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Article ; Online: Lichen planus is associated with depression and anxiety: a cross-sectional study in the All of Us research program.

Hong, Suyeon / Fan, Ryan / Cohen, Jeffrey M

2022 Volume 315, Issue 5, Page(s) 1417–1419

Abstract: Lichen planus (LP) can be accompanied by psychiatric comorbidities. Studies investigating the relationship between LP and clinically diagnosed anxiety and depression are limited. We aimed to determine the association of LP with anxiety and depression by ... ...

Abstract	Lichen planus (LP) can be accompanied by psychiatric comorbidities. Studies investigating the relationship between LP and clinically diagnosed anxiety and depression are limited. We aimed to determine the association of LP with anxiety and depression by conducting a cross-sectional population study of the All of Us research database, a National Institutes of Health cohort. Patients with LP were identified through electronic health record data using codes from the International Classification of Diseases and Systematized Nomenclature of Medicine. We used multivariable logistic regression to assess associations between LP and anxiety and depression before and after controlling for relevant covariates. Among 239,552 participants, 1083 individuals with LP were identified, with an average age of 67.20 years (standard deviation, 11.79) and a female predominance (74% female). The prevalence of depression and anxiety were higher among individuals with LP than in those without (41.6% vs 27.7%, p < 0.001; 43.5% vs 29.6%, p < 0.001). LP remained significantly associated with depression (OR, 1.36; 95% CI, 1.20-1.56, p < 0.001) and anxiety (OR, 1.48; 95% CI, 1.30-1.68, p < 0.001) after controlling for age, sex, hypothyroidism, autoimmune diseases, hypertension, type II diabetes mellitus, cardiovascular disease, and hepatitis C infection. In this cross-sectional study, LP was associated with an increase in odds of having depression and anxiety in multivariable analysis. Further study is needed to better understand the relationship between mental health outcomes and LP to address the needs of patients with LP more completely.
MeSH term(s)	Humans ; Female ; Aged ; Male ; Cross-Sectional Studies ; Depression ; Diabetes Mellitus, Type 2 ; Population Health ; Anxiety ; Lichen Planus
Language	English
Publishing date	2022-11-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	130131-7
ISSN	1432-069X ; 0340-3696
ISSN (online)	1432-069X
ISSN	0340-3696
DOI	10.1007/s00403-022-02459-4
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Article ; Online: Association of psoriasis and systemic lupus erythematosus and mediation effects of tumor necrosis factor-α inhibitors: A cross-sectional study in the All of Us Research Program.

Chen, Gloria F / Hong, Suyeon / Ramachandran, Sarika M / Gehlhausen, Jeff R / Cohen, Jeffrey M

Journal of the American Academy of Dermatology

2023 Volume 90, Issue 1, Page(s) 184–187

MeSH term(s)	Humans ; Tumor Necrosis Factor-alpha ; Cross-Sectional Studies ; Population Health ; Lupus Erythematosus, Systemic/drug therapy ; Lupus Erythematosus, Systemic/epidemiology ; Immunologic Factors ; Psoriasis/drug therapy ; Psoriasis/epidemiology
Chemical Substances	Tumor Necrosis Factor-alpha ; Immunologic Factors
Language	English
Publishing date	2023-09-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	603641-7
ISSN	1097-6787 ; 0190-9622
ISSN (online)	1097-6787
ISSN	0190-9622
DOI	10.1016/j.jaad.2023.09.028
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Article ; Online: Effects of Cognitive Task Training on Dynamic Balance and Gait of Patients with Stroke: A Preliminary Randomized Controlled Study.

Hong, Su-Yeon / Moon, Young / Choi, Jong-Duk

Medical science monitor basic research

2020 Volume 26, Page(s) e925264

Abstract: BACKGROUND The decreased postural control ability of stroke patients affects their ability to balance in various postures such as sitting and standing. This study aimed to determine whether cognitive task training for stroke patients is effective in ... ...

