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  1. Article ; Online: Restless leg syndrome in spinal cord injury: case report.

    McNamara, Shane / Hon, Beverly / Kirshblum, Steven

    Spinal cord series and cases

    2023  Volume 9, Issue 1, Page(s) 19

    Abstract: Case description: Restless leg syndrome (RLS) is a condition infrequently reported in spinal cord injury that causes an uncomfortable sensation in the legs and an urge to move them. We report a case involving a 63-year-old man with incomplete paraplegia ...

    Abstract Case description: Restless leg syndrome (RLS) is a condition infrequently reported in spinal cord injury that causes an uncomfortable sensation in the legs and an urge to move them. We report a case involving a 63-year-old man with incomplete paraplegia with an onset of RLS four years post injury.
    Findings: Based upon history, pramipexole was prescribed for the presumptive diagnosis of RLS, with good effect. Initial workup revealed an anemia (hemoglobin of 9.3 gram/deciliter (g/dl)) and iron deficiency (ferritin of 10 microgram/liter (μg/L)), necessitating further evaluation.
    Conclusion: Due to the complexities in diagnosing RLS in patients with SCI, it is important to be cognizant of symptoms and to consider this diagnosis to initiate the appropriate work-up for an etiology, of which iron deficiency anemia is common.
    MeSH term(s) Male ; Humans ; Middle Aged ; Restless Legs Syndrome/complications ; Restless Legs Syndrome/drug therapy ; Pramipexole ; Spinal Cord Injuries/complications ; Paraplegia/complications
    Chemical Substances Pramipexole (83619PEU5T)
    Language English
    Publishing date 2023-05-04
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 2058-6124
    ISSN (online) 2058-6124
    DOI 10.1038/s41394-023-00576-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Correction: Transient alteration of consciousness in spinal cord injury secondary to Baclofen use: a case report.

    Pisano, Thomas John / Ace, Jessica / Hon, Beverly

    Spinal cord series and cases

    2023  Volume 9, Issue 1, Page(s) 44

    Language English
    Publishing date 2023-08-18
    Publishing country England
    Document type Published Erratum
    ISSN 2058-6124
    ISSN (online) 2058-6124
    DOI 10.1038/s41394-023-00601-6
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  3. Article ; Online: Transient alteration of consciousness in spinal cord injury secondary to Baclofen use: a case report.

    Pisano, Thomas John / Ace, Jessica / Hon, Beverly

    Spinal cord series and cases

    2022  Volume 8, Issue 1, Page(s) 56

    Abstract: Introduction: Oral baclofen is commonly used for spasticity management, especially with neurogenic bladder in spinal cord injury (SCI). A less common side effect of baclofen is transient alterations of consciousness, which can easily be confused for ... ...

    Abstract Introduction: Oral baclofen is commonly used for spasticity management, especially with neurogenic bladder in spinal cord injury (SCI). A less common side effect of baclofen is transient alterations of consciousness, which can easily be confused for altered mental status secondary to orthostatic hypotension in SCI.
    Case presentation: A 43-year-old man with an acute SCI secondary to an aortic dissection was found to have episodes of confusion after titrating oral baclofen from 5 mg three times per day to 10 mg three times per day at an acute rehabilitation facility. Orthostatic hypotension was initially suspected as the cause of transient alterations of consciousness; however, he was never found to be hypotensive during these episodes. His confusion resolved several days after discontinuation of baclofen.
    Discussion: Although, confusion and lightheadedness in SCI are commonly caused by orthostatic hypotension, it is important for physicians to be cognizant of baclofen's side effects, which increase in the setting of acute kidney injury (AKI). If an adverse effect is suspected, baclofen should be tapered while remaining observant for signs of baclofen withdrawal, which can be life-threatening. This case report is a reminder for clinicians to be aware of the uncommon adverse effects of baclofen when initiating therapy in SCI, especially in patients with AKI and neurogenic bladders.
    MeSH term(s) Acute Kidney Injury/chemically induced ; Acute Kidney Injury/complications ; Acute Kidney Injury/drug therapy ; Adult ; Baclofen/adverse effects ; Consciousness ; Humans ; Hypotension, Orthostatic/chemically induced ; Hypotension, Orthostatic/complications ; Hypotension, Orthostatic/drug therapy ; Male ; Spinal Cord Injuries/drug therapy ; Urinary Bladder, Neurogenic/complications
    Chemical Substances Baclofen (H789N3FKE8)
    Language English
    Publishing date 2022-05-21
    Publishing country England
    Document type Case Reports ; Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2058-6124
    ISSN (online) 2058-6124
    DOI 10.1038/s41394-022-00511-z
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  4. Article ; Online: Duplex ultrasound surveillance for deep vein thrombosis after acute traumatic spinal cord injury at rehabilitation admission.

