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Article ; Online: Scenario modeling of ecological security index using system dynamics in Beijing-Tianjin-Hebei urban agglomeration

Hongjie Wang / Chao Bao

Ecological Indicators, Vol 125, Iss , Pp 107613- (2021)

2021

Abstract: Ecological security plays a crucial role in the sustainable development of urban agglomeration, where high population and economic density brings great pressure on eco-system. This paper selected six indicators to build an ecological security index (ESI), ...

Abstract	Ecological security plays a crucial role in the sustainable development of urban agglomeration, where high population and economic density brings great pressure on eco-system. This paper selected six indicators to build an ecological security index (ESI), and constructed a system dynamics (SD) model to simulate and forecast its future scenarios. It aims at establishing the nexus among the socio-economic and ecological indicators, and identifying the key driving factors of ESI. Taking Beijing–Tianjin–Hebei urban agglomeration (BTH) as a case, this paper assessed the historical situation in 2000–2015 and forecasted the future scenarios in 2016–2030. The results show that, the ESI of BTH decreased from 0.665 in 2000 to 0.648 in 2015. It will decrease to 0.632 in 2030 if the existing development mode continues. Though it belonged to the higher security level all along, obvious disparities will exist in 13 cities in BTH according to the spatiotemporal variations of ESI and its six indicators. Low guarantee degree of eco-water use and fragile ecosystem will be the primary risks of BTH all along. As the existing development mode has considered the socio-economic benefits and ecological protection, it is rational to continue for the whole BTH. However, especially in the southeast cities, the ecological development mode should be strengthened. This paper provides a framework to assess the current conditions and forecast the future scenarios of ecological security for urban agglomerations. It also might help to explore the coupling mechanism between human and ecological system.
Keywords	Ecological security index (ESI) ; System dynamics model ; Complex nexus ; Scenario simulation ; Beijing-Tianjin-Hebei urban agglomeration (BTH) ; Ecology ; QH540-549.5
Subject code	910
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A novel in-situ-process technique constructs whole circular cpDNA library

Qiang Zhou / Xianlong Ding / Hongjie Wang / Zunaira Farooq / Liang Wang / Shouping Yang

Plant Methods, Vol 20, Iss 1, Pp 1-

2024 Volume 15

Abstract: Abstract Background The chloroplast genome (cp genome) is directly related to the study and analysis of molecular phylogeny and evolution of plants in the phylogenomics era. The cp genome, whereas, is highly plastic and exists as a heterogeneous mixture ... ...

Abstract	Abstract Background The chloroplast genome (cp genome) is directly related to the study and analysis of molecular phylogeny and evolution of plants in the phylogenomics era. The cp genome, whereas, is highly plastic and exists as a heterogeneous mixture of sizes and physical conformations. It is advantageous to purify/enrich the circular chloroplast DNA (cpDNA) to reduce sequence complexity in cp genome research. Large-insert, ordered DNA libraries are more practical for genomics research than conventional, unordered ones. From this, a technique of constructing the ordered BAC library with the goal-insert cpDNA fragment is developed in this paper. Results This novel in-situ-process technique will efficiently extract circular cpDNA from crops and construct a high-quality cpDNA library. The protocol combines the in-situ chloroplast lysis for the high-purity circular cpDNA with the in-situ substitute/ligation for the high-quality cpDNA library. Individually, a series of original buffers/solutions and optimized procedures for chloroplast lysis in-situ is different than bacterial lysis in-situ; the in-situ substitute/ligation that reacts on the MCE membrane is suitable for constructing the goal-insert, ordered cpDNA library while preventing the large-insert cpDNA fragment breakage. The goal-insert, ordered cpDNA library is arrayed on the microtiter plate by three colonies with the definite cpDNA fragment that are homologous-corresponds to the whole circular cpDNA of the chloroplast. Conclusion The novel in-situ-process technique amply furtherance of research in genome-wide functional analysis and characterization of chloroplasts, such as genome sequencing, bioinformatics analysis, cloning, physical mapping, molecular phylogeny and evolution.
Keywords	In-situ-process ; In-situ lysis ; In-situ substitute/ligation ; BAC library ; Circular cpDNA ; Chloroplast ; Plant culture ; SB1-1110 ; Biology (General) ; QH301-705.5
Subject code	027
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Control mechanisms of different bionic structures for hydrofoil cavitation

Qi Yang / Deyou Li / Tinglan Xiao / Hong Chang / Xiaolong Fu / Hongjie Wang

Ultrasonics Sonochemistry, Vol 102, Iss , Pp 106745- (2024)

2024

Abstract: Cavitation limits the efficient and stable operation of rotating machinery. The exploration of control methods for hydrofoil cavitation is important for improving the performance of hydraulic machinery. The leading-edge protuberances of the humpback ... ...

