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  1. Article ; Online: Association between proteomic biomarkers and myocardial fibrosis measured by MRI

    Hooman Bakhshi / Sam A. Michelhaugh / Scott A. Bruce / Stephen L. Seliger / Xiaoxiao Qian / Bharath Ambale Venkatesh / Vinithra Varadarajan / Pramita Bagchi / Joao A.C. Lima / Christopher deFilippi

    EBioMedicine, Vol 90, Iss , Pp 104490- (2023)

    the multi-ethnic study of atherosclerosisResearch in context

    2023  

    Abstract: Summary: Background: Cardiac magnetic resonance imaging (CMR) determines the extent of interstitial fibrosis, measured by increased extracellular volume (ECV), and replacement fibrosis with late gadolinium myocardial enhancement (LGE). Despite advances ... ...

    Abstract Summary: Background: Cardiac magnetic resonance imaging (CMR) determines the extent of interstitial fibrosis, measured by increased extracellular volume (ECV), and replacement fibrosis with late gadolinium myocardial enhancement (LGE). Despite advances in detection, the pathophysiology of subclinical myocardial fibrosis is incompletely understood. Targeted proteomic discovery technologies enable quantification of low abundance circulating proteins to elucidate cardiac fibrosis mechanisms. Methods: Using a cross-sectional design, we selected 92 LGE+ cases and 92 LGE− demographically matched controls from the Multi-Ethnic Study of Atherosclerosis. Similarly, we selected 156 cases from the highest ECV quartile and matched with 156 cases from the lowest quartile. The plasma serum proteome was analyzed using proximity extension assays to determine differential regulation of 92 proteins previously implicated with cardiovascular disease. Results were analyzed using volcano plots of statistical significance vs. magnitude of change and Bayesian additive regression tree (BART) models to determine importance. Findings: After adjusting for false discovery, higher ECV was significantly associated with 17 proteins. Using BART, Plasminogen activator inhibitor 1, Insulin-like growth factor-binding protein 1, and N-terminal pro-B-type natriuretic peptide were associated with higher ECV after accounting for other proteins and traditional cardiovascular risk factors. In contrast, no circulating proteins were associated with replacement fibrosis. Interpretations: Our results suggest unique circulating proteomic signatures associated with interstitial fibrosis emphasizing its systemic influences. With future validation, protein panels may identify patients who may develop interstitial fibrosis with progression to heart failure. Funding: This research was supported by contracts and grants from NHLBI, NCATS and the Inova Heart and Vascular Institute.
    Keywords Myocardial fibrosis ; Interstitial fibrosis ; Replacement fibrosis ; Proteomic ; Biomarkers ; Cardiac MRI ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Hypoplastic Coronary Artery Disease Presenting with Ventricular Fibrillation Cardiac Arrest

    Abra Guo / Hooman Bakhshi / James O'Hara / Leonard Genovese / Adam Fein / Alireza Maghsoudi / Chirag Sandesara

    European Journal of Case Reports in Internal Medicine (2021)

    2021  

    Abstract: Hypoplastic coronary artery disease is a rare congenital anomaly that may present with ischaemic heart disease, heart failure or sudden cardiac death (SCD). We describe a case of cardiac arrest in a healthy young man. Work-up revealed a hypoplastic left ... ...

    Abstract Hypoplastic coronary artery disease is a rare congenital anomaly that may present with ischaemic heart disease, heart failure or sudden cardiac death (SCD). We describe a case of cardiac arrest in a healthy young man. Work-up revealed a hypoplastic left anterior descending artery. The patient underwent cardioverter-defibrillator implantation for secondary prevention.
    Keywords hypoplastic coronary artery disease ; cardiac arrest ; Medicine ; R
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher SMC MEDIA SRL
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: The clinical spectrum of myocardial injury associated with COVID-19 infection

    Hooman Bakhshi / Nisha Donthi / Emmanuel Ekanem / Shreya Podder / Shashank Sinha / Matthew W. Sherwood / Behnam Tehrani / Wayne Batchelor

    Journal of Community Hospital Internal Medicine Perspectives, Vol 10, Iss 6, Pp 521-

    2020  Volume 522

    Abstract: Although respiratory symptoms are the dominant features of COVID-19 infection, myocardial injury has been described in these patients. Reported cardiac manifestations of COVID-19 infection include myocarditis, arrhythmia and acute coronary syndrome ... ...

    Abstract Although respiratory symptoms are the dominant features of COVID-19 infection, myocardial injury has been described in these patients. Reported cardiac manifestations of COVID-19 infection include myocarditis, arrhythmia and acute coronary syndrome including ST elevation myocardial infarction (STEMI). STEMI is a medical emergency and timely intervention is of utmost importance to prevent mortality and long-term morbidities. In this report, we present a wide spectrum of clinical presentations, management, and outcomes for five patients with COVID-19 infection and ST elevation on ECG.
    Keywords covid-19 ; myocardial injury ; myocarditis ; thrombosis ; st elevation ; Internal medicine ; RC31-1245
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Thrombus entrapped in patent foramen ovale

    Hooman Bakhshi / Zahra Meyghani / Zaid Shakir / Alexander Chen / Dawn Kershner

    Journal of Community Hospital Internal Medicine Perspectives, Vol 5, Iss 4, Pp 1-

    a rare form of thrombus in transit

    2015  Volume 2

    Abstract: In rare cases, thrombus in transit can be entrapped in a patent foramen ovale (PFO). A patient with this condition is at high risk of embolic stroke and death. Early diagnosis and treatment is essential to help prevent stroke and death in these cases. ... ...

