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  1. Article: The genome sequence of the surf clam,

    Holmes, Anna

    Wellcome open research

    2023  Volume 8, Page(s) 227

    Abstract: We present a genome assembly from an ... ...

    Abstract We present a genome assembly from an individual
    Language English
    Publishing date 2023-05-24
    Publishing country England
    Document type Journal Article
    ISSN 2398-502X
    ISSN 2398-502X
    DOI 10.12688/wellcomeopenres.19486.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The genome sequence of the scale worm,

    Darbyshire, Teresa / Bishop, John / Mieszkowska, Nova / Adkins, Patrick / Holmes, Anna

    Wellcome open research

    2022  Volume 7, Page(s) 307

    Abstract: We present a genome assembly from an ... ...

    Abstract We present a genome assembly from an individual
    Language English
    Publishing date 2022-12-21
    Publishing country England
    Document type Journal Article
    ISSN 2398-502X
    ISSN 2398-502X
    DOI 10.12688/wellcomeopenres.18660.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The genome sequence of the turban top shell,

    Adkins, Patrick / Harley, Joanna / Darbyshire, Teresa / Holmes, Anna / Scott-Somme, Kesella / Mieskowska, Nova

    Wellcome open research

    2023  Volume 8, Page(s) 35

    Abstract: We present a genome assembly from an ... ...

    Abstract We present a genome assembly from an individual
    Language English
    Publishing date 2023-01-23
    Publishing country England
    Document type Journal Article
    ISSN 2398-502X
    ISSN 2398-502X
    DOI 10.12688/wellcomeopenres.18792.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The ethics of care.

    Holmes, Anna

    The New Zealand medical journal

    2012  Volume 125, Issue 1350, Page(s) 105–106

    MeSH term(s) Ethics, Medical ; Humans ; Medical Records/standards ; New Zealand ; Patient Discharge/standards ; Patient Transfer/standards
    Language English
    Publishing date 2012-02-24
    Publishing country New Zealand
    Document type Letter
    ZDB-ID 390590-1
    ISSN 1175-8716 ; 0028-8446 ; 0110-7704
    ISSN (online) 1175-8716
    ISSN 0028-8446 ; 0110-7704
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.396: Show issues Location:
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  5. Article ; Online: Potential role of microorganisms in the pathogenesis of rosacea.

    Holmes, Anna D

    Journal of the American Academy of Dermatology

    2013  Volume 69, Issue 6, Page(s) 1025–1032

    Abstract: Rosacea is a skin condition of abnormal inflammation and vascular dysfunction. The active contribution of a microbial agent in the development or progression of rosacea continues to be debated. Research supports the presence of commensal Demodex ... ...

    Abstract Rosacea is a skin condition of abnormal inflammation and vascular dysfunction. The active contribution of a microbial agent in the development or progression of rosacea continues to be debated. Research supports the presence of commensal Demodex folliculorum mites at increased density in the skin and associates Helicobacter pylori infection of the gut with rosacea. Fewer studies implicate Staphylococcus epidermidis, Chlamydophila pneumoniae, and the Demodex-associated bacteria Bacillus oleronius. No research, however, provides a mechanism by which colonization by a microorganism translates to manifestation of the condition. Prevailing and emerging principles in the biology of the microbiome and the pathophysiology of rosacea may help to reconcile these lingering questions. Here the microorganisms implicated in rosacea are reviewed and the reaction of the microbiome to inflammation and to changes in microenvironments and macroenvironments are discussed to explain potential roles for microorganisms in rosacea pathophysiology.
    MeSH term(s) Animals ; Humans ; Mites ; Rosacea/microbiology
    Language English
    Publishing date 2013-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2013.08.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1540: Show issues Location:
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  6. Article: The genome sequence of

    Holmes, Anna / Darbyshire, Teresa / Brennan, Mitchell / McTierney, Sean / Small, Allison

    Wellcome open research

    2022  Volume 7, Page(s) 116

    Abstract: We present a genome assembly from an ... ...

    Abstract We present a genome assembly from an individual
    Language English
    Publishing date 2022-03-29
    Publishing country England
    Document type Journal Article
    ISSN 2398-502X
    ISSN 2398-502X
    DOI 10.12688/wellcomeopenres.17805.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Integrative concepts of rosacea pathophysiology, clinical presentation and new therapeutics.

