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Article ; Online: Transcriptome analysis reveals association of carotenoid metabolism pathway with fruit color in melon

Qiannan Diao / Shoubo Tian / Yanyan Cao / Dongwei Yao / Hongwei Fan / Yongping Zhang

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 13

Abstract: Abstract Flesh color is an important quality of melon (Cucumis melo L.) and is determined mainly by carotenoid content, awarding them with colors, aromas, and nutrients. enhancing the nutritional and health benefits of fruits and vegetables for humans. ... ...

Abstract	Abstract Flesh color is an important quality of melon (Cucumis melo L.) and is determined mainly by carotenoid content, awarding them with colors, aromas, and nutrients. enhancing the nutritional and health benefits of fruits and vegetables for humans. In this study, we performed transcriptomic analysis of two melon inbred line “B-14” (orange-flesh) and “B-6” (white-flesh) at three developmental stages. We observed that the β-carotene content of inbred line “B-6” (14.232 μg/g) was significantly lower than that of inbred line “B-14” (0.534 μg/g). RNA-sequencing and quantitative reverse transcription PCR analyses were performed to identify differentially expressed genes (DEGs) between the two inbred lines at different stages; the DEGs were analyzed using the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes databases (KEGG). We identified 33 structural DEGs in different developmental periods of the two lines that were related to carotenoid metabolism. Among them, PSY, Z-ISO, ZDS, CRTISO, CCD4, VDE1, and NCED2 were highly correlated with carotenoid content. Thus, this study provides a basis for molecular mechanism of carotenoid biosynthesis and flesh color in melon fruit.
Keywords	Medicine ; R ; Science ; Q
Subject code	572
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: China–Burma Geopolitical Relations in the Cold War

Hongwei FAN

Journal of Current Southeast Asian Affairs, Vol 31, Iss 1, Pp 7-

2012 Volume 27

Abstract: This paper explores the historical role of geography in the Sino–Burmese relationship in the context of the Cold War, both before and after the Chinese–American détente and rapprochement in the 1970s. It describes Burma’s fear and distrust of China ... ...

Abstract	This paper explores the historical role of geography in the Sino–Burmese relationship in the context of the Cold War, both before and after the Chinese–American détente and rapprochement in the 1970s. It describes Burma’s fear and distrust of China throughout the Cold War, during which it maintained a policy of neutrality and non-alignment. Burma’s geographic location, sandwiched between its giant neighbours India and China, led it to adopt a realist paradigm and pursue an independent foreign policy. Charac-terizing China’s threat to Burmese national security as “grave” during its period of revolutionary export, the article notes that Burma was cowed into deference and that it deliberately avoided antagonizing China. It also looks at the history of China’s attempts to break out of U.S. encirclement after the Korean War and its successful establishment of Burma as an important buffer state. After the U.S.–China rapprochement in 1972, however, Bur-ma’s geographical significance for Beijing declined. In this context, Burma’s closed-door policy of isolation further lessened its strategic importance for China. Since 1988, however, Burma’s strategic importance to China has been on the rise once again, as it plays a greater role as China’s land bridge to the Indian Ocean and in its energy security and expansion of trade and exports.
Keywords	Political Science ; PR China ; Burma ; cold war ; foreign policy ; geography ; 300 ; 320 ; 327 ; 1950-2011 ; International relations ; JZ2-6530 ; Political institutions and public administration - Asia (Asian studies only) ; JQ1-6651 ; Social sciences and state - Asia (Asian studies only) ; H53
Subject code	950
Language	English
Publishing date	2012-01-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Metabolic Remodeling in Glioma Immune Microenvironment

Runze Qiu / Yue Zhong / Qingquan Li / Yingbin Li / Hongwei Fan

Frontiers in Cell and Developmental Biology, Vol

Intercellular Interactions Distinct From Peripheral Tumors

2021 Volume 9

Abstract: During metabolic reprogramming, glioma cells and their initiating cells efficiently utilized carbohydrates, lipids and amino acids in the hypoxic lesions, which not only ensured sufficient energy for rapid growth and improved the migration to normal ... ...

