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  1. Article ; Online: Chest CT Findings in a Pregnant Patient with 2019 Novel Coronavirus Disease

    Xinggui Liao / Huan Yang / Junfeng Kong / Hongbing Yang

    Balkan Medical Journal, Vol 37, Iss 4, Pp 226-

    2020  Volume 228

    Keywords Medicine ; R
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Galenos Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Immune mobilising T cell receptors redirect polyclonal CD8+ T cells in chronic HIV infection to form immunological synapses

    Zoë Wallace / Jakub Kopycinski / Hongbing Yang / Michelle L. McCully / Christian Eggeling / Jakub Chojnacki / Lucy Dorrell

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    2022  Volume 13

    Abstract: Abstract T cell exhaustion develops in human immunodeficiency virus (HIV) infection due to chronic viral antigenic stimulation. This adaptive response primarily affects virus-specific CD8+ T cells, which may remain dysfunctional despite viral load- ... ...

    Abstract Abstract T cell exhaustion develops in human immunodeficiency virus (HIV) infection due to chronic viral antigenic stimulation. This adaptive response primarily affects virus-specific CD8+ T cells, which may remain dysfunctional despite viral load-reducing antiretroviral therapy; however, abnormalities may also be evident in non-HIV-specific populations. Both could limit the efficacy of cell therapies against viral reservoirs. Here, we show that bulk (polyclonal) CD8+ T cells from people living with HIV (PLWH) express proposed markers of dysfunctional HIV-specific T cells at high levels yet form lytic immunological synapses (IS) and eliminate primary resting infected (HIV Gaglo) CD4+ T cells, when redirected by potent bispecific T cell-retargeting molecules, Immune mobilising monoclonal T cell receptors (TCR) Against Virus (ImmTAV). While PLWH CD8+ T cells are functionally impaired when compared to CD8+ T cells from HIV-naïve donors, ImmTAV redirection enables them to eliminate Gaglo CD4+ T cells that are insensitive to autologous HIV-specific cytolytic T cells. ImmTAV molecules may therefore be able to target HIV reservoirs, which represent a major barrier to a cure.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Therapeutic vaccination following early antiretroviral therapy elicits highly functional T cell responses against conserved HIV-1 regions

    Jakub Kopycinski / Hongbing Yang / Gemma Hancock / Matthew Pace / Ellen Kim / John Frater / Wolfgang Stöhr / Tomás Hanke / Sarah Fidler / Lucy Dorrell / RIVER trial study group

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Volume 10

    Abstract: Abstract ‘Kick and kill’ cure strategies aim to induce HIV protein expression in latently infected cells (kick), and thus trigger their elimination by cytolytic T cells (kill). In the Research in Viral Eradication of HIV Reservoirs trial (NCT02336074), ... ...

    Abstract Abstract ‘Kick and kill’ cure strategies aim to induce HIV protein expression in latently infected cells (kick), and thus trigger their elimination by cytolytic T cells (kill). In the Research in Viral Eradication of HIV Reservoirs trial (NCT02336074), people diagnosed with primary HIV infection received immediate antiretroviral therapy (ART) and were randomised 24 weeks later to either a latency-reversing agent, vorinostat, together with ChAdV63.HIVconsv and MVA.HIVconsv vaccines, or ART alone. This intervention conferred no reduction in HIV-1 reservoir size over ART alone, despite boosting virus-specific CD4+ and CD8+ T cells. The effects of the intervention were examined at the cellular level in the two trial arms using unbiased computational analysis of polyfunctional scores. This showed that the frequency and polyfunctionality of virus-specific CD4+ and CD8+ T cell populations were significantly increased over 12 weeks post-vaccination, compared to the ART-only arm. HIV-specific IL-2-secreting CD8+ T cells also expanded significantly in the intervention arm and were correlated with antiviral activity against heterologous HIV in vitro. Therapeutic vaccination during ART commenced in primary infection can induce functional T cell responses that are phenotypically similar to those of HIV controllers. Analytical therapy interruption may help determine their ability to control HIV in vivo.
    Keywords Medicine ; R ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Hypoxia inducible factors inhibit respiratory syncytial virus infection by modulation of nucleolin expression