    Holmes, Anna D / Steinhoff, Martin

    Experimental dermatology

    2017  Volume 26, Issue 8, Page(s) 659–667

    Abstract: Rosacea is a chronic relapsing inflammatory skin disease with high prevalence worldwide. Recent research suggests that dysregulation of innate and adaptive immune pathways as well as neurovascular changes is present, with different degrees of importance ... ...

    Abstract Rosacea is a chronic relapsing inflammatory skin disease with high prevalence worldwide. Recent research suggests that dysregulation of innate and adaptive immune pathways as well as neurovascular changes is present, with different degrees of importance in the various subtypes. Neither the aetiology, genetics nor pathophysiological basis of the vascular, inflammatory or fibrotic changes is well understood. The clinical spectrum comprises a huge variability from erythema (vasodilation) to papules/pustules (inflammatory infiltrate) to phymata (fibrosis, glandular hyperplasia) making it a valuable human disease model to understand the interplay between the neurovascular and immune systems as well as the progression from chronic inflammation to fibrosis in skin. The lack of appropriate animal models emphasizes the importance of further translational research validating observed molecular pathways under disease conditions. A wide spectrum of physical (UV, temperature), biological (microbiota, food) and endogenous (genetic, stress) stimuli has been discussed as "trigger factors" of rosacea. Novel findings implicate keratinocytes, smooth muscle cells, endothelial cells, macrophages, mast cells, fibroblasts, Th1/Th17 cells, antibody-producing B cells and neurons in the pathobiology of rosacea. So far, pattern recognition receptors like TLR2, transient receptor potential ion channels, cytokines, chemokines and proteases have been implicated as critical receptors/mediators. However, our understanding of the interactive networks on the molecular level is very limited. Identification of critical molecular components of the inflammatory cascade including antimicrobial peptides, the IL-1β inflammasome, TNF, IFN-γ, proteases and neuropeptides may provide the basis for novel pathomechanism-based therapeutic approaches for this frequent and bothersome skin disease.
    Language English
    Publishing date 2017-08
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 1130936-2
    ISSN 1600-0625 ; 0906-6705
    ISSN (online) 1600-0625
    ISSN 0906-6705
    DOI 10.1111/exd.13143
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    Zs.A 3508: Show issues Location:
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  8. Article: Prevention of COVID-19 Following a Single Intramuscular Administration of Adintrevimab: Results From a Phase 2/3 Randomized, Double-Blind, Placebo-Controlled Trial (EVADE).

    Ison, Michael G / Weinstein, Debra F / Dobryanska, Marta / Holmes, Anna / Phelan, Anne-Marie / Li, Yong / Gupta, Deepali / Narayan, Kristin / Tosh, Kazima / Hershberger, Ellie / Connolly, Lynn E / Yalcin, Ilker / Campanaro, Ed / Hawn, Pamela / Schmidt, Pete

    Open forum infectious diseases

    2023  Volume 10, Issue 7, Page(s) ofad314

    Abstract: Background: The prevention of coronavirus disease 2019 (COVID-19) in vulnerable populations is a global health priority. EVADE was a phase 2/3 multicenter, double-blind, randomized, placebo-controlled trial of adintrevimab, an extended-half-life ... ...

    Abstract Background: The prevention of coronavirus disease 2019 (COVID-19) in vulnerable populations is a global health priority. EVADE was a phase 2/3 multicenter, double-blind, randomized, placebo-controlled trial of adintrevimab, an extended-half-life monoclonal antibody, for postexposure (PEP) and pre-exposure prophylaxis (PrEP) of symptomatic COVID-19.
    Methods: Eligible participants (vaccine-naive, aged ≥12 years) were randomized 1:1 to receive a single 300-mg intramuscular injection of adintrevimab or placebo. Primary efficacy end points were reverse transcription polymerase chain reaction (RT-PCR)-confirmed symptomatic COVID-19 through day 28 in the PEP cohort (RT-PCR-negative at baseline) and through month 3 in the PrEP cohort (RT-PCR-negative and seronegative at baseline) among participants randomized before emergence of the severe acute respiratory syndrome coronavirus 2 Omicron variant (November 30, 2021). Safety was assessed through 6 months.
    Results: Between April 27, 2021, and January 11, 2022, 2582 participants were randomized. In the primary efficacy analysis, RT-PCR-confirmed symptomatic COVID-19 occurred in 3/175 (1.7%) vs 12/176 (6.8%) adintrevimab- and placebo-treated PEP participants, respectively (74.9% relative risk reduction [RRR]; standardized risk difference, -5.0%; 95% CI, -8.87% to -1.08%;
    Conclusions: A single intramuscular injection of adintrevimab provided prophylactic efficacy against COVID-19 due to susceptible variants without safety concerns.
    Language English
    Publishing date 2023-06-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofad314
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Evidence-based update on rosacea comorbidities and their common physiologic pathways.

