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  1. AU="Hopyan, Sevan"
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  1. Article: Reconstruction for bone tumours of the shoulder and humerus in children and adolescents.

    Hopyan, Sevan

    Journal of children's orthopaedics

    2021  Volume 15, Issue 4, Page(s) 358–365

    Abstract: Reconstructions for paediatric bone tumours of the shoulder girdle and humerus are intended to optimize placement of the hand in space. Given the longevity of paediatric survivors of sarcoma, durability is an important planning consideration. Here, I ... ...

    Abstract Reconstructions for paediatric bone tumours of the shoulder girdle and humerus are intended to optimize placement of the hand in space. Given the longevity of paediatric survivors of sarcoma, durability is an important planning consideration. Here, I review a subset of approaches based on anatomical site with an emphasis on function and longevity. Often, biological reconstructions that combine living bone with tendon repairs and transfers best address those goals.
    Language English
    Publishing date 2021-08-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2279410-4
    ISSN 1863-2548 ; 1863-2521
    ISSN (online) 1863-2548
    ISSN 1863-2521
    DOI 10.1302/1863-2548.15.210131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6613: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Shape-driven confluent rigidity transition in curved biological tissues.

    Thomas, Evan C / Hopyan, Sevan

    Biophysical journal

    2023  Volume 122, Issue 21, Page(s) 4264–4273

    Abstract: Collective cell motions underlie structure formation during embryonic development. Tissues exhibit emergent multicellular characteristics such as jamming, rigidity transitions, and glassy dynamics, but there remain questions about how those tissue-scale ... ...

    Abstract Collective cell motions underlie structure formation during embryonic development. Tissues exhibit emergent multicellular characteristics such as jamming, rigidity transitions, and glassy dynamics, but there remain questions about how those tissue-scale dynamics derive from local cell-level properties. Specifically, there has been little consideration of the interplay between local tissue geometry and cellular properties influencing larger-scale tissue behaviors. Here, we consider a simple two-dimensional computational vertex model for confluent tissue monolayers, which exhibits a rigidity phase transition controlled by the shape index (ratio of perimeter to square root area) of cells, on surfaces of constant curvature. We show that the critical point for the rigidity transition is a function of curvature such that positively curved systems are likely to be in a less rigid, more fluid, phase. Likewise, negatively curved systems (saddles) are likely to be in a more rigid, less fluid, phase. A phase diagram we generate for the curvature and shape index constitutes a testable prediction from the model. The curvature dependence is interesting because it suggests a natural explanation for more dynamic tissue remodeling and facile growth in regions of higher surface curvature. Conversely, we would predict stability at the base of saddle-shaped budding structures without invoking the need for biochemical or other physical differences. This concept has potential ramifications for our understanding of morphogenesis of budding and branching structures.
    MeSH term(s) Cell Division ; Cell Shape
    Language English
    Publishing date 2023-10-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218078-9
    ISSN 1542-0086 ; 0006-3495
    ISSN (online) 1542-0086
    ISSN 0006-3495
    DOI 10.1016/j.bpj.2023.10.001
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 235: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 2: Show issues

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  3. Article ; Online: Biophysical regulation of early limb bud morphogenesis.

    Hopyan, Sevan

    Developmental biology

    2017  Volume 429, Issue 2, Page(s) 429–433

    Abstract: The physical basis of morphogenesis is a fascinating concern that has been a longstanding interest of developmental biologists. In this review, I attempt to incorporate earlier and recent biophysical concepts and data to explain basic features of early ... ...