Abstract	Cavitation limits the efficient and stable operation of rotating machinery. The exploration of control methods for hydrofoil cavitation is important for improving the performance of hydraulic machinery. The leading-edge protuberances of the humpback flipper and the spine structure of the tail fin of sailfish are two common bionic structures for cavitation control; however, the control effects of both have limitations. Accordingly, in this study, a passive control method for hydrofoil cavitation was developed by combining the two bionic structures. With the large eddy simulation method, the cavitation processes of wavy leading-edge hydrofoil, bionic fin spine structure hydrofoil, and novel bionic combined structure hydrofoil were studied under a cavitation number of σ = 0.8. The control mechanisms of the three bionic structures for the hydrofoil cavitation were investigated. The results indicated that the novel bionic combined hydrofoil realised the superposition and complementation of the control effects of the two single bionic structures and achieved a better cavitation inhibition effect, reducing the total volume of cavitation by 43 %. In addition, it enhanced the stability of the flow field and reduced the standard deviation of the pressure coefficient on the suction surface by up to 46.55 %. This research provides theoretical support for the optimisation and modification of the blades of hydraulic machinery, such as propellers and pump turbines.
Keywords	Hydrofoil cavitation ; Bionic structures ; Passive control ; Large eddy simulation ; Pressure fluctuation ; Chemistry ; QD1-999 ; Acoustics. Sound ; QC221-246
Subject code	600
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Fabrication of Porous Carbon Nanofibers from Polymer Blends Using Template Method for Electrode-Active Materials in Supercapacitor

He Wang / Lan Yao / Hongmei Zuo / Fangtao Ruan / Hongjie Wang

Molecules, Vol 28, Iss 2228, p

2023 Volume 2228

Abstract: Porous carbon nanofibers (PCNFs) with excellent physical and chemical properties have been considered candidate materials for electrodes used in supercapacitors. Herein, we report a facile procedure to fabricate PCNFs through electrospinning blended ... ...

Abstract	Porous carbon nanofibers (PCNFs) with excellent physical and chemical properties have been considered candidate materials for electrodes used in supercapacitors. Herein, we report a facile procedure to fabricate PCNFs through electrospinning blended polymers into nanofibers followed by pre-oxidation and carbonization. Polysulfone (PSF), high amylose starch (HAS), and phenolic resin (PR) are used as three different kinds of template pore-forming agents. The effects of pore-forming agents on the structure and properties of PCNFs have been systematically studied. The surface morphology, chemical components, graphitized crystallization, and pore characteristics of PCNFs are analyzed by scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), and nitrogen adsorption and desorption test, respectively. The pore-forming mechanism of PCNFs is analyzed by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). Fabricated PCNF-R have a specific surface area as high as ~994 m 2 /g, a total pore volume as high as ~0.75 cm 3 /g, and a good graphitization degree. When PCNF-R are used as active materials to fabricate into electrodes, the PCNF-R electrodes show a high specific capacitance ~350 F/g, a good rate capability ~72.6%, a low internal resistance ~0.55 Ω, and an excellent cycling stability ~100% after 10,000 charging and discharging cycles. The design of low-cost PCNFs is expected to be widely applicable for the development of high-performance electrodes for an energy storage field.
Keywords	porous carbon nanofiber ; polymer ; blend ; electrode material ; supercapacitor ; Organic chemistry ; QD241-441
Subject code	620
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comprehensive simulation of resources and environment carrying capacity for urban agglomeration

Chao Bao / Hongjie Wang / Siao Sun

Ecological Indicators, Vol 138, Iss , Pp 108874- (2022)

A system dynamics approach

2022

Abstract: Resources and environment carrying capacity (RECC) is an important concept for regional and urban sustainable development. This study constructs a comprehensive RECC indicator and a system dynamics (SD) model to simulate its historical conditions and ... ...

Abstract	Resources and environment carrying capacity (RECC) is an important concept for regional and urban sustainable development. This study constructs a comprehensive RECC indicator and a system dynamics (SD) model to simulate its historical conditions and future scenarios, stressing the nexus between the socio-economic and eco-environmental factors. This methodology is applied to Beijing–Tianjin–Hebei urban agglomeration (BTH) for the period of 2000–2030. The results show that, in the business-as-usual scenario, BTH’s RECC will present an “S” curve and increase from 100.26 million in 2000 to 129.65 million in 2030. Although it is greatly improved, the risk of population overload will increase, especially in Beijing, Baoding and Langfang city. Moreover, water resources carrying capacity will be the key constraining factor of RECC for BTH and its most cities. Compared with the economic-oriented and ecological-oriented development mode, to maintain the “business-as-usual” development mode is recommended for the whole BTH. However, the south-central cities should take the ecological-oriented development mode to overcome population overload. This research presents a framework to assess RECC under different scenarios for urban agglomeration. The results might provide an important guidance for sustainable urban planning and coupled human-environment system analysis.
Keywords	Resources and environment carrying capacity (RECC) ; Population threshold ; System dynamics (SD) model ; Scenario simulation ; Sustainable urban development ; Ecology ; QH540-549.5
Subject code	910
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Regulation of the Homeostatic Unfolded Protein Response in Diabetic Nephropathy

