LIVIVO - Suchergebnisse -

Suchergebnis

Treffer 1 - 9 von insgesamt 9

Suchoptionen

Artikel ; Online: Klebsiella pneumoniae carbapenamases in Escherichia coli isolated from humans and livestock in rural south-western Uganda.

Tuhamize, Barbra / Asiimwe, Benon B / Kasaza, Kennedy / Sabiiti, Wilber / Holden, Mathew / Bazira, Joel

2023 Band 18, Heft 7, Seite(n) e0288243

Abstract: Background: The accumulation of resistance genes in Escherichia coli (E. coli) strains imposes limitations in the therapeutic options available for the treatment of infections caused by E.coli. Production of Klebsiella pneumoniae carbapenemase (KPC) by ... ...

Abstract	Background: The accumulation of resistance genes in Escherichia coli (E. coli) strains imposes limitations in the therapeutic options available for the treatment of infections caused by E.coli. Production of Klebsiella pneumoniae carbapenemase (KPC) by E. coli renders it resistant to broad-spectrum β-lactam antibiotics. Globally there is existing evidence of spread of carbapenem-resistant E. coli in both humans and livestock driven by acquisition of the several other carbapenemase genes. Overall, there is little information regarding the extent of KPC gene distribution in E. coli. We set out to determine the prevalence, and evaluate the phenotypic and genotypic patterns of KPC in E. coli isolated from humans and their livestock in rural south western Uganda. Methods: A laboratory-based, descriptive cross-sectional study was conducted involving 96 human and 96 livestock isolates collected from agro-pastoralist communities in Mbarara district in south western Uganda. Phenotypic and molecular methods (PCR) were used for presence and identification of KPC genes in the E. coli isolates. A chi-square test of independence was used to evaluate the differences in resistant patterns between carbapenems and isolates. Results: The overall prevalence of carbapenem resistance by disk diffusion susceptibility testing (DST) for both humans and livestock isolates were 41.7% (80/192). DST-based resistance was identical in both human and livestock isolates (41.7%). The prevalence of carbapenem resistance based on Modified Hodge Test (MHT) was 5% (2/40) and 10% (4/40) for humans and livestock isolates respectively. Both human and livestock isolates, 48.7% (95/192) had the KPC gene, higher than phenotypic expression; 41.7% (80/192). blaKPC gene prevalence was overall similar in human isolates (51%; 49/96) vs livestock isolates (47.9%; 46/96). Approximately, 19% (15/80) of the isolates were phenotypically resistant to carbapenems and over 70% (79/112) of the phenotypically sensitive strains harbored the blaKPC gene. Conclusion: Our results suggest that both human and livestock isolates of E. coli in our setting carry the blaKPC gene with a high percentage of strains not actively expressing the blaKPC gene. The finding of fewer isolates carrying the KPC gene than those phenotypically resistant to carbapenems suggests that other mechanisms are playing a role in this phenomenon, calling for further researcher into this phenomenon.
Mesh-Begriff(e)	Humans ; Animals ; Escherichia coli/metabolism ; Klebsiella pneumoniae ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Livestock/metabolism ; Cross-Sectional Studies ; Uganda/epidemiology ; Carbapenems/pharmacology ; Carbapenems/therapeutic use ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; beta-Lactamases/metabolism ; Microbial Sensitivity Tests
Chemische Substanzen	Anti-Bacterial Agents ; Carbapenems ; Bacterial Proteins ; beta-Lactamases (EC 3.5.2.6)
Sprache	Englisch
Erscheinungsdatum	2023-07-13
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0288243
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Über subito bestellen

Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Details ▾
- Kostenpflichtig bestellen

Artikel ; Online: Comparison of Horizontal

Mwakyoma, Adam A / Kidenya, Benson R / Minja, Caroline A / Mushi, Martha F / Sandeman, Alison / Sabiti, Wilber / Holden, Mathew T G / Mshana, Stephen E

Archives of molecular biology and genetics

2023 Band 2, Heft 1, Seite(n) 1–8

Abstract: Background: The dissemination of the extended spectrum β-lactamases (ESBL) producing : Methods: Horizontal : Results: Out of 50 ESBL producing : Conclusion: ESBL ... ...