    Abstract The physical basis of morphogenesis is a fascinating concern that has been a longstanding interest of developmental biologists. In this review, I attempt to incorporate earlier and recent biophysical concepts and data to explain basic features of early limb bud morphogenesis. In particular, I discuss the influence of mesenchymal cohesion and physical properties that might contribute to phase separation of the bud from the lateral plate, the possibility that the early dorsoventral limb bud axis is moulded by the surface ectoderm, and endogenous electric fields that might contribute to oriented cell movements which generate the early limb bud. A combination of quantitative biophysical experimentation and modelling will likely advance this field.
    MeSH term(s) Animals ; Biophysical Phenomena ; Cell Movement ; Cell Polarity ; Electricity ; Limb Buds/cytology ; Limb Buds/embryology ; Limb Buds/physiology ; Mesoderm/cytology ; Mesoderm/embryology ; Morphogenesis
    Language English
    Publishing date 2017--15
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1114-9
    ISSN 1095-564X ; 0012-1606
    ISSN (online) 1095-564X
    ISSN 0012-1606
    DOI 10.1016/j.ydbio.2017.06.034
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 508: Show issues Location:
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  4. Book ; Online: Shape driven confluent rigidity transition in curved biological tissues

    Thomas, Evan / Hopyan, Sevan

    2022  

    Abstract: Collective cell motions underlie structure formation during embryonic development. Tissues exhibit emergent multicellular characteristics such as jamming, rigidity transitions, and glassy dynamics, but there remain questions about how those tissue scale ... ...

    Abstract Collective cell motions underlie structure formation during embryonic development. Tissues exhibit emergent multicellular characteristics such as jamming, rigidity transitions, and glassy dynamics, but there remain questions about how those tissue scale dynamics derive from local cell level properties. Specifically, there has been little consideration of the interplay between local tissue geometry and cellular properties influencing larger scale tissue behaviours. Here we consider a simple two dimensional computational vertex model for confluent tissue monolayers, which exhibits a rigidity phase transition controlled by the shape index (ratio of perimeter to square root area) of cells, on a spherical surface. We show that the critical point for the rigidity transition is a function of curvature such that more highly curved systems are more likely to be in a less rigid, more fluid, phase. A phase diagram we generate for the curvature and shape index constitutes a testable prediction from the model. The curvature dependence is interesting because it suggests a natural explanation for more dynamic tissue remodelling and facile growth in regions of higher surface curvature, without invoking the need for biochemical or other physical differences. This has potential ramifications for our understanding of morphogenesis of budding and branching structures.
    Keywords Physics - Biological Physics ; Condensed Matter - Soft Condensed Matter
    Subject code 612
    Publishing date 2022-04-25
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Management of Brachial Plexus Birth Injury: The SickKids Experience.

    Cawthorn, Thomas R / Hopyan, Sevan / Clarke, Howard M / Davidge, Kristen M

    Seminars in plastic surgery

    2023  Volume 37, Issue 2, Page(s) 89–101

    Abstract: This article describes the approach utilized by the multidisciplinary team at Sick Kids Hospital to evaluate and treat patients with brachial plexus birth injury (BPBI). This approach has been informed by more than 30 years of experience treating over 1, ... ...

    Abstract This article describes the approach utilized by the multidisciplinary team at Sick Kids Hospital to evaluate and treat patients with brachial plexus birth injury (BPBI). This approach has been informed by more than 30 years of experience treating over 1,800 patients with BPBI and continues to evolve over time. The objective of this article is to provide readers with a practical overview of the Sick Kids approach to the management of infants with BPBI.
    Language English
    Publishing date 2023-07-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2077828-4
    ISSN 1535-2188
    ISSN 1535-2188
    DOI 10.1055/s-0043-1769930
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4383: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Biophysical regulation of early limb bud morphogenesis

    Hopyan, Sevan

    Developmental biology. 2017,

    2017  

    Abstract: The physical basis of morphogenesis is a fascinating concern that has been a longstanding interest of developmental biologists. In this review, I attempt to incorporate earlier and recent biophysical concepts and data to explain basic features of early ... ...

