LIVIVO - Search results -

Search results

Result 1 - 10 of total 26

Search options

Article ; Online: The potentiation activity of β-lactam by phomoidrides and oxasetin against methicillin-resistant Staphylococcus aureus.

Honsho, Masako / Kimishima, Aoi / Ikeda, Akari / Iwatsuki, Masato / Nonaka, Kenichi / Matsui, Hidehito / Hanaki, Hideaki / Asami, Yukihiro / Sunazuka, Toshiaki

The Journal of antibiotics

2024 Volume 77, Issue 3, Page(s) 185–188

Abstract: Antimicrobial resistance (AMR) causes a global health threat and enormous damage for humans. Among them, Methicillin-resistant Staphylococcus aureus (MRSA) resistant to first-line therapeutic β-lactam drugs such as meropenem (MEPM) is problematic. ... ...

Abstract	Antimicrobial resistance (AMR) causes a global health threat and enormous damage for humans. Among them, Methicillin-resistant Staphylococcus aureus (MRSA) resistant to first-line therapeutic β-lactam drugs such as meropenem (MEPM) is problematic. Therefore, we focus on combination drug therapy and have been seeking new potentiators of MEPM to combat MRSA. In this paper, we report the isolation of phomoidrides A-D and its new analog, phomoidride H along with a polyketide compound, oxasetin from the culture broth of Neovaginatispora clematidis FKI-8547 strain as potentiators of MEPM against MRSA.
MeSH term(s)	Humans ; Methicillin-Resistant Staphylococcus aureus ; Anti-Bacterial Agents/pharmacology ; beta-Lactams/pharmacology ; Naphthalenes ; Meropenem/pharmacology ; Microbial Sensitivity Tests ; Pyrroles
Chemical Substances	Anti-Bacterial Agents ; beta-Lactams ; oxasetin ; Naphthalenes ; Meropenem (FV9J3JU8B1) ; Pyrroles
Language	English
Publishing date	2024-01-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	390800-8
ISSN	1881-1469 ; 0021-8820 ; 0368-3532
ISSN (online)	1881-1469
ISSN	0021-8820 ; 0368-3532
DOI	10.1038/s41429-023-00691-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 207: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article ; Online: Efflux pump inhibitor, phenylalanine-arginine beta-naphthylamide analog potentiates the activity of 5-O-mycaminosyltylonolide for multi-drug resistant Pseudomonas aeruginosa.

Kimishima, Aoi / Honsho, Masako / Terai, Junsei / Wasuwanich, Paul / Honma, Sota / Matsui, Hidehito / Hanaki, Hideaki / Asami, Yukihiro

The Journal of antibiotics

2024 Volume 77, Issue 5, Page(s) 331–333

Abstract: The emergence and spread of antimicrobial resistance are global threats. Pseudomonas aeruginosa (P. aeruginosa) is responsible for a substantial proportion of this global health issue because of its intrinsic resistance to many antibiotics due to the ... ...

Abstract	The emergence and spread of antimicrobial resistance are global threats. Pseudomonas aeruginosa (P. aeruginosa) is responsible for a substantial proportion of this global health issue because of its intrinsic resistance to many antibiotics due to the impermeability of its outer membrane and its multidrug efflux pump systems. Therefore, therapeutic drugs are limited, and the development of new drugs is extremely challenging. As an alternative approach, we focused on a combinational treatment strategy and found that 5-O-mycaminosyltylonolide (OMT) showed potent antibacterial activity against P. aeruginosa in the presence of an efflux pump inhibitor, phenylalanine-arginine beta-naphthylamide (PAβN). In this report, we prepared a PAβN derivative and compared the potentiation activity of OMT by PAβNs against multidrug-resistant P. aeruginosa clinical isolates.
MeSH term(s)	Pseudomonas aeruginosa/drug effects ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Drug Resistance, Multiple, Bacterial/drug effects ; Microbial Sensitivity Tests ; Dipeptides/pharmacology ; Dipeptides/chemistry ; Drug Synergism ; Humans ; Tylosin/analogs & derivatives
Chemical Substances	Anti-Bacterial Agents ; phenylalanine arginine beta-naphthylamide ; Dipeptides ; 5-O-mycaminosyltylonolide ; Tylosin (YEF4JXN031)
Language	English
Publishing date	2024-03-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	390800-8
ISSN	1881-1469 ; 0021-8820 ; 0368-3532
ISSN (online)	1881-1469
ISSN	0021-8820 ; 0368-3532
DOI	10.1038/s41429-024-00713-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 207: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: A new isomaneonene derivative from the red alga Laurencia cf. mariannensis

