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  1. Book ; Thesis: Quality and cost in health care

    Holthof, Bruno

    measuring and improving performance ; a logistic regression approach

    1994  

    Author's details Bruno Holthof
    Language English
    Size 64 S, graph. Darst
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Leuven, 1994
    Database Former special subject collection: coastal and deep sea fishing

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  2. Article ; Online: Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study.

    Eyre, David W / Lumley, Sheila F / O'Donnell, Denise / Campbell, Mark / Sims, Elizabeth / Lawson, Elaine / Warren, Fiona / James, Tim / Cox, Stuart / Howarth, Alison / Doherty, George / Hatch, Stephanie B / Kavanagh, James / Chau, Kevin K / Fowler, Philip W / Swann, Jeremy / Volk, Denis / Yang-Turner, Fan / Stoesser, Nicole /
    Matthews, Philippa C / Dudareva, Maria / Davies, Timothy / Shaw, Robert H / Peto, Leon / Downs, Louise O / Vogt, Alexander / Amini, Ali / Young, Bernadette C / Drennan, Philip George / Mentzer, Alexander J / Skelly, Donal T / Karpe, Fredrik / Neville, Matt J / Andersson, Monique / Brent, Andrew J / Jones, Nicola / Martins Ferreira, Lucas / Christott, Thomas / Marsden, Brian D / Hoosdally, Sarah / Cornall, Richard / Crook, Derrick W / Stuart, David I / Screaton, Gavin / Peto, Timothy Ea / Holthof, Bruno / O'Donnell, Anne-Marie / Ebner, Daniel / Conlon, Christopher P / Jeffery, Katie / Walker, Timothy M

    eLife

    2020  Volume 9

    Abstract: We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for IgG antibodies. 1128/10,034 (11.2%) staff had evidence of Covid-19 at some ... ...

    Abstract We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for IgG antibodies. 1128/10,034 (11.2%) staff had evidence of Covid-19 at some time. Using questionnaire data provided on potential risk-factors, staff with a confirmed household contact were at greatest risk (adjusted odds ratio [aOR] 4.82 [95%CI 3.45-6.72]). Higher rates of Covid-19 were seen in staff working in Covid-19-facing areas (22.6% vs. 8.6% elsewhere) (aOR 2.47 [1.99-3.08]). Controlling for Covid-19-facing status, risks were heterogenous across the hospital, with higher rates in acute medicine (1.52 [1.07-2.16]) and sporadic outbreaks in areas with few or no Covid-19 patients. Covid-19 intensive care unit staff were relatively protected (0.44 [0.28-0.69]), likely by a bundle of PPE-related measures. Positive results were more likely in Black (1.66 [1.25-2.21]) and Asian (1.51 [1.28-1.77]) staff, independent of role or working location, and in porters and cleaners (2.06 [1.34-3.15]).
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Aged ; Asymptomatic Infections/epidemiology ; Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Female ; Health Personnel/statistics & numerical data ; Hospitals, Teaching/statistics & numerical data ; Humans ; Incidence ; Infectious Disease Transmission, Patient-to-Professional/statistics & numerical data ; Intensive Care Units/statistics & numerical data ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; Risk ; SARS-CoV-2 ; Surveys and Questionnaires ; United Kingdom/epidemiology ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-08-21
    Publishing country England
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.60675
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Differential occupational risks to healthcare workers from SARS-CoV-2: A prospective observational study

    Eyre, David W / Lumley, Sheila F / Campbell, Mark / Sims, Elizabeth / Lawson, Elaine / Warren, Fiona / James, Tim J / Cox, Stuart / Howarth, Alison / Doherty, George / Hatch, Stephanie B / Kavanagh, James / Chau, Kevin K / Fowler, Philip W / Swann, Jeremy / Volk, Denis / Yang-Turner, Dan / Stoesser, Nicole E / Matthews, Philippa C /
    Dudareva, Maria / Davies, Timothy / Shaw, Robert H / Peto, Leon / Downs, Louise O / Vogt, Alexander / Amini, Ali / Young, Bernadette C / Drennan, Philip / Mentzer, Alexander J / Skelly, Donal / Karpe, Fredrik / Neville, Matthew J / Andersson, Monique / Brent, Andrew J / Jones, Nicola / Ferreira, Lucas Martins / Christott, Thomas / Marsden, Brian / Hoosdally, Sarah / Cornall, Richard / Crook, Derrick W / Stuart, Dave / Screaton, Gavin / Group, - Oxford University Hospitals Staff Testing / Peto, Timothy EA / Holthof, Bruno / Ebner, Daniel / Conlon, Christopher P / Jeffery, Katie / Walker, Timothy M

