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  1. Article ; Online: Updating the Standards of Professional Competence in the Field of Toxicology: The Second Generation of Best Practice.

    Soucy, Nicole V / Masten, Susie / Caro, Carla / Arthur, Ann M / Moore, Nadia H / Hooth, Michelle J / Mitkus, Robert

    International journal of toxicology

    2023  Volume 42, Issue 5, Page(s) 430–444

    Abstract: The American Board of Toxicology (ABT), in consultation with ACT Credentialing & Career Services (ACT), performed a practice analysis study of general toxicology in 2020-21. This work follows up on an initial practice analysis commissioned by the ABT and ...

    Abstract The American Board of Toxicology (ABT), in consultation with ACT Credentialing & Career Services (ACT), performed a practice analysis study of general toxicology in 2020-21. This work follows up on an initial practice analysis commissioned by the ABT and conducted in 2014-2015, results of which were published in 2016. The purpose of the current, second-generation study was to update and validate the existing process-based delineation of practice of general toxicologists, including major domains of responsibility and tasks performed in practice. In addition, the study included the review, update, and validation of the knowledge areas required by toxicologists developed by subject-matter experts (SMEs) that have been used for ABT examination development initiatives. Consistent with best practices in the field of credentialing, ABT also contracted with ACT to conduct 2 follow-on activities: a study to evaluate the reliability of a reduced-length ABT examination and a standard setting study to establish a valid passing score for the updated examination. In addition to informing ongoing ABT certification examination and question writing activities, it is anticipated that the results of this practice analysis will be of value to those responsible for developing graduate and undergraduate toxicology curricula, creating continuing education content, and authoring textbooks covering the contemporary practice of toxicology.
    MeSH term(s) Humans ; United States ; Reproducibility of Results ; Professional Competence ; Certification ; Referral and Consultation
    Language English
    Publishing date 2023-06-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1379845-5
    ISSN 1092-874X ; 1091-5818
    ISSN (online) 1092-874X
    ISSN 1091-5818
    DOI 10.1177/10915818231184411
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  2. Article ; Online: Corrigendum to "Systemic exposure and urinary excretion of vanadium following perinatal subchronic exposure to vanadyl sulfate and sodium metavanadate via drinking water" [Toxicol. Lett. 360 (2022) 53-61].

    Waidyanatha, Suramya / Weber, Frank X / Fallacara, Dawn M / Harrington, James M / Levine, Keith / Robinson, Veronica G / Sparrow, Barney R / Stout, Matthew D / Fernando, Reshan / Hooth, Michelle J / Xie, Guanhua / Roberts, Georgia K

    Toxicology letters

    2022  Volume 373, Page(s) 210

    Language English
    Publishing date 2022-11-24
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 433788-8
    ISSN 1879-3169 ; 0378-4274
    ISSN (online) 1879-3169
    ISSN 0378-4274
    DOI 10.1016/j.toxlet.2022.11.008
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  3. Article ; Online: Systemic exposure and urinary excretion of vanadium following perinatal subchronic exposure to vanadyl sulfate and sodium metavanadate via drinking water.

    Waidyanatha, Suramya / Weber, Frank X / Fallacara, Dawn M / Harrington, James M / Levine, Keith / Robinson, Veronica G / Sparrow, Barney R / Stout, Matthew D / Fernando, Reshan / Hooth, Michelle J / Xie, Guanhua / Roberts, Georgia K

    Toxicology letters

    2022  Volume 360, Page(s) 53–61

    Abstract: Vanadium is a ubiquitous environmental contaminant although there are limited data to assess potential adverse human health impact following oral exposure. In support of studies investigating the subchronic toxicity of vanadyl sulfate ( ... ...