Ishii, Takahiro / Tahara, Arisu / Taba, Kanako / Iwatsuki, Masato / Honsho, Masako / Asami, Yukihiro / Nonaka, Kenichi / Hanaki, Hideaki / Teruya, Toshiaki

Journal of Asian Natural Products Research. 2023 July 3, v. 25, no. 7 p.704-710

2023

Abstract: Determining the structures of new natural products from marine species not only enriches our understanding of the diverse chemistry of these species, but can also lead to the discovery of compounds with novel and/or important biological activities. ... ...

Abstract	Determining the structures of new natural products from marine species not only enriches our understanding of the diverse chemistry of these species, but can also lead to the discovery of compounds with novel and/or important biological activities. Herein, we describe the isolation of isomaneonene C (1), a new halogenated C₁₅ acetogenin, and three known compounds, α-snyderol (2), cis-maneonene D (3), and isomaneonene B (4), from the organic extract obtained from the red alga Laurencia cf. mariannensis collected from Iheya Island, Okinawa, Japan. The structures of these secondary metabolites were elucidated spectroscopically. All compounds were inactive at 30 μg/disc against methicillin-resistant Staphylococcus aureus (MRSA) in combination treatment with a β-lactam drug, meropenem.
Keywords	Laurencia ; Ryukyu Archipelago ; chemistry ; meropenem ; methicillin-resistant Staphylococcus aureus ; research ; secondary metabolites ; Halogenated secondary metabolites ; C15 acetogenin ; maneonene ; Rhodomelaceae
Language	English
Dates of publication	2023-0703
Size	p. 704-710.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2077926-4
ISSN	1477-2213 ; 1028-6020
ISSN (online)	1477-2213
ISSN	1028-6020
DOI	10.1080/10286020.2022.2130266
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: Total Synthesis of Fusaramin, Enabling Stereochemical Elucidation, Structure-Activity Relationship, and Uncovering the Hidden Antimicrobial Activity against Plant Pathogenic Fungi.

Kimishima, Aoi / Hagimoto, Daichi / Honsho, Masako / Sakai, Katsuyuki / Honma, Sota / Fuji, Shin-Ichi / Iwatsuki, Masato / Tokiwa, Toshiyuki / Nonaka, Kenichi / Chinen, Takumi / Usui, Takeo / Asami, Yukihiro

Organic letters

2024 Volume 26, Issue 3, Page(s) 597–601

Abstract: Fusaramin ( ...

Abstract	Fusaramin (
MeSH term(s)	Anti-Infective Agents/chemistry ; Fungi ; Structure-Activity Relationship ; Mycotoxins/chemistry
Chemical Substances	Anti-Infective Agents ; sambutoxin (160047-56-3) ; Mycotoxins
Language	English
Publishing date	2024-01-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.3c03792
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Binding Mode-Based Physicochemical Screening Method Using d-Ala-d-Ala Silica Gel and Chemical Modification Approach to Facilitate Discovery of New Macrolactams, Banglactams A and B, from

Kimishima, Aoi / Suzuki, Yuki / Kosaka, Shohei / Honsho, Masako / Honma, Sota / Tsutsumi, Hayama / Inahashi, Yuki / Watanabe, Yoshihiro / Nakashima, Takuji / Asami, Yukihiro / Iwatsuki, Masato

ACS omega

2024 Volume 9, Issue 15, Page(s) 17415–17422

Abstract: Utilizing a binding mode-based physicochemical screening method using d-Ala-d-Ala silica gel, two new macrolactams, named banglactams A ( ...

