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  1. Article ; Online: Heart Development and Regeneration in Non-mammalian Model Organisms

    Jianhong Xia / Zhongxuan Meng / Hongyue Ruan / Wenguang Yin / Yiming Xu / Tiejun Zhang

    Frontiers in Cell and Developmental Biology, Vol

    2020  Volume 8

    Abstract: Cardiovascular disease is a serious threat to human health and a leading cause of mortality worldwide. Recent years have witnessed exciting progress in the understanding of heart formation and development, enabling cardiac biologists to make significant ... ...

    Abstract Cardiovascular disease is a serious threat to human health and a leading cause of mortality worldwide. Recent years have witnessed exciting progress in the understanding of heart formation and development, enabling cardiac biologists to make significant advance in the field of therapeutic heart regeneration. Most of our understanding of heart development and regeneration, including the genes and signaling pathways, are driven by pioneering works in non-mammalian model organisms, such as fruit fly, fish, frog, and chicken. Compared to mammalian animal models, non-mammalian model organisms have special advantages in high-throughput applications such as disease modeling, drug discovery, and cardiotoxicity screening. Genetically engineered animals of cardiovascular diseases provide valuable tools to investigate the molecular and cellular mechanisms of pathogenesis and to evaluate therapeutic strategies. A large number of congenital heart diseases (CHDs) non-mammalian models have been established and tested for the genes and signaling pathways involved in the diseases. Here, we reviewed the mechanisms of heart development and regeneration revealed by these models, highlighting the advantages of non-mammalian models as tools for cardiac research. The knowledge from these animal models will facilitate therapeutic discoveries and ultimately serve to accelerate translational medicine.
    Keywords heart ; development ; regeneration ; non-mammalian ; cardiovascular disease ; animal model ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: HIF1α Regulates Early Metabolic Changes due to Activation of Innate Immunity in Nuclear Reprogramming

    Chun Liu / Hongyue Ruan / Farhan Himmati / Ming-Tao Zhao / Christopher C. Chen / Merna Makar / Ian Y. Chen / Karim Sallam / Edward S. Mocarski / Danish Sayed / Nazish Sayed

    Stem Cell Reports, Vol 14, Iss 2, Pp 192-

    2020  Volume 200

    Abstract: Summary: Innate immune signaling has recently been shown to play an important role in nuclear reprogramming, by altering the epigenetic landscape and thereby facilitating transcription. However, the mechanisms that link innate immune activation and ... ...

    Abstract Summary: Innate immune signaling has recently been shown to play an important role in nuclear reprogramming, by altering the epigenetic landscape and thereby facilitating transcription. However, the mechanisms that link innate immune activation and metabolic regulation in pluripotent stem cells remain poorly defined, particularly with regard to key molecular components. In this study, we show that hypoxia-inducible factor 1α (HIF1α), a central regulator of adaptation to limiting oxygen tension, is an unexpected but crucial regulator of innate immune-mediated nuclear reprogramming. HIF1α is dramatically upregulated as a consequence of Toll-like receptor 3 (TLR3) signaling and is necessary for efficient induction of pluripotency and transdifferentiation. Bioenergetics studies reveal that HIF1α regulates the reconfiguration of innate immune-mediated reprogramming through its well-established role in throwing a glycolytic switch. We believe that results from these studies can help us better understand the influence of immune signaling in tissue regeneration and lead to new therapeutic strategies. : In this article, Sayed and colleagues have identified HIF1α, a central regulator of adaptation to limiting oxygen tension, as an unexpected but crucial regulator of innate immune-mediated nuclear reprogramming. By studying the potential to reprogram via the activation of the innate immune system, we intend to understand the dormant regenerative machinery in humans. Keywords: innate immunity, nuclear reprogramming, transdifferentiation, hypoxia-inducible factor 1, glycolysis, iPSCs, endothelial cells, regeneration, metabolism, chromatin
    Keywords Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2020-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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