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  1. AU="Hofstaedter, Ferdinand"
  2. AU="Ross, Ashley E"
  3. AU="Luque Alarcón, Mónica"

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  1. Book ; Online ; Thesis: Der Proliferationsmarker KI67: Validität und Reliabilität der Messmethoden sowie Eignung als Prognosefaktor für Brustkrebspatienten

    Gleixner, Stefanie [Verfasser] / Hofstädter, Ferdinand [Akademischer Betreuer]

    2018  

    Author's details Stefanie Gleixner ; Betreuer: Ferdinand Hofstädter
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Regensburg
    Publishing place Regensburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Article: Aufgaben der Tumorzentren

    Hofstädter, Ferdinand

    Symposium medical

    2007  Volume 18, Issue 2, Page(s) 32

    Language German
    Document type Article
    ZDB-ID 1161444-4
    ISSN 0943-9250
    Database Current Contents Medicine

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    Zs.A 3374: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article: Qualitätssicherung im Querschnittsfach Pathologie

    Röcken, Christoph / Hofstädter, Ferdinand

    Forum

    2015  Volume 30, Issue 1, Page(s) 25

    Language German
    Document type Article
    ZDB-ID 1218650-8
    ISSN 0947-0255
    Database Current Contents Medicine

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    Zs.A 2355: Show issues Location:
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  4. Article ; Online: Der Beitrag Klinischer Krebsregister für die Nutzenbewertung - Anforderungen und erste Ergebnisse.

    Klinkhammer-Schalke, Monika / Hofstädter, Ferdinand / Gerken, Michael / Benz, Stefan

    Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen

    2016  Volume 112 Suppl 1, Page(s) S3–S10

    Abstract: Following the adoption of the Cancer Screening and Registry Act (KFRG) to advance the development of the early detection of cancer and to promote quality assurance through Clinical Cancer Registries according to Sect. 65c SGB V, the question is raised as ...

    Title translation The contribution of clinical cancer registries to benefit assessments: Requirements and first results.
    Abstract Following the adoption of the Cancer Screening and Registry Act (KFRG) to advance the development of the early detection of cancer and to promote quality assurance through Clinical Cancer Registries according to Sect. 65c SGB V, the question is raised as to what extent population-based clinical cancer registries may contribute not only to direct patient treatment benefits, but also to the requirements of health research and to other issues such as, for example, the evaluation of the benefit of new pharmaceutical products. Efforts to improve a nationwide quality management for oncology have so far not been successful in the development of comprehensive documentation at all levels of care. New organizational structures such as population-based clinical cancer registries were supposed to solve this problem more sufficiently, but they must be accompanied by valid trans-sectorial documentation and evaluation of clinical data. The need for specific real-life outcomes (effectiveness) of specific therapies has led to calls for data from outside randomised clinical trials (efficacy). First results are demonstrated in the present article.
    Language German
    Publishing date 2016
    Publishing country Netherlands
    Document type English Abstract ; Journal Article
    ZDB-ID 2412512-X
    ISSN 2212-0289 ; 1865-9217
    ISSN (online) 2212-0289
    ISSN 1865-9217
    DOI 10.1016/j.zefq.2016.04.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Conference proceedings: GMDS meets Neues Krebsregistergesetz

    Katalinic, Alexander / Hofstädter, Ferdinand

    2013  , Page(s) Abstr.K3

    Event/congress 58. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS); GMDS 2013; Lübeck; Deutsche Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie; 2013
    Keywords Medizin, Gesundheit
    Publishing date 2013-08-27
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/13gmds006
    Database German Medical Science

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  6. Conference proceedings: Die screening-relevante Altersgrenze von = 70 Jahren ist entscheidender für die Durchführung einer adjuvanten Therapie als die Tumorbiologie bei Patientinnen mit Mammakarzinom

    Inwald, Elisabeth C. / Klinkhammer-Schalke, Monika / Koller, Michael / Zeman, Florian / Hofstädter, Ferdinand / Ortmann, Olaf

    2017  , Page(s) V141

    Event/congress 16. Deutscher Kongress für Versorgungsforschung (DKVF); Berlin; Deutsches Netzwerk Versorgungsforschung; 2017
    Keywords Medizin, Gesundheit
    Publishing date 2017-09-26
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/17dkvf087
    Database German Medical Science

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  7. Article ; Online: Secondary sclerosing cholangitis.

    Ruemmele, Petra / Hofstaedter, Ferdinand / Gelbmann, Cornelia M

    Nature reviews. Gastroenterology & hepatology

    2009  Volume 6, Issue 5, Page(s) 287–295

    Abstract: Secondary sclerosing cholangitis (SSC) is a chronic cholestatic biliary disease, characterized by inflammation, obliterative fibrosis of the bile ducts, stricture formation and progressive destruction of the biliary tree that leads to biliary cirrhosis. ... ...