    Hon, Beverly / Botticello, Amanda / Kirshblum, Steven

    The journal of spinal cord medicine

    2019  Volume 43, Issue 3, Page(s) 298–305

    Abstract: Context/objective: ...

    Abstract Context/objective:
    MeSH term(s) Acute Disease ; Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Disease Progression ; Female ; Humans ; Lower Extremity/diagnostic imaging ; Male ; Middle Aged ; Patient Admission ; Pulmonary Embolism/epidemiology ; Pulmonary Embolism/etiology ; Rehabilitation Centers ; Retrospective Studies ; Severity of Illness Index ; Spinal Cord Injuries/diagnostic imaging ; Spinal Cord Injuries/epidemiology ; Spinal Cord Injuries/physiopathology ; Ultrasonography, Doppler, Duplex/statistics & numerical data ; Venous Thrombosis/complications ; Venous Thrombosis/diagnostic imaging ; Venous Thrombosis/epidemiology ; Young Adult
    Language English
    Publishing date 2019-04-02
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1223949-5
    ISSN 2045-7723 ; 1079-0268
    ISSN (online) 2045-7723
    ISSN 1079-0268
    DOI 10.1080/10790268.2019.1585134
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  5. Article ; Online: Pulmonary Embolism After Acute Spinal Cord Injury and COVID-19.

    Pisano, Thomas John / Joki, Jaclyn / Hon, Beverly / Cuccurullo, Sara

    American journal of physical medicine & rehabilitation

    2020  Volume 99, Issue 11, Page(s) 982–985

    Abstract: The coronavirus virus disease 2019 is best known for its pulmonary sequelae. Understanding of the disease process is rapidly growing, and the medical community already appreciates a hypercoagulable state associated with coronavirus virus disease 2019. ... ...

    Abstract The coronavirus virus disease 2019 is best known for its pulmonary sequelae. Understanding of the disease process is rapidly growing, and the medical community already appreciates a hypercoagulable state associated with coronavirus virus disease 2019. Acute spinal cord injury has an inherent increased risk for venous thromboembolism. In this case report, the patient presented with bilateral lower limb weakness and sensory loss secondary to thoracic disc herniation. Incidentally, at the same time as the initial presentation, the patient was also found to have coronavirus virus disease 2019 without significant respiratory symptoms. During hospitalization, the patient developed extensive bilateral lower limb deep vein thrombosis despite chemoprophylaxis. Therapeutic anticoagulation was initiated, yet several days later, he developed pleuritic chest pain. Computed tomography angiography revealed bilateral pulmonary emboli. This case highlights the need for clinicians to have elevated vigilance with regard to screening and treatment for venous thromboembolism in high-risk patients, such as spinal cord injury with a concurrent diagnosis of coronavirus virus disease 2019.
    MeSH term(s) Acute Disease ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/virology ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/virology ; Pulmonary Embolism/virology ; SARS-CoV-2 ; Spinal Cord Injuries/complications ; Spinal Cord Injuries/virology
    Keywords covid19
    Language English
    Publishing date 2020-08-28
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 219390-5
    ISSN 1537-7385 ; 0002-9491 ; 0894-9115
    ISSN (online) 1537-7385
    ISSN 0002-9491 ; 0894-9115
    DOI 10.1097/PHM.0000000000001578
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Pulmonary Embolism After Acute Spinal Cord Injury and COVID-19

    Pisano, Thomas John / Joki, Jaclyn / Hon, Beverly / Cuccurullo, Sara

    Am J Phys Med Rehabil

    Abstract: The coronavirus virus disease 2019 is best known for its pulmonary sequelae. Understanding of the disease process is rapidly growing, and the medical community already appreciates a hypercoagulable state associated with coronavirus virus disease 2019. ... ...

