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Article ; Online: Evaluation and dynamic monitoring of ecological environment quality in mining area based on improved CRSEI index model

Yajing Liu / Hongjian Liu / Chaoqun Yan / Zhengwen Feng / Shuai Zhou

Heliyon, Vol 9, Iss 10, Pp e20787- (2023)

2023

Abstract: Large-scale open-pit mining in mining areas will cause serious damage to the ecological environment. Building a “green mine” is an essential part of implementing sustainable development. In order to explore the changing characteristics of the ... ...

Abstract	Large-scale open-pit mining in mining areas will cause serious damage to the ecological environment. Building a “green mine” is an essential part of implementing sustainable development. In order to explore the changing characteristics of the environmental quality of the open-pit mining area and provide a scientific basis for improving the ecological environment of the mining area. Taking Sijiying open-pit mining area as the research area, based on four Landsat images from 2000 to 2022, the four index components of greenness, humidity, dryness and heat were integrated, and an improved remote sensing ecological index CRSEI was constructed by principal component analysis to dynamically evaluate and monitor the ecological environment quality of the mining area. The results show that the average correlation between CRSEI and the index components is higher than the average correlation between the components, indicating that it has a favorable expression effect on the ecological quality of the mining area. The ecological environmental quality of the study area experienced a shift to the poor grade, and the poor ecological quality area was mainly distributed in industrial and mining land and construction land, with the mean CRSEI of 0.668, 0.474, 0.460 and 0.494, respectively. The results of dynamic monitoring showed that the proportion of ecological improvement area (41.43 %) was greater than that of ecological deterioration area (33.29 %) in the study area in the past 22 years, and additional restoration efforts should be made to achieve sustainable development of the ecological environment.
Keywords	CRSEI ; Open-pit mining area ; Ecological quality assessment ; Principal component analysis ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	910
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Homocysteine levels correlate with AVSS-RigiScan test parameters in men with erectile dysfunction

Xin Qian / Xing Tao / Yangyang Gong / Can Ran / Yougang Feng / Hongjian Liu

Basic and Clinical Andrology, Vol 33, Iss 1, Pp 1-

2023 Volume 7

Abstract: Abstract Background Although elevated homocysteine levels have been shown to affect penile erection, the relationship between homocysteine and erection at the tip or base of the penis has not been extensively studied. Results We found that homocysteine ... ...

Abstract	Abstract Background Although elevated homocysteine levels have been shown to affect penile erection, the relationship between homocysteine and erection at the tip or base of the penis has not been extensively studied. Results We found that homocysteine levels were negatively correlated with the average event rigidity of the base (r = -0.2225, p = 0.0142). Homocysteine levels were also negatively correlated with the average maximum rigidity of the base (r = -0.2164, p = 0.0171). In particular, homocysteine levels were negatively correlated with ∆ Tumescence of the tip (r = -0.1866, p = 0.0404). Similarly, homocysteine was negatively correlated with ∆ Tumescence of the base (r = -0.2257, p = 0.0128). Conclusion Our data showed that homocysteine inhibits penile erection. At the same time, homocysteine levels were negatively correlated with the parameters of the AVSS-RigiScan test.
Keywords	Audio-visual sexual stimulation (AVSS) test ; Erectile function (ED) ; RigiScan plus ; Homocysteine ; Medicine (General) ; R5-920
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Modulation of fracture healing by senescence-associated secretory phenotype (SASP)

Shangkun Zhao / Zhi Qiao / Roman Pfeifer / Hans-Christoph Pape / Keya Mao / Hai Tang / Bin Meng / Songfeng Chen / Hongjian Liu

European Journal of Medical Research, Vol 29, Iss 1, Pp 1-

a narrative review of the current literature

2024 Volume 12

Abstract: Abstract The senescence-associated secretory phenotype (SASP) is a generic term for the secretion of cytokines, such as pro-inflammatory factors and proteases. It is a crucial feature of senescent cells. SASP factors induce tissue remodeling and immune ... ...

