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Article ; Online: Development and optimization of a one step process for the production and sterilization of liposomes using supercritical CO

Penoy, Noémie / Delma, Kouka Luc / Homkar, Nirmayi / Karim Sakira, Abdoul / Egrek, Sabrina / Sacheli, Rosalie / Sacré, Pierre-Yves / Grignard, Bruno / Hayette, Marie-Pierre / Somé, Touridomon Issa / Semdé, Rasmané / Evrard, Brigitte / Piel, Géraldine

International journal of pharmaceutics

2024  Volume 651, Page(s) 123769

Abstract: Liposomes are very interesting drug delivery systems for pharmaceutical and therapeutic purposes. However, liposome sterilization as well as their industrial manufacturing remain challenging. Supercritical carbon dioxide is an innovative technology that ... ...

Abstract Liposomes are very interesting drug delivery systems for pharmaceutical and therapeutic purposes. However, liposome sterilization as well as their industrial manufacturing remain challenging. Supercritical carbon dioxide is an innovative technology that can potentially overcome these limitations. The aim of this study was to optimize a one-step process for producing and sterilizing liposomes using supercritical CO
MeSH term(s) Humans ; Liposomes/chemistry ; Carbon Dioxide/chemistry ; Drug Delivery Systems ; Sterilization ; Infertility
Chemical Substances Liposomes ; Carbon Dioxide (142M471B3J)
Language English
Publishing date 2024-01-04
Publishing country Netherlands
Document type Journal Article
ZDB-ID 428962-6
ISSN 1873-3476 ; 0378-5173
ISSN (online) 1873-3476
ISSN 0378-5173
DOI 10.1016/j.ijpharm.2024.123769
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