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Article: Assessing the risk of prenatal depressive symptoms in Chinese women: an integrated evaluation of serum metabolome, multivitamin supplement intake, and clinical blood indicators.

Yang, Rongrong / Lin, Zhenguo / Cai, Yanhua / Chen, Nan / Zhou, Ying / Zhang, Jie / Hong, Guolin

2024 Volume 14, Page(s) 1234461

Abstract: Background: Prenatal depressive symptoms (PDS) is a serious public health problem. This study aimed to develop an integrated panel and nomogram to assess at-risk populations by examining the association of PDS with the serum metabolome, multivitamin ... ...

Abstract	Background: Prenatal depressive symptoms (PDS) is a serious public health problem. This study aimed to develop an integrated panel and nomogram to assess at-risk populations by examining the association of PDS with the serum metabolome, multivitamin supplement intake, and clinical blood indicators. Methods: This study comprised 221 pregnant women, categorized into PDS and non-PDS groups based on the Edinburgh postnatal depression scale. The participants were divided into training and test sets according to their enrollment time. We conducted logistic regression analysis to identify risk factors, and employed liquid chromatography/high resolution mass spectrometry-based serum metabolome analysis to identify metabolic biomarkers. Multiple factor analysis was used to combine risk factors, clinical blood indicators and key metabolites, and then a nomogram was developed to estimate the probability of PDS. Results: We identified 36 important differential serum metabolites as PDS biomarkers, mainly involved in amino acid metabolism and lipid metabolism. Multivitamin intake works as a protective factor for PDS. The nomogram model, including multivitamin intake, HDL-C and three key metabolites (histidine, estrone and valylasparagine), exhibited an AUC of 0.855 in the training set and 0.774 in the test set, and the calibration curves showed good agreement, indicating that the model had good stability. Conclusion: Our approach integrates multiple models to identify metabolic biomarkers for PDS, ensuring their robustness. Furthermore, the inclusion of dietary factors and clinical blood indicators allows for a comprehensive characterization of each participant. The analysis culminated in an intuitive nomogram based on multimodal data, displaying potential performance in initial PDS risk assessment.
Language	English
Publishing date	2024-01-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2023.1234461
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Article ; Online: The association of serum immunoglobulin and complement levels and liver fibrosis and inflammation stage in patients with chronic hepatitis B.

Lian, Mingjian / Wang, Qianming / Chen, Shidong / Yang, Yuanyuan / Hong, Guolin

Journal of viral hepatitis

2023 Volume 30, Issue 5, Page(s) 437–447

Abstract: The utility of measurement of serum immunoglobulin and complement in chronic hepatitis B (CHB) patients remains controversial. This study aimed to investigate the association of serum immunoglobulin and complement levels and liver fibrosis and ... ...

Abstract	The utility of measurement of serum immunoglobulin and complement in chronic hepatitis B (CHB) patients remains controversial. This study aimed to investigate the association of serum immunoglobulin and complement levels and liver fibrosis and inflammation stage in CHB patients. A total of 687 patients with CHB who underwent liver biopsy were enrolled. Serum immunoglobulin and complement were measured before liver biopsy, and liver pathological results were recorded. Associations of serum immunoglobulin and complement levels and liver fibrosis and inflammation stage were analysed. C3, C4, IgG and IgG1 had statistically significant differences among different fibrosis and different inflammation groups. Both C3 and C4 negatively correlated with fibrosis and inflammation stage, but IgG and IgG1 showed opposite results. C3, C4, IgG and IgG1 had statistical significance to predict ≥S2, ≥S3 and S4, and also had statistical significance to predict ≥G2, ≥G3 and G4. The area under curve (AUC) of the combination of C3, C4 and IgG (C3 + C4 + IgG) for predicting ≥S2, ≥S3 and S4 was 0.640 (95% CI: 0.603, 0.676), 0.674 (95% CI: 0.638, 0.709) and 0.744 (95% CI: 0.710, 0.776), respectively. The AUC of C3 + C4 + IgG for predicting ≥G2, ≥G3 and G4 was 0.723 (95% CI: 0.688, 0.756), 0.674 (95% CI: 0.638, 0.709) and 0.771 (95% CI: 0.738, 0.802), respectively. C3, C4, IgG and IgG1 are correlated with liver fibrosis and inflammation stage in CHB patients. C3, C4, IgG and IgG1 have diagnostic value for liver fibrosis and inflammation. C3 + C4 + IgG may improve diagnostic accuracy.
MeSH term(s)	Humans ; Hepatitis B, Chronic ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/pathology ; Inflammation ; Fibrosis ; Immunoglobulin G ; Complement C4
Chemical Substances	Immunoglobulin G ; Complement C4
Language	English
Publishing date	2023-02-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1212497-7
ISSN	1365-2893 ; 1352-0504
ISSN (online)	1365-2893
ISSN	1352-0504
DOI	10.1111/jvh.13810
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Article: A Cross-Sectional Study of Clostridium Difficile Infection in Inpatients with Antibiotic Associated Diarrhea.

