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Article ; Online: Histoplasmosis of the left wrist in an immunosuppressed host with myasthenia gravis

Noor Abdulhameed / Omar Abdul-Aziz / Meghan Sawyer / Caitlyn Hollingshead, MD / Salman Arif, MD

Translation, Vol 11, Iss

2023 Volume 3

Keywords	Infectious Diseases ; Fungal Infection ; Case Report ; Medicine (General) ; R5-920
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	The University of Toledo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Editor's Note: Antiangiogenic Properties of 17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin: An Orally Bioavailable Heat Shock Protein 90 Modulator.

Kaur, Gurmeet / Belotti, Dorina / Burger, Angelika M / Fisher-Nielson, Kirsten / Borsotti, Patrizia / Riccardi, Elena / Thillainathan, Jagada / Hollingshead, Melinda / Sausville, Edward A / Giavazzi, Raffaella

Clinical cancer research : an official journal of the American Association for Cancer Research

2024 Volume 30, Issue 9, Page(s) 1996

Language	English
Publishing date	2024-05-01
Publishing country	United States
Document type	Published Erratum
ZDB-ID	1225457-5
ISSN	1557-3265 ; 1078-0432
ISSN (online)	1557-3265
ISSN	1078-0432
DOI	10.1158/1078-0432.CCR-24-0857
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Article: Exploiting embryonic niche conditions to grow Wilms tumor blastema in culture.

Wojcik, Heather M / Lovvorn, Harold N / Hollingshead, Melinda / Pierce, Janene / Stotler, Howard / Murphy, Andrew J / Borgel, Suzanne / Phelps, Hannah M / Correa, Hernan / Perantoni, Alan O

Frontiers in oncology

2023 Volume 13, Page(s) 1091274

Abstract: Introduction: Wilms Tumor (WT), or nephroblastoma, is the most common pediatric kidney cancer. Most WTs display a "favorable" triphasic histology, in which the tumor is comprised of blastemal, stromal, and epithelial cell types. Blastemal predominance ... ...

Abstract	Introduction: Wilms Tumor (WT), or nephroblastoma, is the most common pediatric kidney cancer. Most WTs display a "favorable" triphasic histology, in which the tumor is comprised of blastemal, stromal, and epithelial cell types. Blastemal predominance after neoadjuvant chemotherapy or diffuse anaplasia ("unfavorable" histology; 5-8%) portend a worse prognosis. Blastema likely provide the putative cancer stem cells (CSCs), which retain molecular and histologic features characteristic of nephron progenitor cells (NPCs), within WTs. NPCs arise in the metanephric mesenchyme (MM) and populate the cap mesenchyme (CM) in the developing kidney. WT blastemal cells, like NPCs, similarly express markers, SIX2 and CITED1. Tumor xenotransplantation is currently the only dependable method to propagate tumor tissue for research or therapeutic screening, since efforts to culture tumors Methods: Previously, our lab developed niche conditions that support the propagation of murine NPCs in culture. Applying similar conditions to WTs, we assessed our ability to maintain key NPC "stemness" markers, SIX2, NCAM, and YAP1, and CSC marker ALDHI in cells from five distinct untreated patient tumors. Results: Accordingly, our culture conditions maintained the expression of these markers in cultured WT cells through multiple passages of rapidly dividing cells. Discussion: These findings suggest that our culture conditions sustain the WT blastemal population, as previously shown for normal NPCs. As a result, we have developed new WT cell lines and a multi-passage
Language	English
Publishing date	2023-03-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1091274
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Article ; Online: TET2 and DNMT3A mutations and exceptional response to 4'-thio-2'-deoxycytidine in human solid tumor models.

Yang, Sherry X / Hollingshead, Melinda / Rubinstein, Larry / Nguyen, Dat / Larenjeira, Angelo B A / Kinders, Robert J / Difilippantonio, Michael / Doroshow, James H

Journal of hematology & oncology

2021 Volume 14, Issue 1, Page(s) 83

Abstract: Background: Challenges remain on the selection of patients who potentially respond to a class of drugs that target epigenetics for cancer treatment. This study aims to investigate TET2/DNMT3A mutations and antitumor activity of a novel epigenetic agent ... ...