    Abstract The physical basis of morphogenesis is a fascinating concern that has been a longstanding interest of developmental biologists. In this review, I attempt to incorporate earlier and recent biophysical concepts and data to explain basic features of early limb bud morphogenesis. In particular, I discuss the influence of mesenchymal cohesion and physical properties that might contribute to phase separation of the bud from the lateral plate, the possibility that the early dorsoventral limb bud axis is moulded by the surface ectoderm, and endogenous electric fields that might contribute to oriented cell movements which generate the early limb bud. A combination of quantitative biophysical experimentation and modelling will likely advance this field.
    Keywords cohesion ; electric field ; limbs (animal) ; models ; morphogenesis ; separation
    Language English
    Size p. .
    Publishing place Elsevier Inc.
    Document type Article
    Note Pre-press version
    ZDB-ID 1114-9
    ISSN 1095-564X ; 0012-1606
    ISSN (online) 1095-564X
    ISSN 0012-1606
    DOI 10.1016/j.ydbio.2017.06.034
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 76/715: Show issues

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  7. Article ; Online: Recent Advances in the Treatment of Brachial Plexus Birth Injury.

    Zuo, Kevin J / Ho, Emily S / Hopyan, Sevan / Clarke, Howard M / Davidge, Kristen M

    Plastic and reconstructive surgery

    2023  Volume 151, Issue 5, Page(s) 857e–874e

    Abstract: Learning objectives: After studying this article, the participant should be able to: 1. Describe methods of clinical evaluation for neurologic recovery in brachial plexus birth injury. 2. Understand the role of different diagnostic imaging modalities to ...

    Abstract Learning objectives: After studying this article, the participant should be able to: 1. Describe methods of clinical evaluation for neurologic recovery in brachial plexus birth injury. 2. Understand the role of different diagnostic imaging modalities to evaluate the upper limb. 3. List nonsurgical strategies and surgical procedures to manage shoulder abnormality. 4. Explain the advantages and disadvantages of microsurgical nerve reconstruction and distal nerve transfers in brachial plexus birth injury. 5. Recognize the prevalence of pain in this population and the need for greater sensory outcomes evaluation.
    Summary: Brachial plexus birth injury (BPBI) results from closed traction injury to the brachial plexus in the neck during an infant's vertex passage through the birth canal. Although spontaneous upper limb recovery occurs in most instances of BPBI, some infants do not demonstrate adequate motor recovery within an acceptable timeline and require surgical intervention to restore upper limb function. This article reviews major advances in the management of BPBI in the past decade that include improved understanding of shoulder pathology and its impact on observed motor recovery, novel surgical techniques, new insights in sensory function and pain, and global efforts to develop standardized outcomes assessment scales.
    MeSH term(s) Infant ; Humans ; Brachial Plexus Neuropathies/diagnosis ; Brachial Plexus Neuropathies/etiology ; Brachial Plexus Neuropathies/surgery ; Birth Injuries/complications ; Birth Injuries/surgery ; Brachial Plexus/surgery ; Brachial Plexus/injuries ; Neurosurgical Procedures/methods ; Nerve Transfer/methods
    Language English
    Publishing date 2023-04-26
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 208012-6
    ISSN 1529-4242 ; 0032-1052 ; 0096-8501
    ISSN (online) 1529-4242
    ISSN 0032-1052 ; 0096-8501
    DOI 10.1097/PRS.0000000000010047
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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.142: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 293: Show issues

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  8. Article ; Online: Primitive Myxoid Mesenchymal Tumor of Infancy With Brain Metastasis Case Report and Literature Review.

    Raved, Dan / Villani, Anita / Hopyan, Sevan / Chen, Haiying / German, Anna / Gupta, Abha A

    Journal of pediatric hematology/oncology

    2023  Volume 45, Issue 8, Page(s) e980–e983

    Abstract: Primitive myxoid mesenchymal tumor of infancy (PMMTI), a rare soft tissue tumor with distinct characteristics. PMMTI tends to have an aggressive local course, with multiple relapses and poor response to treatment. Rare cases of distant metastases have ... ...