Ma, Xiaobo / Li, Zhimeng / Zheng, Yanqing / Fang, Lili / Lin, Huimei / Xu, Heping / Hong, Guolin

Clinical laboratory

2023 Volume 69, Issue 4

Abstract: Background: Clostridium difficile (C. difficile) is a Gram-positive, anaerobic, spore-forming bacillus that can cause pseudomembranous colitis and other C. difficile-associated diseases, resulting in significant morbidity and mortality. The incidence ... ...

Abstract	Background: Clostridium difficile (C. difficile) is a Gram-positive, anaerobic, spore-forming bacillus that can cause pseudomembranous colitis and other C. difficile-associated diseases, resulting in significant morbidity and mortality. The incidence and clinical features vary by geography. Methods: In this cross-sectional study, we examined the incidence and clinical features of C. difficile infection (CDI) within a 2,900-bed academic medical center in a southern area of China from January 1, 2017, to December 31, 2020. All adult inpatients (aged ≥ 18 years) who submitted loose stool samples for C. difficile testing over this period were considered for the study. Results: This cross-sectional study showed that the average incidence of CDI was 2.07 cases/100,000 hospital patient-days. The mean age of these inpatients was 71.21 ± 2.83 years (range 30 - 93 years), and 83.61% (51/61) were treated in medical units. We found that 85.25% (52/61) of inpatients with CDI were aged > 60 years. Multivariate logistic regression analysis revealed that age > 60 years, and admission to the geriatric treatment unit or neurosurgery treatment unit were indeed independent risk factors for CDI in inpatients. Conclusions: The incidence of CDI in the southern area of China was low. Age > 60 years, and treatment in geriatric or neurosurgery units were independent risk factors for CDI inpatients.
MeSH term(s)	Adult ; Humans ; Aged ; Middle Aged ; Aged, 80 and over ; Clostridioides difficile ; Cross-Sectional Studies ; Inpatients ; Clostridium Infections/diagnosis ; Clostridium Infections/epidemiology ; Risk Factors ; Diarrhea/diagnosis ; Diarrhea/epidemiology ; Diarrhea/chemically induced ; Anti-Bacterial Agents/adverse effects ; Cross Infection/drug therapy
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-04-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2022.220514
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Article ; Online: Background-Free SERS Nanosensor for Endogenous Hydrogen Sulfide Detection Based on Prussian Blue-Coated Gold Nanobipyramids.

Chen, Jiaming / Cheng, Lingjun / Yang, Yuanyuan / Liu, Yating / Su, Canping / He, Yinghao / You, Mingming / Lin, Zhenyu / Hong, Guolin

ACS applied materials & interfaces

2024 Volume 16, Issue 12, Page(s) 14467–14473

Abstract: Surface-enhanced Raman scattering (SERS) has great potential in biological analysis due to its specificity, sensitivity, and non-invasive nature. However, effectively extracting Raman information and avoiding spectral overlapping from biological ... ...

