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  1. Article ; Online: Development of a diagnostic support tool for predicting cervical arterial dissection in primary care.

    Thomas, Lucy Caroline / Holliday, Elizabeth / Attia, John R / Levi, Christopher

    The Journal of manual & manipulative therapy

    2023  Volume 32, Issue 2, Page(s) 173–181

    Abstract: Objectives: Cervical arterial dissection (CAD) is an important cause of stroke in young people which may be missed because early features may mimic migraine or a musculoskeletal presentation. The study aimed to develop a diagnostic support tool for ... ...

    Abstract Objectives: Cervical arterial dissection (CAD) is an important cause of stroke in young people which may be missed because early features may mimic migraine or a musculoskeletal presentation. The study aimed to develop a diagnostic support tool for early identification of CAD.
    Design: Retrospective observational study.
    Setting: Tertiary hospital.
    Participants: Radiologically confirmed CAD cases (
    Main outcome measures: The presence of CAD is confirmed with imaging. Predictive variables included risk factors and clinical characteristics of CAD. Variables with a p-value <0.2 included in a multivariable model. Predictive utility of the model is assessed by calculating area underthe ROC curve (AUC).
    Results: The model including four variables: age 40-55 years (vs < 40), trauma, recent onset headache, and > 2 neurological features, demonstrated excellent discrimination: AUC of 0.953 (95% CI: 0.916, 0.987). A predictive scoring system (total score/7) identified an optimal threshold of ≥ 3 points, with a sensitivity of 87% and specificity of 79%.
    Conclusions: The study identified a diagnostic support tool with four variables to predict increased risk of CAD. Validation in a clinical sample is needed to confirm variables and refine descriptors to enable clinicians to efficiently apply the tool.Optimum cutoff scores of ≥ 3/7 points will help identify those in whom CAD should be considered and further investigation instigated. The potential impact of the tool is to improve early recognition of CAD in those with acute headache or neck pain, thereby facilitating more timely medical intervention, preventing inappropriate treatment, and improving patient outcomes.Wordcount: 3195.
    MeSH term(s) Humans ; Adolescent ; Adult ; Middle Aged ; Vertebral Artery Dissection/diagnostic imaging ; Vertebral Artery Dissection/etiology ; Stroke/complications ; Risk Factors ; Headache/diagnosis ; Primary Health Care
    Language English
    Publishing date 2023-08-31
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 920432-5
    ISSN 2042-6186 ; 1066-9817
    ISSN (online) 2042-6186
    ISSN 1066-9817
    DOI 10.1080/10669817.2023.2250164
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Adapting clinical trials in health research: a guide for clinical researchers.

    Holliday, Elizabeth G / Weaver, Natasha / Barker, Daniel / Oldmeadow, Christopher

    The Medical journal of Australia

    2023  Volume 218, Issue 10, Page(s) 451–454

    MeSH term(s) Humans ; Biomedical Research ; Research Personnel ; Biostatistics ; Research Design
    Language English
    Publishing date 2023-05-01
    Publishing country Australia
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja2.51936
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Correction to: A proposal for capturing interaction and effect modification using DAGs.

    Attia, John / Holliday, Elizabeth / Oldmeadow, Christopher

    International journal of epidemiology

    2022  Volume 51, Issue 5, Page(s) 1702

    Language English
    Publishing date 2022-07-20
    Publishing country England
    Document type Published Erratum
    ZDB-ID 187909-1
    ISSN 1464-3685 ; 0300-5771
    ISSN (online) 1464-3685
    ISSN 0300-5771
    DOI 10.1093/ije/dyac153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A proposal for capturing interaction and effect modification using DAGs.

    Attia, John / Holliday, Elizabeth / Oldmeadow, Christopher

    International journal of epidemiology

    2022  Volume 51, Issue 4, Page(s) 1047–1053

    MeSH term(s) Causality ; Confounding Factors, Epidemiologic ; Humans
    Language English
    Publishing date 2022-06-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 187909-1
    ISSN 1464-3685 ; 0300-5771
    ISSN (online) 1464-3685
    ISSN 0300-5771
    DOI 10.1093/ije/dyac126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Maternal anemia and baby birth size mediate the association between short birth interval and under-five undernutrition in Ethiopia: a generalized structural equation modeling approach.