    Abstract In rare cases, thrombus in transit can be entrapped in a patent foramen ovale (PFO). A patient with this condition is at high risk of embolic stroke and death. Early diagnosis and treatment is essential to help prevent stroke and death in these cases. There is no universal management guideline for this rare condition. The decision between medical versus surgical treatment should be made individually for each patient. We present a case of thrombus in transit entrapped in a PFO that was treated medically by lifelong anticoagulation.
    Keywords PFO ; thrombus ; pulmonary emboli ; right heart strain ; Internal medicine ; RC31-1245
    Language English
    Publishing date 2015-09-01T00:00:00Z
    Publisher Co-Action Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Pneumonia severity index compared to CURB-65 in predicting the outcome of community acquired pneumonia among patients referred to an Iranian emergency

    Mostafa Alavi-Moghaddam / Hooman Bakhshi / Bareza Rezaei / Patricia Khashayar

    Brazilian Journal of Infectious Diseases, Vol 17, Iss 2, Pp 179-

    2013  Volume 183

    Abstract: OBJECTIVE: To compare the prognostic value of the pneumonia severity index and the severity score for community-acquired pneumonia (CURB-65) in predicting mortality and the need for ICU admission of patients with community-acquired pneumonia referred to ... ...

    Abstract OBJECTIVE: To compare the prognostic value of the pneumonia severity index and the severity score for community-acquired pneumonia (CURB-65) in predicting mortality and the need for ICU admission of patients with community-acquired pneumonia referred to our emergency department. MATERIALS AND METHODS: This prospective study was performed on patients with community-acquired pneumonia admitted to the emergency department of Imam Hossein Medical Center, Tehran, Iran. A questionnaire with demographic information, clinical signs and symptoms, laboratory and radiographic findings was completed for each patient. The information required for calculating the pneumonia severity index and CURB-65 were extracted from the medical records. The patients' clinical outcome was also recorded within a month after admission. RESULTS: We studied 200 patients with community-acquired pneumonia (122 men, 78 women). The sensitivity and specificity of CURB-65 in predicting mortality were 100% and 82.3%, respectively. As for pneumonia severity index, the rates were 100% and 75%, respec tively. The sensitivity and specificity rates of CURB-65 and pneumonia severity index in predicting mortality and need for ICU admission were 96.7% and 89.3%, and 90% and 78.7%, respectively. CONCLUSION: CURB-65 seems to be the preferred method to predict mortality and need for ICU admission in patients with community-acquired pneumonia. Despite their comparable specificity and sensitivity, CURB-65 is much easier to implement.
    Keywords CURB-65 ; PSI ; Community-acquired pneumonia ; Infectious and parasitic diseases ; RC109-216 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2013-04-01T00:00:00Z
    Publisher Brazilian Society of Infectious Diseases
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Malrotation following reamed intramedullary nailing of closed tibial fractures

    Adel Ebrahimpour Jafarinejad / Hooman Bakhshi / Maryam Haghnegahdar / Nima Ghomeishi

    Indian Journal of Orthopaedics, Vol 46, Iss 3, Pp 312-

    2012  Volume 316

    Abstract: Background: Rotational malalignment after intramedullary tibial nailing is rarely addressed in clinical studies.Malrotation (especially >10°)of the lower extremity can lead to development and progression of degenerative changes in knee and ankle joints. ... ...

    Abstract Background: Rotational malalignment after intramedullary tibial nailing is rarely addressed in clinical studies.Malrotation (especially >10°)of the lower extremity can lead to development and progression of degenerative changes in knee and ankle joints. The purpose of this study is to determine the incidence and severity of tibial malrotation after reamed intramedullary nailing for closed diaphyseal tibial fractures. Materials and Methods: Sixty patients (53 males and 7 females) with tibial diaphyseal fracture were included in this study. The mean age of the patients was 33.4±13.3 years. All fractures were manually reduced and fixed using reamed intramedullary nailing. A standard method using bilateral limited computerized tomography was used to measure the tibial torsion. A difference greater than 10° between two tibiae was defined as malrotation. Results: Eighteen (30%) patients had malrotation of more than 10°. Malrotation was greater than 15° in seven cases. Good or excellent rotational reduction was achieved in 70% of the patients. There was no statistically significant relation between AO tibial fracture classification and fibular fixation and malrotation of greater than 10°. Conclusions: Considering the high incidence rate of tibial malrotation following intramedullary nailing, we need a precise method to evaluate the torsion intraoperatively to prevent the problem.
    Keywords Computerized tomography ; intramedullary nailing ; malrotation ; Orthopedic surgery ; RD701-811 ; Surgery ; RD1-811 ; Medicine ; R ; Diseases of the musculoskeletal system ; RC925-935 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245
    Subject code 610 ; 616
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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