Abstract	During metabolic reprogramming, glioma cells and their initiating cells efficiently utilized carbohydrates, lipids and amino acids in the hypoxic lesions, which not only ensured sufficient energy for rapid growth and improved the migration to normal brain tissues, but also altered the role of immune cells in tumor microenvironment. Glioma cells secreted interferential metabolites or depriving nutrients to injure the tumor recognition, phagocytosis and lysis of glioma-associated microglia/macrophages (GAMs), cytotoxic T lymphocytes, natural killer cells and dendritic cells, promoted the expansion and infiltration of immunosuppressive regulatory T cells and myeloid-derived suppressor cells, and conferred immune silencing phenotypes on GAMs and dendritic cells. The overexpressed metabolic enzymes also increased the secretion of chemokines to attract neutrophils, regulatory T cells, GAMs, and dendritic cells, while weakening the recruitment of cytotoxic T lymphocytes and natural killer cells, which activated anti-inflammatory and tolerant mechanisms and hindered anti-tumor responses. Therefore, brain-targeted metabolic therapy may improve glioma immunity. This review will clarify the metabolic properties of glioma cells and their interactions with tumor microenvironment immunity, and discuss the application strategies of metabolic therapy in glioma immune silence and escape.
Keywords	glioma ; metabolic reprogramming ; tumor microenvironment ; immune escape ; metabolic therapy ; Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Heat Conduction and Cracking of Functionally Graded Materials Using an FDEM-Based Thermo-Mechanical Coupling Model

Du Han / Hongwei Fan / Chengzeng Yan / Tie Wang / Yu Yang / Sajid Ali / Gang Wang

Applied Sciences, Vol 12, Iss 12279, p

2022 Volume 12279

Abstract: In this paper, the steady-state and transient heat transfer processes of functionally graded materials (FGMs) are analyzed using a coupled thermo-mechanical model in a GPU parallel multiphysics finite–discrete element software, namely MultiFracS. First, ... ...

Abstract	In this paper, the steady-state and transient heat transfer processes of functionally graded materials (FGMs) are analyzed using a coupled thermo-mechanical model in a GPU parallel multiphysics finite–discrete element software, namely MultiFracS. First, the coupled model to handle the heat transfer problem of heterogeneous materials is verified. Then, the advantages and disadvantages of FGMs and composite materials in response to thermal shock loads are compared and the results indicate that FGMs can overcome extreme environments better than composite materials. Finally, the influence of the geometric distribution characteristics of the double-edge cracks in the gradient material plate on the crack propagation is analyzed. The simulation results show that the interaction between the cracks affects the crack propagation path under the thermal load. The inclination angle and spacing of double-edge cracks greatly influence crack propagation. Specifically, a larger inclination angle and spacing can lead to a smaller crack propagation angle. The approach in this paper provides a new quantitative tool for investigating the thermal, elastic, and cracking of functionally graded materials.
Keywords	functionally graded materials ; thermal cracking ; thermal stress ; composite materials ; FDEM ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	670
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Safety, tolerance, and pharmacokinetics of salvianolic acid B in healthy Chinese volunteers

Junlin Cheng / Jun Long / Jingjing Zhang / Le Han / Yunfang Hu / Jianghui Liu / Runze Qiu / Zhibin Zhu / Hongwei Fan

Frontiers in Pharmacology, Vol

A randomized, double-blind, placebo-controlled phase 1 clinical trial

2023 Volume 14

Abstract: Background: Salvianolic acid B (Sal B) is one of the main active ingredients of Salvia miltiorrhiza Bunge. In China, many traditional Chinese medicines have been modified into injections for higher bioavailability and better efficacy. Salvianolic acid ... ...

Abstract	Background: Salvianolic acid B (Sal B) is one of the main active ingredients of Salvia miltiorrhiza Bunge. In China, many traditional Chinese medicines have been modified into injections for higher bioavailability and better efficacy. Salvianolic acid injection has been widely used in the clinic.Objective: This phase 1, randomized, double-blind, placebo-controlled, single-center study aimed to evaluate the safety, tolerance, and pharmacokinetics of Sal B injection in healthy Chinese volunteers.Methods: For the single-ascending-dose study, forty-seven healthy volunteers were randomly divided into 25, 75, 150, 200, 250, and 300 mg groups. For the multiple-ascending-dose study, sixteen healthy volunteers were randomly divided into 150 and 300 mg groups. In each group, volunteers were treated with Sal B or placebo randomly. Their safety was evaluated by a skin test, physical examination, vital sign, laboratory examination, 12-lead electrocardiogram, Holter, and clinical symptoms and signs. Blood samples were collected in 75, 150, and 300 mg single-ascending-dose study groups and 150 mg multiple-ascending-dose study groups to determine the concentration of salvianolic acid B.Results: In single-ascending-dose study groups, there were 41 adverse events in 24 cases (51.1%, 24/47). In multiple-ascending-dose study groups, there were 13 adverse events in eight cases (50.0%, 8/16). Sixty-six volunteers received the skin test, and three of them were excluded because of the positive result. Adverse events related to the treatment included increased alanine aminotransferase (4.0%), increased bilirubin (2.0%), increased creatinine kinase-MB (2.0%), increased brain natriuretic peptide (8.0%), increased urine N-acetyl-β-D-glucosidase (4.0%), dizziness (2.0%), and chest discomfort (2.0%). No serious adverse events occurred. No volunteers withdrew from the trial. Peak plasma concentration and the area under the plasma concentration–time curve of salvianolic acid B progressively increased in a dose-dependent manner in 75, 150, and ...
Keywords	salvianolic acid B ; safety ; tolerance ; pharmacokinetics ; traditional Chinese medicine injection ; Therapeutics. Pharmacology ; RM1-950
Subject code	610 ; 630
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: MOF-in-COF molecular sieving membrane for selective hydrogen separation