    Shifti, Desalegn Markos / Chojenta, Catherine / Holliday, Elizabeth G / Loxton, Deborah

    BMC pediatrics

    2022  Volume 22, Issue 1, Page(s) 108

    Abstract: Background: Studies assessing the association between short birth interval, a birth-to-birth interval of less than 33 months, and under-five undernutrition have produced inconclusive results. This study aimed to assess the relationship between short ... ...

    Abstract Background: Studies assessing the association between short birth interval, a birth-to-birth interval of less than 33 months, and under-five undernutrition have produced inconclusive results. This study aimed to assess the relationship between short birth interval and outcomes of stunting, underweight, and wasting among children aged under-five in Ethiopia, and potential mediation of any associations by maternal anemia and baby birth size.
    Method: Data from the 2016 Ethiopia Demographic and Health Survey (EDHS) was used. Stunting, wasting, and underweight among children aged under-five were outcome variables. Generalized Structural Equation Modeling (GSEM) was used to examine associations between short birth interval and outcomes, and to assess hypothesized mediation by maternal anemia and baby birth size.
    Results: Significant associations between short birth interval and stunting (AOR = 1.49; 95% CI = 1.35, 1.66) and underweight (AOR = 1.43; 95% CI = 1.28, 1.61) were found. There was no observed association between short birth interval and wasting (AOR = 1.05; 95% CI = 0.90, 1.23). Maternal anemia and baby birth size had a significant partial mediation effect on the association between short birth interval and stunting (the coefficient reduced from β = 0.337, p < 0.001 to β = 0.286, p < 0.001) and underweight (the coefficient reduced from β = 0.449, p < 0.001 to β = 0.338, p < 0.001). Maternal anemia and baby birth size mediated 4.2% and 4.6% of the total effect of short birth interval on stunting and underweight, respectively.
    Conclusion: Maternal anemia and baby birth size were identified as mediators of the association between short birth interval and under-five undernutrition status. Policies and programs targeting the reduction of under-five undernutrition should integrate strategies to reduce maternal anemia and small baby birth size in addition to short birth interval.
    MeSH term(s) Anemia/epidemiology ; Birth Intervals ; Child ; Ethiopia/epidemiology ; Female ; Growth Disorders/epidemiology ; Growth Disorders/etiology ; Humans ; Infant ; Latent Class Analysis ; Malnutrition/epidemiology ; Prevalence ; Thinness/epidemiology
    Language English
    Publishing date 2022-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041342-7
    ISSN 1471-2431 ; 1471-2431
    ISSN (online) 1471-2431
    ISSN 1471-2431
    DOI 10.1186/s12887-022-03169-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Exam prediction and the general Practice Registrar Competency Assessment Grid (GPR-CAG).

    Fisher, Katie / Fielding, Alison / Ralston, Anna / Holliday, Elizabeth / Ball, Jean / Tran, Michael / Davey, Andrew / Tapley, Amanda / Magin, Parker

    Education for primary care : an official publication of the Association of Course Organisers, National Association of GP Tutors, World Organisation of Family Doctors

    2024  Volume 34, Issue 5-6, Page(s) 268–276

    Abstract: Background: In GP training, identifying early predictors of poor summative examination performance can be challenging. We aimed to establish whether external clinical teaching visit (ECTV) performance, measured using a validated instrument (GP Registrar ...

