Article ; Online: Exclusively breastmilk-fed preterm infants are at high risk of developing subclinical vitamin K deficiency despite intramuscular prophylaxis at birth.
Journal of thrombosis and haemostasis : JTH
2022 Volume 20, Issue 12, Page(s) 2773–2785
Abstract: Background: There is near-global consensus that all newborns be given parenteral vitamin K: Objectives: To assess the prevalence of functional VK insufficiency in preterm infants based on elevated under-γ-carboxylated (Glu) species of Gla proteins, ... ...
| Abstract | Background: There is near-global consensus that all newborns be given parenteral vitamin K Objectives: To assess the prevalence of functional VK insufficiency in preterm infants based on elevated under-γ-carboxylated (Glu) species of Gla proteins, factor II (PIVKA-II), and osteocalcin (GluOC), synthesized by liver and bone, respectively. Patients/methods: Prospective, multicenter, observational study in preterm infants born <33 weeks' gestation. Blood samples and dietary history were collected before hospital discharge, and after discharge at 2-3 months' corrected age. Outcome measures were serum VK Results: After discharge, breastmilk-fed babies had significantly lower serum VK Conclusions: Preterm infants who remain exclusively or predominantly human breastmilk-fed after neonatal unit discharge are at high risk of developing subclinical VK deficiency in early infancy. Routine postdischarge VK |
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| MeSH term(s) | Infant ; Infant, Newborn ; Humans ; Milk, Human ; Infant, Premature ; Aftercare ; Prospective Studies ; Patient Discharge ; Vitamin K Deficiency/diagnosis ; Vitamin K Deficiency/epidemiology ; Vitamin K Deficiency/prevention & control ; Vitamin K 1 ; Hemorrhage ; Vitamin K |
| Chemical Substances | Vitamin K 1 (84-80-0) ; Vitamin K (12001-79-5) |
| Language | English |
| Publishing date | 2022-10-03 |
| Publishing country | England |
| Document type | Observational Study ; Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2112661-6 |
| ISSN | 1538-7836 ; 1538-7933 |
| ISSN (online) | 1538-7836 |
| ISSN | 1538-7933 |
| DOI | 10.1111/jth.15874 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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