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  1. Article: A neuron's ambrosia: non-autonomous unfolded protein response of the endoplasmic reticulum promotes lifespan.

    Homentcovschi, Stefan / Higuchi-Sanabria, Ryo

    Neural regeneration research

    2021  Volume 17, Issue 2, Page(s) 309–310

    Language English
    Publishing date 2021-07-16
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.317967
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Imaging of Actin Cytoskeletal Integrity During Aging in C. elegans.

    Garcia, Gilberto / Homentcovschi, Stefan / Kelet, Naame / Higuchi-Sanabria, Ryo

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2364, Page(s) 101–137

    Abstract: The actin cytoskeleton plays a fundamental role in the regulation of multiple cellular pathways, including trafficking and locomotion. The functional integrity of the cytoskeleton is important during aging, as the decline of cytoskeletal integrity ... ...

    Abstract The actin cytoskeleton plays a fundamental role in the regulation of multiple cellular pathways, including trafficking and locomotion. The functional integrity of the cytoskeleton is important during aging, as the decline of cytoskeletal integrity contributes to the physiological consequence of aging. Moreover, improving cytoskeletal form and function throughout aging is sufficient to drive life span extension and promote organismal health in multiple model systems. For these reasons, optimized protocols for visualization of the actin cytoskeleton and its downstream consequences on health span and life span are critical for understanding the aging process. In C. elegans, the actin cytoskeleton shows diverse morphologies across tissues, potentially due to the significantly different functions of each cell type. This chapter describes an imaging platform utilizing LifeAct to visualize the actin cytoskeleton in live, whole nematodes throughout the aging process and methods to perform follow-up studies on the life span and health span of these organisms.
    MeSH term(s) Actin Cytoskeleton ; Actins ; Aging ; Animals ; Caenorhabditis elegans ; Cytoskeleton
    Chemical Substances Actins
    Language English
    Publishing date 2021-09-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1661-1_5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Divergent Nodes of Non-autonomous UPR

    Higuchi-Sanabria, Ryo / Durieux, Jenni / Kelet, Naame / Homentcovschi, Stefan / de Los Rios Rogers, Mattias / Monshietehadi, Samira / Garcia, Gilberto / Dallarda, Sofia / Daniele, Joseph R / Ramachandran, Vidhya / Sahay, Arushi / Tronnes, Sarah U / Joe, Larry / Dillin, Andrew

    Cell reports

    2020  Volume 33, Issue 10, Page(s) 108489

    Abstract: In multicellular organisms, neurons integrate a diverse array of external cues to affect downstream changes in organismal health. Specifically, activation of the endoplasmic reticulum (ER) unfolded protein response ( ... ...

    Abstract In multicellular organisms, neurons integrate a diverse array of external cues to affect downstream changes in organismal health. Specifically, activation of the endoplasmic reticulum (ER) unfolded protein response (UPR
    MeSH term(s) Aging ; Animals ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/metabolism ; Dopaminergic Neurons/metabolism ; Dopaminergic Neurons/physiology ; Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum Stress/physiology ; Lipid Metabolism/physiology ; Longevity ; Neurons/metabolism ; Proteostasis/physiology ; Serotonergic Neurons/metabolism ; Serotonergic Neurons/physiology ; Signal Transduction/physiology ; Unfolded Protein Response/genetics ; Unfolded Protein Response/physiology
    Chemical Substances Caenorhabditis elegans Proteins
    Language English
    Publishing date 2020-12-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2020.108489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Cross-species screening platforms identify EPS-8 as a critical link for mitochondrial stress and actin stabilization.

    Moehle, Erica A / Higuchi-Sanabria, Ryo / Tsui, C Kimberly / Homentcovschi, Stefan / Tharp, Kevin M / Zhang, Hanlin / Chi, Hannah / Joe, Larry / de Los Rios Rogers, Mattias / Sahay, Arushi / Kelet, Naame / Benitez, Camila / Bar-Ziv, Raz / Garcia, Gilberto / Shen, Koning / Frankino, Phillip A / Schinzel, Robert T / Shalem, Ophir / Dillin, Andrew

    Science advances

    2021  Volume 7, Issue 44, Page(s) eabj6818

    Abstract: The dysfunction of mitochondria is associated with the physiological consequences of aging and many age-related diseases. Therefore, critical quality control mechanisms exist to protect mitochondrial functions, including the unfolded protein response of ... ...