Abstract	Abstract The senescence-associated secretory phenotype (SASP) is a generic term for the secretion of cytokines, such as pro-inflammatory factors and proteases. It is a crucial feature of senescent cells. SASP factors induce tissue remodeling and immune cell recruitment. Previous studies have focused on the beneficial role of SASP during embryonic development, wound healing, tissue healing in general, immunoregulation properties, and cancer. However, some recent studies have identified several negative effects of SASP on fracture healing. Senolytics is a drug that selectively eliminates senescent cells. Senolytics can inhibit the function of senescent cells and SASP, which has been found to have positive effects on a variety of aging-related diseases. At the same time, recent data suggest that removing senescent cells may promote fracture healing. Here, we reviewed the latest research progress about SASP and illustrated the inflammatory response and the influence of SASP on fracture healing. This review aims to understand the role of SASP in fracture healing, aiming to provide an important clinical prevention and treatment strategy for fracture. Clinical trials of some senolytics agents are underway and are expected to clarify the effectiveness of their targeted therapy in the clinic in the future. Meanwhile, the adverse effects of this treatment method still need further study.
Keywords	Fracture healing ; Bone ; Senescence ; SASP ; Senolytics ; Medicine ; R
Subject code	610
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Complete chloroplast genome molecular structure, comparative and phylogenetic analyses of Sphaeropteris lepifera of Cyatheaceae family

Qingdi Hu / Renjuan Qian / Yanjun Zhang / Xiaohua Ma / Youju Ye / Xule Zhang / Lin Lin / Hongjian Liu / Jian Zheng

Scientific Reports, Vol 13, Iss 1, Pp 1-

a tree fern from China

2023 Volume 14

Abstract: Abstract Sphaeropteris lepifera is a tree fern in the Cyatheaceae, a family that has played an important role in the evolution of plant systems. This study aimed to analyze the complete chloroplast genome of S. lepifera and compared it with previously ... ...

Abstract	Abstract Sphaeropteris lepifera is a tree fern in the Cyatheaceae, a family that has played an important role in the evolution of plant systems. This study aimed to analyze the complete chloroplast genome of S. lepifera and compared it with previously published chloroplast genomes Cyatheaceae family. The chloroplast genome of S. lepifera comprised 162,114 bp, consisting of a large single copy (LSC) region of 86,327 bp, a small single copy (SSC) region of 27,731 bp and a pair of inverted repeats (IRa and IRb) of 24,028 bp each. The chloroplast genome encoded 129 genes, comprising 32 transfer RNAs, 8 ribosomal RNAs, and 89 protein-coding genes. Comparison of the genomes of 7 Cyatheaceae plants showed that the chloroplast genome of S. lepifera was missing the gene trnV-UAC. Expansion of the SSC region led to the difference in the chloroplast genome size of S. lepifera. Eight genes, atpI, ccsA, petA, psaB, rpl16, rpoA, rpoC1, and ycf2 have high nucleic acid diversity and can be regarded as potential molecular markers. The genes trnG-trnR and atpB were suitable for DNA barcodes between different communities of S. lepifera. The S. lepifera groups in Zhejiang Province probably diffused from Pingtan and Ningde, Fujian. The results will provide a basis for species identification, biological studies, and endangerment mechanism of S. lepifera.
Keywords	Medicine ; R ; Science ; Q
Subject code	580 ; 572
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Long non-coding RNA KCNQ1 overlapping transcript 1 promotes the progression of esophageal squamous cell carcinoma by adsorbing microRNA-133b

Haitao Xu / Jing Miao / Shuai Liu / Hongjian Liu / Lianguo Zhang / Qingguang Zhang

Clinics, Vol

2021 Volume 76

Abstract: OBJECTIVE: The long non-coding RNA (lncRNA) KCNQ1 overlapping transcript 1 (KCNQ1OT1) exerts vital regulatory functions in diverse tumors. However, the biological function of KCNQ1OT1 in esophageal squamous cell carcinoma (ESCC) remains unclear. METHODS: ...

