Artikel ; Online: Anti-inflammatory Effects of Ziziphus Jujube Mill on LPS-induced Acute Lung Injury in Mice.
Iranian journal of allergy, asthma, and immunology
2023 Band 22, Heft 3, Seite(n) 281–289
Abstract: Ziziphus Jujuba Mill (Z.J) is a well-known ethnomedical source of biologically active compounds with anti-inflammatory effects. However, its significance in acute lung injury (ALI) has never been studied. The present study aimed to explore whether Z.J ... ...
Abstract | Ziziphus Jujuba Mill (Z.J) is a well-known ethnomedical source of biologically active compounds with anti-inflammatory effects. However, its significance in acute lung injury (ALI) has never been studied. The present study aimed to explore whether Z.J could attenuate lipopolysaccharide (LPS)-induced inflammatory responses in an experimental model of ALI. Male BALB/c mice received an intratracheal administration of LPS (n=32) or phosphate buffer saline (PBS) (control, n=8). Within 1, 11, and 23 h post-LPS injection, mice were randomly assigned to receive intraperitoneal treatments of saline, dexamethasone (2 mg/kg), and 100 and 200 mg/kg of Z.J extracts, respectively. 24 h after intratracheal administration of LPS, bronchoalveolar lavage fluid and lung tissues were harvested and assessed for inflammatory cell influx, tumor necrosis factor-α (TNF-α) levels, and histological assessments. Treatment with Z.J extracts (100 and 200 mg/kg) and dexamethasone effectively reduced LPS-induced neutrophil and other inflammatory cell influx into the lung tissue compared to the untreated group. additionally, both doses of Z.J extracts (100 and 200 mg/kg) significantly ameliorated the lung wet-to-dry ratio and histopathological damage. Furthermore, compared to the untreated ALI mice, Z.J extract at the highest dose could significantly reduce the TNF-α level. The present findings indicated that Z.J could effectively ameliorate LPS-induced ALI inflammatory responses and might be considered a promising alternative therapy for the ALI phenotype. |
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Mesh-Begriff(e) | Mice ; Male ; Animals ; Lipopolysaccharides/pharmacology ; Ziziphus ; Tumor Necrosis Factor-alpha ; Acute Lung Injury/chemically induced ; Acute Lung Injury/drug therapy ; Acute Lung Injury/pathology ; Lung/pathology ; Bronchoalveolar Lavage Fluid ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Dexamethasone/adverse effects ; Mice, Inbred BALB C ; NF-kappa B |
Chemische Substanzen | Lipopolysaccharides ; Tumor Necrosis Factor-alpha ; Anti-Inflammatory Agents ; Dexamethasone (7S5I7G3JQL) ; NF-kappa B |
Sprache | Englisch |
Erscheinungsdatum | 2023-06-16 |
Erscheinungsland | Iran |
Dokumenttyp | Journal Article |
ZDB-ID | 2488724-9 |
ISSN | 1735-5249 ; 1735-1502 |
ISSN (online) | 1735-5249 |
ISSN | 1735-1502 |
DOI | 10.18502/ijaai.v22i3.13056 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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