Abstract	Background: The dissemination of the extended spectrum β-lactamases (ESBL) producing Methods: Horizontal Results: Out of 50 ESBL producing Conclusion: ESBL producing
Sprache	Englisch
Erscheinungsdatum	2023-08-01
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	2831-6754
ISSN (online)	2831-6754
DOI	10.33696/genetics.2.011
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Über subito bestellen

Fernleihe an ZB MED

Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Details ▾
- Kostenpflichtig bestellen

Artikel: Molecular Characterizations of the Coagulase-Negative

Phillip, Shukrani / Mushi, Martha F / Decano, Arun Gonzales / Seni, Jeremiah / Mmbaga, Blandina T / Kumburu, Happiness / Konje, Eveline T / Mwanga, Joseph R / Kidenya, Benson R / Msemwa, Betrand / Gillespie, Stephen / Maldonado-Barragan, Antonio / Sandeman, Alison / Sabiti, Wilber / Holden, Mathew T G / Mshana, Stephen E

Pathogens (Basel, Switzerland)

2023 Band 12, Heft 2

Abstract: Background: There is a growing body of evidence on the potential involvement of coagulase-negative Staphylococci (CoNS) in causing urinary tract infections (UTIs). The aim of this study was to delineate virulence potential, antimicrobial resistance ... ...

Abstract	Background: There is a growing body of evidence on the potential involvement of coagulase-negative Staphylococci (CoNS) in causing urinary tract infections (UTIs). The aim of this study was to delineate virulence potential, antimicrobial resistance genes, and sequence types of CoNS isolated from patients with UTI symptoms and pyuria in Tanzania. Methods: CoNS from patients with UTI symptoms and more than 125 leucocytes/μL were retrieved, subcultured, and whole-genome sequenced. Results: Out of 65 CoNS isolates, 8 species of CoNS were identified;
Sprache	Englisch
Erscheinungsdatum	2023-01-24
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens12020180
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Über subito bestellen

Details ▾
- Kostenpflichtig bestellen

Artikel ; Online: Urogenital pathogens in urine samples of clinically diagnosed urinary tract infected patients in Tanzania: A laboratory based cross-sectional study.

Msemwa, Betrand / Mushi, Martha F / Kidenya, Benson / Okamo, Bernard / Keenan, Katherine / Sabiiti, Wilber / Miyaye, Donald N / Konje, Eveline T / Silago, Vitus / Mirambo, Mariam M / Mwanga, Joseph R / Gillespie, Stephen / Maldonado-Barragan, Antonio / Sandeman, Alison / Holden, Mathew / Mshana, Stephen E

IJID regions

2022 Band 7, Seite(n) 170–175

Abstract: Background: Urogenital pathogens such as : Methods: A cross-sectional study was conducted involving 227 archived urine samples from clinically diagnosed UTI patients with positive leucocyte esterase but negative urine culture results. The urogenital ... ...

Abstract	Background: Urogenital pathogens such as Methods: A cross-sectional study was conducted involving 227 archived urine samples from clinically diagnosed UTI patients with positive leucocyte esterase but negative urine culture results. The urogenital pathogens were detected using pathogen specific singleplex PCR. Data were cleaned and analyzed using STATA version 15. Results: The median age of patients was 31[IQR 23 - 51] years and the majority (174, 76.7%) were females. Two thirds of patients had history of antibiotic use two weeks prior to recruitment (154, 67.8%). A total of 62(27.3%) urine samples were positive for at least one urogenital pathogen. Of 62 positive samples, 9 had two urogenital pathogens and 1 had three urogenital pathogens. The most predominant urogenital pathogen detected was Conclusion: More than a quarter of female patients with clinical symptoms of UTI and routine urine culture negative results were infected with urogenital pathogens mainly
Sprache	Englisch
Erscheinungsdatum	2022-12-27
Erscheinungsland	England
Dokumenttyp	Journal Article
ISSN	2772-7076
ISSN (online)	2772-7076
DOI	10.1016/j.ijregi.2022.12.007
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Über subito bestellen

Fernleihe an ZB MED

Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Details ▾
- Kostenpflichtig bestellen

Artikel ; Online: High rates of homologous recombination in the mite endosymbiont and opportunistic human pathogen Orientia tsutsugamushi.