    Abstract The coronavirus virus disease 2019 is best known for its pulmonary sequelae. Understanding of the disease process is rapidly growing, and the medical community already appreciates a hypercoagulable state associated with coronavirus virus disease 2019. Acute spinal cord injury has an inherent increased risk for venous thromboembolism. In this case report, the patient presented with bilateral lower limb weakness and sensory loss secondary to thoracic disc herniation. Incidentally, at the same time as the initial presentation, the patient was also found to have coronavirus virus disease 2019 without significant respiratory symptoms. During hospitalization, the patient developed extensive bilateral lower limb deep vein thrombosis despite chemoprophylaxis. Therapeutic anticoagulation was initiated, yet several days later, he developed pleuritic chest pain. Computed tomography angiography revealed bilateral pulmonary emboli. This case highlights the need for clinicians to have elevated vigilance with regard to screening and treatment for venous thromboembolism in high-risk patients, such as spinal cord injury with a concurrent diagnosis of coronavirus virus disease 2019.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #733311
    Database COVID19

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  7. Article ; Online: Pulmonary Embolism after Acute Spinal Cord Injury and COVID-19 ; A Case Report

    Pisano, Thomas John / Joki, Jaclyn / Hon, Beverly / Cuccurullo, Sara

    American Journal of Physical Medicine & Rehabilitation

    2020  Volume Publish Ahead of Print

    Keywords Physical Therapy, Sports Therapy and Rehabilitation ; Rehabilitation ; covid19
    Language English
    Publisher Ovid Technologies (Wolters Kluwer Health)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 219390-5
    ISSN 1537-7385 ; 0002-9491 ; 0894-9115
    ISSN (online) 1537-7385
    ISSN 0002-9491 ; 0894-9115
    DOI 10.1097/phm.0000000000001578
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  8. Article ; Online: Somatostatin signaling in neuronal cilia is critical for object recognition memory.

    Einstein, Emily B / Patterson, Carlyn A / Hon, Beverly J / Regan, Kathleen A / Reddi, Jyoti / Melnikoff, David E / Mateer, Marcus J / Schulz, Stefan / Johnson, Brian N / Tallent, Melanie K

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2010  Volume 30, Issue 12, Page(s) 4306–4314

    Abstract: Most neurons possess a single, nonmotile cilium that projects out from the cell surface. These microtubule-based organelles are important in brain development and neurogenesis; however, their function in mature neurons is unknown. Cilia express a ... ...

    Abstract Most neurons possess a single, nonmotile cilium that projects out from the cell surface. These microtubule-based organelles are important in brain development and neurogenesis; however, their function in mature neurons is unknown. Cilia express a complement of proteins distinct from other neuronal compartments, one of which is the somatostatin receptor subtype SST(3). We show here that SST(3) is critical for object recognition memory in mice. sst3 knock-out mice are severely impaired in discriminating novel objects, whereas they retain normal memory for object location. Further, systemic injection of an SST(3) antagonist (ACQ090) disrupts recall of familiar objects in wild-type mice. To examine mechanisms of SST(3), we tested synaptic plasticity in CA1 hippocampus. Electrically evoked long-term potentiation (LTP) was normal in sst3 knock-out mice, while adenylyl cyclase/cAMP-mediated LTP was impaired. The SST(3) antagonist also disrupted cAMP-mediated LTP. Basal cAMP levels in hippocampal lysate were reduced in sst3 knock-out mice compared with wild-type mice, while the forskolin-induced increase in cAMP levels was normal. The SST(3) antagonist inhibited forskolin-stimulated cAMP increases, whereas the SST(3) agonist L-796,778 increased basal cAMP levels in hippocampal slices but not hippocampal lysate. Our results show that somatostatin signaling in neuronal cilia is critical for recognition memory and suggest that the cAMP pathway is a conserved signaling motif in cilia. Neuronal cilia therefore represent a novel nonsynaptic compartment crucial for signaling involved in a specific form of synaptic plasticity and in novelty detection.
    MeSH term(s) 1-Methyl-3-isobutylxanthine/pharmacology ; Action Potentials/drug effects ; Action Potentials/genetics ; Adenylyl Cyclases/metabolism ; Amides/pharmacology ; Animals ; Behavior, Animal ; Bicuculline/analogs & derivatives ; Bicuculline/pharmacology ; Biophysics/methods ; CA1 Region, Hippocampal/cytology ; Cilia/metabolism ; Colforsin/pharmacology ; Cyclic AMP/metabolism ; Discrimination, Psychological ; Electric Stimulation/methods ; Female ; GABA Antagonists/pharmacology ; In Vitro Techniques ; Isoquinolines/pharmacology ; Locomotion/drug effects ; Locomotion/genetics ; Locomotion/physiology ; Long-Term Potentiation/drug effects ; Long-Term Potentiation/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neurons/cytology ; Neuropsychological Tests ; Nitrobenzenes/pharmacology ; Phosphodiesterase Inhibitors/pharmacology ; Receptors, Somatostatin/agonists ; Receptors, Somatostatin/antagonists & inhibitors ; Receptors, Somatostatin/deficiency ; Receptors, Somatostatin/metabolism ; Recognition, Psychology/drug effects ; Recognition, Psychology/physiology ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Somatostatin/metabolism
    Chemical Substances (4-(3,4-difluorophenyl)-piperazine-1-yl)-(2-(3-(6-methoxypyridin- 3-yl)-2-methylpropyl)decahydroisoquinoline-4-yl)methanone ; Amides ; GABA Antagonists ; Isoquinolines ; L796778 ; Nitrobenzenes ; Phosphodiesterase Inhibitors ; Receptors, Somatostatin ; somatostatin receptor 3 ; Colforsin (1F7A44V6OU) ; Somatostatin (51110-01-1) ; Cyclic AMP (E0399OZS9N) ; Adenylyl Cyclases (EC 4.6.1.1) ; adenylate cyclase 3 (EC 4.6.1.1) ; bicuculline methochloride (I3UNE1K4AF) ; 1-Methyl-3-isobutylxanthine (TBT296U68M) ; Bicuculline (Y37615DVKC)
    Language English
    Publishing date 2010-03-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.5295-09.2010
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  9. Article ; Online: Presentation abstracts.

