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  1. Article ; Online: Prevalence and predictors of scar contracture-associated re-hospitalisation among burn inpatients in China

    Zhe Zhu / Weishi Kong / Haibo Wang / Yongqiang Xiao / Ying Shi / Lanxia Gan / Yu Sun / Hongtai Tang / Zhaofan Xia

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Volume 10

    Abstract: Abstract Scar contracture, a common destructive complication causing increased re-hospitalisation rate of burn survivors and aggravated burden on the medical system, may be more seriously in Chinese population because of their higher susceptibility to ... ...

    Abstract Abstract Scar contracture, a common destructive complication causing increased re-hospitalisation rate of burn survivors and aggravated burden on the medical system, may be more seriously in Chinese population because of their higher susceptibility to scar formation. This study aims to evaluate the prevalence and predictors of scar contracture-associated re-hospitalisation among Chinese burn inpatients. This cross-sectional study screened burn inpatients hospitalised during 2013 to 2018 through the Hospital Quality Monitoring System database, among whom re-hospitalised for scar contracture were identified. Variables including sex, age, occupations, burn area, burn site and surgical treatment were analysed. Potential predictors of scar contracture-associated re-hospitalisation among burn inpatients were determined by univariate regression analyses. Of the 220,642 burn inpatients, 2146 (0.97%) were re-hospitalised for scar contracture. The re-hospitalised inpatients were predominantly men and blue-collar workers, showing younger median age at the time of burns, larger burn sizes, and higher percentage of surgical treatment compared other burn inpatients. Significant univariate predictors of scar contracture-associated re-hospitalisation included male sex, age < 50 years, blue-collar work, ≥ 40% total body superficial area burned, inhalation injured, and surgical treatment. Scar contracture is an intractable complication and a significant factor to increase re-hospitalisation rate among Chinese burn inpatients.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Analgesia effect of a fixed nitrous oxide/oxygen mixture on burn dressing pain

    Yuxiang Li / Lu Tang / Jianqiang Yu / Xiuying Dai / Wanfang Zhou / Wannian Zhang / Xiaoyan Hu / Shichu Xiao / Wen Ni / Xiuqiang Ma / Yinsheng Wu / Ming Yao / Guoxia Mu / Guangyi Wang / Wenjun Han / Zhaofan Xia / Hongtai Tang / Jijun Zhao

    Trials, Vol 13, Iss 1, p

    study protocol for a randomized controlled trial

    2012  Volume 67

    Abstract: Abstract Background Procedural burn pain is the most intense acute pain and most likely type of burn injury pain to be undertreated due to the physician’s fear of the adverse effect of analgesia and lack of anesthetist present. At our institution, in ... ...

    Abstract Abstract Background Procedural burn pain is the most intense acute pain and most likely type of burn injury pain to be undertreated due to the physician’s fear of the adverse effect of analgesia and lack of anesthetist present. At our institution, in most of the cases, local burn detersion and debridement were performed at the ward level without any analgesics. This article describes a study designed to test the analgesia effect of a fixed nitrous oxide/oxygen mixture on burn dressing pain. Methods/design The experiment was carried out in three centers. The patients were given a number from 1 to 240. A randomization list was produced by a statistician according to our preliminary study. Due to the severity of the pain suffered, ethically it was decided to help as many as possible, so patients given the letters A, B or C were treated using a canister with the appropriate letter containing preprepared nitrous oxide/oxygen mixture (NOOM). Those with D were given oxygen only, from an identical-looking canister labeled D. Neither patients, nor doctors, nor nurses, nor data collector knew what was in each canister, thus they were all blind. The nursing officer who implemented the intervention handed the doctors envelopes containing the patients’ name and allocation of A, B, C or D. Thus, patients receiving NOOM or oxygen were in the ratio 3:1. Parameters, including pain severity, blood pressure, heart rate, digital oxygen saturation and the Chinese version of the burn specific pain anxiety scale (C-BSPAS), were taken before, during and after dressing for each group. A video and audio record was taken individually for later communication coding and outcome analysis. Rescue analgesic was recorded. Discussion Based on the findings from our previous qualitative study that physician’s reluctance to order narcotic analgesia is due to its adverse effect and from our pilot experiment, this study aims to test the hypothesis that a fixed nitrous oxide/oxygen mixture will promote better burn dressing pain alleviation and ...
    Keywords Analgesia ; Burn procedural pain ; Nitrous oxide ; Medicine (General) ; R5-920
    Subject code 150
    Language English
    Publishing date 2012-05-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Effect of thermal injury on relative anaplerosis and gluconeogenesis in the rat during infusion of [U-13C] propionate.

    Zhaofan, Xia / Jianguang, Tian / Guangyi, Wang / Hongtai, Tang / Shengde, Ge / Horton, Jureta W

    Burns : journal of the International Society for Burn Injuries

    2002  Volume 28, Issue 7, Page(s) 625–630

    Abstract: A new approach for the analysis of hepatic metabolism after burn injury is introduced. Relative anaplerotic, pyruvate recycling and gluconeogenic fluxes were measured by 13C NMR isotopomer analysis of blood glucose from rats with 40% body surface area ... ...