Hongjie Wang / Srikanth Karnati / Thati Madhusudhan

Pharmaceuticals, Vol 15, Iss 401, p

2022 Volume 401

Abstract: A growing body of scientific evidence indicates that protein homeostasis, also designated as proteostasis, is causatively linked to chronic diabetic nephropathy (DN). Experimental studies have demonstrated that the insulin signaling in podocytes maintain ...

Abstract	A growing body of scientific evidence indicates that protein homeostasis, also designated as proteostasis, is causatively linked to chronic diabetic nephropathy (DN). Experimental studies have demonstrated that the insulin signaling in podocytes maintain the homeostatic unfolded protein response (UPR). Insulin signaling via the insulin receptor non-canonically activates the spliced X-box binding protein-1 (sXBP1), a highly conserved endoplasmic reticulum (ER) transcription factor, which regulates the expression of genes that control proteostasis. Defective insulin signaling in mouse models of diabetes or the genetic disruption of the insulin signaling pathway in podocytes propagates hyperglycemia induced maladaptive UPR and DN. Insulin resistance in podocytes specifically promotes activating transcription factor 6 (ATF6) dependent pathogenic UPR. Akin to insulin, recent studies have identified that the cytoprotective effect of anticoagulant serine protease-activated protein C (aPC) in DN is mediated by sXBP1. In mouse models of DN, treatment with chemical chaperones that improve protein folding provides an additional benefit on top of currently used ACE inhibitors. Understanding the molecular mechanisms that transmute renal cell specific adaptive responses and that deteriorate renal function in diabetes will enable researchers to develop new therapeutic regimens for DN. Within this review, we focus on the current understanding of homeostatic mechanisms by which UPR is regulated in DN.
Keywords	unfolded protein response ; ER stress ; diabetic nephropathy ; insulin signaling ; aPC ; podocytes ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
Subject code	571
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Research progress of active ingredients of Scutellaria baicalensis in the treatment of type 2 diabetes and its complications.

Yingrui, Wang / Zheng, Liu / Guoyan, Liu / Hongjie, Wang

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2022 Volume 148, Page(s) 112690

Abstract: Diabetes mellitus is a common disorder of endocrine and metabolic disorders. Long term hyperglycemia can lead to a variety of serious chronic complications, such as diabetic nephropathy, diabetic retinopathy, diabetes cardiovascular disease, and so on, ... ...

Abstract	Diabetes mellitus is a common disorder of endocrine and metabolic disorders. Long term hyperglycemia can lead to a variety of serious chronic complications, such as diabetic nephropathy, diabetic retinopathy, diabetes cardiovascular disease, and so on, threatening human life, health and safety. Scutellaria baicalensis Georgi is one of the most commonly used traditional Chinese medicine. Flavonoids are the main effective components of Scutellaria baicalensis Georgi. The flavonoids are mainly baicalin, baicalein, wogonoside and wogonin. The four have the effects of improving the renal function, insulin resistance and retinopathy of type 2 diabetic patients. The aim of this review is to summarize the pathogenesis and clinical research progress of baicalin, baicalein, wogonoside and wogonin in Scutellaria baicalensis Georgi in the treatment of type 2 diabetes mellitus and its complications.
MeSH term(s)	Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Flavanones ; Flavonoids ; Humans ; Medicine, Chinese Traditional ; Scutellaria baicalensis
Chemical Substances	Flavanones ; Flavonoids
Language	English
Publishing date	2022-02-11
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2022.112690
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Trans-Provincial Convergence of Per Capita Energy Consumption in Urban China, 1990–2015

Chao Bao / Hongjie Wang

Sustainability, Vol 11, Iss 5, p

2019 Volume 1431

Abstract: Recognizing the change in regulation of energy consumption may help China to control total energy consumption and realize sustainable development during rapid urbanization and industrialization. This paper re-examined the trans-provincial convergence of ... ...