    Abstract Vanadium is a ubiquitous environmental contaminant although there are limited data to assess potential adverse human health impact following oral exposure. In support of studies investigating the subchronic toxicity of vanadyl sulfate (V
    MeSH term(s) Animals ; Drinking Water ; Female ; Male ; Rats ; Sodium ; Vanadates/toxicity ; Vanadium/toxicity ; Vanadium/urine ; Vanadium Compounds
    Chemical Substances Drinking Water ; Vanadium Compounds ; Vanadium (00J9J9XKDE) ; Vanadates (3WHH0066W5) ; vanadyl sulfate (6DU9Y533FA) ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2022-03-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 433788-8
    ISSN 1879-3169 ; 0378-4274
    ISSN (online) 1879-3169
    ISSN 0378-4274
    DOI 10.1016/j.toxlet.2022.03.004
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  4. Article ; Online: Corrigendum to "Internal dose of vanadium in rats following repeated exposure to vanadyl sulfate and sodium orthovanadate via drinking water" [Toxicology and Applied Pharmacology 412 (2021) 115395].

    Harrington, James M / Haines, Laura G / Levine, Keith E / Liyanapatirana, Chamindu / Essader, Amal S / Fernando, Reshan A / Robinson, Veronica G / Roberts, Georgia K / Stout, Matthew D / Hooth, Michelle J / Waidyanatha, Suramya

    Toxicology and applied pharmacology

    2021  Volume 423, Page(s) 115546

    Language English
    Publishing date 2021-04-24
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 204477-8
    ISSN 1096-0333 ; 0041-008X
    ISSN (online) 1096-0333
    ISSN 0041-008X
    DOI 10.1016/j.taap.2021.115546
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  5. Article ; Online: Internal dose of vanadium in rats following repeated exposure to vanadyl sulfate and sodium orthovanadate via drinking water.

    Harrington, James M / Haines, Laura G / Levine, Keith E / Liyanapatirana, Chamindu / Essader, Amal S / Fernando, Reshan A / Robinson, Veronica G / Roberts, Georgia K / Stout, Matthew D / Hooth, Michelle J / Waidyanatha, Suramya

    Toxicology and applied pharmacology

    2021  Volume 412, Page(s) 115395

    Abstract: Vanadium is a ubiquitous environmental contaminant that exists in multiple oxidation states. Humans are exposed to vanadyl ( ... ...

    Abstract Vanadium is a ubiquitous environmental contaminant that exists in multiple oxidation states. Humans are exposed to vanadyl (V
    MeSH term(s) Administration, Oral ; Animals ; Body Burden ; Drinking Water ; Female ; Gastric Juice/chemistry ; Gastrointestinal Absorption ; Intestinal Secretions/chemistry ; Liver/metabolism ; Male ; Oxidation-Reduction ; Rats, Sprague-Dawley ; Tissue Distribution ; Toxicokinetics ; Vanadates/administration & dosage ; Vanadates/blood ; Vanadates/pharmacokinetics ; Vanadates/toxicity ; Vanadium Compounds/administration & dosage ; Vanadium Compounds/blood ; Vanadium Compounds/pharmacokinetics ; Vanadium Compounds/toxicity ; Rats
    Chemical Substances Drinking Water ; Vanadium Compounds ; Vanadates (3WHH0066W5) ; vanadyl sulfate (6DU9Y533FA)
    Language English
    Publishing date 2021-01-06
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
    ZDB-ID 204477-8
    ISSN 1096-0333 ; 0041-008X
    ISSN (online) 1096-0333
    ISSN 0041-008X
    DOI 10.1016/j.taap.2021.115395
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Characterization of aqueous formulations of tetra- and pentavalent forms of vanadium in support of test article selection in toxicology studies.

    Mutlu, Esra / Cristy, Tim / Graves, Steven W / Hooth, Michelle J / Waidyanatha, Suramya

    Environmental science and pollution research international

    2016  Volume 24, Issue 1, Page(s) 405–416

    Abstract: Tetravalent ( ... ...

    Abstract Tetravalent (V
    MeSH term(s) Drinking Water/chemistry ; Hydrogen-Ion Concentration ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Toxicity Tests ; Vanadates/chemistry ; Vanadium Compounds/chemistry
    Chemical Substances Drinking Water ; Vanadium Compounds ; Vanadates (3WHH0066W5) ; vanadyl sulfate (6DU9Y533FA)
    Language English
    Publishing date 2016-10-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-016-7803-x
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  7. Article ; Online: Clarification and lessons learned for reporting studies with hydrates. Citation: Roberts et al., 2016. Toxicology Reports 3: 531-538.

    Roberts, Georgia K / Stout, Matthew D / Sayers, Brian / Fallacara, Dawn M / Hejtmancik, Milton R / Waidyanatha, Suramya / Hooth, Michelle J

    Toxicology reports

    2017  Volume 5, Page(s) 207–208

    Language English
    Publishing date 2017-12-30
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 2805786-7
    ISSN 2214-7500 ; 2214-7500
    ISSN (online) 2214-7500
    ISSN 2214-7500
    DOI 10.1016/j.toxrep.2017.12.023
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  8. Article ; Online: Assessment of immunotoxicity in female Fischer 344/N and Sprague Dawley rats and female B

    Shipkowski, Kelly A / Sheth, Christopher M / Smith, Matthew J / Hooth, Michelle J / White, Kimber L / Germolec, Dori R

    Journal of immunotoxicology

    2017  Volume 14, Issue 1, Page(s) 215–227

    Abstract: Sodium dichromate dihydrate (SDD), an inorganic compound containing hexavalent chromium (Cr(VI)), is a common environmental contaminant of groundwater sources due to widespread industrial use. There are indications in the literature that Cr(VI) may ... ...

    Abstract Sodium dichromate dihydrate (SDD), an inorganic compound containing hexavalent chromium (Cr(VI)), is a common environmental contaminant of groundwater sources due to widespread industrial use. There are indications in the literature that Cr(VI) may induce immunotoxic effects following dermal exposure, including acting as both an irritant and a sensitizer; however, the potential immunomodulatory effects of Cr(VI) following oral exposure are relatively unknown. Following the detection of Cr(VI) in drinking water sources, the National Toxicology Program (NTP) conducted extensive evaluations of the toxicity and carcinogenicity of SDD following drinking water exposure, including studies to assess the potential for Cr(VI) to modulate immune function. For the immunotoxicity assessments, female Fischer 344/N (F344/N) and Sprague Dawley (SD) rats and female B
    MeSH term(s) Animals ; Chromates/toxicity ; Chromium/toxicity ; Drinking Water ; Environmental Exposure/adverse effects ; Environmental Pollutants/toxicity ; Groundwater ; Humans ; Immunity, Humoral ; Immunity, Innate ; Immunoglobulin M/blood ; Immunomodulation ; Killer Cells, Natural/immunology ; Mice ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Rats ; Rats, Sprague-Dawley
    Chemical Substances Chromates ; Drinking Water ; Environmental Pollutants ; Immunoglobulin M ; Chromium (0R0008Q3JB) ; chromium hexavalent ion (18540-29-9) ; sodium bichromate (C9G6VY6ZZ4)
    Language English
    Publishing date 2017
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2205064-4
    ISSN 1547-6901 ; 1547-691X
    ISSN (online) 1547-6901
    ISSN 1547-691X
    DOI 10.1080/1547691X.2017.1394932
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  9. Article: 14-Day Toxicity Studies of Tetravalent and Pentavalent Vanadium Compounds in Harlan Sprague Dawley Rats and B6C3F1/N Mice via Drinking Water Exposure.

    Roberts, Georgia K / Stout, Matthew D / Sayers, Brian / Fallacara, Dawn M / Hejtmancik, Milton R / Waidyanatha, Suramya / Hooth, Michelle J

    Toxicology reports

    2016  Volume 3, Page(s) 531–538

    Abstract: Background: The National Toxicology Program (NTP) performed short-term toxicity studies of tetra- and pentavalent vanadium compounds, vanadyl sulfate and sodium metavanadate, respectively. Due to widespread human exposure and a lack of chronic toxicity ... ...

