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  1. Article: Incomplete circle of Willis as a risk factor for intraoperative ischemic events during carotid endarterectomies performed under regional anesthesia - A prospective case-series.

    Gyöngyösi, Zoltán / Belán, Ivett / Nagy, Edit / Fülesdi, Zsófia / Farkas, Orsolya / Végh, Tamás / Hoksbergen, Arjan Willem / Fülesdi, Béla

    Translational neuroscience

    2023  Volume 14, Issue 1, Page(s) 20220293

    Abstract: Background: The role of the willisian collaterals during carotid endarterectomies (CEAs) is a debated issue. The aim of the present work was to test whether an incomplete or non-functional circle of Willis (CoW) is a risk factor for ischemic events ... ...

    Abstract Background: The role of the willisian collaterals during carotid endarterectomies (CEAs) is a debated issue. The aim of the present work was to test whether an incomplete or non-functional circle of Willis (CoW) is a risk factor for ischemic events during CEA.
    Patients and methods: CEAs were performed under local anesthesia. Patients were considered symptomatic (SY) if neurological signs appeared after the cross-clamping phase. In SY patients shunt insertion was performed. CoW on CT angiograms (CTa) were analyzed offline and categorized as non-functional (missing or hypoplastic collaterals) or functional collaterals by three neuroradiologists. Near-infrared spectroscopy (NIRS) was performed throughout the procedure.
    Results: Based on CTa, 67 incomplete circles were found, 54 were asymptomatic (ASY) and 13 were SY. No complete CoW was found among the SY patients. Significant differences could be detected between incomplete and complete circles between ASY and SY groups (Chi-square: 6.08;
    Conclusions: Collateral ability of the CoW may be a risk factor for ischemic events during CEAs. Further studies should delineate whether the preoperative assessment of collateral capacity may be useful in decision-making about shunt use during CEA.
    Language English
    Publishing date 2023-07-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2581219-1
    ISSN 2081-6936 ; 2081-3856
    ISSN (online) 2081-6936
    ISSN 2081-3856
    DOI 10.1515/tnsci-2022-0293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Assessment of malformations, variations and diameters of vessels forming the circle of Willis - An autopsy study in a non-cerebrovascular cohort.

    Orosz, László / Gyöngyösi, Zoltán / Susán, Zsolt / Siró, Péter / Hoksbergen, Arjan Willem / Csiba, László / Fülesdi, Béla

    Translational neuroscience

    2022  Volume 13, Issue 1, Page(s) 398–406

    Abstract: Background a purpose: The collateral capacity of the circle of Willis (CoW) may play an important role in the development of ischemic strokes. The occurrence of classical polygon shows wide geographical variations and morphological data on diameters of ... ...

    Abstract Background a purpose: The collateral capacity of the circle of Willis (CoW) may play an important role in the development of ischemic strokes. The occurrence of classical polygon shows wide geographical variations and morphological data on diameters of the Willisian collaterals are scarce. We aimed to assess CoW variations and vessel diameters in a Central European cohort.
    Subjects and methods: CoWs were removed during routine autopsy. The morphological pattern of the circles was recorded. The prepared circles were then put between two glass plates and tightly compressed. The length of the vessels and half of the circumference were measured under a light microscope enabling measurement with an approximation of 0.1 mm. Vessel diameters were calculated from vessel circumference.
    Results: A total of 110 circles were analysed. Incomplete circles (missing one or two segments of CoW) were found in 25 cases (22.7%). Any forms of anatomical variations were detected in 14 cases (12.7%). When applying the <1 mm diameter threshold for analysis, 36 anterior communicating arteries (32.7%), 53 right posterior communicating arteries (48.2%), 73 left posterior communicating arteries (66.4%) and 18 posterior communicating arteries (16.3%) on both the sides were considered hypoplastic.
    Conclusions: In patients without stroke in their history, complete CoW may be present in >60% of the cases. Our diameter data may serve as reference values for the Central-European population.
    Language English
    Publishing date 2022-11-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2581219-1
    ISSN 2081-6936 ; 2081-3856
    ISSN (online) 2081-6936
    ISSN 2081-3856
    DOI 10.1515/tnsci-2022-0253
    Database MEDical Literature Analysis and Retrieval System OnLINE

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