Abstract	OBJECTIVE: The long non-coding RNA (lncRNA) KCNQ1 overlapping transcript 1 (KCNQ1OT1) exerts vital regulatory functions in diverse tumors. However, the biological function of KCNQ1OT1 in esophageal squamous cell carcinoma (ESCC) remains unclear. METHODS: KCNQ1OT1 expression was detected in ESCC tissues using quantitative real-time polymerase chain reaction (qRT-PCR). Cell proliferation, apoptosis, migration, and invasion were detected by the CCK-8 assay, EdU assay, flow cytometry analysis, and Transwell experiments, respectively. Bioinformatics analysis, luciferase reporter experiments, and RNA immunoprecipitation assays were used to predict and validate the regulatory relationships between KCNQ1OT1, microRNA-133b (miR-133b) and epidermal growth factor receptor (EGFR). RESULTS: KCNQ1OT1 expression was remarkably upregulated in ESCC tissues and cell lines. Overexpression of KCNQ1OT1 markedly promoted ESCC cell proliferation, migration, and invasion and enhanced the expression of N-cadherin, MMP-2, and MMP-9, but inhibited apoptosis and E-cadherin expression in ESCC cell lines; KCNQ1OT1 knockdown exerted the opposite effects. KCNQ1OT1 could directly bind to miR-133b and suppress its expression, and miR-133b reversed the effects of KCNQ1OT1 overexpression in ESCC cells. MiR-133b reduced the expression of epidermal growth factor receptor (EGFR); further, KCNQ1OT1 activated the phosphatidylinositol 3-kinase/AKT serine/threonine kinase 1 (PI3K/AKT) signaling pathway by repressing miR-133b repression and indirectly upregulating EGFR. KCNQ1OT1 expression was positively correlated with EGFR mRNA expression and negatively correlated with miR-133b expression. CONCLUSION: KCNQ1OT1 facilitates ESCC progression by sponging miR-133b and activating the EGFR/PI3K/AKT pathway.
Keywords	KCNQ1OT1 ; miR-133b ; EGFR ; PI3K/AKT ; ESCC ; Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	Elsevier España
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: New Results on Synchronization of Fractional-Order Memristor‐Based Neural Networks via State Feedback Control

Xiaofan Li / Yuan Ge / Hongjian Liu / Huiyuan Li / Jian-an Fang

Complexity, Vol

2020 Volume 2020

Abstract: This paper addresses the synchronization issue for the drive-response fractional-order memristor‐based neural networks (FOMNNs) via state feedback control. To achieve the synchronization for considered drive-response FOMNNs, two feedback controllers are ... ...

Abstract	This paper addresses the synchronization issue for the drive-response fractional-order memristor‐based neural networks (FOMNNs) via state feedback control. To achieve the synchronization for considered drive-response FOMNNs, two feedback controllers are introduced. Then, by adopting nonsmooth analysis, fractional Lyapunov’s direct method, Young inequality, and fractional-order differential inclusions, several algebraic sufficient criteria are obtained for guaranteeing the synchronization of the drive-response FOMNNs. Lastly, for illustrating the effectiveness of the obtained theoretical results, an example is given.
Keywords	Electronic computers. Computer science ; QA75.5-76.95
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Hindawi-Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The mediating roles of coping styles and academic burnout in the relationship between stressors and depressive symptoms among Chinese postgraduates

Hong Shi / Hanfang Zhao / Minfu He / Zheng Ren / Shixun Wang / Li Cui / Jieyu Zhao / Wenjun Li / Yachen Wei / Wenjing Zhang / Ziqiang Chen / Hongjian Liu / Xiumin Zhang

PeerJ, Vol 11, p e

2023 Volume 16064

Abstract: Background Since few studies have incorporated factors like stressors, coping styles, and academic burnout into the same model to analyze their impacts on depressive symptoms, this research attempts to establish an optimal structural model to explore the ...

