LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Hong, Ki Hyun"
  2. AU="Adalbert, V’kovski Philip"
  3. AU="Witte, Martin D"
  4. AU=Sun Yuan
  5. AU=Khan Zeashan Hameed AU=Khan Zeashan Hameed
  6. AU=Andrade D M
  7. AU="Miyata, Fumika"
  8. AU="Ahmad Rizal"
  9. AU="Aponte, Nelson"
  10. AU=Manfredonia Ilaria
  11. AU="Ryu, Jae Sung"
  12. AU="Lo, Bernard"
  13. AU="Pandya, Hardi"
  14. AU="Evans, J Anthony"
  15. AU="Chang, Hanxuan" AU="Chang, Hanxuan"
  16. AU="Bellamy, Kyle" AU="Bellamy, Kyle"
  17. AU="Jensen, Kara L"
  18. AU=Wang Yun
  19. AU=Seimiya H
  20. AU="Victor Babos, Diego"
  21. AU="Giuseppe Sergi"
  22. AU="Nackers, Elke"
  23. AU=Grobler Chistine
  24. AU="Norman H. L. Chiu"
  25. AU="Ioannis Politis"
  26. AU="Scott Nugent"
  27. AU="Sepideh MONSEF"
  28. AU="Wang, Zhaoqi"

Suchergebnis

Treffer 1 - 6 von insgesamt 6

Suchoptionen

  1. Artikel ; Online: 3D hydrogel stem cell niche controlled by host-guest interaction affects stem cell fate and survival rate.

    Hong, Ki Hyun / Song, Soo-Chang

    Biomaterials

    2019  Band 218, Seite(n) 119338

    Abstract: Host-guest interaction using β-cyclodextrin (β-CD) and adamantane (Ad) allows facile modulation of guest molecule concentration in 3D hydrogels. Based on this phenomenon, we prepared a thermosensitive poly(organophosphazene) bearing β-CD hydrogel (β-CD ... ...

    Abstract Host-guest interaction using β-cyclodextrin (β-CD) and adamantane (Ad) allows facile modulation of guest molecule concentration in 3D hydrogels. Based on this phenomenon, we prepared a thermosensitive poly(organophosphazene) bearing β-CD hydrogel (β-CD PPZ, as host) and Ad-Arg-Gly-Asp (Ad-RGD, as guest). The structures of synthesized thermosensitive β-CD PPZ and Ad-RGD were confirmed by
    Mesh-Begriff(e) Adipogenesis/physiology ; Animals ; Cells, Cultured ; Female ; Hydrogels/chemistry ; Magnetic Resonance Spectroscopy ; Mesenchymal Stem Cells/cytology ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Spectroscopy, Fourier Transform Infrared ; Stem Cell Niche/physiology ; Survival Rate ; beta-Cyclodextrins/chemistry
    Chemische Substanzen Hydrogels ; beta-Cyclodextrins ; betadex (JV039JZZ3A)
    Sprache Englisch
    Erscheinungsdatum 2019-07-06
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603079-8
    ISSN 1878-5905 ; 0142-9612
    ISSN (online) 1878-5905
    ISSN 0142-9612
    DOI 10.1016/j.biomaterials.2019.119338
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.B 2371: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  2. Artikel: 3D hydrogel stem cell niche controlled by host-guest interaction affects stem cell fate and survival rate

    Hong, Ki Hyun / Song, Soo-Chang

    Biomaterials. 2019 Oct., v. 218

    2019  

    Abstract: Host-guest interaction using β-cyclodextrin (β-CD) and adamantane (Ad) allows facile modulation of guest molecule concentration in 3D hydrogels. Based on this phenomenon, we prepared a thermosensitive poly(organophosphazene) bearing β-CD hydrogel (β-CD ... ...

