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  1. Book ; Thesis: Bile acids activate NLRP3 inflammasome, promoting murine liver inflammation or fibrosis in a cell type-specific manner

    Holtmann, Theresa Maria

    2022  

    Author's details vorgelegt von Theresa Maria Holtmann
    Language English
    Size 25 Seiten, Illustrationen
    Publishing place Aachen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2022
    Note Diese Dissertation besteht aus einem Aufsatz der bereits in der Zeitschrift "Cells" (2021;10:2618) veröffentlicht wurde
    HBZ-ID HT021558415
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2022 D 516 order for loan Magazin

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  2. Article ; Conference proceedings: Endoscopic treatment of esophageal strictures– a retrospective analysis from a high volume academic endoscopy center

    Çelebi, Ö. / Sigal, M. / Razpotnik, M. / Leonhardt, S. / Holtmann, T. M. / Adler, A. / Tacke, F. / Wree, A.

    Endoscopy

    2024  Volume 56, Issue S 02

    Event/congress ESGE Days 2024, Berlin, Germany, 2024-04-25
    Language English
    Publishing date 2024-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/s-0044-1783245
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 669: Show issues Location:
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    Zs.MO 162: Show issues

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  3. Book ; Thesis: Die Magier vom Osten und der Stern

    Holtmann, Thomas

    Mt 2,1-12 im Kontext frühchristlicher Traditionen

    (Marburger theologische Studien ; 87)

    2005  

    Author's details Thomas Holtmann
    Series title Marburger theologische Studien ; 87
    Keywords Magi ; Star of Bethlehem ; Frühchristentum ; Stern der Weisen ; Exegese ; Magie ; Stern ; Griechisch ; Literatur ; Astronomie ; Astrologie ; Magier
    Language German
    Size XI, 290 S, 210 mm x 170 mm
    Publisher Elwert
    Publishing place Marburg
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Marburg, 2003
    ISBN 3770812751 ; 9783770812752
    Database Former special subject collection: coastal and deep sea fishing

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  4. Book ; Thesis: Die Magier vom Osten und der Stern

    Holtmann, Thomas

    Mt 2,1-12 im Kontext frühchristlicher Traditionen

    (Marburger theologische Studien ; 87)

    2005  

    Author's details Thomas Holtmann
    Series title Marburger theologische Studien ; 87
    Keywords Magi ; Star of Bethlehem ; Frühchristentum ; Stern der Weisen ; Exegese ; Magie ; Stern ; Griechisch ; Literatur ; Astronomie ; Astrologie ; Magier
    Language German
    Size XI, 290 S, 210 mm x 170 mm
    Publisher Elwert
    Publishing place Marburg
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Marburg, 2003
    ISBN 3770812751 ; 9783770812752
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  5. Book ; Thesis: Membranreaktoren zur Estersynthese

    Holtmann, Thomas

    Modellierung und experimentelle Validierung am Beispiel der Ethylacetatsynthese

    (Berichte aus der Verfahrenstechnik)

    2003  

    Author's details Thomas Holtmann
    Series title Berichte aus der Verfahrenstechnik
    Keywords Hohlfaser ; Essigsäureethylester ; Chemische Synthese ; Veresterung ; Gaspermeation ; Membranreaktor
    Language German
    Size VII, 137 S., graph. Darst., 210 mm x 148 mm, 231 gr.
    Publisher Shaker
    Publishing place Aachen
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Dortmund, 2003
    ISBN 3832218971 ; 9783832218973
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  6. Book ; Thesis: Entwicklung eines Intrumentariums zur Emissionsprojektion auf der Basis des Emissionsfaktoransatzes

    Holtmann, Thomas

    (Europäische Hochschulschriften : Reihe 5, Volks- und Betriebswirtschaft ; 2161)

