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  1. Article: Mnemonic utilization in stroke education: FAST and BEFAST adoption by certified comprehensive stroke centers.

    Hogge, Christopher / Goldstein, Larry B / Aroor, Sushanth R

    Frontiers in neurology

    2024  Volume 15, Page(s) 1359131

    Abstract: Introduction: Symptom recognition and timely access to treatment are critical components of acute stroke care systems. Two mnemonics widely used in public educational campaigns for recognizing stroke symptoms include FAST (Face-Arm-Speech-Time) and ... ...

    Abstract Introduction: Symptom recognition and timely access to treatment are critical components of acute stroke care systems. Two mnemonics widely used in public educational campaigns for recognizing stroke symptoms include FAST (Face-Arm-Speech-Time) and BEFAST (Balance-Eyes-Face-Arm Speech-Time). The FAST mnemonic can miss up to 14% of strokes. BEFAST includes common posterior circulation stroke symptoms and has been implemented by several Comprehensive Stroke Centers (CSCs).
    Methods: We sought to analyze the pattern of public educational materials available on the websites of US CSCs. The Joint Commission (JC) quality check website compiles a list containing the names and locations of the country's 217 JC-certified CSCs, which was downloaded in August, 2022. Each CSC's website was searched for educational material containing FAST and BEFAST mnemonics for stroke symptom recognition.
    Results: The FAST mnemonic was listed by 35% of CSCs, the BEFAST by 58%, with 7% listing no specific mnemonic. The highest portion of CSCs using BEFAST was in western (65%) and southeastern (63%) states. The highest percentage of CSCs with no listed mnemonic were in the northeastern (14%) and southeastern (13%) states.
    Conclusion: Consistency is critical in shaping public health education related to stroke symptoms recognition. Our study suggests further effort is needed to unify the public messaging on stroke recognition.
    Language English
    Publishing date 2024-03-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2024.1359131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Capnocytophaga

    Hogge, Christopher / Holzman, Miriam / Khurana, Sahiba / Brankovic, Milos / Chang, Chrystal / Fernandez, Gabriel / Finkel, Diana

    IDCases

    2022  Volume 29, Page(s) e01505

    Abstract: We present a case of polymicrobial sepsis ... ...

    Abstract We present a case of polymicrobial sepsis with
    Language English
    Publishing date 2022-05-27
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2022.e01505
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: T

    Helmold Hait, Sabrina / Hogge, Christopher James / Rahman, Mohammad Arif / Hunegnaw, Ruth / Mushtaq, Zuena / Hoang, Tanya / Robert-Guroff, Marjorie

    Frontiers in immunology

    2021  Volume 11, Page(s) 608003

    Abstract: T follicular helper ( ... ...

    Abstract T follicular helper (T
    MeSH term(s) Animals ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; B-Lymphocytes/virology ; Cells, Cultured ; Coculture Techniques ; Female ; Immunity, Humoral ; Immunity, Mucosal ; Immunogenicity, Vaccine ; Immunologic Memory ; Macaca mulatta ; Membrane Glycoproteins/administration & dosage ; Membrane Glycoproteins/immunology ; Rectum ; SAIDS Vaccines/administration & dosage ; SAIDS Vaccines/immunology ; Simian Immunodeficiency Virus/immunology ; T Follicular Helper Cells/immunology ; T Follicular Helper Cells/metabolism ; T Follicular Helper Cells/virology ; Vaccination ; Vagina ; Viral Envelope Proteins/administration & dosage ; Viral Envelope Proteins/immunology
    Chemical Substances Membrane Glycoproteins ; SAIDS Vaccines ; Viral Envelope Proteins ; gp120 protein, Simian immunodeficiency virus
    Language English
    Publishing date 2021-01-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.608003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: E4orf1 Suppresses

    Sangare, Kotou / Helmold Hait, Sabrina / Moore, Madison / Hogge, Christopher / Hoang, Tanya / Rahman, Mohammad Arif / Venzon, David J / LaBranche, Celia / Montefiori, David / Robert-Guroff, Marjorie / Thomas, Michael A

    Vaccines

    2022  Volume 10, Issue 2

    Abstract: As demonstrated by the recent COVID pandemic, vaccines can reduce the burden arising from infectious agents. Adenoviruses (Ads) with deletion of the early region 1B55K (ΔE1B Ad) are currently being explored for use in vaccine delivery. ... ...