Abstract	Background: Challenges remain on the selection of patients who potentially respond to a class of drugs that target epigenetics for cancer treatment. This study aims to investigate TET2/DNMT3A mutations and antitumor activity of a novel epigenetic agent in multiple human cancer cell lines and animal models. Methods: Seventeen cancer cell lines and multiple xenograft models bearing representative human solid tumors were subjected to 4'-thio-2'-deoxycytidine (T-dCyd) or control treatment. Gene mutations in cell lines were examined by whole exome and/or Sanger sequencing. Specific gene expression was measured in cells and xenograft tumor samples by Western blotting and immunohistochemistry. TET2/DNMT3A mutation status in 47,571 human tumor samples was analyzed at cBioPortal for Cancer Genomics. Results: Cell survival was significantly inhibited by T-dCyd in breast BT549, lung NCI-H23, melanoma SKMEL5 and renal ACHN cancer lines harboring deleterious TET2 and nonsynonymous DNMT3A mutations compared to 13 lines without such mutation pattern (P = 0.007). The treatment upregulated p21 and induced cell cycle arrest in NCI-H23 cells, and dramatically inhibited their xenograft tumor growth versus wildtype models. T-dCyd administrations led to a significant p21 increase and near eradication of tumor cells in the double-mutant xenografts by histological evaluation. TET2/DNMT3A was co-mutated in human lung, breast, skin and kidney cancers and frequently in angioimmunoblastic and peripheral T cell lymphomas and several types of leukemia. Conclusions: Cell and animal models with concurrent mutations in TET2 and DNMT3A were sensitive to T-dCyd treatment. The mutations were detectable in human solid tumors and frequently occur in some hematological malignancies.
MeSH term(s)	Animals ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Cell Line, Tumor ; DNA (Cytosine-5-)-Methyltransferases/genetics ; DNA (Cytosine-5-)-Methyltransferases/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/pharmacology ; Female ; HCT116 Cells ; Humans ; MCF-7 Cells ; Mice ; Mice, Nude ; Mutation ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/metabolism ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; Thionucleosides/pharmacology ; Xenograft Model Antitumor Assays
Chemical Substances	Biomarkers, Tumor ; DNA-Binding Proteins ; Proto-Oncogene Proteins ; Thionucleosides ; Deoxycytidine (0W860991D6) ; 2'-deoxy-4'-thiocytidine (134111-30-1) ; TET2 protein, human (EC 1.13.11.-) ; DNA (Cytosine-5-)-Methyltransferases (EC 2.1.1.37) ; DNA methyltransferase 3A (EC 2.1.1.37)
Language	English
Publishing date	2021-05-26
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2429631-4
ISSN	1756-8722 ; 1756-8722
ISSN (online)	1756-8722
ISSN	1756-8722
DOI	10.1186/s13045-021-01091-5
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Article ; Online: Intraperitoneal and subcutaneous tumor models for assessing anti-neoplastic agents in rodents.

Hollingshead, Melinda

Current protocols in pharmacology

2002 Volume Chapter 5, Page(s) Unit 5.28

Abstract: Evaluation of compounds for in vivo antineoplastic activity can be achieved in a variety of animal models. Two models commonly employed for these studies are the intraperitoneal challenge survival model and the subcutaneous tumor implant model. The ... ...

Abstract	Evaluation of compounds for in vivo antineoplastic activity can be achieved in a variety of animal models. Two models commonly employed for these studies are the intraperitoneal challenge survival model and the subcutaneous tumor implant model. The challenge survival model involves intraperitoneal tumor inoculation, test compound treatment and monitoring for survival. This assay can be modulated for stringency by altering the treatment dose, route and schedule. The second model, subcutaneous tumor implants, is more strenuous as the test compound must cross physiologic barriers to reach the target tumor. Additionally, the subcutaneous model is more labor intensive to setup, monitor and evaluate.
MeSH term(s)	Animals ; Antineoplastic Agents/pharmacology ; Cell Proliferation ; Disease Models, Animal ; HL-60 Cells ; Humans ; Melanoma/drug therapy ; Melanoma/pathology ; Mice ; Mice, Nude ; Mice, SCID ; Neoplasm Staging/methods ; Neoplasm Transplantation/methods ; Peritoneal Neoplasms/drug therapy ; Peritoneal Neoplasms/pathology ; Random Allocation ; Skin Neoplasms/drug therapy ; Skin Neoplasms/pathology ; Xenograft Model Antitumor Assays/methods
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2002-11
Publishing country	United States
Document type	Journal Article
ISSN	1934-8290
ISSN (online)	1934-8290
DOI	10.1002/0471141755.ph0528s18
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Article ; Online: CT and MR imaging of progressive dural involvement by nephrogenic systemic fibrosis.