    1997  

    Author's details Thomas Holtmann
    Series title Europäische Hochschulschriften : Reihe 5, Volks- und Betriebswirtschaft ; 2161
    Keywords Projektion ; Emissionskataster ; Emissionsverringerung
    Language German
    Size XII, 251 S, graph. Darst., Ill., Tab, 21 cm
    Publisher Lang
    Publishing place Frankfurt am Main u.a.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Karlsruhe, 1996
    Note Originally presented as the author's thesis (doctoral)--Universität Karlsruhe, 1996
    ISBN 3631320566 ; 9783631320563
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  7. Book: Entwicklung eines Instrumentariums zur Emissionsprojektion auf der Basis des Emissionsfaktoransatzes

    Holtmann, Thomas

    1997  Volume 2161, Page(s) XII, 251

    Abstract: Die Entwicklung von Emissionsminderungsstrategien erfordert die Abschaetzung der zukuenftigen Wirksamkeit heute zu realisierender Emissionsminderungsmassnahmen. Dies ist insbesondere vor dem Hintergrund der hohen Kosten erforderlich, die mit der ... ...

    Abstract Die Entwicklung von Emissionsminderungsstrategien erfordert die Abschaetzung der zukuenftigen Wirksamkeit heute zu realisierender Emissionsminderungsmassnahmen. Dies ist insbesondere vor dem Hintergrund der hohen Kosten erforderlich, die mit der Allokation solcher Massnahmen verbunden sind. Da die Umweltgesetzgebung ueber die Festlegung von Emissionsgrenzwerten vor allem auf der Technologieebene reglementierend eingreift, muss ein solcher Ansatz auch von dieser Ebene ausgehen. Dazu wird in dieser Arbeit eine Methodik fuer die Durchfuehrung von Emissionsprojektionen fuer Luftschadstoffe aus stationaeren und mobilen Quellen vorgestellt. Hierbei werden die Schadstoffe SOx, NOx, NMVOC, CH4, CO, CO2, N2O und NH3 beruecksichtigt, basierend auf dem europaeischen CORINAIR-Standard fuer die Erstellung von Emissionskatastern und unter Verwendung des Emissionsfaktoransatzes. Die praktische Umsetzung in ein Computerprogramm erfolgte im Rahmen eines EU-Forschungsprojektes in den Jahren 1993 bis 1995. Somit ist es nun moeglich, in Kompatibilitaet zur existierenden europaeischen Systematik fuer Emissionskataster Projektionen durchzufuehren, um Emissionsminderungsstrategien zu evaluieren.
    Keywords Emission ; Emissionsfaktor ; Stickstoffoxid ; Bilanzierung ; Emissionskataster ; Internationale Harmonisierung ; Emissionsprognose ; Emissionsminderung ; Luftschadstoff ; Schwefeloxid ; Kompatibilitaet ; Leichtfluechtige Kohlenwasserstoffe ; Kohlenwasserstoff ; Methan ; Kohlenmonoxid ; Kohlendioxid ; Distickstoffoxid ; Ammoniak ; Berechnungsverfahren ; Computerprogramm ; Zeitverlauf ; Regressionsanalyse ; Emissionsberechnung
    Language German
    Document type Book
    ISBN 3-631-32056-6
    Database OPAC and Environmental database (ULIDAT) of The Federal Environment Agency (UBA)

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  8. Book: Entwicklung eines Instrumentariums zur Emissionsprojektion auf der Basis des Emissionsfaktoransatzes

    Holtmann, Thomas

    1997  Volume 2161, Page(s) XII, 251 S.

    Language German
    Document type Book
    ISBN 3-631-32056-6
    Database OPAC and Environmental database (ULIDAT) of The Federal Environment Agency (UBA)

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  9. Book ; Thesis: Entwicklung eines Instrumentariums zur Emissionsprojektion auf der Basis des Emissionsfaktoransatzes

    Holtmann, Thomas

    (Europäische Hochschulschriften : Reihe 5, Volks- und Betriebswirtschaft ; 2161)

