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  1. Article: Relationship between Aldehyde Dehydrogenase, PD-L1 and Tumor-Infiltrating Lymphocytes with Pathologic Response and Survival in Breast Cancer.

    López Flores, Mariana / Honrado Franco, Emiliano / Sánchez Cousido, Luis Felipe / Minguito-Carazo, Carlos / Sanz Guadarrama, Oscar / López González, Laura / Vallejo Pascual, María Eva / Molina de la Torre, Antonio José / García Palomo, Andrés / López González, Ana

    Cancers

    2022  Volume 14, Issue 18

    Abstract: Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell (CSC) marker related to clinical outcomes in breast cancer (BC). The aim of this study was to analyze the relationship between ALDH1A1, programmed death ligand 1 (PD-L1) and tumor-infiltrating ... ...

    Abstract Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell (CSC) marker related to clinical outcomes in breast cancer (BC). The aim of this study was to analyze the relationship between ALDH1A1, programmed death ligand 1 (PD-L1) and tumor-infiltrating lymphocytes (TILs) in triple negative (TN) and human epidermal growth factor receptor 2-positive (HER2+) BC tumors, and its association with clinicopathological characteristics and outcomes. A retrospective, historical cohort study of patients diagnosed with early or locally advanced BC treated with neoadjuvant chemotherapy was conducted. ALDH1A1, PD-L1 expression and TILs were assessed using immunohistochemistry. A total of 75 patients were analyzed (42.7% TN, 57.3% HER2+ tumors). ALDH1A1+ was related to HTILs (p = 0.005) and PD-L1+ tumors (p = 0.004). ALDH1A1+ tumors presented higher CD3+ (p = 0.008), CD4+ (p = 0.005), CD8+ (p = 0.003) and CD20+ (p = 0.006) TILs. ALDH1A1+ (p = 0.018), PD-L1+ (p = 0.004) and HTILs (p < 0.001) were related to smaller tumors. ALDH1A1+ was related to pathologic complete response (pCR) (p = 0.048). At the end of the follow-up (54.4 [38.3−87.6] months), 47 patients (62.7%) remained disease-free, and 20 (26.7%) had died. HTILs were related to improved disease-free survival (p = 0.027). ALDH1A1+ was related to PD-L1+ and HITLs, that might be related to higher pCR rates with neoadjuvant therapy.
    Language English
    Publishing date 2022-09-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14184418
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Diarrea crónica asociada a un proceso linfoproliferativo.

    Vaquero, Luis / Alvarez-Cuenllas, Begoña / Aparicio, Marta / Rodriguez, Laura / Honrado-Franco, Emiliano / Olcoz, Jose Luis / Vivas, Santiago

    Gastroenterologia y hepatologia

    2013  Volume 36, Issue 7, Page(s) 458–460

    Title translation Chronic diarrhea associated with a lymphoproliferative process.
    MeSH term(s) Adult ; Chronic Disease ; Diarrhea/etiology ; Female ; Humans ; Lymphoproliferative Disorders/complications
    Language Spanish
    Publishing date 2013-08
    Publishing country Spain
    Document type Case Reports ; Letter
    ZDB-ID 632502-6
    ISSN 0210-5705
    ISSN 0210-5705
    DOI 10.1016/j.gastrohep.2013.01.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2044: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Tendencia y distribución municipal de la incidencia de cáncer de mama en el área de salud de León (1996-2010).

    García Martínez, Lidia / Pollán Santamaría, Marina / López-Abente, Gonzalo / Sánchez Jacob, María Mercedes / García Palomo, Andrés / González Martínez, Raquel / Honrado Franco, Emiliano / Martín Sánchez, Vicente

    Revista espanola de salud publica

    2014  Volume 88, Issue 2, Page(s) 261–269

    Abstract: Background: Breast cancer is the most common amongst women. The aim of this study was to analyze the incidence and geographical distribution of breast cancer in the health area of León.: Methods: We designed an observational descriptive study that ... ...