    Abstract: Background Personal protective equipment (PPE) and social distancing are key measures designed to mitigate the risk of occupational SARS-CoV-2 infection in hospitals. Why healthcare workers nevertheless remain at increased risk is uncertain. Methods We ... ...

    Abstract Background Personal protective equipment (PPE) and social distancing are key measures designed to mitigate the risk of occupational SARS-CoV-2 infection in hospitals. Why healthcare workers nevertheless remain at increased risk is uncertain. Methods We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a large UK teaching hospital using nasopharyngeal PCR testing and immunoassays for IgG antibodies. A positive result by either modality was used as a composite outcome. Risk factors for Covid-19 were investigated using multivariable logistic regression. Results 1083/9809(11.0%) staff had evidence of Covid-19 at some time and provided data on potential risk-factors. Staff with a confirmed household contact were at greatest risk (adjusted odds ratio [aOR] 4.63 [95%CI 3.30-6.50]). Higher rates of Covid-19 were seen in staff working in Covid-19-facing areas (21.2% vs. 8.2% elsewhere) (aOR 2.49 [2.00-3.12]). Controlling for Covid-19-facing status, risks were heterogenous across the hospital, with higher rates in acute medicine (1.50 [1.05-2.15]) and sporadic outbreaks in areas with few or no Covid-19 patients. Covid-19 intensive care unit (ICU) staff were relatively protected (0.46 [0.29-0.72]). Positive results were more likely in Black (1.61 [1.20-2.16]) and Asian (1.58 [1.34-1.86]) staff, independent of role or working location, and in porters and cleaners (1.93 [1.25-2.97]). Contact tracing around asymptomatic staff did not lead to enhanced case identification. 24% of staff/patients remained PCR-positive at [≥]6 weeks post-diagnosis. Conclusions Increased Covid-19 risk was seen in acute medicine, among Black and Asian staff, and porters and cleaners. A bundle of PPE-related interventions protected staff in high-risk ICU areas.
    Keywords covid19
    Publisher MedRxiv; WHO
    Document type Article ; Online
    Note WHO #Covidence: #20135038
    DOI 10.1101/2020.06.24.20135038
    Database COVID19

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  4. Article ; Online: Differential occupational risks to healthcare workers from SARS-CoV-2: A prospective observational study

    Eyre, David W / Lumley, Sheila F / O'Donnell, Denise / Campbell, Mark / Sims, Elizabeth / Lawson, Elaine / Warren, Fiona / James, Tim J / Cox, Stuart / Howarth, Alison / Doherty, George / Hatch, Stephanie B / Kavanagh, James / Chau, Kevin K / Fowler, Philip W / Swann, Jeremy / Volk, Denis / Yang-Turner, Dan / Stoesser, Nicole E /
    Matthews, Philippa C / Dudareva, Maria / Davies, Timothy / Shaw, Robert H / Peto, Leon / Downs, Louise O / Vogt, Alexander / Amini, Ali / Young, Bernadette C / Drennan, Philip / Mentzer, Alexander J / Skelly, Donal / Karpe, Fredrik / Neville, Matthew J / Andersson, Monique / Brent, Andrew J / Jones, Nicola / Martins Ferreira, Lucas / Christott, Thomas / Marsden, Brian / Hoosdally, Sarah / Cornall, Richard / Crook, Derrick W / Stuart, Dave / Screaton, Gavin / Oxford University Hospitals Staff Testing Group / Peto, Timothy EA / Holthof, Bruno / O'Donnell, Anne-Marie / Ebner, Daniel / Conlon, Christopher P / Jeffery, Katie / Walker, Timothy M

    medRxiv

    Abstract: Background Personal protective equipment (PPE) and social distancing are key measures designed to mitigate the risk of occupational SARS-CoV-2 infection in hospitals. Why healthcare workers nevertheless remain at increased risk is uncertain. Methods We ... ...