Zelasko, S / Hollingshead, M / Castillo, M / Bouldin, T W

AJNR. American journal of neuroradiology

2008 Volume 29, Issue 10, Page(s) 1880–1882

Abstract: We present a patient with progressive dural calcifications, thickening, and enhancement presumably related to the development of nephrogenic systemic fibrosis (NSF). Head CT demonstrated progressive dural calcifications, whereas MR imaging demonstrated ... ...

Abstract	We present a patient with progressive dural calcifications, thickening, and enhancement presumably related to the development of nephrogenic systemic fibrosis (NSF). Head CT demonstrated progressive dural calcifications, whereas MR imaging demonstrated progressive dural thickening and enhancement during a 3-year period in which the patient received several gadolinium-enhanced MR imaging studies. To the best of our knowledge, dural calcifications are the only described intracranial finding of NSF.
MeSH term(s)	Brain Diseases/diagnosis ; Contrast Media ; Dura Mater/diagnostic imaging ; Dura Mater/pathology ; Female ; Gadolinium ; Humans ; Magnetic Resonance Imaging ; Middle Aged ; Nephrogenic Fibrosing Dermopathy/complications ; Nephrogenic Fibrosing Dermopathy/diagnosis ; Tomography, X-Ray Computed/methods
Chemical Substances	Contrast Media ; Gadolinium (AU0V1LM3JT)
Language	English
Publishing date	2008-10-14
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	603808-6
ISSN	1936-959X ; 0195-6108
ISSN (online)	1936-959X
ISSN	0195-6108
DOI	10.3174/ajnr.A1225
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Zs.A 1580: Show issues

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Article ; Online: Development of a quantitative pharmacodynamic assay for apoptosis in fixed tumor tissue and its application in distinguishing cytotoxic drug-induced DNA double strand breaks from DNA double strand breaks associated with apoptosis.

Dull, Angie B / Wilsker, Deborah / Hollingshead, Melinda / Mazcko, Christina / Annunziata, Christina M / LeBlanc, Amy K / Doroshow, James H / Kinders, Robert J / Parchment, Ralph E

Oncotarget

2018 Volume 9, Issue 24, Page(s) 17104–17116

Abstract: DNA double strand breaks (DSBs) induced by cancer therapeutic agents can lead to DNA damage repair or persistent DNA damage, which can induce apoptotic cell death; however, apoptosis also induces DSBs independent of genotoxic insult. γH2AX is an ... ...

Abstract	DNA double strand breaks (DSBs) induced by cancer therapeutic agents can lead to DNA damage repair or persistent DNA damage, which can induce apoptotic cell death; however, apoptosis also induces DSBs independent of genotoxic insult. γH2AX is an established biomarker for DSBs but cannot distinguish between these mechanisms. Activated cleaved caspase-3 (CC3) promotes apoptosis by enhancing nuclear condensation, DNA fragmentation, and plasma membrane blebbing. Here, we describe an immunofluorescence assay that distinguishes between apoptosis and drug-induced DSBs by measuring coexpression of γH2AX and membrane blebbing-associated CC3 to indicate apoptosis, and γH2AX in the absence of CC3 blebbing to indicate drug-induced DNA damage. These markers were examined in xenograft models following treatment with topotecan, cisplatin, or birinapant. A topotecan regimen conferring tumor regression induced tumor cell DSBs resulting from both apoptosis and direct DNA damage. In contrast, a cisplatin regimen yielding tumor growth delay, but not regression, resulted in tumor cell DSBs due solely to direct DNA damage. MDA-MB-231 xenografts exposed to birinapant, which promotes apoptosis but does not directly induce DSBs, exhibited dose-dependent increases in colocalized γH2AX/CC3 blebbing in tumor cells. Clinical feasibility was established using formalin-fixed, paraffin-embedded biopsies from a canine cancer clinical trial; γH2AX/CC3 colocalization analysis revealed apoptosis induction by two novel indenoisoquinoline topoisomerase I inhibitors, which was consistent with pathologist-assessed apoptosis and reduction of tumor volume. This assay is ready for use in clinical trials to elucidate the mechanism of action of investigational agents and combination regimens intended to inflict DNA damage, apoptotic cell death, or both.
Language	English
Publishing date	2018-03-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.24936
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Article ; Online: Erythrofordins D and E, two new cassaine-type diterpenes from Erythrophleum suaveolens.