    Abstract Host-guest interaction using β-cyclodextrin (β-CD) and adamantane (Ad) allows facile modulation of guest molecule concentration in 3D hydrogels. Based on this phenomenon, we prepared a thermosensitive poly(organophosphazene) bearing β-CD hydrogel (β-CD PPZ, as host) and Ad-Arg-Gly-Asp (Ad-RGD, as guest). The structures of synthesized thermosensitive β-CD PPZ and Ad-RGD were confirmed by 1H NMR and FT-IR. The β-CD PPZ/Ad-RGD mixture was prepared by simple mixing and elicited thermosensitive properties with the formation of gelation in all Ad-RGDs mixing proportions at the body temperature. Strong and controlled host-guest interactions between β-CD PPZ and Ad-RGD were observed in 2D-NOESY, DLS, and TEM. Regulated MSC behaviors were elicited based on the use of controlled Ad-RGD amounts at the level of in vitro and in vivo. As the amount of Ad-RGD was increased in the β-CD PPZ hydrogel, MSC survival rate was enhanced and was prone to express osteogenic factors. While Ad-RGD is absent or low in hydrogel, relatively poor MSC survival rate and adipogenesis were exhibited. Altogether, we verified that survival rate and differentiation of MSCs could be controlled by host-guest interaction system with thermosensitive 3D hydrogel. This proposed 3D hydrogel controlling system with host-guest interaction is expected to be a platform technology as changing guest molecules.
    Schlagwörter adipogenesis ; beta-cyclodextrin ; body temperature ; bone formation ; Fourier transform infrared spectroscopy ; gelation ; hydrogels ; mixing ; nuclear magnetic resonance spectroscopy ; stem cells ; survival rate ; thermosensitivity ; transmission electron microscopy
    Sprache Englisch
    Erscheinungsverlauf 2019-10
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 603079-8
    ISSN 0142-9612
    ISSN 0142-9612
    DOI 10.1016/j.biomaterials.2019.119338
    Datenquelle NAL Katalog (AGRICOLA)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.B 2371: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  3. Artikel: Fine-Tunable and Injectable 3D Hydrogel for On-Demand Stem Cell Niche.

    Hong, Ki Hyun / Kim, Young-Min / Song, Soo-Chang

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2019  Band 6, Heft 17, Seite(n) 1900597

    Abstract: Stem-cell-based tissue engineering requires increased stem cell retention, viability, and control of differentiation. The use of biocompatible scaffolds encapsulating stem cells typically addresses the first two problems. To achieve control of stem cell ... ...

    Abstract Stem-cell-based tissue engineering requires increased stem cell retention, viability, and control of differentiation. The use of biocompatible scaffolds encapsulating stem cells typically addresses the first two problems. To achieve control of stem cell fate, fine-tuned biocompatible scaffolds with bioactive molecules are necessary. However, given that the fine-tuning of stem cell scaffolds is associated with UV irradiation and in situ scaffold gelation, this process is in conflict with injectability. Herein, a fine-tunable and injectable 3D hydrogel system is developed with the use of thermosensitive poly(organophosphazene) bearing β-cyclodextrin (β-CD PPZ) and two types of adamantane-peptides (Ad-peptides) that are associated with mesenchymal stem cell (MSC) differentiation and that serve as stoichiometrically controlled pendants for fine-tuning. Given that complexation of hosts and guests subject to strict stoichiometric control is achieved with simple mixing, these fabricated hydrogels exhibit well-aligned, fine-tuning responses, even in living animals. Injection of MSCs in fine-tuned hydrogels also results in various chondrogenic differentiation levels at three weeks postinjection. This is attributed to the differential controls of Ad-peptides, if MSC preconditioning is excluded. Eventually, the fine-tunable and injectable 3D hydrogel could be applied as platform technology by simply switching the types of peptides bearing adamantane and their stoichiometry.
    Sprache Englisch
    Erscheinungsdatum 2019-07-15
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.201900597
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  4. Artikel ; Online: Long-term anti-inflammatory effects of injectable celecoxib nanoparticle hydrogels for Achilles tendon regeneration.