    Rice, Laura / Sung, JongHun / Keane, Kathleen / Peterson, Elizabeth / Sosnoff, Jacob / Farkas, Gary / Swartz, Ann / Strath, Scott / Gorgey, Ashraf / Berg, Arthur / Gater, David / Dyson-Hudson, Trevor / Malanga, Gerard / Cherian, Chris / Michalec, Monica / Kirshblum, Steven / Miller, Carrie / Garlanger, Kristin / Kortes, Sam /
    Schnorenberg, Alyssa / Slavens, Brooke / Lee, Kenneth / Potter-Baker, Kelsey / Frost, Frederick / Plow, Ela / Solinsky, Ryan / Wilson, Catherine / Henry, Carrie Ann / Lombard, Alexander / Maher, Matthew / Weir, Joseph / Saeed, Sana / Cirnigliaro, Christopher / Specht, Adam / Garbarini, Erica / Augustine, Jonathan / Forrest, Gail / Bauman, William / Wecht, Jill / Hearn, Jasmine / Razvi, Imaduddin S / Sikka, Seema / Callender, Librada / Bennett, Monica / Robertson, Keston / Driver, Simon / Kline-Quiroz, Cristina / Donovan, Jayne / Botticello, Amanda / Arnold, Dannae / Latham, Nancy / Houlihan, Bethlyn / Bickmore, Timothy / Trinh, Ha / Shamekhi, Ameneh / Ellis, Teresa / LaVela, Sherri L / Burkhart, Elizabeth / Kale, Ibuola / Bombardier, Charles / Snoxell, Ellen / Knezevic, Steven / Hong, EunKyoung / Asselin, Pierre / Kornfeld, Stephen / Gorman, Peter / Spungen, Ann / Castillo, Camilo / Cleveland, Christine / Gabet, Joelle / Harrington, Amanda / Arenth, Patricia / Dolbow, David / Luther, Stephen / Finch, Dezon / Bouayad, Lina / Kopp, Marcel / Watzlawick, Ralf / Martus, Peter / Failli, Vieri / Finkenstaedt, Felix / Chen, Yuying / DeVivo, Michael / Dirnagl, Ulrich / Schwab, Jan / LiMonta, James / Santiago, Tiffany / Wu, Yu-Kuang / Harel, Noam / Monden, Kimberley / Trost, Zina / Nguyen, Nguyen / Morse, Leslie / Boals, Adriel / Wenzel, Lisa / Silveira, Stephanie / Hughes, Rosemary / Nosek, Margaret / LeDoux, Tracey / Taylor, Heather / Diaz, Lauren / Robinson-Whelen, Susan / Garshick, Eric / Betz, Kendra / Krause, James / Cao, Yue / Li, Chao / Hon, Beverly / Khong, Cria-May / Dirlikov, Ben / Shem, Kazuko / Charlifue, Susan / Song, Shawn / Burns, Stephen

    The journal of spinal cord medicine

    2018  Volume 41, Issue 5, Page(s) 599–622

    Language English
    Publishing date 2018-08-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1223949-5
    ISSN 2045-7723 ; 1079-0268
    ISSN (online) 2045-7723
    ISSN 1079-0268
    DOI 10.1080/10790268.2018.1498262
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