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  1. Article ; Online: The use of adjustable gastric bands for management of severe and complex obesity.

    Hopkins, James C A / Blazeby, Jane M / Rogers, Chris A / Welbourn, Richard

    British medical bulletin

    2016  Volume 118, Issue 1, Page(s) 64–72

    Abstract: Background: Obesity levels in the UK have reached a sustained high and ∼4% of the population would be candidates for bariatric surgery based upon current UK NICE guidelines, which has important implications for Clinical Commissioning Groups.: Sources ... ...

    Abstract Background: Obesity levels in the UK have reached a sustained high and ∼4% of the population would be candidates for bariatric surgery based upon current UK NICE guidelines, which has important implications for Clinical Commissioning Groups.
    Sources of data: Summary data from Cochrane systematic reviews, randomized controlled trials (RCTs) and cohort studies.
    Areas of agreement: Currently, the only treatment that offers significant and durable weight loss for those with severe and complex obesity is surgery. Three operations account for 95% of all bariatric surgery in the UK, but the NHS offers surgery to only a small fraction of those who could benefit. Laparoscopic adjustable gastric banding (gastric banding) has potentially the lowest risk and up-front costs of the three procedures.
    Areas of controversy: Reliable Level 1 evidence of the relative effectiveness of the operations is lacking.
    Growing points: As a point intervention, weight loss surgery together with the chronic disease management strategy for obesity can prevent significant future disease and mortality, and the NHS should embrace both.
    Areas timely for developing research: Better RCT evidence is needed including clinical effectiveness and economic analysis to answer the important question 'which is the best of the three operations most frequently performed?' This review considers the current evidence for gastric banding for the treatment of severe and complex obesity.
    MeSH term(s) Cost-Benefit Analysis ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/prevention & control ; Female ; Gastroplasty/instrumentation ; Gastroplasty/methods ; Humans ; Male ; Obesity, Morbid/epidemiology ; Obesity, Morbid/surgery ; Practice Guidelines as Topic ; Practice Patterns, Physicians' ; Randomized Controlled Trials as Topic ; Treatment Outcome ; United Kingdom/epidemiology ; Weight Loss
    Language English
    Publishing date 2016-03-31
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 213294-1
    ISSN 1471-8391 ; 0007-1420
    ISSN (online) 1471-8391
    ISSN 0007-1420
    DOI 10.1093/bmb/ldw012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Accumulation of 2-deoxy-D-glucose-6-phosphate as a measure of glucose uptake in the isolated perfused heart: a 31P NMR study.

    Hopkins, James C A / Radda, George K / Veech, Richard L / Clarke, Kieran

    Metabolic engineering

    2004  Volume 6, Issue 1, Page(s) 36–43

    Abstract: The accumulation of 2-deoxy-D-glucose-6-phosphate (2DG6P), detected using 31P NMR spectroscopy, has been used as a measure of the rate of glucose uptake, yet the accuracy of this measurement has not been verified. In this study, isolated rat hearts were ... ...

    Abstract The accumulation of 2-deoxy-D-glucose-6-phosphate (2DG6P), detected using 31P NMR spectroscopy, has been used as a measure of the rate of glucose uptake, yet the accuracy of this measurement has not been verified. In this study, isolated rat hearts were perfused with different substrates or isoproterenol for 30 min before measurement of either 2DG6P accumulation or [2-3H]glucose uptake, without and with insulin. Basal contractile function and metabolite concentrations were the same for all hearts. The basal rates of 2DG6P accumulation differed significantly, depending on the preceding perfusion protocol, and were 38-60% of the [2-3H]glucose uptake rates, whereas insulin-stimulated 2DG6P accumulation was the same or 71% higher than the [2-3H]glucose uptake rates. Therefore the ratio of 2DG6P accumulation/[2-3H]glucose uptake rates varied from 0.38 to 1.71, depending on the prior perfusion conditions or the presence of insulin. The rates of 2DG6P hydrolysis were found to be proportional to the intracellular 2DG6P concentrations, with a K(m) of 17.5mM and V(max) of 1.4 micromol/g dry weight/min. We conclude that the rates of 2DG6P accumulation do not accurately reflect glucose uptake rates under all physiological conditions in the isolated heart and should be used with caution.
    MeSH term(s) Animals ; Glucose-6-Phosphate/analogs & derivatives ; Glucose-6-Phosphate/metabolism ; Insulin/pharmacology ; Isoproterenol/metabolism ; Magnetic Resonance Spectroscopy ; Models, Chemical ; Myocardial Contraction/drug effects ; Myocardial Contraction/physiology ; Myocardium/metabolism ; Perfusion ; Phosphorus Isotopes/metabolism ; Rats
    Chemical Substances Insulin ; Phosphorus Isotopes ; 2-deoxyglucose-6-phosphate (3573-50-0) ; Glucose-6-Phosphate (56-73-5) ; Isoproterenol (L628TT009W)
    Language English
    Publishing date 2004-01-19
    Publishing country Belgium
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1470383-x
    ISSN 1096-7184 ; 1096-7176
    ISSN (online) 1096-7184
    ISSN 1096-7176
    DOI 10.1016/j.ymben.2003.10.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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