Abstract	BACKGROUND The decreased postural control ability of stroke patients affects their ability to balance in various postures such as sitting and standing. This study aimed to determine whether cognitive task training for stroke patients is effective in improving walking and balancing abilities. MATERIAL AND METHODS Seventeen stroke patients (10 males, 7 females) were randomized by ballot to be assigned to the cognitive task group (CBT) or the general task group (GBT). For the cognitive task training, a dual task of balance and cognition using traffic signals, a familiar form to the subjects, was applied as a program. In both groups the interventions were performed for 30 min a day, 3 times a week, for 4 weeks. The timed up and go test (TUG), the Berg balance scale (BBS), and gait ability evaluation were performed to compare the therapeutic effects. RESULTS After the intervention, the BBS showed significant differences in both groups (p<0.05). The cognitive task training group had significant improvement in all outcome scores after the intervention (p<0.05). The TUG score of the CBT group significantly decreased to 6.17 s (p<0.05), but that of the GBT showed no statistically significant change. CONCLUSIONS Cognitive task training could be used in clinical rehabilitation as a more effective intervention method to improve balance and gait ability of stroke patients.
MeSH term(s)	Aged ; Cognition/physiology ; Female ; Gait/physiology ; Humans ; Male ; Middle Aged ; Postural Balance/physiology ; Stroke/physiopathology ; Task Performance and Analysis
Language	English
Publishing date	2020-08-10
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2711344-9
ISSN	2325-4416 ; 2325-4416
ISSN (online)	2325-4416
ISSN	2325-4416
DOI	10.12659/MSMBR.925264
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Article: Surface Modification of ZrO

Cho, Hanjun / Lee, Deunchan / Hong, Suyeon / Kim, Heegyeong / Jo, Kwanghyeon / Kim, Changwook / Yoon, Ilsun

Nanomaterials (Basel, Switzerland)

2022 Volume 12, Issue 14

Abstract: Here, highly transparent nanocomposite films with an adjustable refractive index were fabricated through stable dispersion of ... ...

Abstract	Here, highly transparent nanocomposite films with an adjustable refractive index were fabricated through stable dispersion of ZrO
Language	English
Publishing date	2022-07-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano12142328
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Article: Factors affecting the changes in antihypertensive medications in patients with hypertension.

Chung, Tae Kyu / Jeon, Yoomin / Hong, YeSol / Hong, Suyeon / Moon, Jun Sik / Lee, Howard

Frontiers in cardiovascular medicine

2022 Volume 9, Page(s) 999548

Abstract: As frequent changes in anti-hypertensive (HTN) medications may reduce adherence to the treatments, identifying modifiable factors leading to changes in anti-HTN medications can help clinicians optimize treatment strategies for individual patients. We ... ...

Abstract	As frequent changes in anti-hypertensive (HTN) medications may reduce adherence to the treatments, identifying modifiable factors leading to changes in anti-HTN medications can help clinicians optimize treatment strategies for individual patients. We performed this study to explore the pattern of anti-HTN medications and to identify factors that are associated with the changes in anti-HTN medications. To this end, we used a clinical database of Seoul National University Hospital, extracted, transformed, and loaded by the observational medical outcomes partnership common data model. Demographic and all recorded clinical diagnoses, medications, and procedures data of eligible subjects were collected. Of 636 subjects who were eligible for this study, 297 subjects with a record of ≥1 anti-HTN medication changes and other 297 subjects without a record of medication change were selected for the study population. High diastolic blood pressure (adjusted odds ratio [OR]: 1.02, 95% confidence interval [CI]: 1.001-1.040,
Language	English
Publishing date	2022-09-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.999548
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Article ; Online: Efficacy of genotype-matched vaccine against re-emerging genotype V Japanese encephalitis virus.

Kim, Jae-Deog / Lee, Ah-Ra / Moon, Dah-Hyun / Chung, Young-Uk / Hong, Su-Yeon / Cho, Hyo Je / Kang, Tae Hyun / Jang, Yo Han / Sohn, Myung Hyun / Seong, Baik-Lin / Seo, Sang-Uk

Emerging microbes & infections

2024 Volume 13, Issue 1, Page(s) 2343910

Abstract: Japanese encephalitis (JE), caused by the Japanese encephalitis virus (JEV), is a highly threatening disease with no specific treatment. Fortunately, the development of vaccines has enabled effective defense against JE. However, re-emerging genotype V ( ... ...