    Abstract Background Personal protective equipment (PPE) and social distancing are key measures designed to mitigate the risk of occupational SARS-CoV-2 infection in hospitals. Why healthcare workers nevertheless remain at increased risk is uncertain. Methods We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a large UK teaching hospital using nasopharyngeal PCR testing and immunoassays for IgG antibodies. A positive result by either modality was used as a composite outcome. Risk factors for Covid-19 were investigated using multivariable logistic regression. Results 1083/9809(11.0%) staff had evidence of Covid-19 at some time and provided data on potential risk-factors. Staff with a confirmed household contact were at greatest risk (adjusted odds ratio [aOR] 4.63 [95%CI 3.30-6.50]). Higher rates of Covid-19 were seen in staff working in Covid-19-facing areas (21.2% vs. 8.2% elsewhere) (aOR 2.49 [2.00-3.12]). Controlling for Covid-19-facing status, risks were heterogenous across the hospital, with higher rates in acute medicine (1.50 [1.05-2.15]) and sporadic outbreaks in areas with few or no Covid-19 patients. Covid-19 intensive care unit (ICU) staff were relatively protected (0.46 [0.29-0.72]). Positive results were more likely in Black (1.61 [1.20-2.16]) and Asian (1.58 [1.34-1.86]) staff, independent of role or working location, and in porters and cleaners (1.93 [1.25-2.97]). Contact tracing around asymptomatic staff did not lead to enhanced case identification. 24% of staff/patients remained PCR-positive at ≥6 weeks post-diagnosis. Conclusions Increased Covid-19 risk was seen in acute medicine, among Black and Asian staff, and porters and cleaners. A bundle of PPE-related interventions protected staff in high-risk ICU areas.
    Keywords covid19
    Language English
    Publishing date 2020-06-29
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.06.24.20135038
    Database COVID19

    Full text online

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  5. Article ; Online: Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study