    Kim, Jun / Seo, Bo-Bae / Hong, Ki Hyun / Kim, Sung Eun / Kim, Young-Min / Song, Soo-Chang

    Acta biomaterialia

    2022  Band 144, Seite(n) 183–194

    Abstract: The treatment of chronic Achilles tendonitis (AT) often requires prolonged therapy and invasive therapeutic methods such as surgery or therapeutic endoscopy. To prevent the progression of chronic AT, excessive inflammation must be alleviated at an early ... ...

    Abstract The treatment of chronic Achilles tendonitis (AT) often requires prolonged therapy and invasive therapeutic methods such as surgery or therapeutic endoscopy. To prevent the progression of chronic AT, excessive inflammation must be alleviated at an early stage. Corticosteroids or nonsteroidal anti-inflammatory drugs are generally prescribed to control inflammation; however, the high doses and long therapeutic periods required may lead to serious side effects. Herein, a local injectable poly(organophosphazene) (PPZ) - celecoxib (CXB) nanoparticle (PCNP) hydrogel system with long-term anti-inflammatory effects was developed for the treatment of tendonitis. The amphiphilic structure and thermosensitive mechanical properties of PPZ means that the hydrophobic CXB can be easily incorporated into the hydrophobic core to form PCNP at 4 °C. Following the injection of PCNP into the AT, PCNP hydrogel formed at body temperature and induced long-term local anti-inflammatory effects via sustained release of the PCNP. The therapeutic effects of the injectable PCNP system can alleviate excessive inflammation during the early stages of tissue damage and boost tissue regeneration. This study suggests that PCNP has significant potential as a long-term anti-inflammatory agent through sustained nonsteroidal anti-inflammatory drugs (NSAIDs) delivery and tissue regeneration boosting. STATEMENT OF SIGNIFICANCE: In the treatment of Achilles tendinitis, a long-term anti-inflammatory effect is needed to alleviate excessive inflammation and induce regeneration of the damaged Achilles tendon. Injectable poly(organophosphazene)(PPZ)-celecoxib(CXB) nanoparticles (PCNP) generated a long-term, localized-anti-inflammatory effect in the injected region, which successfully induced the expression of anti-inflammatory cytokines and suppressed pro-inflammatory cytokines, while the PCNPs degraded completely. Accordingly, regeneration of the damaged Achilles tendon was achieved through the long-term anti-inflammatory effect induced by a single PCNP injection. The PCNP system therefore has great potential in long-term NSAIDs delivery for various tissue engineering applications.
    Mesh-Begriff(e) Achilles Tendon ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Anti-Inflammatory Agents, Non-Steroidal ; Celecoxib/pharmacology ; Celecoxib/therapeutic use ; Cytokines/pharmacology ; Humans ; Hydrogels/chemistry ; Inflammation/drug therapy ; Nanoparticles/chemistry ; Nanoparticles/therapeutic use ; Tendinopathy/drug therapy
    Chemische Substanzen Anti-Inflammatory Agents ; Anti-Inflammatory Agents, Non-Steroidal ; Cytokines ; Hydrogels ; Celecoxib (JCX84Q7J1L)
    Sprache Englisch
    Erscheinungsdatum 2022-03-22
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2022.03.033
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  5. Artikel ; Online: A micro-fragmented collagen gel as a cell-assembling platform for critical limb ischemia repair.

    Chung, Haeun / Choi, Jung-Kyun / Hong, Changgi / Lee, Youngseop / Hong, Ki Hyun / Oh, Seung Ja / Kim, Jeongmin / Song, Soo-Chang / Kim, Jong-Wan / Kim, Sang-Heon

    Bioactive materials

    2023  Band 34, Seite(n) 80–97

    Abstract: Critical limb ischemia (CLI) is a devastating disease characterized by the progressive blockage of blood vessels. Although the paracrine effect of growth factors in stem cell therapy made it a promising angiogenic therapy for CLI, poor cell survival in ... ...

