks ; Culturally Competent Care ; Language
    Language English
    Publishing date 2022-11-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph192114323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online ; Thesis: Drug delivery, entry and intracellular trafficking of polymeric nanoparticles

    Hofmann, Daniel

    2014  

    Author's details Daniel Hofmann
    Language English
    Size Online-Ressource
    Publisher Universitätsbibliothek Mainz
    Publishing place Mainz
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Mainz, Univ., Diss., 2014
    Database Former special subject collection: coastal and deep sea fishing

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    Inter-library loan at ZB MED

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  7. Book ; Online ; Thesis: Simulationsgestützte Auslegung von Ordnungsschikanen in Vibrationswendelförderern

    Hofmann, Daniel

    2014  

    Author's details Daniel Hofmann
    Language German
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Techn. Univ., Diss.--München, 2014
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Book ; Online ; Thesis: Simulationsgestützte Auslegung von Ordnungsschikanen in Vibrationswendelförderern

    Hofmann, Daniel

    2014  

    Author's details Daniel Hofmann
    Language German
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Techn. Univ., Diss.--München, 2014
    Database Former special subject collection: coastal and deep sea fishing

    Full text online

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  9. Article ; Online: Exploring Human Antimicrobial Antibody Responses on a Single B Cell Level.

    Hofmann, Daniel / Lai, Jonathan R

    Clinical and vaccine immunology : CVI

    2017  Volume 24, Issue 5

    Abstract: Analysis of monoclonal antibodies (MAbs) derived from single B cell cloning has been highly beneficial for antimicrobial immunotherapy, vaccine design, and advancing our understanding of pathogen-triggered effects on the human immunoglobulin repertoire. ... ...

    Abstract Analysis of monoclonal antibodies (MAbs) derived from single B cell cloning has been highly beneficial for antimicrobial immunotherapy, vaccine design, and advancing our understanding of pathogen-triggered effects on the human immunoglobulin repertoire. Sequencing of variable domains of single B cells, and characterization of binding and functional activities of MAbs derived from those sequences, provides in-depth insight not only into sites of susceptibility for antibody-mediated neutralization or opsonization of the pathogen but also into the dynamics of protective antibody evolution during infection. This information can be utilized to rapidly develop novel immunotherapies of completely human origin and provides a roadmap for structure-based vaccine design that aims to elicit similar protective antibody responses. Here, we summarize recent aspects of the single B cell cloning approach.
    Language English
    Publishing date 2017-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2221082-9
    ISSN 1556-679X ; 1556-6811
    ISSN (online) 1556-679X
    ISSN 1556-6811
    DOI 10.1128/CVI.00544-16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4000: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Book ; Online ; Thesis: Verknüpfungsmodell zuverlässigkeitsrelevanter Informationen in der Produktentwicklung mechatronischer Systeme

    Hofmann, Daniel

    (Berichte aus dem Institut für Maschinenelemente, Antriebstechnik, CAD, Dichtungen, Zuverlässigkeit ; 143)

    2013  

    Title variant Connection model for reliability relevant information in product development of mechatronic systems
    Author's details Daniel Hofmann
    Series title Berichte aus dem Institut für Maschinenelemente, Antriebstechnik, CAD, Dichtungen, Zuverlässigkeit ; 143
    Language German
    Size Online-Ressource
    Publisher IMA
    Publishing place Stuttgart
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Stuttgart, 2013
    Database Former special subject collection: coastal and deep sea fishing

    Full text online

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