Grkovic, Tanja / Evans, Jason R / Akee, Rhone K / Guo, Liang / Davis, Myrtle / Jato, Johnson / Grothaus, Paul G / Ahalt-Gottholm, Michelle / Hollingshead, Melinda / Collins, Jerry M / Newman, David J / O'Keefe, Barry R

Bioorganic & medicinal chemistry letters

2018 Volume 29, Issue 2, Page(s) 134–137

Abstract: Two new cassaine-type diterpenoids, namely erythrofordins D (1) and E (2), sourced from a Cameroon collection of Erythrophleum suaveolens were isolated and assessed for anti-tumor activity. In the NCI-60 cancer cell assay, erythrofordins D (1) and E (2) ... ...

Abstract	Two new cassaine-type diterpenoids, namely erythrofordins D (1) and E (2), sourced from a Cameroon collection of Erythrophleum suaveolens were isolated and assessed for anti-tumor activity. In the NCI-60 cancer cell assay, erythrofordins D (1) and E (2) were found to be cytotoxic in the low micro molar ranges with a mean GI
MeSH term(s)	Caesalpinia/chemistry ; Cell Survival/drug effects ; Diterpenes/chemistry ; Diterpenes/isolation & purification ; Diterpenes/pharmacology ; Dose-Response Relationship, Drug ; Humans ; Molecular Structure ; Myocytes, Cardiac/drug effects ; Structure-Activity Relationship
Chemical Substances	Diterpenes
Language	English
Publishing date	2018-12-10
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2018.12.019
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Zs.A 3203: Show issues

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Article: The hollow fibre model in cancer drug screening: the NCI experience.

Decker, S / Hollingshead, M / Bonomi, C A / Carter, J P / Sausville, E A

European journal of cancer (Oxford, England : 1990)

2004 Volume 40, Issue 6, Page(s) 821–826

Abstract: The in vivo hollow fibre model was developed by the National Cancer Institute (NCI) in the United States of America (USA) at a time when the number of potential anti-cancer drugs arising from in vitro screening efforts exceeded the available capacity for ...

Abstract	The in vivo hollow fibre model was developed by the National Cancer Institute (NCI) in the United States of America (USA) at a time when the number of potential anti-cancer drugs arising from in vitro screening efforts exceeded the available capacity for testing in traditional xenograft models. Updated analysis of the predictive value of the hollow fibre model continues to indicate that the greater the response in the hollow fibre assay, the more likely it is that activity will be seen in subsequent xenograft models. The original 12 cell line hollow fibre panel has been supplemented with histology-specific panels, and we begin here to analyse their utility in predicting activity in subsequent in vivo models. The key goal of using the hollow fibre model as a way to decrease the cost, both financial and in the number of animals used, to evaluate initial evidence of a compound's capacity to act across physiological barriers continues to be reinforced with our enlarging experience.
MeSH term(s)	Animals ; Antineoplastic Agents/therapeutic use ; Drug Design ; Drug Screening Assays, Antitumor/methods ; Forecasting ; Mice ; Models, Biological ; Neoplasm Transplantation ; Neoplasms/drug therapy ; Predictive Value of Tests ; Transplantation, Heterologous ; Tumor Cells, Cultured
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2004-04
Publishing country	England
Document type	Journal Article
ZDB-ID	82061-1
ISSN	1879-0852 ; 0959-8049 ; 0277-5379 ; 0964-1947
ISSN (online)	1879-0852
ISSN	0959-8049 ; 0277-5379 ; 0964-1947
DOI	10.1016/j.ejca.2003.11.029
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Zs.A 456: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Antibody isotypes against the surface glycoproteins of porcine coronavirus in the milk of orally infected sows.

De Buysscher, E / Hollingshead, M

Advances in experimental medicine and biology

1987 Volume 216B, Page(s) 1025–1031

MeSH term(s)	Animals ; Antibodies, Viral/biosynthesis ; Coronaviridae/immunology ; Female ; Gastroenteritis, Transmissible, of Swine/complications ; Gastroenteritis, Transmissible, of Swine/immunology ; Glycoproteins/immunology ; Immunoglobulin A/biosynthesis ; Immunoglobulin G/biosynthesis ; Immunoglobulin Isotypes/biosynthesis ; Milk/immunology ; Pregnancy ; Pregnancy Complications, Infectious/immunology ; Swine ; Transmissible gastroenteritis virus/immunology ; Viral Proteins/immunology ; Viral Structural Proteins
Chemical Substances	Antibodies, Viral ; Glycoproteins ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin Isotypes ; Viral Proteins ; Viral Structural Proteins
Language	English
Publishing date	1987
Publishing country	United States
Document type	Journal Article
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
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