Abstract	Utilizing a binding mode-based physicochemical screening method using d-Ala-d-Ala silica gel, two new macrolactams, named banglactams A (
Language	English
Publishing date	2024-04-05
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.4c00145
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: In vitro

Takemoto, Koji / Nakayama, Ryo / Fujimoto, Koichi / Suzuki, Yumiko / Takarabe, Yukiko / Honsho, Masako / Kitahara, Sachiko / Noguchi, Yoshihiko / Matsui, Hidehito / Hirose, Tomoyasu / Asami, Yukihiro / Hidaka, Jun / Sunazuka, Toshiaki / Hanaki, Hideaki

Antimicrobial agents and chemotherapy

2024 , Page(s) e0160223

Abstract: KSP-1007 is a novel bicyclic boronate-based broad-spectrum β-lactamase inhibitor and is being developed in combination with meropenem (MEM) for the treatment of infections caused by carbapenem-resistant Gram-negative bacteria, a global health concern, ... ...

Abstract	KSP-1007 is a novel bicyclic boronate-based broad-spectrum β-lactamase inhibitor and is being developed in combination with meropenem (MEM) for the treatment of infections caused by carbapenem-resistant Gram-negative bacteria, a global health concern, and here, we describe its characteristics. KSP-1007 exhibited low apparent inhibition constant (
Language	English
Publishing date	2024-05-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/aac.01602-23
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 809: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Einzelsignatur: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: PurA is the main target of aurodox, a type III secretion system inhibitor.

Watanabe, Yoshihiro / Haneda, Takeshi / Kimishima, Aoi / Kuwae, Asaomi / Suga, Takuya / Suzuki, Takahiro / Iwabuchi, Yoshiharu / Honsho, Masako / Honma, Sota / Iwatsuki, Masato / Matsui, Hidehito / Hanaki, Hideaki / Kanoh, Naoki / Abe, Akio / Asami, Yukihiro / Ōmura, Satoshi

Proceedings of the National Academy of Sciences of the United States of America

2024 Volume 121, Issue 17, Page(s) e2322363121

Abstract: Anti-microbial resistance (AMR) is one of the greatest threats to global health. The continual battle between the emergence of AMR and the development of drugs will be extremely difficult to stop as long as traditional anti-biotic approaches are taken. ... ...

Abstract	Anti-microbial resistance (AMR) is one of the greatest threats to global health. The continual battle between the emergence of AMR and the development of drugs will be extremely difficult to stop as long as traditional anti-biotic approaches are taken. In order to overcome this impasse, we here focused on the type III secretion system (T3SS), which is highly conserved in many Gram-negative pathogenic bacteria. The T3SS is known to be indispensable in establishing disease processes but not essential for pathogen survival. Therefore, T3SS inhibitors may be innovative anti-infective agents that could dramatically reduce the evolutionary selective pressure on strains resistant to treatment. Based on this concept, we previously identified a polyketide natural product, aurodox (AD), as a specific T3SS inhibitor using our original screening system. However, despite its promise as a unique anti-infective drug of AD, the molecular target of AD has remained unclear. In this paper, using an innovative chemistry and genetic biology-based approach, we show that AD binds to adenylosuccinate synthase (PurA), which suppresses the production of the secreted proteins from T3SS, resulting in the expression of bacterial virulence both in vitro and in vivo experiments. Our findings illuminate the potential of PurA as a target of anti-infective drugs and vaccination and could open a avenue for application of PurA in the regulation of T3SS.
MeSH term(s)	Type III Secretion Systems/metabolism ; Aurodox/pharmacology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Gram-Negative Bacteria/metabolism ; Bacterial Proteins/metabolism
Chemical Substances	Type III Secretion Systems ; Aurodox (12704-90-4) ; Anti-Bacterial Agents ; Bacterial Proteins
Language	English
Publishing date	2024-04-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2322363121
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1148: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A new tetronomycin analog, broad-spectrum and potent antibiotic against drug-resistant Gram-positive bacteria.

Kimishima, Aoi / Tsuruoka, Iori / Tsutsumi, Hayama / Honsho, Masako / Honma, Sota / Matsui, Hidehito / Sugamata, Miho / Wasuwanich, Paul / Inahashi, Yuki / Hanaki, Hideaki / Asami, Yukihiro

Chemistry & biodiversity

2024 Volume 21, Issue 2, Page(s) e202301834

Abstract: We discovered a new tetronomycin analog, C-32-OH tetronomycin (2) from the Streptomyces sp. K20-0247 strain, which produces tetronomycin (1). After NMR analysis of 2, we determined the planar structure. Futhermore, the absolute stereochemistry of 2 was ... ...