    Eyre, David W / Lumley, Sheila F / O'Donnell, Denise / Campbell, Mark / Sims, Elizabeth / Lawson, Elaine / Warren, Fiona / James, Tim / Cox, Stuart / Howarth, Alison / Doherty, George / Hatch, Stephanie B / Kavanagh, James / Chau, Kevin K / Fowler, Philip W / Swann, Jeremy / Volk, Denis / Yang-Turner, Fan / Stoesser, Nicole /
    Matthews, Philippa C / Dudareva, Maria / Davies, Timothy / Shaw, Robert H / Peto, Leon / Downs, Louise O / Vogt, Alexander / Amini, Ali / Young, Bernadette C / Drennan, Philip George / Mentzer, Alexander J / Skelly, Donal T / Karpe, Fredrik / Neville, Matt J / Andersson, Monique / Brent, Andrew J / Jones, Nicola / Martins Ferreira, Lucas / Christott, Thomas / Marsden, Brian D / Hoosdally, Sarah / Cornall, Richard / Crook, Derrick W / Stuart, David I / Screaton, Gavin / Watson, Adam JR / Taylor, Adan / Chetwynd, Alan / Grassam-Rowe, Alexander / Mighiu, Alexandra S / Livingstone, Angus / Killen, Annabel / Rigler, Caitlin / Harries, Callum / East, Cameron / Lee, Charlotte / Mason, Chris JB / Holland, Christian / Thompson, Connor / Hennesey, Conor / Savva, Constantinos / Kim, David S / Harris, Edward WA / McGivern, Euan J / Qian, Evelyn / Rothwell, Evie / Back, Francesca / Kelly, Gabriella / Watson, Gareth / Howgego, Gregory / Chase, Hannah / Danbury, Hannah / Laurenson-Schafer, Hannah / Ward, Harry L / Hendron, Holly / Vorley, Imogen C / Tol, Isabel / Gunnell, James / Ward, Jocelyn LF / Drake, Jonathan / Wilson, Joseph D / Morton, Joshua / Dequaire, Julie / O'Byrne, Katherine / Motohashi, Kenzo / Harper, Kirsty / Ravi, Krupa / Millar, Lancelot J / Peck, Liam J / Oliver, Madeleine / English, Marcus Rex / Kumarendran, Mary / Wedlich, Matthew / Ambler, Olivia / Deal, Oscar T / Sweeney, Owen / Cowie, Philip / Naudé, Rebecca te Water / Young, Rebecca / Freer, Rosie / Scott, Samuel / Sussmes, Samuel / Peters, Sarah / Pattenden, Saxon / Waite, Seren / Johnson, Síle Ann / Kourdov, Stefan / Santos-Paulo, Stephanie / Dimitrov, Stoyan / Kerneis, Sven / Ahmed-Firani, Tariq / King, Thomas B / Ritter, Thomas G / Foord, Thomas H / De Toledo, Zoe / Christie, Thomas / Gergely, Bernadett / Axten, David / Simons, Emma-Jane / Nevard, Heather / Philips, Jane / Szczurkowska, Justyna / Patel, Kaisha / Smit, Kyla / Warren, Laura / Morgan, Lisa / Smith, Lucianne / Robles, Maria / McKnight, Mary / Luciw, Michael / Gates, Michelle / Sande, Nellia / Turford, Rachel / Ray, Roshni / Rughani, Sonam / Mitchell, Tracey / Bellinger, Trisha / Wharton, Vicki / Justice, Anita / Jesuthasan, Gerald / Wareing, Susan / Huda Mohamad Fadzillah, Nurul / Cann, Kathryn / Kirton, Richard / Sutton, Claire / Salvagno, Claudia / DAmato, Gabriella / Pill, Gemma / Butcher, Lisa / Rylance-Knight, Lydia / Tabirao, Merline / Moroney, Ruth / Wright, Sarah / Peto, Timothy EA / Holthof, Bruno / O'Donnell, Anne-Marie / Ebner, Daniel / Conlon, Christopher P / Jeffery, Katie / Walker, Timothy M

    eLife

    2020  Volume 9

    Abstract: We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for IgG antibodies. 1128/10,034 (11.2%) staff had evidence of Covid-19 at some ... ...

    Abstract We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for IgG antibodies. 1128/10,034 (11.2%) staff had evidence of Covid-19 at some time. Using questionnaire data provided on potential risk-factors, staff with a confirmed household contact were at greatest risk (adjusted odds ratio [aOR] 4.82 [95%CI 3.45–6.72]). Higher rates of Covid-19 were seen in staff working in Covid-19-facing areas (22.6% vs. 8.6% elsewhere) (aOR 2.47 [1.99–3.08]). Controlling for Covid-19-facing status, risks were heterogenous across the hospital, with higher rates in acute medicine (1.52 [1.07–2.16]) and sporadic outbreaks in areas with few or no Covid-19 patients. Covid-19 intensive care unit staff were relatively protected (0.44 [0.28–0.69]), likely by a bundle of PPE-related measures. Positive results were more likely in Black (1.66 [1.25–2.21]) and Asian (1.51 [1.28–1.77]) staff, independent of role or working location, and in porters and cleaners (2.06 [1.34–3.15]).
    Keywords General Biochemistry, Genetics and Molecular Biology ; General Immunology and Microbiology ; General Neuroscience ; General Medicine ; covid19
    Language English
    Publisher eLife Sciences Publications, Ltd
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 2687154-3
    ISSN 2050-084X
    ISSN 2050-084X
    DOI 10.7554/elife.60675
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Book ; Online: Author response