Abstract	Background Since few studies have incorporated factors like stressors, coping styles, and academic burnout into the same model to analyze their impacts on depressive symptoms, this research attempts to establish an optimal structural model to explore the direct and indirect effects of these factors on depressive symptoms. Methods A total of 266 postgraduates completed questionnaires regarding coping styles, academic burnout, stressors, and depressive symptoms. The path analysis was applied for investigating the roles of coping styles and academic burnout in mediating the relationship between stressors and depressive symptoms. Results The total and direct effects of stressors on depressive symptoms were 0.53 and 0.31, respectively. The proportion of the direct effect of stressors on depressive symptoms to its total effect amounted to 58.50%. The indirect effects of academic burnout, positive coping style, and negative coping style on the association between stressors and depressive symptoms were 0.11, 0.04, and 0.03, taking up 20.75%, 7.55%, and 5.66% of the total effect, respectively. The serial indirect effect of positive coping style and academic burnout was 0.02, accounting for 3.77% of the total effect, while that of negative coping style and academic burnout was 0.02, taking up 3.77% of the total effect. Conclusions Coping styles and academic burnout chain jointly mediate the relationship between stressors and depressive symptoms among postgraduates. Thus, encouraging postgraduates to tackle stress positively may reduce the likelihood of the development of academic burnout and further reduce depressive symptoms.
Keywords	Stressors ; Coping styles ; Academic burnout ; Depressive symptoms ; Postgraduates ; Chinese ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	150
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sprifermin

Zongmian Song / Yusheng Li / Chunfeng Shang / Guowei Shang / Hongwei Kou / Jinfeng Li / Songfeng Chen / Hongjian Liu

Frontiers in Cell and Developmental Biology, Vol

Effects on Cartilage Homeostasis and Therapeutic Prospects in Cartilage-Related Diseases

2021 Volume 9

Abstract: When suffering from osteoarthritis (OA), articular cartilage homeostasis is out of balance and the living quality declines. The treatment of knee OA has always been an unsolved problem in the world. At present, symptomatic treatment is mainly adopted for ...

Abstract	When suffering from osteoarthritis (OA), articular cartilage homeostasis is out of balance and the living quality declines. The treatment of knee OA has always been an unsolved problem in the world. At present, symptomatic treatment is mainly adopted for OA. Drug therapy is mainly used to relieve pain symptoms, but often accompanied with adverse reactions; surgical treatment involves the problem of poor integration between the repaired or transplanted tissues and the natural cartilage, leading to the failure of repair. Biotherapy which aims to promote cartilage in situ regeneration and to restore endochondral homeostasis is expected to be an effective method for the prevention and treatment of OA. Disease-modifying osteoarthritis drugs (DMOADs) are intended for targeted treatment of OA. The DMOADs prevent excessive destruction of articular cartilage through anti-catabolism and stimulate tissue regeneration via excitoanabolic effects. Sprifermin (recombinant human FGF18, rhFGF18) is an effective DMOAD, which can not only promote the proliferation of articular chondrocyte and the synthesis of extracellular matrix, increase the thickness of cartilage in a dose-dependent manner, but also inhibit the activity of proteolytic enzymes and remarkedly slow down the degeneration of cartilage. This paper reviews the unique advantages of Sprifermin in repairing cartilage injury and improving cartilage homeostasis, aiming to provide an important strategy for the effective prevention and treatment of cartilage injury-related diseases.
Keywords	sprifermin ; FGF18 ; cartilage homeostasis ; disease modifying osteoarthritis drugs ; osteoarthritis ; cartilage-related diseases ; Biology (General) ; QH301-705.5
Subject code	616
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Contrasting growth, physiological and gene expression responses of Clematis crassifolia and Clematis cadmia to different irradiance conditions

Xiaohua Ma / Renjuan Qian / Xule Zhang / Qingdi Hu / Hongjian Liu / Jian Zheng

Scientific Reports, Vol 9, Iss 1, Pp 1-

2019 Volume 12

Abstract: Abstract Clematis crassifolia and Clematis cadmia Buch.-Ham. ex Hook.f. & Thomson are herbaceous vine plants native to China. C. crassifolia is distributed in shaded areas, while C. cadmia mostly grows in bright, sunny conditions in mountainous and hilly ...

