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  1. Article: Patient Perspectives on Anti-spike Monoclonal Antibody Therapy for Mild to Moderate Coronavirus Disease-2019.

    Razonable, Raymund R / Ganesh, Ravindra / Bishop, Rachel K / Culbertson, Tracy L / Destro Borgen, Molly / Hedin, Michelle C / Hopkins, Laura H / Jackson, Tammy A / Larsen, Jennifer J / Matoush, Jennifer A / Moehnke, Darcie E / Olson, Shelly M / Peterson, Kellie M / Rosedahl, Jordan / Philpot, Lindsey M

    Journal of patient experience

    2022  Volume 9, Page(s) 23743735221105673

    Abstract: Anti-spike monoclonal antibodies emerged as effective early treatment of high-risk individuals with mild-to-moderate COVID-19. Although their clinical and safety outcomes have been reported, patient perspectives of these experimental therapies have not ... ...

    Abstract Anti-spike monoclonal antibodies emerged as effective early treatment of high-risk individuals with mild-to-moderate COVID-19. Although their clinical and safety outcomes have been reported, patient perspectives of these experimental therapies have not been evaluated. In this survey participated by 644/2412 (26.7% response) individuals evaluated for anti-spike monoclonal antibody therapies, the majority of 523 patients who received the antibody infusion were very satisfied with their overall patient experience, the quality of care provided, and various aspects of medical care. They voiced satisfaction with the communication with providers before and during treatment, including education provided about monoclonal antibody treatment, the potential benefits and adverse effects, detailed instructions on the process of infusion, and safety protocols employed at the infusion facilities. Nearly a quarter (23.6%) of 121 patients who declined therapy indicated they would accept treatment should it be offered again. These patient perspectives may be used to guide healthcare facilities and providers in optimizing the care provided to high-risk outpatients with COVID-19.
    Language English
    Publishing date 2022-06-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2857285-3
    ISSN 2374-3743 ; 2374-3735
    ISSN (online) 2374-3743
    ISSN 2374-3735
    DOI 10.1177/23743735221105673
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A Framework for Outpatient Infusion of Antispike Monoclonal Antibodies to High-Risk Patients with Mild-to-Moderate Coronavirus Disease-19: The Mayo Clinic Model.

    Razonable, Raymund R / Aloia, Nicole C E / Anderson, Ryan J / Anil, Gokhan / Arndt, Lori L / Arndt, Richard F / Ausman, Sara E / Bell, Sarah J / Bierle, Dennis M / Billings, Marcie L / Bishop, Rachel K / Cramer, Carl H / Culbertson, Tracy L / Dababneh, Ala S / Derr, Amber N / Epps, Kevin / Flaker, Susan M / Ganesh, Ravindra / Gilmer, Mary A /
    Urena, Eric Gomez / Gulden, Christopher R / Haack, Tamara L / Hanson, Sara N / Herzog, Jenna R / Heyliger, Alexander / Hokanson, Lex D / Hopkins, Laura H / Horecki, Richard J / Krishna, Bipinchandra Hirisave / Huskins, W Charles / Jackson, Tammy A / Johnson, Ryan R / Jorgenson, Betty / Kudrna, Cory / Kennedy, Brian D / Klingsporn, Mary K / Kottke, Brian / Larsen, Jennifer J / Lessard, Sarah R / Lutwick, Larry I / Malone, Edward J / Matoush, Jennifer A / Micallef, Ivana N / Moehnke, Darcie E / Mohamed, Muhanad / Ness, Colleena N / Olson, Shelly M / Orenstein, Robert / Palraj, Raj / Patel, Janki / Paulson, Damian J / Phelan, David / Peinovich, Margaret T / Ramsey, Wilford L / Rau-Kane, Taunya J / Reid, Kevin I / Reinschmidt, Karen J / Seville, Maria Teresa / Skold, Erin C / Smith, Jill M / Speicher, Leigh L / Spielman, Laurie A / Springer, Donna J / Sweeten, Perry W / Tempelis, Jennifer M / Tulledge-Scheitel, Sidna / Vergidis, Paschalis / Whipple, Daniel C / Wilker, Caroline G / Destro Borgen, Molly J

    Mayo Clinic proceedings

    2021  Volume 96, Issue 5, Page(s) 1250–1261

    Abstract: The administration of spike monoclonal antibody treatment to patients with mild to moderate COVID-19 is very challenging. This article summarizes essential components and processes in establishing an effective spike monoclonal antibody infusion program. ... ...

    Abstract The administration of spike monoclonal antibody treatment to patients with mild to moderate COVID-19 is very challenging. This article summarizes essential components and processes in establishing an effective spike monoclonal antibody infusion program. Rapid identification of a dedicated physical infrastructure was essential to circumvent the logistical challenges of caring for infectious patients while maintaining compliance with regulations and ensuring the safety of our personnel and other patients. Our partnerships and collaborations among multiple different specialties and disciplines enabled contributions from personnel with specific expertise in medicine, nursing, pharmacy, infection prevention and control, electronic health record (EHR) informatics, compliance, legal, medical ethics, engineering, administration, and other critical areas. Clear communication and a culture in which all roles are welcomed at the planning and operational tables are critical to the rapid development and refinement needed to adapt and thrive in providing this time-sensitive beneficial therapy. Our partnerships with leaders and providers outside our institutions, including those who care for underserved populations, have promoted equity in the access of monoclonal antibodies in our regions. Strong support from institutional leadership facilitated expedited action when needed, from a physical, personnel, and system infrastructure standpoint. Our ongoing real-time assessment and monitoring of our clinical program allowed us to improve and optimize our processes to ensure that the needs of our patients with COVID-19 in the outpatient setting are met.
    MeSH term(s) Antibodies, Monoclonal/administration & dosage ; Antiviral Agents/administration & dosage ; COVID-19/epidemiology ; COVID-19/therapy ; Clinical Protocols ; Critical Pathways/organization & administration ; Critical Pathways/trends ; Efficiency, Organizational ; Home Infusion Therapy/methods ; Home Infusion Therapy/standards ; Humans ; Intersectoral Collaboration ; Organizational Culture ; Program Development/methods ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; Severity of Illness Index ; Spike Glycoprotein, Coronavirus/antagonists & inhibitors ; Spike Glycoprotein, Coronavirus/immunology ; United States/epidemiology
    Chemical Substances Antibodies, Monoclonal ; Antiviral Agents ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2021-03-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2021.03.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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