    Abstract The dysfunction of mitochondria is associated with the physiological consequences of aging and many age-related diseases. Therefore, critical quality control mechanisms exist to protect mitochondrial functions, including the unfolded protein response of the mitochondria (UPR
    Language English
    Publishing date 2021-10-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.abj6818
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Lysosomal recycling of amino acids affects ER quality control.

    Higuchi-Sanabria, Ryo / Shen, Koning / Kelet, Naame / Frankino, Phillip A / Durieux, Jenni / Bar-Ziv, Raz / Sing, Cierra N / Garcia, Enrique J / Homentcovschi, Stefan / Sanchez, Melissa / Wu, Rui / Tronnes, Sarah U / Joe, Larry / Webster, Brant / Ahilon-Jeronimo, Alex / Monshietehadi, Samira / Dallarda, Sofia / Pender, Corinne / Pon, Liza A /
    Zoncu, Roberto / Dillin, Andrew

    Science advances

    2020  Volume 6, Issue 26, Page(s) eaaz9805

    Abstract: Recent work has highlighted the fact that lysosomes are a critical signaling hub of metabolic processes, providing fundamental building blocks crucial for anabolic functions. How lysosomal functions affect other cellular compartments is not fully ... ...

    Abstract Recent work has highlighted the fact that lysosomes are a critical signaling hub of metabolic processes, providing fundamental building blocks crucial for anabolic functions. How lysosomal functions affect other cellular compartments is not fully understood. Here, we find that lysosomal recycling of the amino acids lysine and arginine is essential for proper ER quality control through the UPR
    Language English
    Publishing date 2020-06-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.aaz9805
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Adhesion-mediated mechanosignaling forces mitohormesis.

    Tharp, Kevin M / Higuchi-Sanabria, Ryo / Timblin, Greg A / Ford, Breanna / Garzon-Coral, Carlos / Schneider, Catherine / Muncie, Jonathon M / Stashko, Connor / Daniele, Joseph R / Moore, Andrew S / Frankino, Phillip A / Homentcovschi, Stefan / Manoli, Sagar S / Shao, Hao / Richards, Alicia L / Chen, Kuei-Ho / Hoeve, Johanna Ten / Ku, Gregory M / Hellerstein, Marc /
    Nomura, Daniel K / Saijo, Karou / Gestwicki, Jason / Dunn, Alexander R / Krogan, Nevan J / Swaney, Danielle L / Dillin, Andrew / Weaver, Valerie M

    Cell metabolism

    2021  Volume 33, Issue 7, Page(s) 1322–1341.e13

    Abstract: Mitochondria control eukaryotic cell fate by producing the energy needed to support life and the signals required to execute programed cell death. The biochemical milieu is known to affect mitochondrial function and contribute to the dysfunctional ... ...

    Abstract Mitochondria control eukaryotic cell fate by producing the energy needed to support life and the signals required to execute programed cell death. The biochemical milieu is known to affect mitochondrial function and contribute to the dysfunctional mitochondrial phenotypes implicated in cancer and the morbidities of aging. However, the physical characteristics of the extracellular matrix are also altered in cancerous and aging tissues. Here, we demonstrate that cells sense the physical properties of the extracellular matrix and activate a mitochondrial stress response that adaptively tunes mitochondrial function via solute carrier family 9 member A1-dependent ion exchange and heat shock factor 1-dependent transcription. Overall, our data indicate that adhesion-mediated mechanosignaling may play an unappreciated role in the altered mitochondrial functions observed in aging and cancer.
    MeSH term(s) Adult ; Animals ; Animals, Genetically Modified ; Caenorhabditis elegans ; Cell Adhesion/physiology ; Cell Respiration ; Cells, Cultured ; Extracellular Matrix/metabolism ; Female ; HEK293 Cells ; Humans ; Hyperglycemia/metabolism ; Hyperglycemia/pathology ; Hyperglycemia/physiopathology ; Integrins/physiology ; Ion Exchange ; Mechanotransduction, Cellular/physiology ; Mice ; Microscopy, Confocal ; Middle Aged ; Mitochondria/metabolism ; Mitochondria/physiology ; Mitochondrial Dynamics/physiology ; Oxidative Stress/physiology ; Reactive Oxygen Species/metabolism ; Signal Transduction/physiology ; Sodium-Hydrogen Exchanger 1/physiology ; Time-Lapse Imaging
    Chemical Substances Integrins ; Reactive Oxygen Species ; Sodium-Hydrogen Exchanger 1
    Language English
    Publishing date 2021-05-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Video-Audio Media
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2021.04.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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