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  1. AU="Hongtao Tie"
  2. AU="Bhati, Saurabh Kumar"
  3. AU="Choi, Hyunho"
  4. AU="Jayaprakash, Balamuralikrishna"
  5. AU="Lee, Brian H"
  6. AU="May, Susann"
  7. AU="Remondes-Costa, Sónia"
  8. AU="Lauren Sauer"
  9. AU="G Saiz, Paula"
  10. AU="Stoica, George"
  11. AU=Odorizzi Pamela M.
  12. AU=Pollaers Katherine
  13. AU="Stefanova, Veselina"
  14. AU="Geraldine M. O’Connor"
  15. AU="Jim E. Banta"
  16. AU="Marti-Bonmati, Luis"
  17. AU="Doris Kampner"
  18. AU="Luca Soraci"

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  1. Artikel ; Online: Thinkings on the reform of medical education system in China

    Hongtao Tie / Yuxiang Luo / Dan Chen

    Medical Education Online, Vol 29, Iss

    2024  Band 1

    Abstract: ABSTRACTDifferent clinical medicine programs exist in China, which are mainly the 3-year junior college medical program, the 5-year medical bachelor’s degree program, the 5 + 3 medical master’s degree program, and the 8-year medical doctoral degree ... ...

    Abstract ABSTRACTDifferent clinical medicine programs exist in China, which are mainly the 3-year junior college medical program, the 5-year medical bachelor’s degree program, the 5 + 3 medical master’s degree program, and the 8-year medical doctoral degree program. Medical graduates obtain different degrees from various medical programs, leading to inequality and polarization of the cultivation. The extended length of schooling discourages talented students from pursuing clinical medicine. The current situation has worsened due to the mismatch between clinical competence and promotion, as well as insufficient remuneration. The most critical reform measure is to establish separate degree systems for scientific research skill training and clinical training, which helps clarify the boundaries between these two. Students who receive academic postgraduate education obtain academic degrees, such as the master of medical science and doctor of philosophy; students who take part in the national standardized resident training, specialist training, or general practitioner training obtain professional degrees, such as master of medicine and doctor of medicine. It is imperative to consider shortening the duration of medical education, with an ideal limit of eight years on average. Optimizing the way to promotion and raising the expenditure of remuneration are also crucial. The reform of medical education system in China still has a long way to go and requires gradual adjustment and optimization.
    Schlagwörter Medical education ; postgraduate education ; clinical training ; medical reformation ; medical practitioners ; Special aspects of education ; LC8-6691 ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 370
    Sprache Englisch
    Erscheinungsdatum 2024-12-01T00:00:00Z
    Verlag Taylor & Francis Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel: Paeoniflorin protects against liver ischemia/reperfusion injury in mice via inhibiting HMGB1‐TLR4 signaling pathway

    Xie, Tianjun / Ke Li / Xia Gong / Rong Jiang / Wenya Huang / Xiahong Chen / Hongtao Tie / Qin Zhou / Shengwang Wu / Jingyuan Wan / Bin Wang

    Phytotherapy research. 2018 Nov., v. 32, no. 11

    2018  

    Abstract: Hepatic ischemia/reperfusion (I/R) injury is a major cause of high morbidity and mortality after liver resection, transplantation, and hemorrhagic shock. Paeoniflorin (PF), the main substance of glucosides in Radix Paeoniae Alba, has been widely used to ... ...

    Abstract Hepatic ischemia/reperfusion (I/R) injury is a major cause of high morbidity and mortality after liver resection, transplantation, and hemorrhagic shock. Paeoniflorin (PF), the main substance of glucosides in Radix Paeoniae Alba, has been widely used to treat various hepatic inflammatory diseases including I/R injury. However, the underlying mechanisms of PF on hepatic I/R injury remain further investigated. In this study, the liver I/R model was performed by clamping the portal vein and hepatic artery with an atraumatic clamp for 90 min followed by 6 hr reperfusion. PF (100 mg/kg) was given three times a day by gavage before I/R. The blood and hepatic samples were collected to evaluate liver injury and molecular indexes. The results showed that PF pretreatment significantly inhibited I/R‐induced serum ALT and AST activities (40.3% and 53.8% those of I/R group, respectively), hepatic pathological damages and hepatic apoptosis (P < 0.01), and infiltration of neutrophils into liver. In addition, PF suppressed the production of pro‐inflammatory cytokines (P < 0.01), decreased the expression of high mobility group box‐1 (HMGB1), and down‐regulated toll‐like receptors 4 (TLR4) and phosphorylated ERK1/2, JNK1/2, p38, and NF‐κB signal molecules expression in the I/R‐operated mice. These findings indicated that PF played a protective role in liver I/R injury, and this protection was associated with inhibition of I/R‐activated HMGB1‐TLR4 signaling pathway to attenuate hepatic inflammation responses.
    Schlagwörter Toll-like receptor 4 ; alanine transaminase ; apoptosis ; aspartate transaminase ; blood serum ; cytokines ; glucosides ; hepatic artery ; inflammation ; ischemia ; liver ; mice ; models ; morbidity ; mortality ; neutrophils ; nucleoproteins ; portal vein ; protective effect ; reperfusion injury ; resection ; signal transduction ; transcription factor NF-kappa B
    Sprache Englisch
    Erscheinungsverlauf 2018-11
    Umfang p. 2247-2255.
    Erscheinungsort John Wiley & Sons, Ltd
    Dokumenttyp Artikel
    Anmerkung JOURNAL ARTICLE
    ZDB-ID 639136-9
    ISSN 1099-1573 ; 0951-418X
    ISSN (online) 1099-1573
    ISSN 0951-418X
    DOI 10.1002/ptr.6161
    Datenquelle NAL Katalog (AGRICOLA)

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