    Holmes, Anna D / Spoendlin, Julia / Chien, Anna L / Baldwin, Hilary / Chang, Anne Lynn S

    Journal of the American Academy of Dermatology

    2017  

    Abstract: Rosacea is a common chronic inflammatory disease affecting the facial skin whose etiology and pathophysiology are the subject of much investigation. Risk factors include genetic and environmental elements that may predispose individuals to localized ... ...

    Abstract Rosacea is a common chronic inflammatory disease affecting the facial skin whose etiology and pathophysiology are the subject of much investigation. Risk factors include genetic and environmental elements that may predispose individuals to localized inflammation and abnormal neurovascular responses to stimuli. Recent studies have introduced an array of systemic rosacea comorbidities, such as inflammatory bowel disease and neurologic conditions, that can be challenging to synthesize. We critically review the current data behind reported rosacea comorbidities and identify and highlight underrecognized physiologic mediators shared among rosacea and associated comorbidities. This information may be helpful in addressing patient questions about potential systemic implications of rosacea and can serve as a candidate platform for future research to understand rosacea and improve treatments.
    Language English
    Publishing date 2017-10-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2017.07.055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1540: Show issues Location:
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  10. Article ; Online: Nicotine does not enhance basic semantic priming.

    Holmes, Anna D / Chenery, Helen J / Copland, David A

    Psychopharmacology

    2010  Volume 211, Issue 3, Page(s) 259–265

    Abstract: Rationale: Utilising a cognitively demanding strategy-based priming paradigm, we recently observed that acute transdermal nicotine selectively influenced controlled semantic processing but not related-word links within semantic memory per se as reported ...

    Abstract Rationale: Utilising a cognitively demanding strategy-based priming paradigm, we recently observed that acute transdermal nicotine selectively influenced controlled semantic processing but not related-word links within semantic memory per se as reported by Holmes et al. (Int J Neuropsychopharmacol 11:389-399, 2008).
    Objective: The current study employed a less cognitively demanding priming paradigm to investigate whether nicotine influences the activation/access of links within semantic memory, and if the selective nicotinic influence on controlled but not automatic semantic processing could also be observed with these more general priming procedures.
    Methods: Transdermal nicotine patches (7 mg/24 h) were administered to healthy young adults in a double-blind, placebo-controlled, crossover design. The automatic priming task ( n = 18) had a low relatedness proportion (RP) and was presented at a short stimulus onset asynchrony (SOA), while the controlled priming task ( n = 18) had a high RP and long SOA.
    Results: The patterns of priming effects indicated that automatic and controlled processing were operating for the respective tasks. However, a nicotinic influence on semantic processing was not evident for either task, nor was interplay of nicotine and relatedness observed.
    Conclusions: Together, the findings from the previous and current study suggest that an influence of nicotine on semantic processing may only emerge when effortful controlled processing is invoked. Furthermore, the findings suggest that nicotinic modulation of links within semantic memory may only be mediated by mnemonic processes.
    MeSH term(s) Adolescent ; Adult ; Cognition/drug effects ; Female ; Humans ; Male ; Memory/drug effects ; Nicotine/pharmacology ; Psychomotor Performance/drug effects ; Reaction Time/drug effects ; Semantics
    Chemical Substances Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2010-06-16
    Publishing country Germany
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 130601-7
    ISSN 1432-2072 ; 0033-3158
    ISSN (online) 1432-2072
    ISSN 0033-3158
    DOI 10.1007/s00213-010-1886-8
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