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  1. Article ; Online: Weak Bimetal Coupling-Assisted MN

    Cai, Hong-Xue / Wang, Juan / Guo, Yuan-Ru / Pan, Qing-Jiang

    Inorganic chemistry

    2024  Volume 63, Issue 15, Page(s) 6734–6742

    Abstract: The design of multimetal catalysts holds immense significance for efficient ... ...

    Abstract The design of multimetal catalysts holds immense significance for efficient CO
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.4c00058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Pathological mechanisms of cold and mechanical stress in modulating cancer progression.

    Hou, Yun-Jing / Yang, Xin-Xin / He, Lin / Meng, Hong-Xue

    Human cell

    2024  Volume 37, Issue 3, Page(s) 593–606

    Abstract: Environmental temperature and cellular mechanical force are the inherent factors that participate in various biological processes and regulate cancer progress, which have been hot topics worldwide. They occupy a dominant part in the cancer tissues ... ...

    Abstract Environmental temperature and cellular mechanical force are the inherent factors that participate in various biological processes and regulate cancer progress, which have been hot topics worldwide. They occupy a dominant part in the cancer tissues through different approaches. However, extensive investigation regarding pathological mechanisms in the carcinogenic field. After research, we found cold stress via two means to manipulate tumors: neuroscience and mechanically sensitive ion channels (MICHs) such as TRP families to regulate the physiological and pathological activities. Excessive cold stimulation mediated neuroscience acting on every cancer stage through the hypothalamus-pituitary-adrenocorticoid (HPA) to reach the target organs. Comparatively speaking, mechanical force via Piezo of MICHs controls cancer development. The progression of cancer depends on the internal activation of proto-oncogenes and the external tumorigenic factors; the above two means eventually lead to genetic disorders at the molecular level. This review summarizes the interaction of bidirectional communication between them and the tumor. It covers the main processes from cytoplasm to nucleus related to metastasis cascade and tumor immune escape.
    MeSH term(s) Humans ; Stress, Mechanical ; Neoplasms/genetics ; Neoplasms/pathology ; Carcinogenesis ; Ion Channels/genetics ; Cold Temperature
    Chemical Substances Ion Channels
    Language English
    Publishing date 2024-03-27
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1149134-6
    ISSN 1749-0774 ; 0914-7470
    ISSN (online) 1749-0774
    ISSN 0914-7470
    DOI 10.1007/s13577-024-01049-y
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3676: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Genetic-variant hotspots and hotspot clusters in the human genome facilitating adaptation while increasing instability

    Xi Long / Hong Xue

    Human Genomics, Vol 15, Iss 1, Pp 1-

    2021  Volume 23

    Abstract: Abstract Background Genetic variants, underlining phenotypic diversity, are known to distribute unevenly in the human genome. A comprehensive understanding of the distributions of different genetic variants is important for insights into genetic ... ...

    Abstract Abstract Background Genetic variants, underlining phenotypic diversity, are known to distribute unevenly in the human genome. A comprehensive understanding of the distributions of different genetic variants is important for insights into genetic functions and disorders. Methods Herein, a sliding-window scan of regional densities of eight kinds of germline genetic variants, including single-nucleotide-polymorphisms (SNPs) and four size-classes of copy-number-variations (CNVs) in the human genome has been performed. Results The study has identified 44,379 hotspots with high genetic-variant densities, and 1135 hotspot clusters comprising more than one type of hotspots, accounting for 3.1% and 0.2% of the genome respectively. The hotspots and clusters are found to co-localize with different functional genomic features, as exemplified by the associations of hotspots of middle-size CNVs with histone-modification sites, work with balancing and positive selections to meet the need for diversity in immune proteins, and facilitate the development of sensory-perception and neuroactive ligand-receptor interaction pathways in the function-sparse late-replicating genomic sequences. Genetic variants of different lengths co-localize with retrotransposons of different ages on a “long-with-young” and “short-with-all” basis. Hotspots and clusters are highly associated with tumor suppressor genes and oncogenes (p < 10−10), and enriched with somatic tumor CNVs and the trait- and disease-associated SNPs identified by genome-wise association studies, exceeding tenfold enrichment in clusters comprising SNPs and extra-long CNVs. Conclusions In conclusion, the genetic-variant hotspots and clusters represent two-edged swords that spearhead both positive and negative genomic changes. Their strong associations with complex traits and diseases also open up a potential “Common Disease-Hotspot Variant” approach to the missing heritability problem.
    Keywords Frequency independent ; Genetic diversity ; Missing heritability ; Retrotransposon ; Recombination-selection co-saturation ; Replication timing ; Medicine ; R ; Genetics ; QH426-470
    Subject code 616
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Klotho-derived peptide KP1 ameliorates SARS-CoV-2-associated acute kidney injury.