Sonthayanon, Piengchan / Peacock, Sharon J / Chierakul, Wirongrong / Wuthiekanun, Vanaporn / Blacksell, Stuart D / Holden, Mathew T G / Bentley, Stephen D / Feil, Edward J / Day, Nicholas P J

PLoS neglected tropical diseases

2010 Band 4, Heft 7, Seite(n) e752

Abstract: Orientia tsutsugamushi is an intracellular alpha-proteobacterium which resides in trombiculid mites, and is the causative agent of scrub typhus in East Asia. The genome sequence of this species has revealed an unprecedented number of repeat sequences, ... ...

Abstract	Orientia tsutsugamushi is an intracellular alpha-proteobacterium which resides in trombiculid mites, and is the causative agent of scrub typhus in East Asia. The genome sequence of this species has revealed an unprecedented number of repeat sequences, most notably of the genes encoding the conjugative properties of a type IV secretion system (T4SS). Although this observation is consistent with frequent intragenomic recombination, the extent of homologous recombination (gene conversion) in this species is unknown. To address this question, and to provide a protocol for the epidemiological surveillance of this important pathogen, we have developed a multilocus sequence typing (MLST) scheme based on 7 housekeeping genes (gpsA, mdh, nrdB, nuoF, ppdK, sucD, sucB). We applied this scheme to the two published genomes, and to DNA extracted from blood taken from 84 Thai scrub typhus patients, from 20 cultured Thai patient isolates, 1 Australian patient sample, and from 3 cultured type strains. These data demonstrated that the O. tsutsugamushi population was both highly diverse [Simpson's index (95% CI) = 0.95 (0.92-0.98)], and highly recombinogenic. These results are surprising given the intracellular life-style of this species, but are broadly consistent with results obtained for Wolbachia, which is an alpha-proteobacterial reproductive parasite of arthropods. We also compared the MLST data with ompA sequence data and noted low levels of consistency and much higher discrimination by MLST. Finally, twenty-five percent of patients in this study were simultaneously infected with multiple sequence types, suggesting multiple infection caused by either multiple mite bites, or multiple strains co-existing within individual mites.
Mesh-Begriff(e)	Animals ; Bacterial Typing Techniques/methods ; DNA Fingerprinting/methods ; DNA, Bacterial/chemistry ; DNA, Bacterial/genetics ; Humans ; Mites/microbiology ; Orientia tsutsugamushi/genetics ; Orientia tsutsugamushi/isolation & purification ; Polymorphism, Genetic ; Recombination, Genetic ; Scrub Typhus/microbiology ; Sequence Analysis, DNA/methods
Chemische Substanzen	DNA, Bacterial
Sprache	Englisch
Erscheinungsdatum	2010-07-20
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2727
ISSN (online)	1935-2735
ISSN	1935-2727
DOI	10.1371/journal.pntd.0000752
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Über subito bestellen

Details ▾
- Kostenpflichtig bestellen

Artikel ; Online: Evolution and Global Transmission of a Multidrug-Resistant, Community-Associated Methicillin-Resistant Staphylococcus aureus Lineage from the Indian Subcontinent.

Steinig, Eike J / Duchene, Sebastian / Robinson, D Ashley / Monecke, Stefan / Yokoyama, Maho / Laabei, Maisem / Slickers, Peter / Andersson, Patiyan / Williamson, Deborah / Kearns, Angela / Goering, Richard V / Dickson, Elizabeth / Ehricht, Ralf / Ip, Margaret / O'Sullivan, Matthew V N / Coombs, Geoffrey W / Petersen, Andreas / Brennan, Grainne / Shore, Anna C /

Coleman, David C / Pantosti, Annalisa / de Lencastre, Herminia / Westh, Henrik / Kobayashi, Nobumichi / Heffernan, Helen / Strommenger, Birgit / Layer, Franziska / Weber, Stefan / Aamot, Hege Vangstein / Skakni, Leila / Peacock, Sharon J / Sarovich, Derek / Harris, Simon / Parkhill, Julian / Massey, Ruth C / Holden, Mathew T G / Bentley, Stephen D / Tong, Steven Y C

mBio

2019 Band 10, Heft 6

Abstract: The evolution and global transmission of antimicrobial resistance have been well documented for Gram-negative bacteria and health care-associated epidemic pathogens, often emerging from regions with heavy antimicrobial use. However, the degree to which ... ...