    Abstract Critical limb ischemia (CLI) is a devastating disease characterized by the progressive blockage of blood vessels. Although the paracrine effect of growth factors in stem cell therapy made it a promising angiogenic therapy for CLI, poor cell survival in the harsh ischemic microenvironment limited its efficacy. Thus, an imperative need exists for a stem-cell delivery method that enhances cell survival. Here, a collagen microgel (CMG) cell-delivery scaffold (40 × 20 μm) was fabricated via micro-fragmentation from collagen-hyaluronic acid polyionic complex to improve transplantation efficiency. Culturing human adipose-derived stem cells (hASCs) with CMG enabled integrin receptors to interact with CMG to form injectable 3-dimensional constructs (CMG-hASCs) with a microporous microarchitecture and enhanced mass transfer. CMG-hASCs exhibited higher cell survival (p < 0.0001) and angiogenic potential in tube formation and aortic ring angiogenesis assays than cell aggregates. Injection of CMG-hASCs intramuscularly into CLI mice increased blood perfusion and limb salvage ratios by 40 % and 60 %, respectively, compared to cell aggregate-treated mice. Further immunofluorescent analysis revealed that transplanted CMG-hASCs have greater muscle regenerative and angiogenic potential, with enhanced cell survival than cell aggregates (p < 0.05). Collectively, we propose CMG as a cell-assembling platform and CMG-hASCs as promising therapeutics to treat CLI.
    Sprache Englisch
    Erscheinungsdatum 2023-12-16
    Erscheinungsland China
    Dokumenttyp Journal Article
    ISSN 2452-199X
    ISSN (online) 2452-199X
    DOI 10.1016/j.bioactmat.2023.12.008
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  6. Artikel ; Online: Injectable polymeric nanoparticle hydrogel system for long-term anti-inflammatory effect to treat osteoarthritis.

    Seo, Bo-Bae / Kwon, Youngjoong / Kim, Jun / Hong, Ki Hyun / Kim, Sung-Eun / Song, Hae-Ryong / Kim, Young-Min / Song, Soo-Chang

    Bioactive materials

    2021  Band 7, Seite(n) 14–25

    Abstract: Treatment of osteoarthritis (OA) by administration of corticosteroids is a commonly used method in clinics using anti-inflammatory medicine. Oral administration or intra-articular injection of corticosteroids can reduce the pain and progress of cartilage ...

    Abstract Treatment of osteoarthritis (OA) by administration of corticosteroids is a commonly used method in clinics using anti-inflammatory medicine. Oral administration or intra-articular injection of corticosteroids can reduce the pain and progress of cartilage degeneration, but they are usually insufficient to show local and long-term anti-inflammatory effects because of their fast clearance in the body. In this study, we suggest an injectable anti-OA drug depot system for sustained drug release that provides long-term effective therapeutic advantages. Amphiphilic poly(organophosphazene), which has temperature-dependent nanoparticle forming and sol-gel transition behaviors when dissolved in aqueous solution, was synthesized for triamcinolone acetonide (TCA) delivery. Because hydrophobic parts of the polymer can interact with hydrophobic parts of the TCA, the TCA was encapsulated into the self-assembled polymeric nanoparticles. The TCA-encapsulated polymeric nanoparticles (TePNs) were well dispersed in an aqueous solution below room temperature so that they can be easily injected as a sol state into an intra-articular region. However, the TePNs solution transforms immediately to a viscose 3D hydrogel like a synovial fluid in the intra-articular region via the conducted body temperature. An
    Sprache Englisch
    Erscheinungsdatum 2021-07-07
    Erscheinungsland China
    Dokumenttyp Journal Article
    ISSN 2452-199X
    ISSN (online) 2452-199X
    DOI 10.1016/j.bioactmat.2021.05.028
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Zum Seitenanfang