Abstract	Recognizing the change in regulation of energy consumption may help China to control total energy consumption and realize sustainable development during rapid urbanization and industrialization. This paper re-examined the trans-provincial convergence of per capita energy consumption from 1990–2015 using five different kinds of methods for 30 Chinese provinces. Results show that per capita energy consumption across Chinese provinces was convergent. However, the results obtained by different methods were slightly different. First, it shows a weak beta-unconditional convergence during the entire period, as well as a significant beta-unconditional and conditional piecewise convergence from 1990–2000 and 2001–2015. Second, it shows a significant sigma-convergence indicated by a marked decrease in the standard deviation of logarithm (SDlog) and the coefficient of variation (CV). Third, the kernel density curve became narrower during 1990–2015, indicating that the per capita energy consumption of each Chinese province converged to a common equilibrium level, which was about 80% of the national average. Fourth, the intra-distributional mobility index implied a weak gamma-convergence. Fifth, the first difference of DF (Dickey-Fuller), ADF (Augmented Dickey-Fuller), and PP (Phillips-Perron) unit-root tests all suggested a stochastic convergence. On the whole, the results from this paper contribute to a more in-depth understanding of the status quo of per capita energy consumption in China, as well as a meaningful implication for differentiated energy policies and sustainable development strategies.
Keywords	energy consumption ; convergence ; geographical difference ; provincial China ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	550
Language	English
Publishing date	2019-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: PARM1 Drives Smooth Muscle Cell Proliferation in Pulmonary Arterial Hypertension via AKT/FOXO3A Axis

Zhen He / Teding Chang / Yu Chen / Hongjie Wang / Lei Dai / Hesong Zeng

International Journal of Molecular Sciences, Vol 24, Iss 6385, p

2023 Volume 6385

Abstract: Pulmonary arterial hypertension (PAH) is a group of severe, progressive, and debilitating diseases with limited therapeutic options. This study aimed to explore novel therapeutic targets in PAH through bioinformatics and experiments. Weighted gene co- ... ...

Abstract	Pulmonary arterial hypertension (PAH) is a group of severe, progressive, and debilitating diseases with limited therapeutic options. This study aimed to explore novel therapeutic targets in PAH through bioinformatics and experiments. Weighted gene co-expression network analysis (WGCNA) was applied to detect gene modules related to PAH, based on the GSE15197, GSE113439, and GSE117261. GSE53408 was applied as validation set. Subsequently, the validated most differentially regulated hub gene was selected for further ex vivo and in vitro assays. PARM1 , TSHZ2 , and CCDC80 were analyzed as potential intervention targets for PAH. Consistently with the bioinformatic results, our ex vivo and in vitro data indicated that PARM1 expression increased significantly in the lung tissue and/or pulmonary artery of the MCT-induced PAH rats and hypoxia-induced PAH mice in comparison with the respective controls. Besides, a similar expression pattern of PARM1 was found in the hypoxia- and PDGF--treated isolated rat primary pulmonary arterial smooth muscle cells (PASMCs). In addition, hypoxia/PDGF--induced PARM1 protein expression could promote the elevation of phosphorylation of AKT, phosphorylation of FOXO3A and PCNA, and finally the proliferation of PASMCs in vitro, whereas PARM1 siRNA treatment inhibited it. Mechanistically, PARM1 promoted PAH via AKT/FOXO3A/PCNA signaling pathway-induced PASMC proliferation.
Keywords	pulmonary arterial hypertension ; weighted gene co-expression network analysis (WGCNA) ; PARM1 ; AKT ; FOXO3A ; proliferation ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610 ; 570
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Analysis of the Influencing Factors of Crystalline Blockages in Mountain Tunnel Drainage Systems Based on Decision Analysis Methods

Chen Lu / Jinhua Xu / Long Wang / Hongjie Wang / Biao He / Chongming Tian / Wangping Qian

Applied Sciences, Vol 13, Iss 3721, p

2023 Volume 3721

Abstract: Crystalline blockages in mountain tunnel drainage systems are becoming a common environmental problem. Considering the lack of research on the influence degree of the factors affecting crystalline blockages in mountain tunnel drainage systems, this paper ...

Abstract	Crystalline blockages in mountain tunnel drainage systems are becoming a common environmental problem. Considering the lack of research on the influence degree of the factors affecting crystalline blockages in mountain tunnel drainage systems, this paper classified and evaluated the importance of relevant factors through decision analysis methods. Our purpose is to provide a comprehensive understanding of the primary factors causing crystalline blockages in tunnels. The influence factors are selected and categorized through a literature review, and then the influence factors are screened twice by the expert scoring method and the gray-whitening weighted function clustering method to eliminate the less important influence factors. Finally, the influence factors are evaluated systematically according to the hierarchical analysis method. The results indicate that the factors affecting the crystalline blockage of the drainage system can be divided into five categories: hydrology, geology, shotcrete materials, drainage facilities, and the cave environment. Among these factors, shotcrete materials are the key factors affecting the problem of crystalline blockages. Specifically, the density of shotcrete and the content of calcium in cement have a significant impact on the crystalline blockages, which have the following comprehensive weights: 0.221 and 0.152, respectively. Since the shotcrete materials are human controllable factors, they can be taken as the key research objects to solve the problem of crystalline blockages.
Keywords	environmental problem ; mountain tunnels ; drainage systems ; crystalline blockage ; decision analysis ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	910
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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