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  1. Article ; Online: A newly developed kit for dental apical root resorption detection: efficacy and acceptability.

    Tan, Jun Hong Steven / Yazid, Farinawati / Kasim, Nurfathiha Abu / Ariffin, Shahrul Hisham Zainal / Wahab, Rohaya Megat Abdul

    BMC oral health

    2024  Volume 24, Issue 1, Page(s) 298

    Abstract: Objectives: To determine the efficacy of a newly developed kit in dentine sialophosphoprotein (DSPP) detection and compare it with enzyme-linked immunosorbent assay (ELISA). User acceptance was also determined.: Materials and methods: This cross- ... ...

    Abstract Objectives: To determine the efficacy of a newly developed kit in dentine sialophosphoprotein (DSPP) detection and compare it with enzyme-linked immunosorbent assay (ELISA). User acceptance was also determined.
    Materials and methods: This cross-sectional study consisted of 45 subjects who were divided into 3 groups based on the severity of root resorption using radiographs: normal (RO), mild (RM), and severe (RS). DSPP in GCF samples was analyzed using both methods. Questionnaires were distributed to 30 orthodontists to evaluate future user acceptance.
    Results: The sensitivity and specificity of the kit were 0.98 and 0.8 respectively. The DSPP concentrations measured using ELISA were the highest in the RS group (6.33 ± 0.85 ng/mL) followed by RM group (3.77 ± 0.36 ng/mL) and the RO group had the lowest concentration (2.23 ± 0.55 ng/mL). The new kit portrayed similar results as the ELISA, the optical density (OD) values were the highest in the RS group (0.62 ± 0.10) followed by RM group (0.33 ± 0.03) and the RO group (0.19 ± 0.06). The differences among all the groups were statistically significant (p < 0.05) for both methods. The Pearson correlation coefficient showed a statistically significant (p < 0.001) strong and positive correlation between DSPP concentrations and OD values.
    Conclusions: The new kit was validated to detect the colour intensities of different severity of root resorptions. Most of the responses to the survey were positive towards the new kit for being a safer and simpler method to detect apical root resorption.
    MeSH term(s) Humans ; Extracellular Matrix Proteins ; Root Resorption/diagnostic imaging ; Cross-Sectional Studies ; Sialoglycoproteins ; Gingival Crevicular Fluid/chemistry ; Phosphoproteins ; Biomarkers/analysis
    Chemical Substances Extracellular Matrix Proteins ; Sialoglycoproteins ; Phosphoproteins ; Biomarkers
    Language English
    Publishing date 2024-03-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091511-1
    ISSN 1472-6831 ; 1472-6831
    ISSN (online) 1472-6831
    ISSN 1472-6831
    DOI 10.1186/s12903-024-04056-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Enhanced Recovery After Surgery and Perioperative Laryngectomy Outcomes.

    Frenkel, Catherine H / Donahue, Erin E / Brickman, Daniel / Hong, Steven / Milas, Zvonimir L

    The Laryngoscope

    2023  Volume 134, Issue 5, Page(s) 2262–2268

    Abstract: Objective: Patients undergoing laryngectomy are particularly vulnerable to postoperative complications secondary to social and nutritional barriers, substance abuse, and prior cancer treatment. Enhanced Recovery After Surgery (ERAS) programs may ... ...