Abstract	We discovered a new tetronomycin analog, C-32-OH tetronomycin (2) from the Streptomyces sp. K20-0247 strain, which produces tetronomycin (1). After NMR analysis of 2, we determined the planar structure. Futhermore, the absolute stereochemistry of 2 was deduced based on the biosynthetic pathway of 1 in the K20-0247 strain and a comparison of experimental electronic circular dichroism (ECD) results of 1 with 2. While 2 exihibits potent antibacterial activity aganist Gram-positive baceria including vancomycin-intermediate Staphylococcus aureus (VISA) strains and vancomycin-resistant Enterococci (VRE), the antibacterial activity of 2 shows 16-32-folds weaker than that of 1 suggesting that the C-34 methyl group in 1 is one of the very important functinal group. Moreover, we evaluated the ionophore activity of 1 and 2 and neither compound shows ionophore activity at reasonable concetrations. Our research suggests that 1 and 2 would have different target(s) from an ionophore mechanism in the antibacterial activity and tetronomycins are promising natural products for broad-spectrum antibiotics.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Ethers ; Gram-Positive Bacteria ; Ionophores ; Microbial Sensitivity Tests
Chemical Substances	Anti-Bacterial Agents ; tetronomycin (82206-10-8) ; Ethers ; Ionophores
Language	English
Publishing date	2024-02-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202301834
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: A new isomaneonene derivative from the red alga

Ishii, Takahiro / Tahara, Arisu / Taba, Kanako / Iwatsuki, Masato / Honsho, Masako / Asami, Yukihiro / Nonaka, Kenichi / Hanaki, Hideaki / Teruya, Toshiaki

Journal of Asian natural products research

2022 Volume 25, Issue 7, Page(s) 704–710

Abstract	Determining the structures of new natural products from marine species not only enriches our understanding of the diverse chemistry of these species, but can also lead to the discovery of compounds with novel and/or important biological activities. Herein, we describe the isolation of isomaneonene C (
MeSH term(s)	Laurencia/chemistry ; Molecular Structure ; Methicillin-Resistant Staphylococcus aureus ; Acetogenins/pharmacology ; Acetogenins/chemistry
Chemical Substances	Acetogenins
Language	English
Publishing date	2022-10-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2077926-4
ISSN	1477-2213 ; 1028-6020
ISSN (online)	1477-2213
ISSN	1028-6020
DOI	10.1080/10286020.2022.2130266
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: A new selective inhibitor for IMP-1 metallo-β-lactamase, 3Z,5E-octa-3,5-diene-1,3,4-tricarboxylic acid-3,4-anhydride.

Ikeda, Akari / Ikegaya, Yoshiki / Honsho, Masako / Matsui, Hidehito / Nonaka, Kenichi / Ishii, Takahiro / Asami, Yukihiro / Hanaki, Hideaki / Hirose, Tomoyasu / Sunazuka, Toshiaki

Bioorganic & medicinal chemistry

2022 Volume 78, Page(s) 117109

Abstract: 3Z,5E-Octa-3,5-diene-1,3,4-tricarboxylic acid-3,4-anhydride (ODTAA, 1) was isolated from Paecilomyces sp. FKI-6801 for its selective IMP-1 MBL inhibitory activity. The first total synthesis of 1 from the commercially available compound was achieved in 9 ... ...

Abstract	3Z,5E-Octa-3,5-diene-1,3,4-tricarboxylic acid-3,4-anhydride (ODTAA, 1) was isolated from Paecilomyces sp. FKI-6801 for its selective IMP-1 MBL inhibitory activity. The first total synthesis of 1 from the commercially available compound was achieved in 9 steps with 28% overall yield. Introduction of catechol to the maleic anhydride of 1 improved the IC
MeSH term(s)	Humans ; Pseudomonas Infections ; Anhydrides ; Maleic Anhydrides ; Microbial Sensitivity Tests ; Pseudomonas aeruginosa ; beta-Lactamases ; Anti-Bacterial Agents/pharmacology
Chemical Substances	Anhydrides ; Maleic Anhydrides ; beta-Lactamases (EC 3.5.2.6) ; Anti-Bacterial Agents
Language	English
Publishing date	2022-12-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1161284-8
ISSN	1464-3391 ; 0968-0896
ISSN (online)	1464-3391
ISSN	0968-0896
DOI	10.1016/j.bmc.2022.117109
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 3815: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito