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  1. AU="Hooper, Alice"
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  1. Article: SARS-CoV-2 3CL-protease inhibitors derived from ML300: investigation of P1 and replacements of the 1,2,3-benzotriazole.

    Hooper, Alice / Macdonald, Jonathan D / Reilly, Brenna / Maw, Joshua / Wirrick, Aidan P / Han, Sang Hoon / Lindsey, A Abigail / Rico, Emma G / Romigh, Todd / Goins, Christopher M / Wang, Nancy S / Stauffer, Shaun

    Research square

    2023  

    Abstract: Starting from ... ...

    Abstract Starting from compound
    Language English
    Publishing date 2023-05-11
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-2880312/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Structure-Based Optimization of ML300-Derived, Noncovalent Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV-2 3CL

    Han, Sang Hoon / Goins, Christopher M / Arya, Tarun / Shin, Woo-Jin / Maw, Joshua / Hooper, Alice / Sonawane, Dhiraj P / Porter, Matthew R / Bannister, Breyanne E / Crouch, Rachel D / Lindsey, A Abigail / Lakatos, Gabriella / Martinez, Steven R / Alvarado, Joseph / Akers, Wendell S / Wang, Nancy S / Jung, Jae U / Macdonald, Jonathan D / Stauffer, Shaun R

    Journal of medicinal chemistry

    2021  Volume 65, Issue 4, Page(s) 2880–2904

    Abstract: Starting from the MLPCN probe compound ML300, a structure-based optimization campaign was initiated against the recent severe acute respiratory syndrome coronavirus (SARS-CoV-2) main protease ( ... ...

    Abstract Starting from the MLPCN probe compound ML300, a structure-based optimization campaign was initiated against the recent severe acute respiratory syndrome coronavirus (SARS-CoV-2) main protease (3CL
    MeSH term(s) Animals ; Antiviral Agents/chemical synthesis ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; COVID-19/metabolism ; Chlorocebus aethiops ; Coronavirus 3C Proteases/antagonists & inhibitors ; Coronavirus 3C Proteases/isolation & purification ; Coronavirus 3C Proteases/metabolism ; Crystallography, X-Ray ; Cysteine Proteinase Inhibitors/chemical synthesis ; Cysteine Proteinase Inhibitors/chemistry ; Cysteine Proteinase Inhibitors/pharmacology ; Dose-Response Relationship, Drug ; Glutamine/chemistry ; Glutamine/pharmacology ; Humans ; Ketones/chemistry ; Ketones/pharmacology ; Microbial Sensitivity Tests ; Models, Molecular ; Molecular Structure ; Peptidomimetics/chemistry ; Peptidomimetics/pharmacology ; SARS-CoV-2/drug effects ; SARS-CoV-2/enzymology ; Vero Cells ; Virus Replication/drug effects ; COVID-19 Drug Treatment
    Chemical Substances Antiviral Agents ; Cysteine Proteinase Inhibitors ; Ketones ; Peptidomimetics ; Glutamine (0RH81L854J) ; 3C-like protease, SARS coronavirus (EC 3.4.22.-) ; Coronavirus 3C Proteases (EC 3.4.22.28)
    Language English
    Publishing date 2021-08-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.1c00598
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 151: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MB 1: Show issues

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  3. Article: A general and mild two-step procedure for the synthesis of aryl and heteroaryl sulfonamides from the corresponding iodides

    Ho, Danny K.H / Chan, Lily / Hooper, Alice / Brennan, Paul E

    Tetrahedron letters. 2011 Feb. 16, v. 52, no. 7

    2011  

    Abstract: A mild two-step preparation of aryl and heteroaryl sulfonyl chlorides and sulfonamides from their corresponding iodides is developed. Acid labile functionalities are shown to be stable under both the copper-catalysed coupling and the subsequent oxidative ...

    Abstract A mild two-step preparation of aryl and heteroaryl sulfonyl chlorides and sulfonamides from their corresponding iodides is developed. Acid labile functionalities are shown to be stable under both the copper-catalysed coupling and the subsequent oxidative chlorination.
    Keywords chemical structure ; chlorides ; chlorination ; iodides ; sulfonamides
    Language English
    Dates of publication 2011-0216
    Size p. 820-823.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2010.12.050
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.

    Gong, Grace Q / Bilanges, Benoit / Allsop, Ben / Masson, Glenn R / Roberton, Victoria / Askwith, Trevor / Oxenford, Sally / Madsen, Ralitsa R / Conduit, Sarah E / Bellini, Dom / Fitzek, Martina / Collier, Matt / Najam, Osman / He, Zhenhe / Wahab, Ben / McLaughlin, Stephen H / Chan, A W Edith / Feierberg, Isabella / Madin, Andrew /
    Morelli, Daniele / Bhamra, Amandeep / Vinciauskaite, Vanesa / Anderson, Karen E / Surinova, Silvia / Pinotsis, Nikos / Lopez-Guadamillas, Elena / Wilcox, Matthew / Hooper, Alice / Patel, Chandni / Whitehead, Maria A / Bunney, Tom D / Stephens, Len R / Hawkins, Phillip T / Katan, Matilda / Yellon, Derek M / Davidson, Sean M / Smith, David M / Phillips, James B / Angell, Richard / Williams, Roger L / Vanhaesebroeck, Bart

    Nature

    2023  Volume 618, Issue 7963, Page(s) 159–168

    Abstract: Harnessing the potential beneficial effects of kinase signalling through the generation of direct kinase activators remains an underexplored area of drug ... ...

    Abstract Harnessing the potential beneficial effects of kinase signalling through the generation of direct kinase activators remains an underexplored area of drug development
    MeSH term(s) Humans ; Neoplasms/drug therapy ; Nerve Regeneration/drug effects ; Protein Isoforms/agonists ; Signal Transduction/drug effects ; Class I Phosphatidylinositol 3-Kinases/chemistry ; Class I Phosphatidylinositol 3-Kinases/drug effects ; Cardiotonic Agents/pharmacology ; Animals ; Biocatalysis/drug effects ; Protein Conformation/drug effects ; Neurites/drug effects ; Reperfusion Injury/prevention & control ; Nerve Crush ; Cell Proliferation/drug effects
    Chemical Substances Protein Isoforms ; PIK3CA protein, human (EC 2.7.1.137) ; Class I Phosphatidylinositol 3-Kinases (EC 2.7.1.137) ; Cardiotonic Agents
    Language English
    Publishing date 2023-05-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-023-05972-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  5. Article ; Online: Progress towards a public chemogenomic set for protein kinases and a call for contributions.

    Drewry, David H / Wells, Carrow I / Andrews, David M / Angell, Richard / Al-Ali, Hassan / Axtman, Alison D / Capuzzi, Stephen J / Elkins, Jonathan M / Ettmayer, Peter / Frederiksen, Mathias / Gileadi, Opher / Gray, Nathanael / Hooper, Alice / Knapp, Stefan / Laufer, Stefan / Luecking, Ulrich / Michaelides, Michael / Müller, Susanne / Muratov, Eugene /
    Denny, R Aldrin / Saikatendu, Kumar S / Treiber, Daniel K / Zuercher, William J / Willson, Timothy M

    PloS one

    2017  Volume 12, Issue 8, Page(s) e0181585

    Abstract: Protein kinases are highly tractable targets for drug discovery. However, the biological function and therapeutic potential of the majority of the 500+ human protein kinases remains unknown. We have developed physical and virtual collections of small ... ...

    Abstract Protein kinases are highly tractable targets for drug discovery. However, the biological function and therapeutic potential of the majority of the 500+ human protein kinases remains unknown. We have developed physical and virtual collections of small molecule inhibitors, which we call chemogenomic sets, that are designed to inhibit the catalytic function of almost half the human protein kinases. In this manuscript we share our progress towards generation of a comprehensive kinase chemogenomic set (KCGS), release kinome profiling data of a large inhibitor set (Published Kinase Inhibitor Set 2 (PKIS2)), and outline a process through which the community can openly collaborate to create a KCGS that probes the full complement of human protein kinases.
    MeSH term(s) Databases, Pharmaceutical ; Drug Discovery/methods ; Genomics/methods ; Humans ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/pharmacology ; Structure-Activity Relationship
    Chemical Substances Protein Kinase Inhibitors ; Small Molecule Libraries
    Language English
    Publishing date 2017-08-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0181585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Fat-free cookery

    Hooper, Alice Record

    1958  

    MeSH term(s) Cooking ; Diet ; Fats
    Language English
    Size vi, 112 p.
    Publisher Oxford Univ. Press
    Publishing place Cape Town
    Document type Book
    Database Catalogue of the US National Library of Medicine (NLM)

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