    Abstract As demonstrated by the recent COVID pandemic, vaccines can reduce the burden arising from infectious agents. Adenoviruses (Ads) with deletion of the early region 1B55K (ΔE1B Ad) are currently being explored for use in vaccine delivery. Δ
    Language English
    Publishing date 2022-02-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines10020295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A Mucosal Adenovirus Prime/Systemic Envelope Boost Vaccine Regimen Elicits Responses in Cervicovaginal and Alveolar Macrophages of Rhesus Macaques Associated With Delayed SIV Acquisition and B Cell Help.

    Hunegnaw, Ruth / Helmold Hait, Sabrina / Enyindah-Asonye, Gospel / Rahman, Mohammad Arif / Ko, Eun-Ju / Hogge, Christopher J / Hoang, Tanya / Robert-Guroff, Marjorie

    Frontiers in immunology

    2020  Volume 11, Page(s) 571804

    Abstract: Vaccine strategies targeting the mucosal portal of entry may prevent HIV acquisition and systemic infection. Macrophages in cervicovaginal compartments are one of the first cell types to encounter virus upon vaginal exposure. Their activation can lead to ...

    Abstract Vaccine strategies targeting the mucosal portal of entry may prevent HIV acquisition and systemic infection. Macrophages in cervicovaginal compartments are one of the first cell types to encounter virus upon vaginal exposure. Their activation can lead to recruitment of additional macrophages and CD4
    MeSH term(s) AIDS Vaccines/immunology ; Adenoviridae/genetics ; Animals ; Antibodies, Viral/metabolism ; B-Lymphocytes/immunology ; Cervix Uteri/immunology ; Cytokines/metabolism ; Disease Resistance ; Female ; HIV Infections/immunology ; HIV-1/physiology ; Humans ; Immunization, Secondary ; Macaca mulatta ; Macrophages, Alveolar/immunology ; Membrane Glycoproteins/immunology ; Mucous Membrane/immunology ; SAIDS Vaccines/immunology ; Simian Acquired Immunodeficiency Syndrome/immunology ; Simian Immunodeficiency Virus/physiology ; Vaccines, Synthetic ; Vagina/immunology ; Viral Envelope Proteins/immunology
    Chemical Substances AIDS Vaccines ; Antibodies, Viral ; Cytokines ; Membrane Glycoproteins ; SAIDS Vaccines ; Vaccines, Synthetic ; Viral Envelope Proteins ; gp120 protein, Simian immunodeficiency virus
    Language English
    Publishing date 2020-09-30
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.571804
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Overexpression of CD6 and PD-1 Identifies Dysfunctional CD8

    Enyindah-Asonye, Gospel / Nwankwo, Anthony / Rahman, Mohammad Arif / Hunegnaw, Ruth / Hogge, Christopher / Helmold Hait, Sabrina / Ko, Eun-Ju / Hoang, Tanya / Robert-Guroff, Marjorie

    Frontiers in immunology

    2020  Volume 10, Page(s) 3005

    Abstract: Effective ... ...

    Abstract Effective CD8
    MeSH term(s) Animals ; Antigens, CD/genetics ; Antigens, CD/metabolism ; Antigens, Differentiation, T-Lymphocyte/genetics ; Antigens, Differentiation, T-Lymphocyte/metabolism ; Biomarkers ; CD4 Lymphocyte Count ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Cytokines/metabolism ; Disease Progression ; Female ; Gene Expression ; Immunophenotyping ; Macaca mulatta ; Major Histocompatibility Complex/genetics ; Male ; Programmed Cell Death 1 Receptor/genetics ; Programmed Cell Death 1 Receptor/metabolism ; Simian Acquired Immunodeficiency Syndrome/genetics ; Simian Acquired Immunodeficiency Syndrome/immunology ; Simian Acquired Immunodeficiency Syndrome/metabolism ; Simian Acquired Immunodeficiency Syndrome/virology ; Simian Immunodeficiency Virus ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; Viral Load
    Chemical Substances Antigens, CD ; Antigens, Differentiation, T-Lymphocyte ; Biomarkers ; CD6 antigen ; Cytokines ; PDCD1 protein, human ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2020-01-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.03005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Mucosal-associated invariant T (MAIT) cells provide B-cell help in vaccinated and subsequently SIV-infected Rhesus Macaques.