    Abstract Background: The National Toxicology Program (NTP) performed short-term toxicity studies of tetra- and pentavalent vanadium compounds, vanadyl sulfate and sodium metavanadate, respectively. Due to widespread human exposure and a lack of chronic toxicity data, there is concern for human health following oral exposure to soluble vanadium compounds.
    Objectives: To compare the potency and toxicological profile of vanadyl sulfate and sodium metavanadate using a short-term in vivo toxicity assay.
    Methods: Adult male and female Harlan Sprague Dawley (HSD) rats and B6C3F1/N mice, 5 per group, were exposed to vanadyl sulfate or sodium metavanadate, via drinking water, at concentrations of 0, 125, 250, 500, 1000 or 2000 mg/L for 14 days. Water consumption, body weights and clinical observations were recorded throughout the study; organ weights were collected at study termination.
    Results: Lower water consumption, up to -80% at 2000 mg/L, was observed at most exposure concentrations for animals exposed to either vanadyl sulfate or sodium metavanadate and was accompanied by decreased body weights at the highest concentrations for both compounds. Animals in the 1000 and 2000 mg/L sodium metavanadate groups were removed early due to overt toxicity. Thinness was observed in high-dose animals exposed to either compound, while lethargy and abnormal gait were only observed in vanadate-exposed animals.
    Conclusions: Based on clinical observations and overt toxicity, sodium metavanadate appears to be more toxic than vanadyl sulfate. Differential toxicity cannot be explained by differences in total vanadium intake, based on water consumption, and may be due to differences in disposition or mechanism of toxicity.
    Language English
    Publishing date 2016-05-12
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 2805786-7
    ISSN 2214-7500
    ISSN 2214-7500
    DOI 10.1016/j.toxrep.2016.05.001
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  10. Article: 14-day toxicity studies of tetravalent and pentavalent vanadium compounds in Harlan Sprague Dawley rats and B6C3F1/N mice via drinking water exposure

    Roberts, Georgia K / Stout, Matthew D / Sayers, Brian / Fallacara, Dawn M / Hejtmancik, Milton R / Waidyanatha, Suramya / Hooth, Michelle J

    Toxicology reports. 2016, v. 3

    2016  

    Abstract: The National Toxicology Program (NTP) performed short-term toxicity studies of tetra- and pentavalent vanadium compounds, vanadyl sulfate and sodium metavanadate, respectively. Due to widespread human exposure and a lack of chronic toxicity data, there ... ...

    Abstract The National Toxicology Program (NTP) performed short-term toxicity studies of tetra- and pentavalent vanadium compounds, vanadyl sulfate and sodium metavanadate, respectively. Due to widespread human exposure and a lack of chronic toxicity data, there is concern for human health following oral exposure to soluble vanadium compounds.To compare the potency and toxicological profile of vanadyl sulfate and sodium metavanadate using a short-term in vivo toxicity assay.Adult male and female Harlan Sprague Dawley (HSD) rats and B6C3F1/N mice, 5 per group, were exposed to vanadyl sulfate or sodium metavanadate, via drinking water, at concentrations of 0, 125, 250, 500, 1000 or 2000mg/L for 14 days. Water consumption, body weights and clinical observations were recorded throughout the study; organ weights were collected at study termination.Lower water consumption, up to −80% at 2000mg/L, was observed at most exposure concentrations for animals exposed to either vanadyl sulfate or sodium metavanadate and was accompanied by decreased body weights at the highest concentrations for both compounds. Animals in the 1000 and 2000mg/L sodium metavanadate groups were removed early due to overt toxicity. Thinness was observed in high-dose animals exposed to either compound, while lethargy and abnormal gait were only observed in vanadate-exposed animals.Based on clinical observations and overt toxicity, sodium metavanadate appears to be more toxic than vanadyl sulfate. Differential toxicity cannot be explained by differences in total vanadium intake, based on water consumption, and may be due to differences in disposition or mechanism of toxicity.
    Keywords chronic toxicity ; females ; gait ; human health ; humans ; males ; oral exposure ; sodium ; sulfates ; vanadium ; vanadyl ions
    Language English
    Size p. 531-538.
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2805786-7
    ISSN 2214-7500
    ISSN 2214-7500
    DOI 10.1016/j.toxrep.2016.05.001
    Database NAL-Catalogue (AGRICOLA)

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