Hongwei Fan / Manhua Peng / Ina Strauss / Alexander Mundstock / Hong Meng / Jürgen Caro

Nature Communications, Vol 12, Iss 1, Pp 1-

2021 Volume 10

Abstract: Covalent organic frameworks (COFs) are promising materials for separation membranes, but their wide pores prevent selective gas separation through molecular sieving. Here, the authors demonstrate a Metal-organic framework (MOF)-in-COF membrane with a ... ...

Abstract	Covalent organic frameworks (COFs) are promising materials for separation membranes, but their wide pores prevent selective gas separation through molecular sieving. Here, the authors demonstrate a Metal-organic framework (MOF)-in-COF membrane with a significant enhancement of separation selectivity of hydrogen over other gases.
Keywords	Science ; Q
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Ginsenosides Rg1 and CK Control Temozolomide Resistance in Glioblastoma Cells by Modulating Cholesterol Efflux and Lipid Raft Distribution

Runze Qiu / Jingjing Zhang / Chun Ge / Yue Zhong / Suo Liu / Qingquan Li / Jianjun Zou / Hongwei Fan / Yingbin Li

Evidence-Based Complementary and Alternative Medicine, Vol

2022 Volume 2022

Abstract: Background. Cholesterol efflux and lipid raft redistribution contribute to attenuating temozolomide resistance of glioblastoma. Ginsenosides are demonstrated to modify cholesterol metabolism and lipid raft distribution, and the brain distribution and ... ...

Abstract	Background. Cholesterol efflux and lipid raft redistribution contribute to attenuating temozolomide resistance of glioblastoma. Ginsenosides are demonstrated to modify cholesterol metabolism and lipid raft distribution, and the brain distribution and central nervous effects of whose isoforms Rb1, Rg1, Rg3, and CK have been identified. This study aimed to reveal the role of Rb1, Rg1, Rg3, and CK in the drug resistance of glioblastoma. Methods. The effects of ginsenosides on cholesterol metabolism in temozolomide-resistant U251 glioblastoma cells were evaluated by cholesterol content and efflux assay, confocal laser, qRT-PCR, and Western blot. The roles of cholesterol and ginsenosides in temozolomide resistance were studied by CCK-8, flow cytometry, and Western blot, and the mechanism of ginsenosides attenuating resistance was confirmed by inhibitors. Results. Cholesterol protected the survival of resistant U251 cells from temozolomide stress and upregulated multidrug resistance protein (MDR)1, which localizes in lipid rafts. Resistant cells tended to store cholesterol intracellularly, with limited cholesterol efflux and LXRα expression to maintain the distribution of lipid rafts. Ginsenosides Rb1, Rg1, Rg3, and CK reduced intracellular cholesterol and promoted cholesterol efflux in resistant cells, causing lipid rafts to accumulate in specific regions of the membrane. Rg1 and CK also upregulated LXRα expression and increased the cytotoxicity of temozolomide in the presence of cholesterol. We further found that cholesterol efflux induction, lipid raft redistribution, and temozolomide sensitization by Rg1 and CK were induced by stimulating LXRα. Conclusions. Ginsenosides Rg1 and CK controlled temozolomide resistance in glioblastoma cells by regulating cholesterol metabolism, which are potential synergists for temozolomide therapy.
Keywords	Other systems of medicine ; RZ201-999
Subject code	616
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Differences in reward processing between putative cell types in primate prefrontal cortex.

Hongwei Fan / Xiaochuan Pan / Rubin Wang / Masamichi Sakagami

PLoS ONE, Vol 12, Iss 12, p e

2017 Volume 0189771

Abstract: Single-unit studies in monkeys have demonstrated that neurons in the prefrontal cortex predict the reward type, reward amount or reward availability associated with a stimulus. To examine contributions of pyramidal cells and interneurons in reward ... ...

