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  1. Article: In vitro

    Ikehata, Mari / Konnai, Satoru / Okagawa, Tomohiro / Abe, Kentaro / Honma, Mitsuru / Kitamura, Toru / Maekawa, Naoya / Suzuki, Yasuhiko / Murata, Shiro / Ohashi, Kazuhiko

    Frontiers in veterinary science

    2023  Volume 10, Page(s) 1145445

    Abstract: Calf diarrhea adversely affects growth and sometimes results in mortality, leading to severe economic losses to the cattle industry. Antibiotics are useful in the treatment against bacterial diarrhea, but not against viral, protozoan, and antibiotic- ... ...

    Abstract Calf diarrhea adversely affects growth and sometimes results in mortality, leading to severe economic losses to the cattle industry. Antibiotics are useful in the treatment against bacterial diarrhea, but not against viral, protozoan, and antibiotic-resistant bacterial diarrhea. Therefore, there are growing requirements for a novel control method for calf diarrhea. Probiotics have been considered promising candidates for preventive and supportive therapy for calf diarrhea for many years. A recent study has revealed that
    Language English
    Publishing date 2023-04-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2023.1145445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Enhancement of Vaccine-Induced T-Cell Responses by PD-L1 Blockade in Calves.

    Okagawa, Tomohiro / Konnai, Satoru / Nakamura, Hayato / Ganbaatar, Otgontuya / Sajiki, Yamato / Watari, Kei / Noda, Haruka / Honma, Mitsuru / Kato, Yukinari / Suzuki, Yasuhiko / Maekawa, Naoya / Murata, Shiro / Ohashi, Kazuhiko

    Vaccines

    2023  Volume 11, Issue 3

    Abstract: Interactions between programmed death 1 (PD-1) and PD-ligand 1 (PD-L1) cause functional exhaustion of T cells by inducing inhibitory signals, thereby attenuating effector functions of T cells. We have developed an anti-bovine PD-L1 blocking antibody (Ab) ...

    Abstract Interactions between programmed death 1 (PD-1) and PD-ligand 1 (PD-L1) cause functional exhaustion of T cells by inducing inhibitory signals, thereby attenuating effector functions of T cells. We have developed an anti-bovine PD-L1 blocking antibody (Ab) and have demonstrated that blockade of the interaction between PD-1 and PD-L1 reactivates T-cell responses in cattle. In the present study, we examined the potential utility of PD-1/PD-L1-targeted immunotherapy in enhancing T-cell responses to vaccination. Calves were inoculated with a hexavalent live-attenuated viral vaccine against bovine respiratory infections in combination with treatment with an anti-PD-L1 Ab. The expression kinetics of PD-1 in T cells and T-cell responses to viral antigens were measured before and after vaccination to evaluate the adjuvant effect of anti-PD-L1 Ab. PD-1 expression was upregulated in vaccinated calves after the administration of a booster vaccination. The activation status of CD4
    Language English
    Publishing date 2023-03-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11030559
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Direct evidence of the preventive effect of milk replacer-based probiotic feeding in calves against severe diarrhea.

    Kayasaki, Fumi / Okagawa, Tomohiro / Konnai, Satoru / Kohara, Junko / Sajiki, Yamato / Watari, Kei / Ganbaatar, Otgontuya / Goto, Shinya / Nakamura, Hayato / Shimakura, Honami / Minato, Erina / Kobayashi, Atsushi / Kubota, Manabu / Terasaki, Nobuhiro / Takeda, Akira / Noda, Haruka / Honma, Mitsuru / Maekawa, Naoya / Murata, Shiro /
    Ohashi, Kazuhiko

    Veterinary microbiology

    2021  Volume 254, Page(s) 108976

    Abstract: Diarrhea is a major cause of death in calves and this is linked directly to economic loss in the cattle industry. Fermented milk replacer (FMR) has been used widely in clinical settings for calf feeding to improve its health and growth. However, the ... ...