    Abstract Secondary sclerosing cholangitis (SSC) is a chronic cholestatic biliary disease, characterized by inflammation, obliterative fibrosis of the bile ducts, stricture formation and progressive destruction of the biliary tree that leads to biliary cirrhosis. SSC is thought to develop as a consequence of known injuries or secondary to pathological processes of the biliary tree. The most frequently described causes of SSC are longstanding biliary obstruction, surgical trauma to the bile duct and ischemic injury to the biliary tree in liver allografts. SSC may also follow intra-arterial chemotherapy. Sclerosing cholangitis in critically ill patients is a largely unrecognized new form of SSC, and is associated with rapid progression to liver cirrhosis. The mechanisms leading to cholangiopathy in critically ill patients are widely unknown; however, the available clinical data indicate that ischemic injury to the intrahepatic biliary tree may be one of the earliest events in the development of this severe form of sclerosing cholangitis. Therapeutic options for most forms of SSC are limited, and patients with SSC who do not undergo transplantation have significantly reduced survival compared with patients with primary sclerosing cholangitis. Sclerosing cholangitis in critically ill patients, in particular, is associated with rapid disease progression and poor outcome.
    MeSH term(s) Cholangitis, Sclerosing/diagnosis ; Cholangitis, Sclerosing/etiology ; Cholangitis, Sclerosing/therapy ; Humans ; Prognosis
    Language English
    Publishing date 2009-04-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2493722-8
    ISSN 1759-5053 ; 1759-5045
    ISSN (online) 1759-5053
    ISSN 1759-5045
    DOI 10.1038/nrgastro.2009.46
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 97: Show issues

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  8. Article ; Online: Epithelial-mesenchymal transformation markers E-cadherin and survivin predict progression of stage pTa urothelial bladder carcinoma.

    Breyer, Johannes / Gierth, Michael / Shalekenov, Sanzhar / Aziz, Atiqullah / Schäfer, Julius / Burger, Maximilian / Denzinger, Stefan / Hofstädter, Ferdinand / Giedl, Christian / Otto, Wolfgang

    World journal of urology

    2016  Volume 34, Issue 5, Page(s) 709–716

    Abstract: Purpose: To determine whether the immunohistochemical markers survivin and E-cadherin can predict progress at initially diagnosed Ta bladder cancer.: Methods: We retrospectively searched for every initially diagnosed pTa urothelial bladder carcinoma ... ...

    Abstract Purpose: To determine whether the immunohistochemical markers survivin and E-cadherin can predict progress at initially diagnosed Ta bladder cancer.
    Methods: We retrospectively searched for every initially diagnosed pTa urothelial bladder carcinoma having been treated at our single-center hospital in Germany from January 1992 up to December 2004. Follow-up was recorded up to June 2010, with recurrence or progress being the endpoints. Immunohistochemical staining and analysis of survivin and E-cadherin of the TURB specimens were performed. Outcome dependency of progression and no progression with immunohistochemical staining was analyzed using uni- and multivariate regression analysis, Kaplan-Meier analysis and uni- and multivariate Cox regression analysis.
    Results: Overall, 233 patients were included. Forty-two percent of those were tumor free in their follow-up TURBs, 46 % had at least one pTa recurrence and 12 % even showed progress to at least pT1 bladder cancer. Aberrant staining of E-cadherin was found within 71 % of patients with progression in contrast to only 40 % in cases without progression (p = 0.004). Of all progressed patients, 92 % showed overexpression of survivin in their initial pTa specimen compared to 61 % without progression (p = 0.001). Kaplan-Meier analysis revealed aberrant E-cadherin staining to be associated with worse progression-free survival (PFS) (p = 0.005) as well as overexpression of survivin (p = 0.003). In multivariate Cox regression analysis, strong E-cadherin staining was an independent prognosticator for better PFS (p = 0.033) and multifocality (p = 0.046) and tumor size over 3 cm (p = 0.042) were prognosticators for worse PFS.
    Conclusion: Adding the immunohistochemical markers survivin and E-cadherin could help to identify patients at risk of developing a progressive disease in initial stage pTa bladder cancer.
    MeSH term(s) Aged ; Aged, 80 and over ; Cadherins/analysis ; Carcinoma, Transitional Cell/chemistry ; Carcinoma, Transitional Cell/pathology ; Disease Progression ; Epithelial-Mesenchymal Transition ; Female ; Humans ; Inhibitor of Apoptosis Proteins/analysis ; Male ; Middle Aged ; Neoplasm Staging ; Retrospective Studies ; Urinary Bladder Neoplasms/chemistry ; Urinary Bladder Neoplasms/pathology
    Chemical Substances BIRC5 protein, human ; CDH1 protein, human ; Cadherins ; Inhibitor of Apoptosis Proteins
    Language English
    Publishing date 2016-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 380333-8
    ISSN 1433-8726 ; 0724-4983
    ISSN (online) 1433-8726
    ISSN 0724-4983
    DOI 10.1007/s00345-015-1690-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1832: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Article ; Online: Expression of aquaporin water channels in human urothelial carcinoma: correlation of AQP3 expression with tumour grade and stage.