Abstract	The evolution and global transmission of antimicrobial resistance have been well documented for Gram-negative bacteria and health care-associated epidemic pathogens, often emerging from regions with heavy antimicrobial use. However, the degree to which similar processes occur with Gram-positive bacteria in the community setting is less well understood. In this study, we traced the recent origins and global spread of a multidrug-resistant, community-associated
Mesh-Begriff(e)	Anti-Bacterial Agents/pharmacology ; Asia/epidemiology ; Community-Acquired Infections/epidemiology ; Community-Acquired Infections/microbiology ; Community-Acquired Infections/transmission ; Drug Resistance, Multiple, Bacterial ; Evolution, Molecular ; Genome, Bacterial ; Humans ; India ; Methicillin-Resistant Staphylococcus aureus/classification ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Methicillin-Resistant Staphylococcus aureus/genetics ; Methicillin-Resistant Staphylococcus aureus/isolation & purification ; Phylogeny ; Staphylococcal Infections/epidemiology ; Staphylococcal Infections/microbiology ; Staphylococcal Infections/transmission ; Staphylococcus aureus/classification ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/genetics ; Staphylococcus aureus/isolation & purification
Chemische Substanzen	Anti-Bacterial Agents
Sprache	Englisch
Erscheinungsdatum	2019-11-26
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mBio.01105-19
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Über subito bestellen

Details ▾
- Kostenpflichtig bestellen

Artikel ; Online: Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles.

Nandi, Tannistha / Holden, Matthew T G / Holden, Mathew T G / Didelot, Xavier / Mehershahi, Kurosh / Boddey, Justin A / Beacham, Ifor / Peak, Ian / Harting, John / Baybayan, Primo / Guo, Yan / Wang, Susana / How, Lee Chee / Sim, Bernice / Essex-Lopresti, Angela / Sarkar-Tyson, Mitali / Nelson, Michelle / Smither, Sophie / Ong, Catherine /

Aw, Lay Tin / Hoon, Chua Hui / Michell, Stephen / Studholme, David J / Titball, Richard / Chen, Swaine L / Parkhill, Julian / Tan, Patrick

Genome research

2014 Band 25, Heft 1, Seite(n) 129–141

Abstract: Burkholderia pseudomallei (Bp) is the causative agent of the infectious disease melioidosis. To investigate population diversity, recombination, and horizontal gene transfer in closely related Bp isolates, we performed whole-genome sequencing (WGS) on ... ...

