Article ; Online: Relationship Between Apparent Systemic Clearance of Vemurafenib and Toxicity in Patients With Melanoma.
Journal of clinical pharmacology
2021 Volume 61, Issue 9, Page(s) 1243–1248
Abstract: Vemurafenib, a B rapidly accelerated fibrosarcoma inhibitor, is commonly used in combination of cobimetinib for the treatment of melanoma. In the current study, we evaluated the relationship between vemurafenib exposure, as measured by the estimated ... ...
| Abstract | Vemurafenib, a B rapidly accelerated fibrosarcoma inhibitor, is commonly used in combination of cobimetinib for the treatment of melanoma. In the current study, we evaluated the relationship between vemurafenib exposure, as measured by the estimated apparent clearance (CL |
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| MeSH term(s) | Aged ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/therapeutic use ; Azetidines/therapeutic use ; Dose-Response Relationship, Drug ; Female ; Humans ; Male ; Melanoma/drug therapy ; Metabolic Clearance Rate ; Middle Aged ; Patient Acuity ; Piperidines/therapeutic use ; Prospective Studies ; Vemurafenib/adverse effects ; Vemurafenib/pharmacokinetics ; Vemurafenib/therapeutic use | |||||
| Chemical Substances | Antineoplastic Agents ; Azetidines ; Piperidines ; Vemurafenib (207SMY3FQT) ; cobimetinib (ER29L26N1X) | |||||
| Language | English | |||||
| Publishing date | 2021-08-07 | |||||
| Publishing country | England | |||||
| Document type | Clinical Trial, Phase II ; Clinical Trial, Phase III ; Journal Article ; Multicenter Study ; Randomized Controlled Trial | |||||
| ZDB-ID | 188980-1 | |||||
| ISSN | 1552-4604 ; 0091-2700 ; 0021-9754 | |||||
| ISSN (online) | 1552-4604 | |||||
| ISSN | 0091-2700 ; 0021-9754 | |||||
| DOI | 10.1002/jcph.1882 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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