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  1. Book ; Collection: Encyclopedia of AIDS

    Hope, Thomas J. / Richman, Douglas D. / Stevenson, Mario

    (Springer reference)

    2018  

    Author's details Thomas J. Hope, Douglas D. Richman, Mario Stevenson editors-in-chief
    Series title Springer reference
    Keywords AIDS ; HIV ; Immunology ; Infectious Diseases ; Virology
    Subject code 610
    Language English
    Dates of publication 2018-2018
    Size 3 Bände
    Publisher Springer
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Collection (display volumes)
    HBZ-ID HT019686669
    ISBN 978-1-4939-7100-8 ; 1-4939-7100-X ; 9781493971015 ; 9781493971022 ; 1493971018 ; 1493971026
    DOI 10.1007/978-1-4939-7101-5
    Database Catalogue ZB MED Medicine, Health

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  2. Book: Encyclopedia of AIDS / volume 1

    Hope, Thomas J. / Richman, Douglas D. / Stevenson, Mario

    2018  

    Author's details Thomas J. Hope, Douglas D. Richman, Mario Stevenson editors-in-chief
    Collection Encyclopedia of AIDS
    Language English
    Size lx, 598 Seiten, Illustrationen
    Publishing country United States
    Document type Book
    HBZ-ID HT019698170
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2018 A 761 available for loan (reading room) Lesesaal EG

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  3. Book: Encyclopedia of AIDS / volume 2

    Hope, Thomas J. / Richman, Douglas D. / Stevenson, Mario

    2018  

    Author's details Thomas J. Hope, Douglas D. Richman, Mario Stevenson editors-in-chief
    Collection Encyclopedia of AIDS
    Language English
    Size lx Seiten, Seite 600 - 1427, Illustrationen
    Publishing country United States
    Document type Book
    HBZ-ID HT019698181
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2018 A 762 available for loan (reading room) Lesesaal EG

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Book: Encyclopedia of AIDS / volume 3

    Hope, Thomas J. / Richman, Douglas D. / Stevenson, Mario

    2018  

    Author's details Thomas J. Hope, Douglas D. Richman, Mario Stevenson editors-in-chief
    Collection Encyclopedia of AIDS
    Language English
    Size lx Seiten, Seite 1430 - 2192, Illustrationen
    Publishing country United States
    Document type Book
    HBZ-ID HT019698185
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2018 A 763 available for loan (reading room) Lesesaal EG

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  5. Article ; Online: Can a Traditional Chinese Medicine Contribute to a Cure for HIV?

    Hope, Thomas J

    AIDS research and human retroviruses

    2017  Volume 33, Issue 2, Page(s) 89

    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639130-8
    ISSN 1931-8405 ; 0889-2229
    ISSN (online) 1931-8405
    ISSN 0889-2229
    DOI 10.1089/aid.2017.29001.hop
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1928: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Upcoming Implementation of NIH Funding Caps Invites Researcher Feedback.

    Hope, Thomas J

    AIDS research and human retroviruses

    2017  Volume 33, Issue 6, Page(s) iii

    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639130-8
    ISSN 1931-8405 ; 0889-2229
    ISSN (online) 1931-8405
    ISSN 0889-2229
    DOI 10.1089/aid.2017.29004.tjh
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1928: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Inflammation weakens HIV prevention.

    Hope, Thomas J

    Nature medicine

    2017  Volume 24, Issue 4, Page(s) 384–385

    MeSH term(s) Acquired Immunodeficiency Syndrome ; Female ; Genitalia ; HIV ; HIV Infections/prevention & control ; Humans ; Inflammation ; Tenofovir
    Chemical Substances Tenofovir (99YXE507IL)
    Language English
    Publishing date 2017-02-28
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/nm.4534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4212: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 39: Show issues

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  8. Article ; Online: VIROLOGY. Visualizing trans-infection.

    Hope, Thomas J

    Science (New York, N.Y.)