    Rahman, Mohammad Arif / Ko, Eun-Ju / Bhuyan, Farzana / Enyindah-Asonye, Gospel / Hunegnaw, Ruth / Helmold Hait, Sabrina / Hogge, Christopher James / Venzon, David J / Hoang, Tanya / Robert-Guroff, Marjorie

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 10060

    Abstract: Mucosal-associated invariant T (MAIT) cells help combat opportunistic infections. Thus, MAIT cells are of interest in HIV/SIV vaccination and infection. We investigated MAIT cell dynamics and function in rhesus macaque blood and bronchoalveolar lavage ( ... ...

    Abstract Mucosal-associated invariant T (MAIT) cells help combat opportunistic infections. Thus, MAIT cells are of interest in HIV/SIV vaccination and infection. We investigated MAIT cell dynamics and function in rhesus macaque blood and bronchoalveolar lavage (BAL) following mucosal adenovirus (Ad)-SIV recombinant priming, intramuscular SIV envelope boosting and infection following repeated low-dose intravaginal SIV exposures. Increased frequencies of blood MAIT cells over the course of vaccination were observed, which were maintained even 12-weeks post-SIV infection. BAL MAIT cells only increased after the first Ad immunization. Vaccination increased MAIT cell levels in blood and BAL expressing the antiviral cytokine IFN-γ and TNF-α and the proliferation marker Ki67. Upon T cell-specific α-CD3, α-CD28 stimulation, MAIT cells showed a greater capacity to secrete cytokines/chemokines associated with help for B cell activation, migration and regulation compared to CD3
    MeSH term(s) Animals ; B-Lymphocytes/metabolism ; Bronchoalveolar Lavage Fluid/immunology ; Female ; Interferon-gamma/metabolism ; Ki-67 Antigen/metabolism ; Longitudinal Studies ; Lymphocyte Activation ; Macaca mulatta ; Mucosal-Associated Invariant T Cells/metabolism ; Simian Acquired Immunodeficiency Syndrome/immunology ; Simian Acquired Immunodeficiency Syndrome/prevention & control ; Simian Immunodeficiency Virus/immunology ; Tumor Necrosis Factor-alpha/metabolism ; Vaccination/veterinary
    Chemical Substances Ki-67 Antigen ; Tumor Necrosis Factor-alpha ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2020-06-22
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-66964-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: An SAMT-247 Microbicide Provides Potent Protection against Intravaginal Simian Immunodeficiency Virus Infection of Rhesus Macaques, whereas an Added Vaccine Component Elicits Mixed Outcomes.

    Helmold Hait, Sabrina / Hogge, Christopher James / Rahman, Mohammad Arif / Ko, Eun-Ju / Hunegnaw, Ruth / Mushtaq, Zuena / Enyindah-Asonye, Gospel / Hoang, Tanya / Miller Jenkins, Lisa M / Appella, Ettore / Appella, Daniel H / Robert-Guroff, Marjorie

    Journal of immunology (Baltimore, Md. : 1950)

    2020  Volume 204, Issue 12, Page(s) 3315–3328

    Abstract: Because of microbicide noncompliance and lack of a durable, highly effective vaccine, a combined approach might improve HIV prophylaxis. We tested whether a vaccine-microbicide combination would enhance protection against SIV infection in rhesus macaques. ...

    Abstract Because of microbicide noncompliance and lack of a durable, highly effective vaccine, a combined approach might improve HIV prophylaxis. We tested whether a vaccine-microbicide combination would enhance protection against SIV infection in rhesus macaques. Four macaque groups included vaccine only, vaccine-microbicide, microbicide only, and controls. Vaccine groups were primed twice mucosally with replicating adenovirus type 5 host range mutant SIV env/rev, gag, and nef recombinants and boosted twice i.m. with SIV gp120 proteins in alum. Controls and the microbicide-only group received adenovirus type 5 host range mutant empty vector and alum. The microbicide was SAMT-247, a 2-mercaptobenzamide thioester that targets the viral nucleocapsid protein NCp7, causing zinc ejection and preventing RNA encapsidation. Following vaccination, macaques were challenged intravaginally with repeated weekly low doses of SIV
    MeSH term(s) Adenoviridae/immunology ; Adjuvants, Immunologic/pharmacology ; Animals ; Anti-Infective Agents/pharmacology ; Antibodies, Viral/immunology ; Benzamides/pharmacology ; Cells, Cultured ; Female ; Gene Products, gag/immunology ; Genetic Vectors/immunology ; Humans ; Immunity, Cellular/drug effects ; Immunity, Cellular/immunology ; Immunity, Humoral/drug effects ; Immunity, Humoral/immunology ; Macaca mulatta/immunology ; Macaca mulatta/virology ; Membrane Glycoproteins/immunology ; Pilot Projects ; SAIDS Vaccines/immunology ; Simian Acquired Immunodeficiency Syndrome/drug therapy ; Simian Acquired Immunodeficiency Syndrome/immunology ; Simian Acquired Immunodeficiency Syndrome/prevention & control ; Simian Acquired Immunodeficiency Syndrome/virology ; Simian Immunodeficiency Virus/drug effects ; Simian Immunodeficiency Virus/immunology ; Viral Envelope Proteins/immunology
    Chemical Substances Adjuvants, Immunologic ; Anti-Infective Agents ; Antibodies, Viral ; Benzamides ; Gene Products, gag ; Membrane Glycoproteins ; S-acyl-2-mercaptobenzamide thioester ; SAIDS Vaccines ; Viral Envelope Proteins ; gp120 protein, Simian immunodeficiency virus
    Language English
    Publishing date 2020-05-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2000165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A Pathogenic Role for Splenic B1 Cells in SIV Disease Progression in Rhesus Macaques.