    Abstract Background: In GP training, identifying early predictors of poor summative examination performance can be challenging. We aimed to establish whether external clinical teaching visit (ECTV) performance, measured using a validated instrument (GP Registrar Competency Assessment Grid, GPR-CAG) is predictive of Royal Australian College of General Practitioners (RACGP) Fellowship examination performance.
    Methods: A retrospective cohort study including GP registrars in New South Wales/Australian Capital Territory with ECTV data recorded during their first training term (GPT1), between 2014 and 2018, who attempted at least one Fellowship examination. Independent variables of interest included the four GPR-CAG factors assessed in GPT1 ('patient-centredness/caring', 'formulating hypotheses/management plans', 'professional responsibilities', 'physical examination skills'). Outcomes of interest included individual scores of the three summative examinations (Applied Knowledge Test (AKT); Key Feature Problem (KFP); and the Objective Structured Clinical Examination (OSCE)) and overall Pass/Fail status. Univariable and multivariable regression analyses were performed.
    Results: Univariably, there were statistically significant associations (
    Discussion: ECTV performance, via GPR-CAG scores, is predictive of RACGP Fellowship exam performance. The univariable findings highlight the pragmatic utility of ECTVs in flagging registrars who are at-risk of poor exam performance, facilitating early intervention. The multivariable associations of GPR-CAG scores and examination performance suggest that these scores provide predictive ability beyond that of other known predictors.
    MeSH term(s) Humans ; Retrospective Studies ; Australia ; Clinical Competence ; General Practice/education ; Family Practice/education
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2074818-8
    ISSN 1475-990X ; 1473-9879
    ISSN (online) 1475-990X
    ISSN 1473-9879
    DOI 10.1080/14739879.2023.2269884
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  7. Article ; Online: Colposcopic outcomes for symptomatic patients with a negative oncogenic human papillomavirus test.

    Mitchell, Georgina / Phung, Jason / Holliday, Elizabeth / Day, Tania

    The Australian & New Zealand journal of obstetrics & gynaecology

    2021  Volume 61, Issue 5, Page(s) 798–801

    Abstract: This study assesses outcomes of colposcopy referrals for post-coital, intermenstrual, or other abnormal bleeding with negative oncogenic human papillomavirus and negative to low-grade cytology. Of 112 cases with median age of 34.5 years, cervical biopsy ... ...

    Abstract This study assesses outcomes of colposcopy referrals for post-coital, intermenstrual, or other abnormal bleeding with negative oncogenic human papillomavirus and negative to low-grade cytology. Of 112 cases with median age of 34.5 years, cervical biopsy occurred in 19%, treatment of ectropion in 19%, endometrial sampling in 8%, polypectomy in 4%, and contraceptive change in 2%. No cervical or endometrial neoplasia was detected. Patients with bleeding symptoms and reassuring co-test may instead attend a general gynaecology clinic.
    MeSH term(s) Adult ; Alphapapillomavirus ; Cervical Intraepithelial Neoplasia/surgery ; Colposcopy ; Female ; Humans ; Papillomaviridae ; Papillomavirus Infections/complications ; Papillomavirus Infections/diagnosis ; Pregnancy ; Uterine Cervical Neoplasms ; Vaginal Smears
    Language English
    Publishing date 2021-06-20
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 390815-x
    ISSN 1479-828X ; 0004-8666
    ISSN (online) 1479-828X
    ISSN 0004-8666
    DOI 10.1111/ajo.13398
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: E-cigarette use and cigarette smoking initiation among Australian women who have never smoked.

    Melka, Alemu / Chojenta, Catherine / Holliday, Elizabeth / Loxton, Deborah

    Drug and alcohol review

    2020  Volume 40, Issue 1, Page(s) 68–77

    Abstract: Introduction and aim: Evidence regarding the association between e-cigarette use and subsequent initiation of smoking mostly relates to the US population. In Australia, no studies are available investigating the association between the uses of e- ... ...