Abstract	Burkholderia pseudomallei (Bp) is the causative agent of the infectious disease melioidosis. To investigate population diversity, recombination, and horizontal gene transfer in closely related Bp isolates, we performed whole-genome sequencing (WGS) on 106 clinical, animal, and environmental strains from a restricted Asian locale. Whole-genome phylogenies resolved multiple genomic clades of Bp, largely congruent with multilocus sequence typing (MLST). We discovered widespread recombination in the Bp core genome, involving hundreds of regions associated with multiple haplotypes. Highly recombinant regions exhibited functional enrichments that may contribute to virulence. We observed clade-specific patterns of recombination and accessory gene exchange, and provide evidence that this is likely due to ongoing recombination between clade members. Reciprocally, interclade exchanges were rarely observed, suggesting mechanisms restricting gene flow between clades. Interrogation of accessory elements revealed that each clade harbored a distinct complement of restriction-modification (RM) systems, predicted to cause clade-specific patterns of DNA methylation. Using methylome sequencing, we confirmed that representative strains from separate clades indeed exhibit distinct methylation profiles. Finally, using an E. coli system, we demonstrate that Bp RM systems can inhibit uptake of non-self DNA. Our data suggest that RM systems borne on mobile elements, besides preventing foreign DNA invasion, may also contribute to limiting exchanges of genetic material between individuals of the same species. Genomic clades may thus represent functional units of genetic isolation in Bp, modulating intraspecies genetic diversity.
Mesh-Begriff(e)	Animals ; Burkholderia pseudomallei/genetics ; DNA Primers ; DNA, Bacterial/genetics ; Epigenesis, Genetic ; Escherichia coli/genetics ; Female ; Gene Deletion ; Genetic Association Studies ; Genome, Bacterial ; Genomics ; Haplotypes ; Humans ; Melioidosis/microbiology ; Mice ; Mice, Inbred BALB C ; Multilocus Sequence Typing ; Phylogeny ; Polymorphism, Single Nucleotide ; Recombination, Genetic ; Sequence Analysis, DNA ; Transcriptome
Chemische Substanzen	DNA Primers ; DNA, Bacterial
Sprache	Englisch
Erscheinungsdatum	2014-09-18
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1284872-4
ISSN	1549-5469 ; 1088-9051 ; 1054-9803
ISSN (online)	1549-5469
ISSN	1088-9051 ; 1054-9803
DOI	10.1101/gr.177543.114
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Verfügbar in ZB MED Köln/Königswinter

Zs.A 3729: Hefte anzeigen			Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 8: Hefte anzeigen

Über subito bestellen

Details ▾
- Im ZB MED-Bestand
- Kostenpflichtig bestellen

Artikel ; Online: Evolution and Global Transmission of a Multidrug-Resistant, Community-Associated Methicillin-Resistant Staphylococcus aureus Lineage from the Indian Subcontinent

Steinig, Eike J. / Duchene, Sebastian / Robinson, D. Ashley / Monecke, Stefan / Yokoyama, Maho / Laabei, Maisem / Slickers, Peter / Andersson, Patiyan / Williamson, Deborah / Kearns, Angela / Goering, Richard V. / Dickson, Elizabeth / Ehricht, Ralf / Ip, Margaret / O'Sullivan, Matthew V. N. / Coombs, Geoffrey W. / Petersen, Andreas / Brennan, Grainne / Shore, Anna C. /

Coleman, David C. / Pantosti, Annalisa / de Lencastre, Herminia / Westh, Henrik / Kobayashi, Nobumichi / Heffernan, Helen / Strommenger, Birgit / Layer, Franziska / Weber, Stefan / Vangstein Aamot, Hege / Skakni, Leila / Peacock, Sharon J. / Sarovich, Derek / Harris, Simon / Parkhill, Julian / Massey, Ruth C. / Holden, Mathew T. G. / Bentley, Stephen D. / Tong, Steven Y. C.

2019

Abstract	The evolution and global transmission of antimicrobial resistance have been well documented for Gram-negative bacteria and health care-associated epidemic pathogens, often emerging from regions with heavy antimicrobial use. However, the degree to which similar processes occur with Gram-positive bacteria in the community setting is less well understood. In this study, we traced the recent origins and global spread of a multidrug-resistant, community-associated Staphylococcus aureus lineage from the Indian subcontinent, the Bengal Bay clone (ST772). We generated whole-genome sequence data of 340 isolates from 14 countries, including the first isolates from Bangladesh and India, to reconstruct the evolutionary history and genomic epidemiology of the lineage. Our data show that the clone emerged on the Indian subcontinent in the early 1960s and disseminated rapidly in the 1990s. Short-term outbreaks in community and health care settings occurred following intercontinental transmission, typically associated with travel and family contacts on the subcontinent, but ongoing endemic transmission was uncommon. Acquisition of a multidrug resistance integrated plasmid was instrumental in the emergence of a single dominant and globally disseminated clade in the early 1990s. Phenotypic data on biofilm, growth, and toxicity point to antimicrobial resistance as the driving force in the evolution of ST772. The Bengal Bay clone therefore combines the multidrug resistance of traditional health care-associated clones with the epidemiological transmission of community-associated methicillin-resistant S. aureus (MRSA). Our study demonstrates the importance of whole-genome sequencing for tracking the evolution of emerging and resistant pathogens. It provides a critical framework for ongoing surveillance of the clone on the Indian subcontinent and elsewhere. IMPORTANCE The Bengal Bay clone (ST772) is a community-associated and multidrug-resistant Staphylococcus aureus lineage first isolated from Bangladesh and India in 2004. In this ...
Schlagwörter	antimicrobial resistance ; Bengal Bay ; CA-MRSA ; genomic epidemiology ; global transmission ; India ; phenotyping ; phylodynamics ; ST772 ; South Asia ; Sta ; WGS ; 610 Medizin und Gesundheit ; ddc:610
Thema/Rubrik (Code)	900
Sprache	Englisch
Erscheinungsdatum	2019-11-26
Verlag	Robert Koch-Institut
Erscheinungsland	de
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

