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  1. Article ; Online: The Finnish current care guideline for open-angle glaucoma.

    Leinonen, Sanna / Harju, Mika / Hagman, Juha / Honkamo, Marja / Marttila, Liisa / Määttä, Marko / Saarela, Villa / Vaajanen, Anu / Vesti, Eija / Komulainen, Jorma

    Acta ophthalmologica

    2024  Volume 102, Issue 2, Page(s) 151–171

    Abstract: This article is an English translation of the 4th Finnish Current Care Guideline for diagnostics, treatment and follow-up of primary open-angle glaucoma, normal-tension glaucoma and pseudoexfoliative glaucoma. This guideline is based on systematic ... ...

    Abstract This article is an English translation of the 4th Finnish Current Care Guideline for diagnostics, treatment and follow-up of primary open-angle glaucoma, normal-tension glaucoma and pseudoexfoliative glaucoma. This guideline is based on systematic literature reviews and expert opinions with Finland's geographical and operational healthcare environment in mind.
    MeSH term(s) Humans ; Glaucoma, Open-Angle/diagnosis ; Glaucoma, Open-Angle/therapy ; Exfoliation Syndrome/diagnosis ; Exfoliation Syndrome/therapy ; Finland/epidemiology ; Intraocular Pressure ; Glaucoma
    Language English
    Publishing date 2024-01-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2408333-1
    ISSN 1755-3768 ; 1755-375X
    ISSN (online) 1755-3768
    ISSN 1755-375X
    DOI 10.1111/aos.16612
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Synchronous functional magnetic resonance eye imaging, video ophthalmoscopy, and eye surface imaging reveal the human brain and eye pulsation mechanisms.

    Ebrahimi, Seyed-Mohsen / Tuunanen, Johanna / Saarela, Ville / Honkamo, Marja / Huotari, Niko / Raitamaa, Lauri / Korhonen, Vesa / Helakari, Heta / Järvelä, Matti / Kaakinen, Mika / Eklund, Lauri / Kiviniemi, Vesa

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 2250

    Abstract: The eye possesses a paravascular solute transport pathway that is driven by physiological pulsations, resembling the brain glymphatic pathway. We developed synchronous multimodal imaging tools aimed at measuring the driving pulsations of the human eye, ... ...

    Abstract The eye possesses a paravascular solute transport pathway that is driven by physiological pulsations, resembling the brain glymphatic pathway. We developed synchronous multimodal imaging tools aimed at measuring the driving pulsations of the human eye, using an eye-tracking functional eye camera (FEC) compatible with magnetic resonance imaging (MRI) for measuring eye surface pulsations. Special optics enabled integration of the FEC with MRI-compatible video ophthalmoscopy (MRcVO) for simultaneous retinal imaging along with functional eye MRI imaging (fMREye) of the BOLD (blood oxygen level dependent) contrast. Upon optimizing the fMREye parameters, we measured the power of the physiological (vasomotor, respiratory, and cardiac) eye and brain pulsations by fast Fourier transform (FFT) power analysis. The human eye pulsated in all three physiological pulse bands, most prominently in the respiratory band. The FFT power means of physiological pulsation for two adjacent slices was significantly higher than in one-slice scans (RESP1 vs. RESP2; df = 5, p = 0.045). FEC and MRcVO confirmed the respiratory pulsations at the eye surface and retina. We conclude that in addition to the known cardiovascular pulsation, the human eye also has respiratory and vasomotor pulsation mechanisms, which are now amenable to study using non-invasive multimodal imaging of eye fluidics.
    MeSH term(s) Humans ; Magnetic Resonance Imaging/methods ; Brain/physiology ; Ophthalmoscopy ; Retina/diagnostic imaging ; Magnetic Resonance Spectroscopy
    Language English
    Publishing date 2024-01-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-51069-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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