Abstract	Surface-enhanced Raman scattering (SERS) has great potential in biological analysis due to its specificity, sensitivity, and non-invasive nature. However, effectively extracting Raman information and avoiding spectral overlapping from biological background interference remain major challenges. In this study, we developed a background-free SERS nanosensor consisting of gold nanobipyramids (Au NBPs) core-Prussian blue (PB) shell (Au NBPs@PB), for endogenous H
MeSH term(s)	Humans ; Metal Nanoparticles ; Hydrogen Sulfide/analysis ; Gold ; Reproducibility of Results ; Spectrum Analysis, Raman/methods ; Ferrocyanides
Chemical Substances	Hydrogen Sulfide (YY9FVM7NSN) ; ferric ferrocyanide (TLE294X33A) ; Gold (7440-57-5) ; Ferrocyanides
Language	English
Publishing date	2024-03-16
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c17385
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Article ; Online: Diagnostic accuracy of mac-2 binding protein glycosylation isomer for diagnosing hepatitis B-related fibrosis: a meta-analysis.

Lian, Ming Jian / Chen, Zhi Qi / Wang, Qian Ming / Zheng, Gang Sen / Hong, GuoLin

Journal of digestive diseases

2022

Abstract: Background and aim: Mac-2 binding protein glycosylation isomer (M2BPGi) is a novel biomarker for liver fibrosis. Inconsistent results on the accuracy of M2BPGi for predicting hepatitis B virus (HBV)-related fibrosis are found. The purpose of this study ... ...

Abstract	Background and aim: Mac-2 binding protein glycosylation isomer (M2BPGi) is a novel biomarker for liver fibrosis. Inconsistent results on the accuracy of M2BPGi for predicting hepatitis B virus (HBV)-related fibrosis are found. The purpose of this study was to evaluate the accuracy of M2BPGi for predicting HBV-related liver fibrosis using meta analysis. Patients and methods: EMBASE, PubMed, Web of Science, and some other databases was searched comprehensively before March 2022. Eligible studies were selected and relevant parameters were abstracted. Quality assessment was carried out in accordance to the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). The pooled diagnostic estimates including sensitivity, specificity, areas under summary receiver operating characteristic curves (AUC), and others were calculated. Before pooling the estimates, threshold effect was assessed. Subgroup analyses based relative parameters were performed. Results: Eleven studies including 1836 patients were included. None of the eleven studies met all the criteria of QUADAS-2. Threshold effect was found (r=0.757, P=0.011) for predicting severe fibrosis. The sensitivity and specificity for predicting significant fibrosis and cirrhosis were 0.68 (0.65-0.71) and 0.67 (0.64-0.70), 0.65 (0.57-0.72) and 0.79 (0.77-0.81), respectively. AUC of M2BPGi for predicting significant fibrosis, severe fibrosis, and cirrhosis were 0.741, 0.766, 0.792, respectively. No publication bias was found. The results of subgroup analyses were similar to the overall results. Conclusion: M2BPGi has moderate diagnostic accuracy for predicting HBV-related significant fibrosis, severe fibrosis, and cirrhosis. Further studies stratified by etiology, liver inflammation, treatment and other parameters are urgently needed. This article is protected by copyright. All rights reserved.
Language	English
Publishing date	2022-10-17
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	2317117-0
ISSN	1751-2980 ; 1751-2972
ISSN (online)	1751-2980
ISSN	1751-2972
DOI	10.1111/1751-2980.13140
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Article: Evaluation of a two-test strategy for HIV screening in a low-prevalence setting and the indications for optimizing clinical management.

Huang, Yu / Liu, Haiyue / Dai, Shuhui / Lan, Xiaoying / Liu, Shuojie / Ren, Xiaoying / Huang, Chaoyang / Li, Xun / Hong, Guolin

Heliyon

2023 Volume 9, Issue 9, Page(s) e19400

Abstract: Objectives: To evaluate a two-test strategy for HIV screening in the low-prevalence population and to assess the feasibility of utilizing the optimal signal-to-cutoff (S/CO) threshold on the chemiluminescence immunoassay(CMIA) and an additional rapid ... ...