    Abstract Objective: Patients undergoing laryngectomy are particularly vulnerable to postoperative complications secondary to social and nutritional barriers, substance abuse, and prior cancer treatment. Enhanced Recovery After Surgery (ERAS) programs may mitigate this vulnerability and improve postoperative complications and oncologic outcomes. The objective of this study is to evaluate the postoperative complication rate and oncologic outcomes of patients undergoing laryngectomy before and after ERAS program implementation.
    Methods: A historic cohort of 50 patients who underwent laryngectomy at the Levine Cancer Institute, Charlotte, North Carolina from 2014 to 2019 (pre-ERAS) was compared to 33 patients who underwent laryngectomy after ERAS implementation from 2019 to 2020. The primary outcomes included length of stay (LOS), Clavien-Dindo postoperative complications through 30 days following discharge, overall survival (OS), and recurrence-free survival between pre-ERAS and ERAS groups.
    Results: Demographic characteristics between the two groups were similar. ERAS pathway implementation led to core care element consistency and improvement in the clinical perioperative course, including preoperative nutritional intervention (p = 0.009), postoperative ventilator independence (p = 0.0004), and refractory nausea/emesis (p = 0.18). Severe (≥ grade 3) complications (p = 0.49) and LOS (p = 0.68) were similar between groups. No significant difference in Cox proportional modeling of OS (p = 0.60) or recurrence-free survival (p = 0.17) was noted.
    Conclusions: ERAS did not improve LOS, major postoperative complications, or oncologic outcomes in this cohort of patients who underwent laryngectomy. However, ERAS positively influenced secondary endpoints within the laryngectomy perioperative course, conferring qualitative health care benefits.
    Level of evidence: 3 Laryngoscope, 134:2262-2268, 2024.
    MeSH term(s) Humans ; Enhanced Recovery After Surgery ; Laryngectomy ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Period ; Preoperative Care ; Length of Stay ; Retrospective Studies ; Perioperative Care
    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.31199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: CT-Guided Retrieval of a Retained, Migrating Oral Cavity Grill Brush Bristle.

    Miller, Nathaniel W / Perkins, Jonathan N / Hong, Steven S / Costello, Justin E

    Journal of vascular and interventional radiology : JVIR

    2021  Volume 32, Issue 10, Page(s) 1516–1517

    MeSH term(s) Foreign Bodies/diagnostic imaging ; Foreign Bodies/surgery ; Humans ; Mouth ; Tomography, X-Ray Computed
    Language English
    Publishing date 2021-07-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1137756-2
    ISSN 1535-7732 ; 1051-0443
    ISSN (online) 1535-7732
    ISSN 1051-0443
    DOI 10.1016/j.jvir.2021.06.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Mapping protein-exopolysaccharide binding interaction in

    Vo, Luan H / Hong, Steven / Stepler, Kaitlyn E / Liyanaarachchi, Sureshee M / Yang, Jack / Nemes, Peter / Poulin, Myles B

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Bacterial biofilms consist of cells encased in an extracellular polymeric substance (EPS) composed of exopolysaccharides, extracellular DNA, and proteins that are critical for cell-cell adhesion and protect the cells from environmental stress, antibiotic ...

    Abstract Bacterial biofilms consist of cells encased in an extracellular polymeric substance (EPS) composed of exopolysaccharides, extracellular DNA, and proteins that are critical for cell-cell adhesion and protect the cells from environmental stress, antibiotic treatments, and the host immune response. Degrading EPS components or blocking their production have emerged as promising strategies for prevention or dispersal of bacterial biofilms, but we still have little information about the specific biomolecular interactions that occur between cells and EPS components and how those interactions contribute to biofilm production.
    Language English
    Publishing date 2023-08-29
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.08.29.555326
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online: These Maps Are Made For Walking

    Ewen, Parker / Li, Adam / Chen, Yuxin / Hong, Steven / Vasudevan, Ram

    Real-Time Terrain Property Estimation for Mobile Robots

    2022  

    Abstract: The equations of motion governing mobile robots are dependent on terrain properties such as the coefficient of friction, and contact model parameters. Estimating these properties is thus essential for robotic navigation. Ideally any map estimating ... ...

    Abstract The equations of motion governing mobile robots are dependent on terrain properties such as the coefficient of friction, and contact model parameters. Estimating these properties is thus essential for robotic navigation. Ideally any map estimating terrain properties should run in real time, mitigate sensor noise, and provide probability distributions of the aforementioned properties, thus enabling risk-mitigating navigation and planning. This paper addresses these needs and proposes a Bayesian inference framework for semantic mapping which recursively estimates both the terrain surface profile and a probability distribution for terrain properties using data from a single RGB-D camera. The proposed framework is evaluated in simulation against other semantic mapping methods and is shown to outperform these state-of-the-art methods in terms of correctly estimating simulated ground-truth terrain properties when evaluated using a precision-recall curve and the Kullback-Leibler divergence test. Additionally, the proposed method is deployed on a physical legged robotic platform in both indoor and outdoor environments, and we show our method correctly predicts terrain properties in both cases. The proposed framework runs in real-time and includes a ROS interface for easy integration.
    Keywords Computer Science - Robotics ; Electrical Engineering and Systems Science - Image and Video Processing
    Subject code 629
    Publishing date 2022-05-25
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Predictors of loss to follow-up from HIV antiretroviral therapy in Namibia.