    Abstract A new approach for the analysis of hepatic metabolism after burn injury is introduced. Relative anaplerotic, pyruvate recycling and gluconeogenic fluxes were measured by 13C NMR isotopomer analysis of blood glucose from rats with 40% body surface area injury, and from rats exposed to sham injury. A short chain fatty acid, [U-13C] propionate which is avidly extracted by the liver, was infused intravenously to deliver 13C into the citric acid cycle. There was no difference in the multiplets detected in the glucose carbon-2 (C-2) anomer from blood or liver after 45 or 60 min of infusion of propionate, indicating that steady-state isotopic conditions were achieved. Gluconeogenesis relative to citric acid cycle flux was not altered by burn injury; in both sham and burn groups the rate of glucose production was about equal to flux through citrate synthase. In the sham group of animals the rate of entry of carbon skeletons into the citric acid cycle was about four times citric acid cycle flux in animals after thermal injury. Similarly, flux through pyruvate kinase (again relative to citrate synthase) was significantly increased in burn injury.
    MeSH term(s) Animals ; Blood Glucose/metabolism ; Burns/metabolism ; Carbon Dioxide/blood ; Carbon Isotopes ; Citric Acid Cycle ; Gluconeogenesis ; Hemodynamics ; Liver/metabolism ; Magnetic Resonance Spectroscopy ; Male ; Partial Pressure ; Propionates ; Rats ; Rats, Sprague-Dawley
    Chemical Substances Blood Glucose ; Carbon Isotopes ; Propionates ; Carbon Dioxide (142M471B3J) ; propionic acid (JHU490RVYR)
    Language English
    Publishing date 2002-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 197308-3
    ISSN 1879-1409 ; 0305-4179
    ISSN (online) 1879-1409
    ISSN 0305-4179
    DOI 10.1016/s0305-4179(02)00098-0
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  4. Article ; Online: Analgesia effect of a fixed nitrous oxide/oxygen mixture on burn dressing pain: study protocol for a randomized controlled trial.

    Yuxiang, Li / Lu, Tang / Jianqiang, Yu / Xiuying, Dai / Wanfang, Zhou / Wannian, Zhang / Xiaoyan, Hu / Shichu, Xiao / Wen, Ni / Xiuqiang, Ma / Yinsheng, Wu / Ming, Yao / Guoxia, Mu / Guangyi, Wang / Wenjun, Han / Zhaofan, Xia / Hongtai, Tang / Jijun, Zhao

    Trials

    2012  Volume 13, Page(s) 67

    Abstract: Background: Procedural burn pain is the most intense acute pain and most likely type of burn injury pain to be undertreated due to the physician's fear of the adverse effect of analgesia and lack of anesthetist present. At our institution, in most of ... ...

    Abstract Background: Procedural burn pain is the most intense acute pain and most likely type of burn injury pain to be undertreated due to the physician's fear of the adverse effect of analgesia and lack of anesthetist present. At our institution, in most of the cases, local burn detersion and debridement were performed at the ward level without any analgesics. This article describes a study designed to test the analgesia effect of a fixed nitrous oxide/oxygen mixture on burn dressing pain.
    Methods/design: The experiment was carried out in three centers. The patients were given a number from 1 to 240. A randomization list was produced by a statistician according to our preliminary study. Due to the severity of the pain suffered, ethically it was decided to help as many as possible, so patients given the letters A, B or C were treated using a canister with the appropriate letter containing preprepared nitrous oxide/oxygen mixture (NOOM). Those with D were given oxygen only, from an identical-looking canister labeled D. Neither patients, nor doctors, nor nurses, nor data collector knew what was in each canister, thus they were all blind. The nursing officer who implemented the intervention handed the doctors envelopes containing the patients' name and allocation of A, B, C or D. Thus, patients receiving NOOM or oxygen were in the ratio 3:1. Parameters, including pain severity, blood pressure, heart rate, digital oxygen saturation and the Chinese version of the burn specific pain anxiety scale (C-BSPAS), were taken before, during and after dressing for each group. A video and audio record was taken individually for later communication coding and outcome analysis. Rescue analgesic was recorded.
    Discussion: Based on the findings from our previous qualitative study that physician's reluctance to order narcotic analgesia is due to its adverse effect and from our pilot experiment, this study aims to test the hypothesis that a fixed nitrous oxide/oxygen mixture will promote better burn dressing pain alleviation and outcomes. Analyses will focus on the effects of the experimental intervention on pain severity during dressing (primary outcomes); physiological parameters, C-BSPAS and acceptance of both health care professionals and patients (secondary outcomes). If this model of analgesia for burn pain management implemented by nurses proves successful, it could potentially be implemented widely in hospital and prehospital settings and improve patients' satisfaction and quality of life.
    Trial registration: (Clinical Trials Identifier: CHICTR-TRC11001690).
    MeSH term(s) Administration, Inhalation ; Analgesics/administration & dosage ; Bandages/adverse effects ; Burns/complications ; Burns/psychology ; Burns/therapy ; China ; Double-Blind Method ; Humans ; Nitrous Oxide/administration & dosage ; Oxygen/administration & dosage ; Pain/diagnosis ; Pain/etiology ; Pain/prevention & control ; Pain/psychology ; Pain Management/methods ; Pain Measurement ; Research Design ; Severity of Illness Index ; Time Factors ; Treatment Outcome ; Video Recording
    Chemical Substances Analgesics ; Nitrous Oxide (K50XQU1029) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2012-05-24
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1468-6708
    ISSN (online) 1745-6215 ; 1468-6694
    ISSN 1468-6708
    DOI 10.1186/1745-6215-13-67
    Database MEDical Literature Analysis and Retrieval System OnLINE

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