    Xu, Jie / Lin, Enqing / Hong, Xue / Li, Li / Gu, Jun / Zhao, Jinghong / Liu, Youhua

    Frontiers in pharmacology

    2024  Volume 14, Page(s) 1333389

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2024-01-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1333389
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  5. Article: 不同河岸缓冲区尺度下土地利用方式对嘎呀河流域水质的影响.

    Wang, Hong-Xue / Wu, Wei / Wang, Qi-Kun / Yang, Xue-Qi / Yin, Xu-Wang

    Ying yong sheng tai xue bao = The journal of applied ecology

    2024  Volume 34, Issue 12, Page(s) 3203–3213

    Abstract: River water quality is influenced by land use and landscape distribution patterns. Quantifying the relationship between land use, landscape pattern and water quality factor at different riparian buffer zone scales is of great significance for rational ... ...

    Title translation Impact of land use pattern on water quality under different riparian buffer zone scales in Gaya River Basin, Northeast China.
    Abstract River water quality is influenced by land use and landscape distribution patterns. Quantifying the relationship between land use, landscape pattern and water quality factor at different riparian buffer zone scales is of great significance for rational land use planning and water quality improvement. Based on water quality data from 91 sites in May 2021 in the Gaya River Basin, we analyzed the spatial characteristics of land use types and landscape patterns at the riparian buffer zone scales. With redundancy analysis (RDA) and generalized additive models (GAM), we examined the effects of land use and landscape patterns on river water quality. The results showed that water quality was primarily impacted by total nitrogen (TN). Farmland was the dominant land use type at riparian buffer zone of 50, 100 and 500 m. The sampling sites were classified into farmland dominant group and farmland other group. Forest was dominant at riparian buffer zone of 1000, 1500, 2000 m, and the sampling sites were classified into forest dominant group and forest other group. 100 m riparian buffer zone was the strongest scale in the Gaya River, and 1000 m was the second. Land use types in the forest dominant group were closely related with electrical conductivity, dissolved oxygen, phosphate, permanganate index and ammonium (NH
    MeSH term(s) Water Quality ; Rivers ; Environmental Monitoring/methods ; China ; Phosphates ; Nitrogen/analysis ; Oxides ; Manganese Compounds
    Chemical Substances permanganic acid (14333-13-2) ; Phosphates ; Nitrogen (N762921K75) ; Oxides ; Manganese Compounds
    Language Chinese
    Publishing date 2024-03-21
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2881809-X
    ISSN 1001-9332
    ISSN 1001-9332
    DOI 10.13287/j.1001-9332.202312.026
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  6. Article ; Online: Lower Blood Lipid Level Is Associated with the Occurrence of Parkinson's Disease: A Meta-Analysis and Systematic Review.

    Hong, Xue / Guo, Wenting / Li, Shanshan

    International journal of clinical practice

    2022  Volume 2022, Page(s) 9773038

    Abstract: Background: The changes of blood lipid levels in patients with Parkinson's disease (PD) and its clinical relevance remain unclear. We aimed to evaluate the potential association of blood lipid and the occurrence of PD, to provide evidence to the ... ...

    Abstract Background: The changes of blood lipid levels in patients with Parkinson's disease (PD) and its clinical relevance remain unclear. We aimed to evaluate the potential association of blood lipid and the occurrence of PD, to provide evidence to the clinical treatment and nursing care of PD.
    Methods: We searched PubMed, Medline, Web of Science, Cochrane Library, Wanfang Database, Weipu Database, and China National Knowledge Infrastructure for studies related to the blood lipid levels and PD until November 30, 2021. Two researchers independently screened the literature and extricated the data including the levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of included studies. RevMan5.3 and Stata 12.0 software were used for statistical processing and analysis.
    Results: A total of 15 cohort studies with 9740 participants involving 2032 PD patients and 7708 controls were included. Meta-analysis indicated that TC (SMD = -0.29, 95% CI -0.55∼-0.03,
    Conclusions: Lower blood TC, TG, HDL-C, and LDL-C level are associated with the occurrence of PD. Limited by sample size and study population, further high-quality, large-sample clinical trials in different areas are needed to further determine the relationship between blood lipids and PD in the future.
    MeSH term(s) Cholesterol, HDL ; Cholesterol, LDL ; Humans ; Lipids ; Parkinson Disease/epidemiology ; Triglycerides
    Chemical Substances Cholesterol, HDL ; Cholesterol, LDL ; Lipids ; Triglycerides
    Language English
    Publishing date 2022-06-09
    Publishing country India
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 1386246-7
    ISSN 1742-1241 ; 1368-5031
    ISSN (online) 1742-1241
    ISSN 1368-5031
    DOI 10.1155/2022/9773038
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.301: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Short stature associated with a novel mutation in the aggrecan gene: A case report and literature review.