    Hong, Steven Y / Winston, Anna / Mutenda, Nicholus / Hamunime, Ndapewa / Roy, Tuhin / Wanke, Christine / Tang, Alice M / Jordan, Michael R

    PloS one

    2022  Volume 17, Issue 4, Page(s) e0266438

    Abstract: Despite progress on population-level HIV viral suppression, unknown outcomes amongst people who have initiated antiretroviral therapy (ART) in low- and middle-income countries, commonly referred to as loss to follow-up (LTFU), remains a barrier. The mean ...

    Abstract Despite progress on population-level HIV viral suppression, unknown outcomes amongst people who have initiated antiretroviral therapy (ART) in low- and middle-income countries, commonly referred to as loss to follow-up (LTFU), remains a barrier. The mean global estimate of LTFU is 20%, exceeding the World Health Organization target of <15%. Pervasive predictors associated with LTFU include younger age, low body mass index, low CD4 count, advanced HIV clinical stage and certain ART regimens. In Namibia, ART use by eligible individuals exceeds 85%, surpassing the global average. Nonetheless, LTFU remains a barrier to achieving viral suppression and requires research to elucidate context-specific factors. An observational cohort study was conducted in Namibia in 2012 by administering surveys to individuals who presented for HIV care and initiated ART for the first time. Additional data were collected from routine medical data monitoring systems. Participants classified as LTFU at 12 months were traced to confirm their status. Predictors of LTFU were analyzed using multivariable logistic regression. Of those who presented consecutively to initiate ART, 524 were identified as eligible to enroll in the study, 497 enrolled, and 474 completed the baseline questionnaire. The cohort had mean age 36 years, 39% were male, mean CD4 cell count 222 cells/mm3, 17% were WHO HIV clinical stage III-IV, and 14% started efavirenz-based regimens. Tracing participants classified as LTFU yielded a re-categorization from 27.8% (n = 132) to 14.3% (n = 68) LTFU. In the final multivariable model, factors associated with confirmed LTFU status were: younger age (OR 0.97, 95% CI 1.00-1.06, p = 0.02); male sex (OR 2.34, CI 1.34-4.06, p = 0.003); difficulty leaving work or home to attend clinic (OR 2.55, CI 1.40-4.65, p = 0.002); and baseline efavirenz-based regimen (OR 2.35, CI 1.22-4.51, p = 0.01). Interventions to reduce LTFU should therefore target young men, particularly those who report difficulty leaving work or home to attend clinic and are on an efavirenz-based regimen.
    MeSH term(s) Adult ; Anti-HIV Agents/therapeutic use ; Anti-Retroviral Agents/therapeutic use ; Female ; Follow-Up Studies ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Humans ; Lost to Follow-Up ; Male ; Namibia/epidemiology
    Chemical Substances Anti-HIV Agents ; Anti-Retroviral Agents
    Language English
    Publishing date 2022-04-14
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, N.I.H., Extramural
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0266438
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Taking care to the patients: a qualitative evaluation of a community-based ART care program in northern Namibia.

    Katirayi, Leila / Shoopala, Naemi / Mitruka, Kiren / Mengistu, Assegid / Woelk, Godfrey / Baughman, Andrew L / Mutandi, Gram / Hong, Steven Y / Hamunime, Ndapewa

    BMC health services research

    2022  Volume 22, Issue 1, Page(s) 498

    Abstract: Background: Namibia is a large sparsely populated country with a high prevalence of HIV. People living with HIV who reside in remote areas often travel long distances through tough desert terrain to access HIV care and treatment. To address this barrier, ...