    1997  

    Author's details Thomas Holtmann
    Series title Europäische Hochschulschriften : Reihe 5, Volks- und Betriebswirtschaft ; 2161
    Keywords Luftverschmutzung ; Prognoseverfahren ; Umweltstatistik ; Immissionsschutz ; Computerunterstützung ; Theorie ; EU-Staaten ; Energiewirtschaft ; 17*27*37*47*57*67*18*28*38*48*58*68*81*82*83*84*85*86
    Language German
    Size XII, 251 S. : graph. Darst
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Zugl.: Karlsruhe, Univ., Diss., 1996
    Note Literaturverz. S. 159 - 170
    ISBN 3631320566 ; 9783631320563
    Database ECONomics Information System

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  10. Article ; Online: Oxidized linoleic acid metabolites induce liver mitochondrial dysfunction, apoptosis, and NLRP3 activation in mice.

    Schuster, Susanne / Johnson, Casey D / Hennebelle, Marie / Holtmann, Theresa / Taha, Ameer Y / Kirpich, Irina A / Eguchi, Akiko / Ramsden, Christopher E / Papouchado, Bettina G / McClain, Craig J / Feldstein, Ariel E

    Journal of lipid research

    2018  Volume 59, Issue 9, Page(s) 1597–1609

    Abstract: Circulating oxidized linoleic acid (LA) metabolites (OXLAMs) are increased in patients with nonalcoholic steatohepatitis (NASH) and their levels correlate with disease severity. However, the mechanisms by which OXLAMs contribute to NASH development are ... ...

    Abstract Circulating oxidized linoleic acid (LA) metabolites (OXLAMs) are increased in patients with nonalcoholic steatohepatitis (NASH) and their levels correlate with disease severity. However, the mechanisms by which OXLAMs contribute to NASH development are incompletely understood. We tested the hypothesis that LA or OXLAMs provided directly through the diet are involved in the development of hepatic injury. C57BL/6 mice were fed an isocaloric high-fat diet containing low LA, high LA, or OXLAMs for 8 weeks. The livers of OXLAM-fed mice showed lower triglyceride concentrations, but higher FA oxidation and lipid peroxidation in association with increased oxidative stress. OXLAM-induced mitochondrial dysfunction was associated with reduced Complex I protein and hepatic ATP levels, as well as increased mitochondrial biogenesis and cytoplasmic mitochondrial DNA. Oxidative stress increased thioredoxin-interacting protein (TXNIP) in the liver and stimulated the activation of mitochondrial apoptosis signal-regulating kinase 1 (ASK1) leading to apoptosis. We also found increased levels of NOD-like receptor protein 3 (NLRP3) inflammasome components and Caspase-1 activation in the livers of OXLAM-fed mice. In vitro, OXLAMs induced hepatocyte cell death, which was partly dependent on Caspase-1 activation. This study identified key mechanisms by which dietary OXLAMs contribute to NASH development, including mitochondrial dysfunction, hepatocyte cell death, and NLRP3 inflammasome activation.
    MeSH term(s) Animals ; Apoptosis/drug effects ; Body Weight/drug effects ; Carrier Proteins/metabolism ; Diet, High-Fat/adverse effects ; Gene Expression Regulation/drug effects ; Inflammasomes/metabolism ; Linoleic Acid/metabolism ; Linoleic Acid/pharmacology ; Lipid Peroxidation/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Mitochondria, Liver/drug effects ; Mitochondria, Liver/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Oxidative Stress/drug effects ; Thioredoxins/metabolism
    Chemical Substances Carrier Proteins ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Txnip protein, mouse ; Thioredoxins (52500-60-4) ; Linoleic Acid (9KJL21T0QJ)
    Language English
    Publishing date 2018-07-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 80154-9
    ISSN 1539-7262 ; 0022-2275
    ISSN (online) 1539-7262
    ISSN 0022-2275
    DOI 10.1194/jlr.M083741
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 175: Show issues Location:
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