    Abstract Diarrhea is a major cause of death in calves and this is linked directly to economic loss in the cattle industry. Fermented milk replacer (FMR) has been used widely in clinical settings for calf feeding to improve its health and growth. However, the protective efficacy of FMR on calf diarrhea remains unclear. In this study, we verified the preventive effects of FMR feeding on calf diarrhea using an experimental infection model of bovine rotavirus (BRV) in newborn calves and a field study in dairy farms with calf diarrhea. In addition, we evaluated the protective efficacy of lactic acid bacteria-supplemented milk replacer (LAB-MR) in an experimental infection model. In the experimental infection, calves fed FMR or high-concentrated LAB-MR had diarrhea, but the water content of feces was lower and more stable than that of calves fed normal milk replacer. The amount of milk intake also decreased temporarily, but recovered immediately in the FMR- and LAB-MR-fed calves. As compared with the control calves, FMR- or LAB-MR-fed calves showed less severe or reduced histopathological lesions of enteritis in the intestinal mucosa. In a field study using dairy calves, FMR feeding significantly reduced the incidence of enteritis, mortality from enteritis, duration of a series of treatment for enteritis, number of consultations, and cost of medical care for the disease. These results suggest that feeding milk replacer-based probiotics to calves reduces the severity of diarrhea and tissue damage to the intestinal tract caused by BRV infection and provides significant clinical benefits to the prevention and treatment of calf diarrhea.
    MeSH term(s) Animal Feed/analysis ; Animals ; Cattle ; Cattle Diseases/prevention & control ; Cattle Diseases/virology ; Cultured Milk Products ; Diarrhea/prevention & control ; Diarrhea/therapy ; Diarrhea/veterinary ; Dietary Supplements ; Enteritis/prevention & control ; Enteritis/veterinary ; Female ; Intestinal Mucosa/pathology ; Intestinal Mucosa/virology ; Male ; Milk ; Pregnancy ; Probiotics/administration & dosage ; Probiotics/therapeutic use ; Rotavirus Infections/prevention & control ; Rotavirus Infections/therapy ; Rotavirus Infections/veterinary ; Weaning
    Language English
    Publishing date 2021-01-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 753154-0
    ISSN 1873-2542 ; 0378-1135
    ISSN (online) 1873-2542
    ISSN 0378-1135
    DOI 10.1016/j.vetmic.2020.108976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2917: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Direct evidence of the preventive effect of milk replacer–based probiotic feeding in calves against severe diarrhea

    Kayasaki, Fumi / Okagawa, Tomohiro / Konnai, Satoru / Kohara, Junko / Sajiki, Yamato / Watari, Kei / Ganbaatar, Otgontuya / Goto, Shinya / Nakamura, Hayato / Shimakura, Honami / Minato, Erina / Kobayashi, Atsushi / Kubota, Manabu / Terasaki, Nobuhiro / Takeda, Akira / Noda, Haruka / Honma, Mitsuru / Maekawa, Naoya / Murata, Shiro /
    Ohashi, Kazuhiko

    Veterinary microbiology. 2021 Mar., v. 254

    2021  

    Abstract: Diarrhea is a major cause of death in calves and this is linked directly to economic loss in the cattle industry. Fermented milk replacer (FMR) has been used widely in clinical settings for calf feeding to improve its health and growth. However, the ... ...

    Abstract Diarrhea is a major cause of death in calves and this is linked directly to economic loss in the cattle industry. Fermented milk replacer (FMR) has been used widely in clinical settings for calf feeding to improve its health and growth. However, the protective efficacy of FMR on calf diarrhea remains unclear. In this study, we verified the preventive effects of FMR feeding on calf diarrhea using an experimental infection model of bovine rotavirus (BRV) in newborn calves and a field study in dairy farms with calf diarrhea. In addition, we evaluated the protective efficacy of lactic acid bacteria-supplemented milk replacer (LAB-MR) in an experimental infection model. In the experimental infection, calves fed FMR or high-concentrated LAB-MR had diarrhea, but the water content of feces was lower and more stable than that of calves fed normal milk replacer. The amount of milk intake also decreased temporarily, but recovered immediately in the FMR– and LAB-MR–fed calves. As compared with the control calves, FMR– or LAB-MR–fed calves showed less severe or reduced histopathological lesions of enteritis in the intestinal mucosa. In a field study using dairy calves, FMR feeding significantly reduced the incidence of enteritis, mortality from enteritis, duration of a series of treatment for enteritis, number of consultations, and cost of medical care for the disease. These results suggest that feeding milk replacer–based probiotics to calves reduces the severity of diarrhea and tissue damage to the intestinal tract caused by BRV infection and provides significant clinical benefits to the prevention and treatment of calf diarrhea.
    Keywords Rotavirus ; cattle industry ; death ; diarrhea ; enteritis ; feces ; fermented milk ; financial economics ; histopathology ; intestinal mucosa ; lactic acid ; milk ; milk consumption ; milk replacer ; models ; mortality ; neonates ; probiotics ; water content
    Language English
    Dates of publication 2021-03
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-light
    ZDB-ID 753154-0
    ISSN 1873-2542 ; 0378-1135
    ISSN (online) 1873-2542
    ISSN 0378-1135
    DOI 10.1016/j.vetmic.2020.108976
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2917: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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