Abstract	Single-unit studies in monkeys have demonstrated that neurons in the prefrontal cortex predict the reward type, reward amount or reward availability associated with a stimulus. To examine contributions of pyramidal cells and interneurons in reward processing, single-unit activity was extracellularly recorded in prefrontal cortices of four monkeys performing a reward prediction task. Based on their shapes of spike waveforms, prefrontal neurons were classified into broad-spike and narrow-spike units that represented putative pyramidal cells and interneurons, respectively. We mainly observed that narrow-spike neurons showed higher firing rates but less bursty discharges than did broad-spike neurons. Both narrow-spike and broad-spike cells selectively responded to the stimulus, reward and their interaction, and the proportions of each type of selective neurons were similar between the two cell classes. Moreover, the two types of cells displayed equal reliability of reward or stimulus discrimination. Furthermore, we found that broad-spike and narrow-spike cells showed distinct mechanisms for encoding reward or stimulus information. Broad-spike neurons raised their firing rate relative to the baseline rate to represent the preferred reward or stimulus information, whereas narrow-spike neurons inhibited their firing rate lower than the baseline rate to encode the non-preferred reward or stimulus information. Our results suggest that narrow-spike and broad-spike cells were equally involved in reward and stimulus processing in the prefrontal cortex. They utilized a binary strategy to complementarily represent reward or stimulus information, which was consistent with the task structure in which the monkeys were required to remember two reward conditions and two visual stimuli.
Keywords	Medicine ; R ; Science ; Q
Subject code	612
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Corrected Adaptive Balancing Approach of Motorized Spindle Considering Air Gap Unbalance

Hongwei Fan / Jin Wang / Sijie Shao / Minqing Jing / Heng Liu / Xuhui Zhang

Applied Sciences, Vol 10, Iss 6, p

2020 Volume 2197

Abstract: Motorized spindles widely used for high-speed precision machine tools are very sensitive to the mass unbalance of rotors; thus, their balancing problem is always a research hotspot. Although many significant studies were done regarding the theory and ... ...

Abstract	Motorized spindles widely used for high-speed precision machine tools are very sensitive to the mass unbalance of rotors; thus, their balancing problem is always a research hotspot. Although many significant studies were done regarding the theory and application of various rotor balancing technologies for motorized spindles, the particularity of motorized spindles is not carefully considered in the existing balancing approaches. When the rotor unbalance of a motorized spindle occurs in operation, it is subject to both the mass unbalance-induced inertia force and air gap unbalance-induced electromagnetic force, which is an important feature that distinguishes the motorized spindle from a mechanical spindle. This paper describes an investigation into the corrected adaptive balancing approach of a motorized spindle by newly introducing a coefficient representing the removing effect of the air gap unbalance of the motor on the balancing capacity into the balancing formula. The determination of the newly defined coefficient refers to the calculation of electromagnetic force caused by the dynamic air gap eccentricity of motor; thus, much attention is paid to the analytical derivation of the unbalanced magnetic pull (UMP). Finally, a motorized spindle with an electromagnetic ring balancer was developed; then, the balancing tests and vibration signal analysis were done to validate the effectiveness of the newly proposed balancing approach in residual vibration reduction. It can be seen from the test results under different cases that the proposed balancing approach is effective.
Keywords	motorized spindle ; air gap unbalance ; unbalanced magnetic pull (ump) ; adaptive balancing ; balancing test ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	621
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Tuberculosis Infection in Chinese Patients with Giant Cell Arteritis

Yun Zhang / Dongmei Wang / Yue Yin / Yu Wang / Hongwei Fan / Wen Zhang / Xuejun Zeng

Scientific Reports, Vol 9, Iss 1, Pp 1-

2019 Volume 6

Abstract: Abstract Giant cell arteritis (GCA) is a medium- and large-vessel vasculitis with an onset age after 50 years. Takayasu arteritis (TA), which is also a large-vessel vasculitis with an onset age earlier than 40 years, was suggested to be associated with ... ...

Abstract	Abstract Giant cell arteritis (GCA) is a medium- and large-vessel vasculitis with an onset age after 50 years. Takayasu arteritis (TA), which is also a large-vessel vasculitis with an onset age earlier than 40 years, was suggested to be associated with tuberculosis (TB). However, the association between GCA and TB was rarely reported. This study was to retrospectively analyze clinical data of GCA patients at Peking Union Medical College Hospital and elucidate the association between GCA and TB. Ninety-one patients diagnosed with GCA were included in the study. A total of 20 patients (22.0%) had a history of active tuberculosis and received anti-tuberculosis therapy. On comparing the clinical features of patients with GCA and concomitant TB and those without TB, obvious weight loss (P = 0.011), lower percentage of dyslipidemia (P = 0.042), higher percentage of anti-phospholipid antibodies (P = 0.010), and lower white blood cells (P = 0.006) were noted in the TB group. In conclusion, this study demonstrated the percentage of TB history in patients with GCA was higher than that in the Chinese general population. Clinicians should recognize the possibility of comorbid TB in patients with obvious weight loss and relatively lower white blood cell count.
Keywords	Medicine ; R ; Science ; Q
Subject code	616 ; 610
Language	English
Publishing date	2019-10-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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