Abstract	Japanese encephalitis (JE), caused by the Japanese encephalitis virus (JEV), is a highly threatening disease with no specific treatment. Fortunately, the development of vaccines has enabled effective defense against JE. However, re-emerging genotype V (GV) JEV poses a challenge as current vaccines are genotype III (GIII)-based and provide suboptimal protection. Given the isolation of GV JEVs from Malaysia, China, and the Republic of Korea, there is a concern about the potential for a broader outbreak. Under the hypothesis that a GV-based vaccine is necessary for effective defense against GV JEV, we developed a pentameric recombinant antigen using cholera toxin B as a scaffold and mucosal adjuvant, which was conjugated with the E protein domain III of GV by genetic fusion. This GV-based vaccine antigen induced a more effective immune response in mice against GV JEV isolates compared to GIII-based antigen and efficiently protected animals from lethal challenges. Furthermore, a bivalent vaccine approach, inoculating simultaneously with GIII- and GV-based antigens, showed protective efficacy against both GIII and GV JEVs. This strategy presents a promising avenue for comprehensive protection in regions facing the threat of diverse JEV genotypes, including both prevalent GIII and GI as well as emerging GV strains.
MeSH term(s)	Encephalitis Virus, Japanese/genetics ; Encephalitis Virus, Japanese/immunology ; Encephalitis Virus, Japanese/classification ; Animals ; Genotype ; Encephalitis, Japanese/prevention & control ; Encephalitis, Japanese/immunology ; Encephalitis, Japanese/virology ; Japanese Encephalitis Vaccines/immunology ; Japanese Encephalitis Vaccines/administration & dosage ; Japanese Encephalitis Vaccines/genetics ; Mice ; Antibodies, Viral/immunology ; Antibodies, Viral/blood ; Humans ; Mice, Inbred BALB C ; Female ; Antigens, Viral/immunology ; Antigens, Viral/genetics ; Vaccine Efficacy ; Cholera Toxin/genetics ; Cholera Toxin/immunology
Chemical Substances	Japanese Encephalitis Vaccines ; Antibodies, Viral ; Antigens, Viral ; Cholera Toxin (9012-63-9)
Language	English
Publishing date	2024-04-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2681359-2
ISSN	2222-1751 ; 2222-1751
ISSN (online)	2222-1751
ISSN	2222-1751
DOI	10.1080/22221751.2024.2343910
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Article ; Online: Hazardous characteristics of dust waste from metal manufacturing industries in South Korea.

Yoon, Cheol-Woo / Yoon, Young-Sam / Hong, Su-Yeon / Jeon, Tea-Wan / Shin, Sun-Kyoung

Waste management & research : the journal of the International Solid Wastes and Public Cleansing Association, ISWA

2021 Volume 39, Issue 12, Page(s) 1471–1479

Abstract: The Ministry of Environment, South Korea, is involved in efforts to reduce safety-related accidents that could occur during hazardous waste disposal and minimise the environmental impacts of waste disposal. To reach such goals, new factors have been ... ...

Abstract	The Ministry of Environment, South Korea, is involved in efforts to reduce safety-related accidents that could occur during hazardous waste disposal and minimise the environmental impacts of waste disposal. To reach such goals, new factors have been added that contribute to the hazardous characteristics of hazardous waste. The Ministry is also expanding regulations on inorganic and organic components present in hazardous waste for these factors and continues to correct the classification system to establish standards for waste components. Metallic dust, for example, is mostly generated during the operation of melting furnaces or precipitators and dangerous materials contained in this dust may cause accidents, such as explosions or fires. South Korean accident cases have confirmed that waste containing hazardous materials, such as Mg, Al and Mg-Al alloys, can cause such events. Therefore, this study analysed 28 dust samples collected from the dust accumulated in precipitators in 28 metal manufacturing facilities in South Korea. Nine samples were flammable and four samples were reactive to water. Two samples also exhibited leaching toxicities. The results applied to relevant laws in South Korea showed that the proportion of waste containing hazardous characteristics increased from 7.14% in the previous management category to 39.29% in the extended category, an overall increase of 32.15 percentage points.
MeSH term(s)	Dust/analysis ; Hazardous Waste ; Manufacturing Industry ; Refuse Disposal ; Republic of Korea
Chemical Substances	Dust ; Hazardous Waste
Language	English
Publishing date	2021-03-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1480483-9
ISSN	1096-3669 ; 1399-3070 ; 0734-242X
ISSN (online)	1096-3669 ; 1399-3070
ISSN	0734-242X
DOI	10.1177/0734242X21996552
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Article ; Online: Development of surface engineered antigenic exosomes as vaccines for respiratory syncytial virus.