Abstract	Abstract Clematis crassifolia and Clematis cadmia Buch.-Ham. ex Hook.f. & Thomson are herbaceous vine plants native to China. C. crassifolia is distributed in shaded areas, while C. cadmia mostly grows in bright, sunny conditions in mountainous and hilly landscapes. To understand the potential mechanisms involved in the irradiance responses of C. crassifolia and C. cadmia, we conducted a pot experiment under three irradiance treatments with natural irradiation and two different levels of shading. Various growth, photosynthetic, oxidative and antioxidative parameters and the relative expression of irradiance-related genes were examined. In total, 15 unigenes were selected for the analysis of gene expression. The exposure of C. crassifolia to high irradiance resulted in growth inhibition coupled with increased levels of chlorophyll, increased catalase, peroxidase, and superoxide dismutase activity and increased expression of c144262_g2, c138393_g1 and c131300_g2. In contrast, under high irradiance conditions, C. cadmia showed an increase in growth and soluble protein content accompanied by a decrease in the expression of c144262_g2, c133872_g1, and c142530_g1, suggesting their role in the acclimation of C. cadmia to a high-irradiance environment. The 15 unigenes were differentially expressed in C. crassifolia and C. cadmia under different irradiance conditions. Thus, our study revealed that there are essential differences in the irradiance adaptations of C. crassifolia and C. cadmia due to the differential physiological and molecular mechanisms underlying their irradiance responses, which result from their long-term evolution in contrasting habitats.
Keywords	Medicine ; R ; Science ; Q
Subject code	580
Language	English
Publishing date	2019-11-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: New Progress in Basic Research of Macrophages in the Pathogenesis and Treatment of Low Back Pain

Miaoheng Yan / Zongmian Song / Hongwei Kou / Guowei Shang / Chunfeng Shang / Xiangrong Chen / Yanhui Ji / Deming Bao / Tian Cheng / Jinfeng Li / Xiao Lv / Hongjian Liu / Songfeng Chen

Frontiers in Cell and Developmental Biology, Vol

2022 Volume 10

Abstract: Low back pain (LBP) is quite common in clinical practice, which can lead to long-term bed rest or even disability. It is a worldwide health problem remains to be solved. LBP can be induced or exacerbated by abnormal structure and function of spinal ... ...

Abstract	Low back pain (LBP) is quite common in clinical practice, which can lead to long-term bed rest or even disability. It is a worldwide health problem remains to be solved. LBP can be induced or exacerbated by abnormal structure and function of spinal tissue such as intervertebral disc (IVD), dorsal root ganglion (DRG) and muscle; IVD degeneration (IVDD) is considered as the most important among all the pathogenic factors. Inflammation, immune response, mechanical load, and hypoxia etc., can induce LBP by affecting the spinal tissue, among which inflammation and immune response are the key link. Inflammation and immune response play a double-edged sword role in LBP. As the main phagocytic cells in the body, macrophages are closely related to body homeostasis and various diseases. Recent studies have shown that macrophages are the only inflammatory cells that can penetrate the closed nucleus pulposus, expressed in various structures of the IVD, and the number is positively correlated with the degree of IVDD. Moreover, macrophages play a phagocytosis role or regulate the metabolism of DRG and muscle tissues through neuro-immune mechanism, while the imbalance of macrophages polarization will lead to more inflammatory factors to chemotaxis and aggregation, forming an “inflammatory waterfall” effect similar to “positive feedback,” which greatly aggravates LBP. Regulation of macrophages migration and polarization, inhibition of inflammation and continuous activation of immune response by molecular biological technology can markedly improve the inflammatory microenvironment, and thus effectively prevent and treat LBP. Studies on macrophages and LBP were mainly focused in the last 3–5 years, attracting more and more scholars’ attention. This paper summarizes the new research progress of macrophages in the pathogenesis and treatment of LBP, aiming to provide an important clinical prevention and treatment strategy for LBP.
Keywords	macrophages ; inflammatory immune response ; low back pain ; intervertebral disc degeneration ; muscle ; dorsal root ganglion ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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