    Yin, Li-Ping / Zheng, Hong-Xue / Zhu, Hong

    World journal of clinical cases

    2022  Volume 10, Issue 9, Page(s) 2811–2817

    Abstract: Background: Mutations in the aggrecan (: Case summary: A 2-year-old male patient visited us due to growth retardation. The patient presented symmetrical short stature (height 79 cm, < -2 SD) without facial features and other congenital abnormalities. ...

    Abstract Background: Mutations in the aggrecan (
    Case summary: A 2-year-old male patient visited us due to growth retardation. The patient presented symmetrical short stature (height 79 cm, < -2 SD) without facial features and other congenital abnormalities. Whole-exome sequencing revealed a heterozygous pathogenic variant c. 871C>T (p. Gln291*) of
    Conclusion: Heterozygous c. 871C>T (p. Gln291*) variation of the
    Language English
    Publishing date 2022-01-16
    Publishing country United States
    Document type Case Reports
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v10.i9.2811
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  8. Article ; Online: Data on breastfeeding and state policies in the United States

    Chun Chen / Hong Xue / Qi Zhang

    Data in Brief, Vol 37, Iss , Pp 107210- (2021)

    2021  

    Abstract: Breastfeeding is critically important to maternal and child health in the United States. Examining the relationship between breastfeeding outcomes and state policies requires multidisciplinary efforts to link data from various sources. This article ... ...

    Abstract Breastfeeding is critically important to maternal and child health in the United States. Examining the relationship between breastfeeding outcomes and state policies requires multidisciplinary efforts to link data from various sources. This article describes an integrated dataset that was used to understand the relationship between participation in a nutrition assistance program and low-income children's breastfeeding outcomes [1]. This dataset merged public health information from the National Immunization Surveys Data from 2006 to 2016 and matching state policy data from the Correlates of State Policy Project (CSPP), the U.S. Department of Agriculture/Economic Research Services (USDA/ERS) Supplemental Nutrition Assistance Program (SNAP) Policy Index, the U.S. Bureau of Labor Statistics (BLS), Centers for Medicare & Medicaid Services (CMS), and the Census Bureau. The integrated dataset compiles variables in breastfeeding outcome, child's and mother's socio-demographic characteristics, and state-level policy measures, including SNAP participation rates, SNAP policy indices, unemployment rates, and Children's Health Insurance Program (CHIP) enrollment rates. This multidisciplinary dataset included information on a total of 219,904 children with 98 variables.
    Keywords Breastfeeding ; State policy ; Supplemental nutrition assistance policy ; Maternal and child health ; Computer applications to medicine. Medical informatics ; R858-859.7 ; Science (General) ; Q1-390
    Subject code 360
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Re: Maternal transmission of SARS‐COV‐2 to the neonate, and possible routes for such transmission: a systematic review and critical analysis: An International Journal of Obstetrics and Gynaecology

    Rui‐hong, Xue

    BJOG

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #913441
    Database COVID19

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  10. Article ; Online: A User-Unfriendly Draft

    Hong Xue

    Journal of International Commercial Law and Technology, Vol 7, Iss 4, Pp 350-

    3rd Revision of the Chinese Copyright Law

    2012  Volume 354

    Abstract: Chinese Copyright Law is going to be revised for the third time. A Draft of the 3rd Revision was released for public consultation. As a critical reading of the Draft, the paper points out a variety of defects of the Draft, including restricting fair use, ...

    Abstract Chinese Copyright Law is going to be revised for the third time. A Draft of the 3rd Revision was released for public consultation. As a critical reading of the Draft, the paper points out a variety of defects of the Draft, including restricting fair use, unreasonably expanding the scope of copyright and neighbouring rights, strengthening copyright enforcement and collective management, and stretching legal protection for technological measures and right management information. Although China has enacted the national strategy of indigenous intellectual property and the 3rd Revision is not under imminent trade pressure, the Draft fails to correct the misconceptions, such as “the more the better” (more copyright protection and enforcement, the better economic growth and social development), “one size fits all” and “modelling on US law” and misses the opportunities to revamp its Copyright Law in the new century.
    Keywords copyright ; Chinese copyright law ; neighbouring rights ; collective management ; technological measures ; Information technology ; T58.5-58.64 ; Industrial engineering. Management engineering ; T55.4-60.8 ; Technology (General) ; T1-995 ; Technology ; T ; DOAJ:Computer Science ; DOAJ:Technology and Engineering ; Law in general. Comparative and uniform law. Jurisprudence ; K1-7720 ; Law ; K ; DOAJ:Law ; DOAJ:Law and Political Science
    Subject code 340
    Language English
    Publishing date 2012-10-01T00:00:00Z
    Publisher International Association of IT Lawyers
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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