    Abstract Primitive myxoid mesenchymal tumor of infancy (PMMTI), a rare soft tissue tumor with distinct characteristics. PMMTI tends to have an aggressive local course, with multiple relapses and poor response to treatment. Rare cases of distant metastases have been described before. We described the second case of PMMTI with brain metastasis.
    MeSH term(s) Humans ; Infant ; Neoplasm Recurrence, Local/pathology ; Sarcoma ; Soft Tissue Neoplasms/pathology ; Brain Neoplasms
    Language English
    Publishing date 2023-07-21
    Publishing country United States
    Document type Review ; Case Reports ; Journal Article
    ZDB-ID 1231152-2
    ISSN 1536-3678 ; 1077-4114 ; 0192-8562
    ISSN (online) 1536-3678
    ISSN 1077-4114 ; 0192-8562
    DOI 10.1097/MPH.0000000000002721
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1537: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Management of Brachial Plexus Birth Injury: The SickKids Experience

    Cawthorn, Thomas R. / Hopyan, Sevan / Clarke, Howard M. / Davidge, Kristen M.

    Seminars in Plastic Surgery

    (Brachial Plexus Birth injuries)

    2023  Volume 37, Issue 02, Page(s) 89–101

    Abstract: This article describes the approach utilized by the multidisciplinary team at Sick Kids Hospital to evaluate and treat patients with brachial plexus birth injury (BPBI). This approach has been informed by more than 30 years of experience treating over 1, ... ...

    Series title Brachial Plexus Birth injuries
    Abstract This article describes the approach utilized by the multidisciplinary team at Sick Kids Hospital to evaluate and treat patients with brachial plexus birth injury (BPBI). This approach has been informed by more than 30 years of experience treating over 1,800 patients with BPBI and continues to evolve over time. The objective of this article is to provide readers with a practical overview of the Sick Kids approach to the management of infants with BPBI.
    Keywords brachial plexus ; birth injury ; microsurgery ; glenohumeral dysplasia
    Language English
    Publishing date 2023-05-01
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2077828-4
    ISSN 1536-0067 ; 1535-2188
    ISSN (online) 1536-0067
    ISSN 1535-2188
    DOI 10.1055/s-0043-1769930
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4383: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Patterning the embryonic pulmonary mesenchyme.

    Goodwin, Katharine / Jaslove, Jacob M / Tao, Hirotaka / Zhu, Min / Hopyan, Sevan / Nelson, Celeste M

    iScience

    2022  Volume 25, Issue 3, Page(s) 103838

    Abstract: Smooth muscle guides the morphogenesis of several epithelia during organogenesis, including the mammalian airways. However, it remains unclear how airway smooth muscle differentiation is spatiotemporally patterned and whether it originates from ... ...

    Abstract Smooth muscle guides the morphogenesis of several epithelia during organogenesis, including the mammalian airways. However, it remains unclear how airway smooth muscle differentiation is spatiotemporally patterned and whether it originates from transcriptionally distinct mesenchymal progenitors. Using single-cell RNA-sequencing of embryonic mouse lungs, we show that the pulmonary mesenchyme contains a continuum of cell identities, but no transcriptionally distinct progenitors. Transcriptional variability correlates with spatially distinct sub-epithelial and sub-mesothelial mesenchymal compartments that are regulated by Wnt signaling. Live-imaging and tension-sensors reveal compartment-specific migratory behaviors and cortical forces and show that sub-epithelial mesenchyme contributes to airway smooth muscle. Reconstructing differentiation trajectories reveals early activation of cytoskeletal and Wnt signaling genes. Consistently, Wnt activation induces the earliest stages of smooth muscle differentiation and local accumulation of mesenchymal F-actin, which influences epithelial morphology. Our single-cell approach uncovers the principles of pulmonary mesenchymal patterning and identifies a morphogenetically active mesenchymal layer that sculpts the airway epithelium.
    Language English
    Publishing date 2022-01-29
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2022.103838
    Database MEDical Literature Analysis and Retrieval System OnLINE

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