    Abstract Background: Namibia is a large sparsely populated country with a high prevalence of HIV. People living with HIV who reside in remote areas often travel long distances through tough desert terrain to access HIV care and treatment. To address this barrier, community-based antiretroviral therapy (C-BART) sites were established in Okongo (2007-2008) and Eenhana districts (2016) of northern Namibia with the goal of bringing HIV and other health services closer patients' homes. We conducted a qualitative evaluation of the acceptability and challenges of C-BART to guide program improvement.
    Methods: For this qualitative descriptive study, research assistants collected data (August-December 2017) through in-depth interviews with 40 patients, seven health extension workers, and 11 policy/program managers, and through four focus group discussions with healthcare workers. Interviews were audio-recorded, translated, and coded using MAXQDA v.12. Data were analyzed using thematic analysis.
    Results: The evaluation identified five themes: community ownership, acceptance of the C-BART sites, benefits of the C-BART program for the PLHIV community and their social networks, benefits of the C-BART program to the main health facility, and challenges with the C-BART program. The C-BART program was reported as life-changing by many patients who had previously struggled to afford four-wheel drive vehicles to access care. Patients and healthcare workers perceived that the community as a whole benefited from the C-BART sites not only due to the financial pressure lifted from friends and family members previously asked to help cover expensive transportation, but also due to the perception of diminished stigmatization of people living with HIV and improved health. The C-BART sites became a source of community and social support for those accessing the sites. Healthcare workers reported greater job satisfaction and decongestion of health facilities. The challenges that they reported included delays in authorization of vehicles for transportation to C-BART sites and lack of incentives to provide services in the community.
    Conclusion: The C-BART program can serve as a model of care to expand access to HIV care and treatment and other health services to populations in remote settings, including rural and difficult-to-reach regions. The needs of healthcare workers should also be considered for the optimal delivery of such a model.
    MeSH term(s) Anti-Retroviral Agents/therapeutic use ; Focus Groups ; HIV Infections/drug therapy ; Humans ; Namibia ; Qualitative Research
    Chemical Substances Anti-Retroviral Agents
    Language English
    Publishing date 2022-04-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050434-2
    ISSN 1472-6963 ; 1472-6963
    ISSN (online) 1472-6963
    ISSN 1472-6963
    DOI 10.1186/s12913-022-07928-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The COVID-19 Airway Management Isolation Chamber (CAMIC) for Ears.

    Tolisano, Anthony M / Blood, Timothy C / Riley, Charles A / Ruhl, Douglas S / Hong, Steven S

    The Laryngoscope

    2020  Volume 130, Issue 11, Page(s) 2690–2692

    MeSH term(s) Adult ; Airway Management/instrumentation ; Airway Management/methods ; COVID-19/prevention & control ; COVID-19/transmission ; Cholesteatoma, Middle Ear/surgery ; Disease Transmission, Infectious/prevention & control ; Humans ; Male ; Otologic Surgical Procedures/adverse effects ; Otologic Surgical Procedures/instrumentation ; Otologic Surgical Procedures/methods ; Patient Isolators/virology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-20
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.28942
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Hazards and Management of Wire Bristle ingestions: A Systematic Review.

    Miller, Nathaniel / Noller, Michael / Leon, Matthew / Moreh, Yonatan / Watson, Nora L / Costello, Justin / Hong, Steven

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

    2021  Volume 167, Issue 4, Page(s) 632–644

    Abstract: Objective: Inadvertently ingested grill brush bristles can lodge in various locations and lead to a variety of injuries. They can also be difficult to identify and remove. Our primary objective was to perform a systematic review of cases reported in the ...