    Abstract Introduction and aim: Evidence regarding the association between e-cigarette use and subsequent initiation of smoking mostly relates to the US population. In Australia, no studies are available investigating the association between the uses of e-cigarettes and smoking initiation among young adults who have never smoked. This study aimed to determine the association between lifetime e-cigarette use and subsequent initiation of cigarette smoking among tobacco-naïve Australian women aged 20-27.
    Design and methods: The current study used data (n = 5398) from the third (2015) and fourth (2016) surveys collected from a cohort of Australian women born in 1989-1995 who participated in the Australian Longitudinal Study on Women's Health. Multivariable logistic regression was used to identify the association between lifetime e-cigarette use at the baseline survey and initiation of cigarette smoking (smoked 100 cigarettes or more in the last year) at the follow up adjusting for possible confounders. Effects were expressed as odds ratios with 95% confidence interval.
    Results: The mean (± SD) age of the study participants at baseline (third survey) was 22.5 (±1.7). Ever e-cigarette use at baseline was positively associated with smoking initiation at follow up (adjusted odds ratio 3.71; 95% confidence interval 2.33, 5.93). History of depression, binge drinking and higher childhood adversity score were also risk factors for subsequent smoking initiation in the follow up.
    Discussion and conclusions: This study identified a strong association between e-cigarette use and subsequent initiation of smoking. Enforcing the existing restriction of sale and supply of e-liquid containing nicotine is essential to prevent never smokers from nicotine addiction via e-cigarettes.
    MeSH term(s) Adult ; Australia/epidemiology ; Cigarette Smoking ; Electronic Nicotine Delivery Systems ; Humans ; Longitudinal Studies ; Nicotiana ; Vaping ; Young Adult
    Language English
    Publishing date 2020-08-04
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1080442-0
    ISSN 1465-3362 ; 0959-5236
    ISSN (online) 1465-3362
    ISSN 0959-5236
    DOI 10.1111/dar.13131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Effects of short birth interval on neonatal, infant and under-five child mortality in Ethiopia: a nationally representative observational study using inverse probability of treatment weighting.

    Shifti, Desalegn Markos / Chojenta, Catherine / Holliday, Elizabeth / Loxton, Deborah

    BMJ open

    2021  Volume 11, Issue 8, Page(s) e047892

    Abstract: Objective: To assess the effect of short birth interval (SBI) on neonatal, infant, and under-five mortality in Ethiopia.: Design: A nationally representative cross-sectional survey.: Setting: This study used data from the Ethiopia Demographic and ... ...

    Abstract Objective: To assess the effect of short birth interval (SBI) on neonatal, infant, and under-five mortality in Ethiopia.
    Design: A nationally representative cross-sectional survey.
    Setting: This study used data from the Ethiopia Demographic and Health Survey 2016.
    Participants: A total of 8448 women who had at least two live births during the 5 years preceding the survey were included in the analysis.
    Outcome measures: Neonatal mortality (death of the child within 28 days of birth), infant mortality (death between birth and 11 months) and under-five mortality (death between birth and 59 months) were the outcome variables.
    Methods: Weighted logistic regression analysis based on inverse probability of treatment weights was used to estimate exposure effects adjusted for potential confounders.
    Results: The adjusted ORs (AORs) of neonatal mortality were about 85% higher among women with SBI (AOR=1.85, 95% CI=1.19 to 2.89) than those without. The odds of infant mortality were twofold higher (AOR=2.16, 95% CI=1.49 to 3.11) among women with SBI. The odds of under-five child mortality were also about two times (AOR=2.26, 95% CI=1.60 to 3.17) higher among women with SBI.
    Conclusion: SBI has a significant effect on neonatal, infant and under-five mortality in Ethiopia. Interventions targeting SBI are warranted to reduce neonatal, infant and under-five mortality.
    MeSH term(s) Birth Intervals ; Child ; Child Mortality ; Cross-Sectional Studies ; Ethiopia/epidemiology ; Female ; Humans ; Infant ; Infant, Newborn ; Pregnancy ; Probability
    Language English
    Publishing date 2021-08-18
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2020-047892
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Hints of unique genetic effects for type 2 diabetes in India.

    Holliday, Elizabeth G

    Diabetes

    2013  Volume 62, Issue 5, Page(s) 1369–1370

    MeSH term(s) Diabetes Mellitus, Type 2/genetics ; Female ; Humans ; Male ; Polymorphism, Single Nucleotide ; Sarcoglycans/genetics
    Chemical Substances SGCG protein, human ; Sarcoglycans
    Language English
    Publishing date 2013-04-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80085-5
    ISSN 1939-327X ; 0012-1797
    ISSN (online) 1939-327X
    ISSN 0012-1797
    DOI 10.2337/db12-1836
    Database MEDical Literature Analysis and Retrieval System OnLINE

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