    2015  Volume 350, Issue 6260, Page(s) 511–512

    MeSH term(s) Animals ; HIV Infections/immunology ; HIV-1/physiology ; Humans ; Leukemia Virus, Murine/physiology ; Lymphocytes/virology ; Retroviridae Infections/immunology ; Sialic Acid Binding Ig-like Lectin 1/physiology ; Virus Internalization
    Chemical Substances Sialic Acid Binding Ig-like Lectin 1
    Language English
    Publishing date 2015-10-30
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aad5409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 27: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 77: Show issues

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  9. Article: Barriers of Mucosal Entry of HIV/SIV.

    Carias, Ann M / Hope, Thomas J

    Current immunology reviews

    2019  Volume 15, Issue 1, Page(s) 4–13

    Abstract: Most new HIV infections, over 80%, occur through sexual transmission. During sexual transmission, the virus must bypass specific female and male reproductive tract anatomical barriers to encounter viable target cells. Understanding the generally ... ...

    Abstract Most new HIV infections, over 80%, occur through sexual transmission. During sexual transmission, the virus must bypass specific female and male reproductive tract anatomical barriers to encounter viable target cells. Understanding the generally efficient ability of these barrier to exclude HIV and the precise mechanisms of HIV translocation beyond these genital barriers is essential for vaccine and novel therapeutic development. In this review, we explore the mucosal, barriers of cervico-vaginal and penile tissues that comprise the female and male reproductive tracts. The unique cellular assemblies f the squamous and columnar epithelium are illustrate highlighting their structure and function. Each anatomical tissue offers a unique barrier to virus entry in healthy individuals. Unfortunately barrier dysfunction can lead to HIV transmission. How these diverse mucosal barriers have the potential to fail is considered, highlighting those anatomical areas that are postulated to offer a weaker barrier and are; therefore, more susceptible to viral ingress. Risk factors, such as sexually transmitted infections, microbiome dysbiosis, and high progestin environments are also associated with increased acquisition of HIV. How these states may affect the integrity of mucosal barriers leading to HIV acquisition are discussed suggesting mechanisms of transmission and revealing potential targets for intervention.
    Language English
    Publishing date 2019-12-11
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2274820-9
    ISSN 1875-631X ; 1573-3955
    ISSN (online) 1875-631X
    ISSN 1573-3955
    DOI 10.2174/1573395514666180604084404
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7010: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: A New Generation of Functional Tagged Proteins for HIV Fluorescence Imaging.

    Mamede, João I / Griffin, Joseph / Gambut, Stéphanie / Hope, Thomas J

    Viruses

    2021  Volume 13, Issue 3

    Abstract: During the last decade, there was a marked increase in the development of tools and techniques to study the molecular mechanisms of the HIV replication cycle by using fluorescence microscopy. Researchers often apply the fusion of tags and fluorophores to ...

    Abstract During the last decade, there was a marked increase in the development of tools and techniques to study the molecular mechanisms of the HIV replication cycle by using fluorescence microscopy. Researchers often apply the fusion of tags and fluorophores to viral proteins, surrogate proteins, or dyes to follow individual virus particles while they progress throughout infection. The inclusion of such fusion motifs or surrogates frequently disrupts viral infectivity or results in a change of the wild-type phenotype. Here, we detail the construction and functional characterization of two new constructs where we fused fluorescent proteins to the N-terminus of HIV-1 Integrase. In the first, IN is recruited into assembling particles via a codon optimized Gag to complement other viral constructs, while the second is fused to a Gag-Pol expression vector fully capable of integration. Our data shows that N-terminal tagged IN is functional for integration by both recovery of integration of catalytically inactive IN and by the successful infectivity of viruses carrying only labeled IN. These tools will be important to study the individual behavior of viral particles and associate such behavior to infectivity.
    MeSH term(s) Cell Line ; Cell Line, Tumor ; Fluorescence ; HEK293 Cells ; HIV Infections/virology ; HIV-1/genetics ; HeLa Cells ; Humans ; Integrases/genetics ; Optical Imaging/methods ; Viral Proteins/genetics ; Virion/genetics ; Virus Replication/genetics
    Chemical Substances Viral Proteins ; Integrases (EC 2.7.7.-)
    Language English
    Publishing date 2021-02-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13030386
    Database MEDical Literature Analysis and Retrieval System OnLINE

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