LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 6 of total 6

Search options

  1. Article: High-throughput screening of the effects of 90 xenobiotics on the simplified human gut microbiota model (SIHUMIx): a metaproteomic and metabolomic study.

    Castañeda-Monsalve, Victor / Fröhlich, Laura-Fabienne / Haange, Sven-Bastiaan / Homsi, Masun Nabhan / Rolle-Kampczyk, Ulrike / Fu, Qiuguo / von Bergen, Martin / Jehmlich, Nico

    Frontiers in microbiology

    2024  Volume 15, Page(s) 1349367

    Abstract: The human gut microbiota is a complex microbial community with critical functions for the host, including the transformation of various chemicals. While effects on microorganisms has been evaluated using single-species models, their functional effects ... ...

    Abstract The human gut microbiota is a complex microbial community with critical functions for the host, including the transformation of various chemicals. While effects on microorganisms has been evaluated using single-species models, their functional effects within more complex microbial communities remain unclear. In this study, we investigated the response of a simplified human gut microbiota model (SIHUMIx) cultivated in an
    Language English
    Publishing date 2024-02-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1349367
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: How do green and black coffee brews and bioactive interaction with gut microbiome affect its health outcomes? Mining evidence from mechanistic studies, metagenomics and clinical trials

    Farag, Mohamed A. / von Bergen, Martin / Saleh, Basma M. / Homsi, Masun Nabhan / Abd El-Al, Mohamed S.

    Trends in food science & technology. 2021 Dec., v. 118

    2021  

    Abstract: The gut microbiome has become a hot topic in recent years with increasing reports on the positive role of a well-balanced gut microbiota composition for one's health and well-being. A number of dietary factors can modulate gut composition, although few ... ...

    Abstract The gut microbiome has become a hot topic in recent years with increasing reports on the positive role of a well-balanced gut microbiota composition for one's health and well-being. A number of dietary factors can modulate gut composition, although few publications have focused on common daily beverages impact on the gut microbiome. Coffee is a worldwide beverage consumed mostly as black coffee that is originally derived from green coffee beans post roasting. To enhance the taste and aroma, green coffee is typically roasted and to further affect its chemical composition and rationalize for the different health outcomes. Roasted seeds contain a high caffeine levels versus phenolic acids i.e., chlorogenic acid enrichment in green coffee suggestive that they interact differently with gut microbiota and to affect its metabolism.The present review provides a mechanistic insight on the effects of black and green coffee chemicals on the gut microbiome. We present herein the first comprehensive review of how coffee natural bioactive such as caffeine and chlorogenic acid and its process derived chemicals i.e., melanoidins can specifically influence gut homeostasis, and likewise via gut microbiota-mediated coffee chemicals metabolism.The role of gut microbiota in affecting coffee chemicals and the potential of mining metagenomics data to uncover gut microbiome community and carbohydrate active enzyme (CAZyme) profile associated with coffee consumption are presented for the first time. Moreover, our metagenomics analysis in silico showed a decrease in abundance in either Desulfofarcimen or Mycoplasma genera, confirmed the basic coffee-gut microbial enzymes repertoire found in the literature and highlights for the first time the coffee CAZyme biomarkers encoded by the human gut microbiome.
    Keywords Mycoplasma ; biomarkers ; caffeine ; carbohydrates ; chemical composition ; chlorogenic acid ; computer simulation ; digestive system ; homeostasis ; humans ; intestinal microorganisms ; melanoidins ; metagenomics ; odors ; taste
    Language English
    Dates of publication 2021-12
    Size p. 920-937.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1049246-x
    ISSN 1879-3053 ; 0924-2244
    ISSN (online) 1879-3053
    ISSN 0924-2244
    DOI 10.1016/j.tifs.2021.11.004
    Database NAL-Catalogue (AGRICOLA)

    Full text online

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 5184: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Cocoa seeds and chocolate products interaction with gut microbiota; mining microbial and functional biomarkers from mechanistic studies, clinical trials and 16S rRNA amplicon sequencing.

    Farag, Mohamed A / Hariri, Mohamad Louai M / Ehab, Aya / Homsi, Masun Nabhan / Zhao, Chao / von Bergen, Martin

    Critical reviews in food science and nutrition

    2022  Volume 64, Issue 10, Page(s) 3122–3138

    Abstract: In recent years, gut microbiome has evolved as a focal point of interest with growing recognition that a well-balanced gut microbiota is highly relevant to an individual's health status. The present review provides a mechanistic insight on the effects of ...