    Title translation Municipal distribution and trend of the incidence of breast cancer in the health area of León, Spain (1996-2010).
    Abstract Background: Breast cancer is the most common amongst women. The aim of this study was to analyze the incidence and geographical distribution of breast cancer in the health area of León.
    Methods: We designed an observational descriptive study that included women enrolled in the Hospital Tumor Registry of the Centro Asistencial Universitario in León with a diagnosis of breast malignant neoplasm (ICD-9: 174, ICD-10: 50) between 01/01/1996 and 31/12/2010 and resident in the health area of León. To study the spatial distribution, we estimated municipal relative risks (RR) smoothed by fitting the Besag, York and Mollié model and the posterior probability (PP) of RR > 1 using Bayesian methods.
    Results: A total of 2379 cases were included. The number of new cases and the crude incidence rate have both increased in every triennium, from 72,7 (1996-1998) to 101,5 (2008-2010) per 100,000 women. The age adjusted rates per 100,000 women (European standard population) increased from 58,0 during the first triennium to 69,4 during the last one. An average annual increase of 1,3% was observed. Several municipalities from the health area of León showed risks higher than a 10%. The PP were higher than 0.9 only in the municipality of León.
    Conclusion: The observed rates are among the lowest in our country. Nevertheless, the number of cases and the incidence rates have increased progressively.
    MeSH term(s) Adult ; Age Distribution ; Aged ; Aged, 80 and over ; Breast Neoplasms/epidemiology ; Female ; Humans ; Incidence ; Middle Aged ; Registries/statistics & numerical data ; Small-Area Analysis ; Spain/epidemiology ; Young Adult
    Language Spanish
    Publishing date 2014-03
    Publishing country Spain
    Document type English Abstract ; Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1288657-9
    ISSN 2173-9110 ; 0034-8899 ; 1135-5727
    ISSN (online) 2173-9110
    ISSN 0034-8899 ; 1135-5727
    DOI 10.4321/S1135-57272014000200008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 483: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Incidencia hospitalaria, tendencia y distribución municipal del cáncer de próstata en el área de salud de León (1996-2010).

    Martín Sánchez, Vicente / García-Sanz, Miguel / García-Martínez, Lidia / Del Canto Cabero, Marbella / Campanario-Pérez, Francisco / González Sevilla, Paquita / Estévez Iglesias, Lorena / Honrado Franco, Emiliano / Cuesta-Díaz de Rada, Ana / García Díez, Fructuoso / López-Abente, Gonzalo

    Revista espanola de salud publica

    2015  Volume 89, Issue 6, Page(s) 575–583

    Abstract: Background: Prostate cancer (PC) is the most prevalent among men and yet its risk factors are little known. This article aims to determine the hospital incidence, trend and municipal distribution of PC in Health Area of León (HAL).: Methods: We ... ...

    Title translation Hospital incidence, trends and municipal distribution of prostate cancer in health area of León, Spain (1996-2010).
    Abstract Background: Prostate cancer (PC) is the most prevalent among men and yet its risk factors are little known. This article aims to determine the hospital incidence, trend and municipal distribution of PC in Health Area of León (HAL).
    Methods: We included new cases of prostate cancer (ICD-9: 185, ICD-10: C61) enrolled in the Hospital Tumor Registry of the Complejo Asistencial Universitario de León, between 1996 to 2010 with residence in HAL. We calculated crude triennial hospital incidences and adjusted at global and European population. As denominator we used the INE population data disaggregated by five-year age groups of residents in municipalities of the HAL. To analyze the spatial distribution, we estimated municipal relative risks (RR) smoothed by fitting the Besag, York and Mollié model and the posterior probability (PP) of RR >1 using Bayesian methods.
    Results: 3,366 cases were included. Standardized rates at European population amounted of 30.3 (1996-98) to 119.0 (2008-2010) new cases per 100,000 men. The number of organ-confined cases were increased from 281 (1999-2001) to 999 (2008-2010). PSA determinations amounted from 30,985 (1999-2001) to 117 396 (2008-2010).
    Conclusions: A great increase was observed in the frequency of PC at the expense of organ-confined cases which correlate very well with PSA determinations performed in HAL. There were no differences of interest in the municipal distribution incidences.
    MeSH term(s) Adult ; Aged ; Bayes Theorem ; Cities/epidemiology ; Hospitals/statistics & numerical data ; Humans ; Incidence ; Infant ; Male ; Middle Aged ; Models, Statistical ; Prostatic Neoplasms/epidemiology ; Spain/epidemiology ; Urban Health/statistics & numerical data ; Young Adult
    Language Spanish
    Publishing date 2015-11
    Publishing country Spain
    Document type English Abstract ; Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1288657-9
    ISSN 2173-9110 ; 0034-8899 ; 1135-5727
    ISSN (online) 2173-9110
    ISSN 0034-8899 ; 1135-5727
    DOI 10.4321/S1135-57272015000600005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 483: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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