    Xiaodong Zhuang / Giulia Gallo / Parul Sharma / Jiyeon Ha / Andrea Magri / Helene Borrmann / James M. Harris / Senko Tsukuda / Eleanor Bentley / Adam Kirby / Simon de Neck / Hongbing Yang / Peter Balfe / Peter A.C. Wing / David Matthews / Adrian L. Harris / Anja Kipar / James P. Stewart / Dalan Bailey /
    Jane A. McKeating

    iScience, Vol 27, Iss 1, Pp 108763- (2024)

    2024  

    Abstract: Summary: Respiratory syncytial virus (RSV) is a global healthcare problem, causing respiratory illness in young children and elderly individuals. Our knowledge of the host pathways that define susceptibility to infection and disease severity are limited. ...

    Abstract Summary: Respiratory syncytial virus (RSV) is a global healthcare problem, causing respiratory illness in young children and elderly individuals. Our knowledge of the host pathways that define susceptibility to infection and disease severity are limited. Hypoxia inducible factors (HIFs) define metabolic responses to low oxygen and regulate inflammatory responses in the lower respiratory tract. We demonstrate a role for HIFs to suppress RSV entry and RNA replication. We show that hypoxia and HIF prolyl-hydroxylase inhibitors reduce the expression of the RSV entry receptor nucleolin and inhibit viral cell-cell fusion. We identify a HIF regulated microRNA, miR-494, that regulates nucleolin expression. In RSV-infected mice, treatment with the clinically approved HIF prolyl-hydroxylase inhibitor, Daprodustat, reduced the level of infectious virus and infiltrating monocytes and neutrophils in the lung. This study highlights a role for HIF-signalling to limit multiple aspects of RSV infection and associated inflammation and informs future therapeutic approaches for this respiratory pathogen.
    Keywords Molecular biology ; Omics ; Transcriptomics ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Distribution and pollution evaluation of fluoride in a soil–water–plant system in Shihezi, Xinjiang, China

    Yu, Li / Bang-Ce Ye / Chunfeng Du / Hongbing Yang / Jianjian Zhang

    Human and ecological risk assessment. 2018 Feb. 17, v. 24, no. 2

    2018  

    Abstract: Fluoride (F) pollution is a serious environmental problem in some areas of China, but it has yet to be reported in a soil–water–plant system in Shihezi, Xinjiang. This study was undertaken to investigate the distribution and migration rule of F in soil, ... ...

    Abstract Fluoride (F) pollution is a serious environmental problem in some areas of China, but it has yet to be reported in a soil–water–plant system in Shihezi, Xinjiang. This study was undertaken to investigate the distribution and migration rule of F in soil, water, and plants, and to evaluate F pollution of soil. Results showed that the average concentration of total F (T-F) in the topsoil in the northwest, north, and southeast of Shihezi was higher than the national average T-F (478 mg/kg), while it was lower in southwest. The highest T-F contents of the soil profile were detected in the depth of 20 cm. The F content in groundwater in the northwest region was higher than the GB/T 14848–93 (1.0 mg/L), whereas the F contents in other water samples were within the standard. The F contents (1.75−2.81 mg/kg) in plant leaves were higher than the food limits (1.0 mg/kg). The obtained comprehensive pollution index of the soil was 1.86, which means a mild concentration of F in Shihezi. This research has reference value for the study of F pollution and comprehensive control in the northwest oasis with the typical arid and saline conditions.
    Keywords fluorides ; groundwater ; leaves ; oases ; soil pollution ; soil profiles ; topsoil ; China
    Language English
    Dates of publication 2018-0217
    Size p. 445-455.
    Publishing place Taylor & Francis
    Document type Article
    ISSN 1549-7860
    DOI 10.1080/10807039.2017.1385386
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Corrigendum to ‘Therapeutic vaccination refocuses T-cell responses towards conserved regions of HIV-1 in early treated individuals (BCN 01 study)’ EClinicalMedicine 11 (2019) 65–80