Hong, Suyeon / Ruan, Shaobo / Greenberg, Zachary / He, Mei / McGill, Jodi L

Scientific reports

2021 Volume 11, Issue 1, Page(s) 21358

Abstract: Respiratory syncytial virus (RSV) is one of the main pathogens associated with lower respiratory tract infections in infants and young children worldwide. Exosomes secreted by antigen presenting cells (APCs) can elicit immune responses by carrying major ... ...

Abstract	Respiratory syncytial virus (RSV) is one of the main pathogens associated with lower respiratory tract infections in infants and young children worldwide. Exosomes secreted by antigen presenting cells (APCs) can elicit immune responses by carrying major histocompatibility complex (MHC) class I molecules complexed with antigenic peptides and other co-stimulating factors. Therefore, we developed novel immunomagnetic nanographene particles to sequentially isolate, surface engineer, and release intact dendritic cell (DC) exosomes for use as a potential vaccine platform against RSV. The H-2D
MeSH term(s)	Animals ; CD8-Positive T-Lymphocytes/immunology ; Cell Line ; Dendritic Cells/immunology ; Exosomes/immunology ; Exosomes/transplantation ; Histocompatibility Antigens Class I/immunology ; Histocompatibility Antigens Class I/therapeutic use ; Humans ; Mice, Inbred C57BL ; Peptides/immunology ; Peptides/therapeutic use ; Respiratory Syncytial Virus Infections/immunology ; Respiratory Syncytial Virus Infections/prevention & control ; Respiratory Syncytial Virus Vaccines/immunology ; Respiratory Syncytial Virus Vaccines/therapeutic use ; Respiratory Syncytial Virus, Human/immunology ; Viral Proteins/immunology ; Viral Proteins/therapeutic use ; Mice
Chemical Substances	Histocompatibility Antigens Class I ; Peptides ; Respiratory Syncytial Virus Vaccines ; Viral Proteins
Language	English
Publishing date	2021-11-01
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-00765-x
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Article ; Online: The serotonin reuptake inhibitor fluoxetine induces human fetal membrane sterile inflammation through p38 MAPK activation.

Fabrizio, Veronica A / Lindsay, Christina V / Wilcox, Maya / Hong, Suyeon / Lynn, Tatyana / Norwitz, Errol R / Yonkers, Kimberly A / Abrahams, Vikki M

Journal of reproductive immunology

2022 Volume 155, Page(s) 103786

Abstract: Serotonin Reuptake Inhibitors (SRIs) are often used as first line therapy for depression and other psychiatric disorders. SRI use during pregnancy is associated with preterm premature rupture of membranes (PPROM) and subsequent preterm birth. The ... ...