Abstract	Objectives: To evaluate a two-test strategy for HIV screening in the low-prevalence population and to assess the feasibility of utilizing the optimal signal-to-cutoff (S/CO) threshold on the chemiluminescence immunoassay(CMIA) and an additional rapid test on the gold immune-chromatography assay (GICA) for screening positive patients and optimization of clinical management. Methods: We conducted a retrospective study of samples analyzed by the fourth-generation Architect HIV Ag/Ab combo assay (CMIA) in a large medical center between June 2017 and August 2020. Reactive samples underwent a second screening test using the rapid test GICA, followed by Western blot (WB) as the confirmatory test. Receiver operating characteristic (ROC) curve analysis was used to determine the optimal S/CO. We calculated sensitivity, specificity, and predictive value based on our population. The performance of the single-test strategy (CMIA) was compared with that of the two-test strategy (CMIA and GICA). Logistic regression was used to analyze the factors of clinical characteristics leading to false positive results. Results: A total of 220558 samples were screened by CMIA, and 429 patients met the inclusion criteria. Of these, CMIA produced 199 false-positive results with a median S/CO of 1.93(IQR1.45-3.68) and 230 positive results with a median S/CO of 455.1 (IQR169.3-709.7). The optimal S/CO of the single-test strategy was 8.82, which achieved a sensitivity of 100% and a positive predictive value (PPV) of 90.9%. The two-test strategy (CMIA and GICA) provided a sensitivity of 100% and a PPV of 98.7%, which best correlated with the confirmatory test WB. The combination of S/CO 8.82 on the CMIA assay and additional test results of GICA can be defined as four types used to interpret HIV serostatus. The false positive rate (FPR) was high in the female, the age≤18 group, the pre-operative patients, and the patients from the clinical departments of Pediatrics, Gynecology and Obstetrics, and Oncology, etc. Conclusions: The false positive rate is high in the low-prevalence setting by using CMIA. The two-test strategy (CMIA and GICA) is recommended for HIV screening in hospitals. Hopefully, the clinicians will be able to interpret HIV serostatus and facilitate clinical decision-making while waiting for the confirmatory results.
Language	English
Publishing date	2023-08-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e19400
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Article ; Online: Highly specific and sensitive sandwich-type electrochemiluminescence biosensor for HPV16 DNA detection based on the base-stacking effect and bovine serum albumin carrier platform.

Cheng, Lingjun / He, Yinghao / Yang, Yuanyuan / Su, Canping / He, Hongzhang / You, Mingming / Chen, Jiaming / Lin, Zhenyu / Hong, Guolin

Biosensors & bioelectronics

2023 Volume 241, Page(s) 115706

Abstract: The detection of specific DNA sequences and the identification of single nucleotide polymorphisms are important for disease diagnosis. Herein, by combining the high specificity of the base-stacking effect with the high reproducibility of bovine serum ... ...

Abstract	The detection of specific DNA sequences and the identification of single nucleotide polymorphisms are important for disease diagnosis. Herein, by combining the high specificity of the base-stacking effect with the high reproducibility of bovine serum albumin (BSA) modified electrodes and the high loading performance of DNA nanoclews (DNA NCs), a novel sandwich-type electrochemiluminescence (ECL) biosensor is reported for the highly specific detection of HPV16 (chosen as the model target). The capture probes are loaded by BSA carrier platforms modified on the gold electrode surface to improve reproducibility. DNA NCs loaded with a large amount of Ru(phen)
MeSH term(s)	Biosensing Techniques/methods ; Human papillomavirus 16/genetics ; Serum Albumin, Bovine ; Reproducibility of Results ; Luminescent Measurements/methods ; DNA/chemistry ; Electrochemical Techniques/methods ; Limit of Detection ; Gold/chemistry
Chemical Substances	Serum Albumin, Bovine (27432CM55Q) ; DNA (9007-49-2) ; Gold (7440-57-5)
Language	English
Publishing date	2023-09-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2023.115706
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Article: Co-Reactant-Mediated Low-Potential Anodic Electrochemiluminescence Platform and Its Immunosensing Application

Hong, Guolin / Su, Canping / Lai, Mingchun / Huang, Zhongnan / Weng, Zhimin / Chen, Yaling / Deng, Haohua / Chen, Wei / Peng, Huaping

Analytical chemistry. 2022 Aug. 31, v. 94, no. 36

2022

Abstract: Screening high-performance anodic electrochemiluminescence (ECL) systems with low triggering potential is a promising way to broaden their applications. In addition to electrochemiluminophore, co-reactant also plays an important role in the ECL process, ... ...