    Beatriz Mothe / Christian Manzardo / Alvaro Sanchez-Bernabeu / Pep Coll / Sara Morón-López / Maria C. Puertas / Miriam Rosas-Umbert / Patricia Cobarsi / Roser Escrig / Núria Perez-Alvarez / Irene Ruiz / Cristina Rovira / Michael Meulbroek / Alison Crook / Nicola Borthwick / Edmund G. Wee / Hongbing Yang / Jose M. Miró / Lucy Dorrell /
    Bonaventura Clotet / Javier Martinez-Picado / Christian Brander / Tomáš Hanke

    EClinicalMedicine, Vol 18, Iss , Pp - (2020)

    2020  

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Therapeutic Vaccination Refocuses T-cell Responses Towards Conserved Regions of HIV-1 in Early Treated Individuals (BCN 01 study)

    Beatriz Mothe / Christian Manzardo / Alvaro Sanchez-Bernabeu / Pep Coll / Sara Morón-López / Maria C. Puertas / Miriam Rosas-Umbert / Patricia Cobarsi / Roser Escrig / Núria Perez-Alvarez / Irene Ruiz / Cristina Rovira / Michael Meulbroek / Alison Crook / Nicola Borthwick / Edmund G. Wee / Hongbing Yang / Jose M. Miró / Lucy Dorrell /
    Bonaventura Clotet / Javier Martinez-Picado / Christian Brander / Tomáš Hanke

    EClinicalMedicine, Vol 11, Iss , Pp 65-

    2019  Volume 80

    Abstract: Background: Strong and broad antiviral T-cell responses targeting vulnerable sites of HIV-1 will likely be a critical component for any effective cure strategy. Methods: BCN01 trial was a phase I, open-label, non-randomized, multicenter study in HIV-1- ... ...

    Abstract Background: Strong and broad antiviral T-cell responses targeting vulnerable sites of HIV-1 will likely be a critical component for any effective cure strategy. Methods: BCN01 trial was a phase I, open-label, non-randomized, multicenter study in HIV-1-positive individuals diagnosed and treated during early HIV-1 infection to evaluate two vaccination regimen arms, which differed in the time (8 versus 24 week) between the ChAdV63.HIVconsv prime and MVA.HIVconsv boost vaccinations. The primary outcome was safety. Secondary endpoints included frequencies of vaccine-induced IFN-γ+ CD8+ T cells, in vitro virus-inhibitory capacity, plasma HIV-1 RNA and total CD4+ T-cells associated HIV-1 DNA. (NCT01712425). Findings: No differences in safety, peak magnitude or durability of vaccine-induced responses were observed between long and short interval vaccination arms. Grade 1/2 local and systemic post-vaccination events occurred in 22/24 individuals and resolved within 3 days. Weak responses to conserved HIV-1 regions were detected in 50% of the individuals before cART initiation, representing median of less than 10% of their total HIV-1-specific T cells. All participants significantly elevated these subdominant T-cell responses, which after MVA.HIVconsv peaked at median (range) of 938 (73-6,805) IFN-γ SFU/106 PBMC, representing on average 58% of their total anti-HIV-1 T cells. The decay in the size of the HIV-1 reservoir was consistent with the first year of early cART initiation in both arms. Interpretation: Heterologous prime-boost vaccination with ChAdV63-MVA/HIVconsv was well-tolerated and refocused pre-cART T-cell responses towards more protective epitopes, in which immune escape is frequently associated with reduced HIV-1 replicative fitness and which are common to most global HIV-1 variants. Funding: HIVACAT Catalan research program for an HIV vaccine and Fundació Gloria Soler. Vaccine manufacture was jointly funded by the Medical Research Council (MRC) UK and the UK Department for International Development (DFID) ...
    Keywords Medicine (General) ; R5-920
    Subject code 570
    Language English
    Publishing date 2019-05-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Correction