Volltext online

Volltext online

Zusatzmaterialien

Fernleihe an ZB MED

Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Artikel: Complete sequence and organization of pBtoxis, the toxin-coding plasmid of Bacillus thuringiensis subsp. israelensis.

Berry, Colin / O'Neil, Susan / Ben-Dov, Eitan / Jones, Andrew F / Murphy, Lee / Quail, Michael A / Holden, Mathew T G / Harris, David / Zaritsky, Arieh / Parkhill, Julian

Applied and environmental microbiology

2002 Band 68, Heft 10, Seite(n) 5082–5095

Abstract: The entire 127,923-bp sequence of the toxin-encoding plasmid pBtoxis from Bacillus thuringiensis subsp. israelensis is presented and analyzed. In addition to the four known Cry and two known Cyt toxins, a third Cyt-type sequence was found with an ... ...

Abstract	The entire 127,923-bp sequence of the toxin-encoding plasmid pBtoxis from Bacillus thuringiensis subsp. israelensis is presented and analyzed. In addition to the four known Cry and two known Cyt toxins, a third Cyt-type sequence was found with an additional C-terminal domain previously unseen in such proteins. Many plasmid-encoded genes could be involved in several functions other than toxin production. The most striking of these are several genes potentially affecting host sporulation and germination and a set of genes for the production and export of a peptide antibiotic.
Mesh-Begriff(e)	Bacillus thuringiensis/genetics ; Bacterial Toxins/genetics ; DNA Replication ; DNA, Bacterial/analysis ; DNA, Bacterial/genetics ; DNA, Circular/genetics ; Genes ; Genes, Bacterial ; Genome, Bacterial ; Molecular Sequence Data ; Plasmids/genetics ; Virulence/genetics
Chemische Substanzen	Bacterial Toxins ; DNA, Bacterial ; DNA, Circular
Sprache	Englisch
Erscheinungsdatum	2002-01-29
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	223011-2
ISSN	1098-5336 ; 0099-2240
ISSN (online)	1098-5336
ISSN	0099-2240
DOI	10.1128/AEM.68.10.5082-5095.2002
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Verfügbar in ZB MED Köln/Königswinter

Zs.B 201: Hefte anzeigen

Standort:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Über subito bestellen

Details ▾
- Im ZB MED-Bestand
- Kostenpflichtig bestellen

Zum Seitenanfang

Ihre letzten Suchen

Zusatzmaterialien

Kategorien

Über subito bestellen

Zusatzmaterialien

Kategorien

Über subito bestellen

Fernleihe an ZB MED

Zusatzmaterialien

Kategorien

Über subito bestellen

Zusatzmaterialien

Kategorien

Über subito bestellen

Fernleihe an ZB MED

Zusatzmaterialien

Kategorien

Über subito bestellen

Zusatzmaterialien

Kategorien

Über subito bestellen

Zusatzmaterialien

Kategorien

Verfügbar in ZB MED Köln/Königswinter

Über subito bestellen

Volltext online

Zusatzmaterialien

Kategorien

Fernleihe an ZB MED

Zusatzmaterialien

Kategorien

Verfügbar in ZB MED Köln/Königswinter

Über subito bestellen