Abstract	Screening high-performance anodic electrochemiluminescence (ECL) systems with low triggering potential is a promising way to broaden their applications. In addition to electrochemiluminophore, co-reactant also plays an important role in the ECL process, since the oxidation of co-reactants is one of the most important steps in the anodic ECL process. Herein, a novel co-reactant-mediated high-performance low-potential Au nanocluster (AuNC)-based ECL system has been successfully developed. Benefiting from the isopropyl substitution and hydroxyl addition to the triethylamine (TEA), the BSA-AuNC/2-(diisopropylamino)ethanol (DIPEA-OH) ECL system achieved higher energy efficiency at a lower potential of 0.75 V. In addition, compared with the BSA-AuNC/TEA system, the ECL intensity and quantum yield (ΦECL) with DIPEA-OH as a co-reactant increased 22.34-fold and 13-fold (as high as 68.17%), respectively. Based on the low potential, high ΦECL of the AuNC/DIPEA-OH ECL system, a sandwich-type immunosensor has been constructed for a highly selective SARS-CoV-2 N protein assay. In the absence of any complex signal amplification strategies, the ECL immunosensor for the SARS-CoV-2 N protein detection showed a linear range of 0.001–100 ng/mL and a detection limit of 0.35 pg/mL. Moreover, the ECL platform had good reproducibility and stability and exhibited acceptable detection performance in the detection of actual serum samples. This work established a framework for in-depth design and study of anode ECL co-reactants for AuNCs and other luminophores, and expanded the potential application of ECL sensors in the clinical diagnosis of COVID-19.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; analytical chemistry ; anodes ; blood serum ; detection limit ; electrochemiluminescence ; energy efficiency ; immunosensors ; nanogold ; oxidation ; triethylamine
Language	English
Dates of publication	2022-0831
Size	p. 12500-12506.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.2c02726
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Article: [Meta-analysis of the diagnostic efficacy of heparin binding protein in adult sepsis].

Chen, Shidong / Zhang, Cuixia / Hong, Guolin / Wang, Qianming / Lian, Mingjian

Zhonghua wei zhong bing ji jiu yi xue

2020 Volume 31, Issue 11, Page(s) 1330–1334

Abstract: Objective: To evaluate the accuracy of heparin binding protein (HBP) in the diagnosis of adult sepsis by meta-analysis.: Methods: The retrospective, randomized controlled and prospective researches on the diagnosis of adult sepsis using HBP were ... ...