    Sven Létourneau / Eung-Jun Im / Tumelo Mashishi / Choechoe Brereton / Anne Bridgeman / Hongbing Yang / Lucy Dorrell / Tao Dong / Bette Korber / Andrew J. McMichael / Tomáš Hanke

    PLoS ONE, Vol 6, Iss

    Design and Pre-Clinical Evaluation of a Universal HIV-1 Vaccine

    2011  Volume 3

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Correction

    Sven Létourneau / Eung-Jun Im / Tumelo Mashishi / Choechoe Brereton / Anne Bridgeman / Hongbing Yang / Lucy Dorrell / Tao Dong / Bette Korber / Andrew J. McMichael / Tomáš Hanke

    PLoS ONE, Vol 6, Iss

    Design and Pre-Clinical Evaluation of a Universal HIV-1 Vaccine.

    2011  Volume 3

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Identification of effective subdominant anti-HIV-1 CD8+ T cells within entire post-infection and post-vaccination immune responses.

    Gemma Hancock / Hongbing Yang / Elisabeth Yorke / Emma Wainwright / Victoria Bourne / Alyse Frisbee / Tamika L Payne / Mark Berrong / Guido Ferrari / Denis Chopera / Tomas Hanke / Beatriz Mothe / Christian Brander / M Juliana McElrath / Andrew McMichael / Nilu Goonetilleke / Georgia D Tomaras / Nicole Frahm / Lucy Dorrell

    PLoS Pathogens, Vol 11, Iss 2, p e

    2015  Volume 1004658

    Abstract: Defining the components of an HIV immunogen that could induce effective CD8+ T cell responses is critical to vaccine development. We addressed this question by investigating the viral targets of CD8+ T cells that potently inhibit HIV replication in vitro, ...

    Abstract Defining the components of an HIV immunogen that could induce effective CD8+ T cell responses is critical to vaccine development. We addressed this question by investigating the viral targets of CD8+ T cells that potently inhibit HIV replication in vitro, as this is highly predictive of virus control in vivo. We observed broad and potent ex vivo CD8+ T cell-mediated viral inhibitory activity against a panel of HIV isolates among viremic controllers (VC, viral loads <5000 copies/ml), in contrast to unselected HIV-infected HIV Vaccine trials Network (HVTN) participants. Viral inhibition of clade-matched HIV isolates was strongly correlated with the frequency of CD8+ T cells targeting vulnerable regions within Gag, Pol, Nef and Vif that had been identified in an independent study of nearly 1000 chronically infected individuals. These vulnerable and so-called "beneficial" regions were of low entropy overall, yet several were not predicted by stringent conservation algorithms. Consistent with this, stronger inhibition of clade-matched than mismatched viruses was observed in the majority of subjects, indicating better targeting of clade-specific than conserved epitopes. The magnitude of CD8+ T cell responses to beneficial regions, together with viral entropy and HLA class I genotype, explained up to 59% of the variation in viral inhibitory activity, with magnitude of the T cell response making the strongest unique contribution. However, beneficial regions were infrequently targeted by CD8+ T cells elicited by vaccines encoding full-length HIV proteins, when the latter were administered to healthy volunteers and HIV-positive ART-treated subjects, suggesting that immunodominance hierarchies undermine effective anti-HIV CD8+ T cell responses. Taken together, our data support HIV immunogen design that is based on systematic selection of empirically defined vulnerable regions within the viral proteome, with exclusion of immunodominant decoy epitopes that are irrelevant for HIV control.
    Keywords Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2015-02-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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