    Rubenwolf, Peter C / Otto, Wolfgang / Denzinger, Stefan / Hofstädter, Ferdinand / Wieland, Wolf / Georgopoulos, Nikolaos T

    World journal of urology

    2013  Volume 32, Issue 4, Page(s) 991–997

    Abstract: Purpose: To study the expression, localization and potential clinical significance of aquaporin water channels both in well-established urothelial cancer (UC) cell lines and in human bladder carcinoma specimens of different stages and grades and to ... ...

    Abstract Purpose: To study the expression, localization and potential clinical significance of aquaporin water channels both in well-established urothelial cancer (UC) cell lines and in human bladder carcinoma specimens of different stages and grades and to discuss the clinical relevance of the findings.
    Methods: AQP transcript and protein expression by RT4, RT112 and T24 UC cell lines was investigated using reverse transcriptase polymerase chain reaction and immunofluorescence labelling. Immunohistochemistry (IHC) was used to assess AQP protein expression in 94 UC specimens of various grades and stages.
    Results: AQP3 and 9 transcripts were expressed in low-grade RT4 and RT112, but not in high-grade T24 cells. By contrast, AQP4 mRNA was absent in RT4, but expressed by RT112 and T24. Transcripts for AQP7 and 11 were detected in all three UC cell lines. Immunofluorescence microscopy confirmed the expression of AQP3, 4 and 7 at the protein level. By IHC, AQP3 was shown to be intensely expressed by 86 %, 66 % and 33 % of specimens of stage pTa, pT1 and pT2 tumours, respectively (p < 0.001). Whereas 100 % of G1 tumours were positive, only 73 % and 55 % of G2 and G3 tumours were found to express AQP3 (p = 0.004).
    Conclusions: This is the first study to demonstrate that several AQPs are expressed in UC. Our results indicate that there is a correlation between AQP3 protein expression and tumour stage and grade, with AQP3 expression being reduced or lost in tumours of higher grade and stage. Taken together with the available evidence from other studies, we conclude that AQPs may play a role in the progression of UC and, in particular, that this could be of prognostic value.
    MeSH term(s) Aquaporin 3/genetics ; Aquaporin 3/metabolism ; Aquaporins/genetics ; Aquaporins/metabolism ; Biopsy ; Carcinoma, Transitional Cell/genetics ; Carcinoma, Transitional Cell/metabolism ; Carcinoma, Transitional Cell/pathology ; Cell Line, Tumor ; Disease Progression ; Gene Expression Regulation, Neoplastic ; Humans ; In Vitro Techniques ; Neoplasm Grading ; Neoplasm Staging ; Prognosis ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder Neoplasms/metabolism ; Urinary Bladder Neoplasms/pathology
    Chemical Substances AQP3 protein, human ; Aquaporins ; Aquaporin 3 (158801-98-0)
    Language English
    Publishing date 2013-09-11
    Publishing country Germany
    Document type Comparative Study ; Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 380333-8
    ISSN 1433-8726 ; 0724-4983
    ISSN (online) 1433-8726
    ISSN 0724-4983
    DOI 10.1007/s00345-013-1153-9
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  10. Article ; Online: Male infertility: assessment of juvenile testicular dysfunction and risk for malignancy in cryptorchid boys based on resin section evaluation.

    Schroeder, Josef A / Siegmund, Heiko I / Roesch, Wolfgang / Hadziselimovic, Faruk / Hofstaedter, Ferdinand

    Ultrastructural pathology

    2013  Volume 37, Issue 5, Page(s) 373–377

    Abstract: Infertility is sometimes more a man's problem than a woman's, failure of one or both of the testes to descend (cryptorchidism) being the most frequent genital malformation in boys. Untreated, the undescended testis impairs germ cell development and ... ...

    Abstract Infertility is sometimes more a man's problem than a woman's, failure of one or both of the testes to descend (cryptorchidism) being the most frequent genital malformation in boys. Untreated, the undescended testis impairs germ cell development and significantly reduces adult fertility. A-dark spermatogonia are the stem cells for all future spermatozoa, and their depletion can be reliably estimated in resin semithin sections. Additionally, there is an increased risk of testicular preneoplasia in the form of carcinoma in situ (CIS) cells. The authors report how the pathologic biopsy examination of juvenile cryptorchid testes can assess infertility and malignancy risk.
    MeSH term(s) Age Factors ; Biopsy ; Carcinoma in Situ/etiology ; Carcinoma in Situ/ultrastructure ; Case-Control Studies ; Child ; Child, Preschool ; Cryptorchidism/complications ; Cryptorchidism/pathology ; Epoxy Resins ; Humans ; Infertility, Male/etiology ; Infertility, Male/pathology ; Male ; Microscopy, Electron ; Neoplasms, Germ Cell and Embryonal/etiology ; Neoplasms, Germ Cell and Embryonal/ultrastructure ; Risk Factors ; Spermatogonia/ultrastructure ; Testicular Neoplasms/etiology ; Testicular Neoplasms/ultrastructure ; Testis/ultrastructure
    Chemical Substances Epoxy Resins ; EPON (67076-53-3)
    Language English
    Publishing date 2013-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 603269-2
    ISSN 1521-0758 ; 0191-3123
    ISSN (online) 1521-0758
    ISSN 0191-3123
    DOI 10.3109/01913123.2013.818603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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