Abstract	Objective: To evaluate the accuracy of heparin binding protein (HBP) in the diagnosis of adult sepsis by meta-analysis. Methods: The retrospective, randomized controlled and prospective researches on the diagnosis of adult sepsis using HBP were reviewed by searching VIP network, China National Knowledge Infrastructure (CNKI), Wanfang database, PubMed, Embase and Web of Science from foundation to August 2018. The researches were selected according to inclusion and exclusion criteria, and QUADAS was used to evaluate the quality of eligible studies. Metadisc 14.0 was used to analyze the threshold effect, pool the estimation and do Meta regression analysis. Publication bias was assessed using Stata 12.0 with Deeks funnel plot. Results: A total of 728 related literatures were searched and 14 studies were enrolled in this study with a total of 2 023 subjects, with 1 120 in sepsis group and 903 in non-sepsis control group (795 patients with non-sepsis and 108 healthy volunteers). The total score of literature quality was 14-23, indicating that the overall quality was good. Meta-analysis showed that Spearman correlation coefficient between sensitivity logorithm and 1-specificity logorithm of 14 groups of data was 0.106 (P = 0.719), indicating no threshold effect. The pooled sensitivity was 0.74 [95% confidence interval (95%CI) was 0.72-0.77], the pooled specificity was 0.73 (95%CI was 0.70-0.76), the diagnostic odds ratio (DOR) was 14.15 (95%CI was 7.77-25.78), and the area under summary receiver operating characteristic curve (AUC) was 0.865. Deeks funnel plot was asymmetrical on the left and right (P = 0.60), indicating that there was no publication bias of the eligible studies. Conclusions: HBP has good accuracy for the diagnosis of adult sepsis and it can be used as an auxiliary index for adult sepsis diagnosis.
MeSH term(s)	Adult ; Carrier Proteins ; China ; Heparin ; Humans ; Prospective Studies ; Retrospective Studies ; Sensitivity and Specificity ; Sepsis/diagnosis
Chemical Substances	Carrier Proteins ; Heparin (9005-49-6)
Language	Chinese
Publishing date	2020-01-10
Publishing country	China
Document type	Journal Article ; Meta-Analysis
ISSN	2095-4352
ISSN	2095-4352
DOI	10.3760/cma.j.issn.2095-4352.2019.11.004
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Article ; Online: Diagnostic Value of Vaginal Microecology, Serum miR-18a, and PD-L1 for Identifying HPV-Positive Cervical Cancer.

Zhang, Yumei / Qiu, Sujuan / Guo, Yueli / Zhang, Jiaqin / Wu, Xiaoqing / Hong, Guolin

Technology in cancer research & treatment

2021 Volume 20, Page(s) 1533033821995281

Abstract: Objective: We aimed to investigate the diagnostic value of the vaginal microecology, serum miR-18a, and programmed death ligand-1 (PD-L1) for human papillomavirus (HPV)-positive cervical cancer.: Methods: Eighty-four patients with HPV-positive ... ...

Abstract	Objective: We aimed to investigate the diagnostic value of the vaginal microecology, serum miR-18a, and programmed death ligand-1 (PD-L1) for human papillomavirus (HPV)-positive cervical cancer. Methods: Eighty-four patients with HPV-positive cervical cancer were assigned to the observation group, 107 HPV-positive patients without cervical cancer were assigned to the positive group, and 191 healthy women were assigned to the control group. Vaginal microecology and serum levels of miR-18a and PD-L1 on the surface of CD4 Results: Women in the control group had better vaginal microecology and lower levels of miR-18a and PD-L1 than those in the observation and the positive groups (all P < 0.05). Compared with the positive group, the observation group had similar vaginal microecology (all P > 0.05) but higher levels of miR-18a and PD-L1 (all P < 0.05). Moreover, the patients at stage III had higher levels of miR-18a and PD-L1 than those at stage I and II (all P < 0.05). The values of area under the curve for miR-18a and PD-L1 in the diagnosis of HPV-positive cervical cancer were over 0.8 (all P < 0.001). Conclusion: Patients with HPV-positive cervical cancer have vaginal microbial dysbiosis and high serum levels of miR-18a and PD-L1. miR-18a and PD-L1 have diagnostic value for identifying HPV-positive cervical cancer.
MeSH term(s)	Adult ; B7-H1 Antigen/metabolism ; Biomarkers, Tumor ; Circulating MicroRNA ; Disease Susceptibility ; Female ; Gene Expression ; Humans ; Liquid Biopsy ; MicroRNAs/blood ; MicroRNAs/genetics ; Microbiota ; Middle Aged ; Papillomavirus Infections/complications ; Papillomavirus Infections/virology ; Prognosis ; ROC Curve ; T-Lymphocyte Subsets/metabolism ; Uterine Cervical Neoplasms/blood ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/etiology ; Vagina/microbiology
Chemical Substances	B7-H1 Antigen ; Biomarkers, Tumor ; CD274 protein, human ; Circulating MicroRNA ; MIRN18A microRNA, human ; MicroRNAs
Language	English
Publishing date	2021-02-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2146365-7
ISSN	1533-0338 ; 1533-0346
ISSN (online)	1533-0338
ISSN	1533-0346
DOI	10.1177/1533033821995281
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