    Enyindah-Asonye, Gospel / Nwankwo, Anthony / Hogge, Christopher / Rahman, Mohammad Arif / Helmold Hait, Sabrina / Hunegnaw, Ruth / Ko, Eun-Ju / Hoang, Tanya / Venzon, David J / Robert-Guroff, Marjorie

    Frontiers in immunology

    2019  Volume 10, Page(s) 511

    Abstract: B1 cells spontaneously produce protective natural antibodies which provide the first line of defense against a variety of pathogens. Although these natural antibodies share similar autoreactive features with several HIV-1 broadly neutralizing antibodies, ...

    Abstract B1 cells spontaneously produce protective natural antibodies which provide the first line of defense against a variety of pathogens. Although these natural antibodies share similar autoreactive features with several HIV-1 broadly neutralizing antibodies, the role of B1 cells in HIV/SIV disease progression is unknown. We report the presence of human-like B1 cells in rhesus macaques. During chronic SIV infection, we found that the frequency of splenic CD11b
    MeSH term(s) Animals ; B-Lymphocyte Subsets/immunology ; CD4-Positive T-Lymphocytes/immunology ; Disease Progression ; Female ; Macaca mulatta ; Simian Acquired Immunodeficiency Syndrome/immunology ; Simian Immunodeficiency Virus/immunology ; Spleen/immunology ; Viral Load/methods
    Language English
    Publishing date 2019-03-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.00511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Differential Effect of Mucosal NKp44

    Rahman, Mohammad Arif / Ko, Eun-Ju / Enyindah-Asonye, Gospel / Helmold Hait, Sabrina / Hogge, Christopher / Hunegnaw, Ruth / Venzon, David J / Hoang, Tanya / Robert-Guroff, Marjorie

    Journal of immunology (Baltimore, Md. : 1950)

    2019  Volume 203, Issue 9, Page(s) 2459–2471

    Abstract: NK cells are essential for controlling viral infections. We investigated NK cell and innate lymphoid cell (ILC) dynamics and function in rhesus macaque rectal tissue and blood following mucosal priming with replicating adenovirus (Ad)-SIV recombinants, ... ...

    Abstract NK cells are essential for controlling viral infections. We investigated NK cell and innate lymphoid cell (ILC) dynamics and function in rhesus macaque rectal tissue and blood following mucosal priming with replicating adenovirus (Ad)-SIV recombinants, systemic boosting with SIV envelope protein, and subsequent repeated low-dose intravaginal SIV exposures. Mucosal memory-like NK and ILC subsets in rectal and vaginal tissues of chronically infected macaques were also evaluated. No differences in NK cell or ILC frequencies or cytokine production were seen between vaccinated and Ad-empty/alum controls, suggesting responses were due to the Ad-vector and alum vaccine components. Mucosal NKp44
    MeSH term(s) Animals ; Antibody-Dependent Cell Cytotoxicity ; Female ; Immunity, Innate ; Immunity, Mucosal ; Killer Cells, Natural/immunology ; Lymphocyte Subsets/immunology ; Macaca mulatta ; Natural Cytotoxicity Triggering Receptor 2/analysis ; Rectum/immunology ; SAIDS Vaccines/immunology ; Simian Acquired Immunodeficiency Syndrome/immunology ; Vaccination ; Vagina/immunology
    Chemical Substances NCR2 protein, human ; Natural Cytotoxicity Triggering Receptor 2 ; SAIDS Vaccines
    Language English
    Publishing date 2019-09-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1900572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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