    Eyre, David W / Lumley, Sheila F / O'Donnell, Denise / Campbell, Mark / Sims, Elizabeth / Lawson, Elaine / Warren, Fiona / James, Tim / Cox, Stuart / Howarth, Alison / Doherty, George / Hatch, Stephanie B / Kavanagh, James / Chau, Kevin K / Fowler, Philip W / Swann, Jeremy / Volk, Denis / Yang-Turner, Fan / Stoesser, Nicole /
    Matthews, Philippa C / Dudareva, Maria / Davies, Timothy / Shaw, Robert H / Peto, Leon / Downs, Louise O / Vogt, Alexander / Amini, Ali / Young, Bernadette C / Drennan, Philip George / Mentzer, Alexander J / Skelly, Donal T / Karpe, Fredrik / Neville, Matt J / Andersson, Monique / Brent, Andrew J / Jones, Nicola / Martins Ferreira, Lucas / Christott, Thomas / Marsden, Brian D / Hoosdally, Sarah / Cornall, Richard / Crook, Derrick W / Stuart, David I / Screaton, Gavin / Watson, Adam JR / Taylor, Adan / Chetwynd, Alan / Grassam-Rowe, Alexander / Mighiu, Alexandra S / Livingstone, Angus / Killen, Annabel / Rigler, Caitlin / Harries, Callum / East, Cameron / Lee, Charlotte / Mason, Chris JB / Holland, Christian / Thompson, Connor / Hennesey, Conor / Savva, Constantinos / Kim, David S / Harris, Edward WA / McGivern, Euan J / Qian, Evelyn / Rothwell, Evie / Back, Francesca / Kelly, Gabriella / Watson, Gareth / Howgego, Gregory / Chase, Hannah / Danbury, Hannah / Laurenson-Schafer, Hannah / Ward, Harry L / Hendron, Holly / Vorley, Imogen C / Tol, Isabel / Gunnell, James / Ward, Jocelyn LF / Drake, Jonathan / Wilson, Joseph D / Morton, Joshua / Dequaire, Julie / O'Byrne, Katherine / Motohashi, Kenzo / Harper, Kirsty / Ravi, Krupa / Millar, Lancelot J / Peck, Liam J / Oliver, Madeleine / English, Marcus Rex / Kumarendran, Mary / Wedlich, Matthew / Ambler, Olivia / Deal, Oscar T / Sweeney, Owen / Cowie, Philip / Naudé, Rebecca te Water / Young, Rebecca / Freer, Rosie / Scott, Samuel / Sussmes, Samuel / Peters, Sarah / Pattenden, Saxon / Waite, Seren / Johnson, Síle Ann / Kourdov, Stefan / Santos-Paulo, Stephanie / Dimitrov, Stoyan / Kerneis, Sven / Ahmed-Firani, Tariq / King, Thomas B / Ritter, Thomas G / Foord, Thomas H / De Toledo, Zoe / Christie, Thomas / Gergely, Bernadett / Axten, David / Simons, Emma-Jane / Nevard, Heather / Philips, Jane / Szczurkowska, Justyna / Patel, Kaisha / Smit, Kyla / Warren, Laura / Morgan, Lisa / Smith, Lucianne / Robles, Maria / McKnight, Mary / Luciw, Michael / Gates, Michelle / Sande, Nellia / Turford, Rachel / Ray, Roshni / Rughani, Sonam / Mitchell, Tracey / Bellinger, Trisha / Wharton, Vicki / Justice, Anita / Jesuthasan, Gerald / Wareing, Susan / Huda Mohamad Fadzillah, Nurul / Cann, Kathryn / Kirton, Richard / Sutton, Claire / Salvagno, Claudia / DAmato, Gabriella / Pill, Gemma / Butcher, Lisa / Rylance-Knight, Lydia / Tabirao, Merline / Moroney, Ruth / Wright, Sarah / Peto, Timothy EA / Holthof, Bruno / O'Donnell, Anne-Marie / Ebner, Daniel / Conlon, Christopher P / Jeffery, Katie / Walker, Timothy M

    Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study

    2020  

    Keywords covid19
    Publisher eLife Sciences Publications, Ltd
    Publishing country uk
    Document type Book ; Online
    DOI 10.7554/elife.60675.sa2
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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