Article ; Online: The role of innate immunity in asthma development and protection: Lessons from the environment.
2020 Volume 50, Issue 3, Page(s) 282–290
Abstract: Asthma, a complex, chronic disease characterized by airway inflammation, hyperresponsiveness and remodelling, affects over 300 million people worldwide. While the disease is typically associated with exaggerated allergen-induced type 2 immune responses, ... ...
Abstract | Asthma, a complex, chronic disease characterized by airway inflammation, hyperresponsiveness and remodelling, affects over 300 million people worldwide. While the disease is typically associated with exaggerated allergen-induced type 2 immune responses, these responses are strongly influenced by environmental exposures that stimulate innate immune pathways capable of promoting or protecting from asthma. The dual role played by innate immunity in asthma pathogenesis offers multiple opportunities for both research and clinical interventions and is the subject of this review. |
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MeSH term(s) | Allergens/immunology ; Asthma/immunology ; Environmental Exposure/adverse effects ; Humans ; Immunity, Innate ; Th2 Cells/immunology |
Chemical Substances | Allergens |
Language | English |
Publishing date | 2020-06-09 |
Publishing country | England |
Document type | Journal Article ; Review |
ZDB-ID | 645204-8 |
ISSN | 1365-2222 ; 0954-7894 ; 0960-2178 |
ISSN (online) | 1365-2222 |
ISSN | 0954-7894 ; 0960-2178 |
DOI | 10.1111/cea.13508 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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