    Abstract In recent years, gut microbiome has evolved as a focal point of interest with growing recognition that a well-balanced gut microbiota is highly relevant to an individual's health status. The present review provides a mechanistic insight on the effects of cocoa chemicals on the gut microbiome and further reveals
    MeSH term(s) Humans ; Chocolate/analysis ; Gastrointestinal Microbiome ; RNA, Ribosomal, 16S/genetics ; Feces ; Cacao ; Seeds ; Biomarkers
    Chemical Substances RNA, Ribosomal, 16S ; Biomarkers
    Language English
    Publishing date 2022-10-03
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1037504-1
    ISSN 1549-7852 ; 1040-8398
    ISSN (online) 1549-7852
    ISSN 1040-8398
    DOI 10.1080/10408398.2022.2130159
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1459: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Acoustic monitoring allows detection of honeybee queen presence and absence ; Akustisches Monitoring kann die An- und Abwesenheit der Honigbienenkönigin detektieren

    Uthoff, Cassandra / Homsi, Masun Nabhan / Garcia Martinez, Victor Jose / Nowak, Jacek / Rennert, Michel / Jehmlich, Nico / Beckmann, Michael / Remmler, Paul / Bumberger, Jan / Hardt, Michael / Pistorius, Jens / Jäger, Sylvo / von Bergen, Martin

    2024  

    Keywords Text ; abstract_or_summary ; ddc:630
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article: Effect of Gut Microbiota Biotransformation on Dietary Tannins and Human Health Implications.

    Sallam, Ibrahim E / Abdelwareth, Amr / Attia, Heba / Aziz, Ramy K / Homsi, Masun Nabhan / von Bergen, Martin / Farag, Mohamed A

    Microorganisms

    2021  Volume 9, Issue 5

    Abstract: Tannins represent a heterogeneous group of high-molecular-weight polyphenols that are ubiquitous among plant families, especially in cereals, as well as in many fruits and vegetables. Hydrolysable and condensed tannins, in addition to phlorotannins from ... ...

    Abstract Tannins represent a heterogeneous group of high-molecular-weight polyphenols that are ubiquitous among plant families, especially in cereals, as well as in many fruits and vegetables. Hydrolysable and condensed tannins, in addition to phlorotannins from marine algae, are the main classes of these bioactive compounds. Despite their low bioavailability, tannins have many beneficial pharmacological effects, such as anti-inflammatory, antioxidant, antidiabetic, anticancer, and cardioprotective effects. Microbiota-mediated hydrolysis of tannins produces highly bioaccessible metabolites, which have been extensively studied and account for most of the health effects attributed to tannins. This review article summarises the effect of the human microbiota on the metabolism of different tannin groups and the expected health benefits that may be induced by such mutual interactions. Microbial metabolism of tannins yields highly bioaccessible microbial metabolites that account for most of the systemic effects of tannins. This article also uses explainable artificial intelligence to define the molecular signatures of gut-biotransformed tannin metabolites that are correlated with chemical and biological activity. An understanding of microbiota-tannin interactions, tannin metabolism-related phenotypes (metabotypes) and chemical tannin-metabolites motifs is of great importance for harnessing the biological effects of tannins for drug discovery and other health benefits.
    Language English
    Publishing date 2021-04-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms9050965
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Effect of Gut Microbiota Biotransformation on Dietary Tannins and Human Health Implications

    Sallam, Ibrahim E / Abdelwareth, Amr / Attia, Heba / Aziz, Ramy K / Homsi, Masun Nabhan / von Bergen, Martin / Farag, Mohamed A

    Microorganisms. 2021 Apr. 29, v. 9, no. 5

    2021  

    Abstract: Tannins represent a heterogeneous group of high-molecular-weight polyphenols that are ubiquitous among plant families, especially in cereals, as well as in many fruits and vegetables. Hydrolysable and condensed tannins, in addition to phlorotannins from ... ...

    Abstract Tannins represent a heterogeneous group of high-molecular-weight polyphenols that are ubiquitous among plant families, especially in cereals, as well as in many fruits and vegetables. Hydrolysable and condensed tannins, in addition to phlorotannins from marine algae, are the main classes of these bioactive compounds. Despite their low bioavailability, tannins have many beneficial pharmacological effects, such as anti-inflammatory, antioxidant, antidiabetic, anticancer, and cardioprotective effects. Microbiota-mediated hydrolysis of tannins produces highly bioaccessible metabolites, which have been extensively studied and account for most of the health effects attributed to tannins. This review article summarises the effect of the human microbiota on the metabolism of different tannin groups and the expected health benefits that may be induced by such mutual interactions. Microbial metabolism of tannins yields highly bioaccessible microbial metabolites that account for most of the systemic effects of tannins. This article also uses explainable artificial intelligence to define the molecular signatures of gut-biotransformed tannin metabolites that are correlated with chemical and biological activity. An understanding of microbiota–tannin interactions, tannin metabolism-related phenotypes (metabotypes) and chemical tannin-metabolites motifs is of great importance for harnessing the biological effects of tannins for drug discovery and other health benefits.
    Keywords antioxidants ; artificial intelligence ; bioavailability ; biotransformation ; drugs ; human health ; humans ; hydrolysis ; intestinal microorganisms ; metabolism ; metabolites ; phlorotannins
    Language English
    Dates of publication 2021-0429
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms9050965
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top