    Abstract Objective: Inadvertently ingested grill brush bristles can lodge in various locations and lead to a variety of injuries. They can also be difficult to identify and remove. Our primary objective was to perform a systematic review of cases reported in the literature, with analysis of trends in clinical presentation and success of diagnostic modalities and treatment approaches.
    Data sources: Cases of reported grill brush bristle ingestion reported in PubMed, PubMed Central, and Google Scholar databases through April 30, 2021.
    Review methods: Databases were searched for the following terms: ("ingestion" OR "injury" OR "barbeque" OR "BBQ" OR "grill" OR "foreign body" OR "brush" AND "wire" OR "bristle"). Data were collected on patient demographics, clinical presentation, and treatment course. Statistical analysis was performed on characteristics with low risk of confounding.
    Results: An overall 57 studies involving 91 patients were included. Grill brush bristles presented most commonly in the upper aerodigestive tract (48/91), followed by the abdomen (26/91) and deep neck (17/91). Computed tomography was the most accurate imaging modality for initial diagnosis, identifying 92.8% of bristles. Less invasive or adjunctive techniques such as endoscopy, intraoperative imaging, or minimally invasive surgery may be useful particularly for bristles located in the head and neck given the low rate of success of transoral surgery (66.7%).
    Conclusion: Although this review of retained bristle may be biased toward complex cases, retained grill brush bristles represent an underrecognized and difficult-to-manage hazard. When cases are suspected, clinicians should obtain computed tomography imaging based on presentation and tailor management appropriately.
    MeSH term(s) Foreign Bodies/diagnostic imaging ; Foreign Bodies/surgery ; Humans ; Tomography, X-Ray Computed
    Language English
    Publishing date 2021-11-30
    Publishing country England
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0161-6439 ; 0194-5998
    ISSN (online) 1097-6817
    ISSN 0161-6439 ; 0194-5998
    DOI 10.1177/01945998211062156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Latent Class Analysis of Barriers to Care Among Emergency Department Patients.

    Abar, Beau / Holub, Ashley / Hong, Steven / Aaserude, Eric / DeRienzo, Vincent

    The western journal of emergency medicine

    2019  Volume 20, Issue 2, Page(s) 256–261

    Abstract: Introduction: Emergency department (ED) patients experience a variety of barriers to care that can lead to unnecessary or repeated visits. By identifying the patterns of barriers experienced by subsets of the ED patient population, future researchers ... ...

    Abstract Introduction: Emergency department (ED) patients experience a variety of barriers to care that can lead to unnecessary or repeated visits. By identifying the patterns of barriers experienced by subsets of the ED patient population, future researchers might effectively design interventions to circumvent these barriers and improve care. This study sought to identify classes of individuals with regard to perceived barriers to care.
    Methods: Over a 10-week period, two medical students distributed surveys to eligible patients ≥18 years who presented to the ED. After consent, patients provided demographics data and rated their perceived access to care on nine specific items (scored 1-5). We used latent class analysis (LCA), a parametric clustering method, to determine patient groups. Demographic characteristics were then compared across classes.
    Results: We enrolled a total of 637 patients. Results of the LCA indicated that a six-class solution fit best: 1) low barriers (60%); 2) "work responsibility" barriers (13%); 3) economic-related barriers (10%); 4) "appointment difficulty" barriers (8%); 5) "illness and care responsibilities" barriers (6%); and 6) diverse barriers (2%). Patients in the low-barriers class were the oldest across classes (p<.001). Individuals in the low-barriers class were also more likely to be White (p=.015) and have private insurance (p<.001) than those in the "appointment difficulty," "illness and care responsibilities," and diverse barriers classes.
    Conclusion: LCA suggests there are six distinct classes of patients with regard to perceived access to care. These classes may be used as a potential starting point in designing targeted interventions for ED patients to improve continuity of care.
    MeSH term(s) Adolescent ; Adult ; Age Distribution ; Aged ; Appointments and Schedules ; Continuity of Patient Care/standards ; Continuity of Patient Care/statistics & numerical data ; Emergency Service, Hospital/statistics & numerical data ; Female ; Health Services Accessibility/statistics & numerical data ; Humans ; Latent Class Analysis ; Male ; Middle Aged ; New York ; Surveys and Questionnaires ; Young Adult
    Language English
    Publishing date 2019-02-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2375700-0
    ISSN 1936-9018 ; 1936-9018
    ISSN (online) 1936-9018
    ISSN 1936-9018
    DOI 10.5811/westjem.2018.11.40144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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