Abstract	Serotonin Reuptake Inhibitors (SRIs) are often used as first line therapy for depression and other psychiatric disorders. SRI use during pregnancy is associated with preterm premature rupture of membranes (PPROM) and subsequent preterm birth. The objective of this study was to investigate the mechanism(s) responsible for SRI-associated PPROM. Putative mechanisms underlying PPROM include fetal membrane (FM) inflammation, increased apoptosis, and/or accelerated senescence, the later which may be reversed by statins. Human FM explants from normal term deliveries without labor, infection, or antidepressant use were treated with or without the SRI, fluoxetine (FLX), either alone or in the presence of a p38 MAPK inhibitor or the statins, simvastatin or rosuvastatin. FMs were also collected from women either unexposed or exposed to FLX during pregnancy. FLX significantly increased FM p38 MAPK activity and secretion of inflammatory IL-6. Inhibition of p38 MAPK reduced FM IL-6 secretion in response to FLX. Statins did not reduce the SRI-induced FM IL-6 production. FMs from women exposed to FLX during pregnancy expressed elevated levels of p38 MAPK activity compared to matched unexposed women. FMs exposed to FLX did not exhibit signs of increased apoptosis and/or accelerated senescence. These results indicate that the SRI, FLX, may induce sterile FM inflammation during pregnancy through activation of the p38 MAPK pathway, and in the absence of apoptosis and senescence. These findings may better inform clinicians and patients as they weigh the risks and benefits of SRI antidepressant treatment during pregnancy.
MeSH term(s)	Pregnancy ; Humans ; Infant, Newborn ; Female ; Fluoxetine/adverse effects ; Fluoxetine/metabolism ; Selective Serotonin Reuptake Inhibitors/adverse effects ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; p38 Mitogen-Activated Protein Kinases/metabolism ; Interleukin-6/metabolism ; Premature Birth/metabolism ; Fetal Membranes, Premature Rupture ; Extraembryonic Membranes/metabolism ; Antidepressive Agents/metabolism ; Inflammation/metabolism
Chemical Substances	Fluoxetine (01K63SUP8D) ; Selective Serotonin Reuptake Inhibitors ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Interleukin-6 ; Antidepressive Agents
Language	English
Publishing date	2022-12-13
Publishing country	Ireland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	424421-7
ISSN	1872-7603 ; 0165-0378
ISSN (online)	1872-7603
ISSN	0165-0378
DOI	10.1016/j.jri.2022.103786
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Article ; Online: FcRγ- NK Cell Induction by Specific Cytomegalovirus and Expansion by Subclinical Viral Infections in Rhesus Macaques.

Lee, Jaewon / Chang, W L William / Scott, Jeannine M / Hong, Suyeon / Lee, Taehyung / Deere, Jesse D / Park, Peter H / Sparger, Ellen E / Dandekar, Satya / Hartigan-O'Connor, Dennis J / Barry, Peter A / Kim, Sungjin

Journal of immunology (Baltimore, Md. : 1950)

2023 Volume 211, Issue 3, Page(s) 443–452

Abstract: Adaptive" NK cells, characterized by FcRγ deficiency and enhanced responsiveness to Ab-bound, virus-infected cells, have been found in certain hCMV-seropositive individuals. Because humans are exposed to numerous microbes and environmental agents, ... ...

Abstract	"Adaptive" NK cells, characterized by FcRγ deficiency and enhanced responsiveness to Ab-bound, virus-infected cells, have been found in certain hCMV-seropositive individuals. Because humans are exposed to numerous microbes and environmental agents, specific relationships between hCMV and FcRγ-deficient NK cells (also known as g-NK cells) have been challenging to define. Here, we show that a subgroup of rhesus CMV (RhCMV)-seropositive macaques possesses FcRγ-deficient NK cells that stably persist and display a phenotype resembling human FcRγ-deficient NK cells. Moreover, these macaque NK cells resembled human FcRγ-deficient NK cells with respect to functional characteristics, including enhanced responsiveness to RhCMV-infected target in an Ab-dependent manner and hyporesponsiveness to tumor and cytokine stimulation. These cells were not detected in specific pathogen-free (SPF) macaques free of RhCMV and six other viruses; however, experimental infection of SPF animals with RhCMV strain UCD59, but not RhCMV strain 68-1 or SIV, led to induction of FcRγ-deficient NK cells. In non-SPF macaques, coinfection by RhCMV with other common viruses was associated with higher frequencies of FcRγ-deficient NK cells. These results support a causal role for specific CMV strain(s) in the induction of FcRγ-deficient NK cells and suggest that coinfection by other viruses further expands this memory-like NK cell pool.
MeSH term(s)	Animals ; Humans ; Cytomegalovirus/genetics ; Cytomegalovirus Infections ; Macaca mulatta ; Coinfection ; Virus Diseases ; Killer Cells, Natural
Language	English
Publishing date	2023-06-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.2200380
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