Article: The Effects of Pregnancy on Amino Acid Levels and Nitrogen Disposition.
2023 Volume 13, Issue 2
Abstract: Limited data are available on the effects of pregnancy on the maternal metabolome. Therefore, the objective of this study was to use metabolomics analysis to determine pathways impacted by pregnancy followed by targeted confirmatory analysis to provide ... ...
| Abstract | Limited data are available on the effects of pregnancy on the maternal metabolome. Therefore, the objective of this study was to use metabolomics analysis to determine pathways impacted by pregnancy followed by targeted confirmatory analysis to provide more powerful conclusions about metabolic alterations during pregnancy. Forty-seven pregnant women, 18-50 years of age were included in this study, with each subject serving as their own control. Plasma samples were collected between 25 and 28 weeks gestation and again ≥3 months postpartum for metabolomics analysis utilizing an HILIC/UHPLC/MS/MS assay with confirmatory targeted specific concentration analysis for 10 of the significantly altered amino acids utilizing an LC/MS assay. Principle component analysis (PCA) on metabolomics data clearly separated pregnant and postpartum groups and identified outliers in a preliminary assessment. Of the 980 metabolites recorded, 706 were determined to be significantly different between pregnancy and postpartum. Pathway analysis revealed three significantly impacted pathways, arginine biosynthesis ( |
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| Language | English |
| Publishing date | 2023-02-07 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2662251-8 |
| ISSN | 2218-1989 |
| ISSN | 2218-1989 |
| DOI | 10.3390/metabo13020242 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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