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  1. Article ; Online: Respiratorische Allergien bei Kindern und Jugendlichen--Stellenwert der Komponentendiagnostik und spezifischen Immuntherapie.

    Horak, Fritz

    Wiener medizinische Wochenschrift (1946)

    2015  Volume 165, Issue 17-18, Page(s) 347–353

    Abstract: Respiratory allergies of children and adolescents are an important issue in allergology. In parallel to increasing prevalence rates also research has rapidly been developing for the last 10 years. Today we can better understand complex systems to improve ...

    Title translation Respiratory allergies in children and adolescents: the role of component-resolved diagnosis and specific immunotherapy.
    Abstract Respiratory allergies of children and adolescents are an important issue in allergology. In parallel to increasing prevalence rates also research has rapidly been developing for the last 10 years. Today we can better understand complex systems to improve our diagnostic and therapeutic accuracy. In addition to medical history, skin-prick-testing and analysis of specific IgE to allergen extracts, component resolved diagnosis has gained importance in the last years. While being increasingly helpful in the diagnosis of insect-venom and food-allergies, component-based diagnosis can also improve the management of patients with respiratory allergies. Concerning different therapeutic approaches like allergen-avoidance or symptomatic therapy, specific immunotherapy (SIT) is one of the most interesting therapy-options, as it is still the only causal therapy available. After reasonable patient-selection and the selection of the right allergen and product, SIT has a very good risk/benefit-ration and can induce long-term immuno-tolerance to specific allergens.
    MeSH term(s) Adolescent ; Allergens/immunology ; Child ; Desensitization, Immunologic/methods ; Epitopes/immunology ; Humans ; Immunoglobulin E/blood ; Intradermal Tests ; Recurrence ; Respiratory Hypersensitivity/etiology ; Respiratory Hypersensitivity/immunology ; Respiratory Hypersensitivity/therapy
    Chemical Substances Allergens ; Epitopes ; Immunoglobulin E (37341-29-0)
    Language German
    Publishing date 2015-09
    Publishing country Austria
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 123613-1
    ISSN 1563-258X ; 0254-7945 ; 0043-5341
    ISSN (online) 1563-258X
    ISSN 0254-7945 ; 0043-5341
    DOI 10.1007/s10354-015-0375-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: T-cell subset changes during the first year of pre-seasonal allergoid allergen-specific immunotherapy.

    Reithofer, Manuel / Boell, Simone Lisa / Kitzmueller, Claudia / Horak, Fritz / Bohle, Barbara / Jahn-Schmid, Beatrice

    Heliyon

    2023  Volume 9, Issue 11, Page(s) e21878

    Abstract: Allergen-specific immunotherapy (AIT) is the only treatment for type I allergy, which achieves long-lasting effects. Repeated subcutaneous applications of allergen extracts cause a protective antibody response and an immune deviation of T cells. In AIT ... ...

    Abstract Allergen-specific immunotherapy (AIT) is the only treatment for type I allergy, which achieves long-lasting effects. Repeated subcutaneous applications of allergen extracts cause a protective antibody response and an immune deviation of T cells. In AIT with allergoids, chemically modified allergen extracts are injected. During a so-called special pre-seasonal application scheme, after the initial phase of applying increased doses of allergoids is followed by natural allergen exposure as a maintenance phase. The effectiveness of allergoid vaccines has been described regarding the improvement of clinical symptoms and the development of protective humoral responses. In this longitudinal observational study, we sought to investigate changes at the T cell level in pre-seasonal AIT with allergoid. Different subsets within CD4
    Language English
    Publishing date 2023-11-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e21878
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: FDA warning montelukast 03.2020-Statement of the Austrian working group of pediatric pulmonology and allergology.

    Zschocke, Anna / Horak, Fritz / Eber, Ernst / Frischer, Thomas / Simma, Burkhardt / Stetzl, Wolfgang / Riedler, Josef / Szépfalusi, Zsolt / Zacharasiewicz, Angela

    Wiener klinische Wochenschrift

    2021  Volume 134, Issue 1-2, Page(s) 86–88

    Abstract: Montelukast, a leukotriene receptor antagonist (LTRA) has been approved for use in Europe since 1998. Indications for use (from the age of 6 months) include mild to moderate asthma, seasonal allergic rhinitis with asthma, and the prevention of exercise- ... ...

    Abstract Montelukast, a leukotriene receptor antagonist (LTRA) has been approved for use in Europe since 1998. Indications for use (from the age of 6 months) include mild to moderate asthma, seasonal allergic rhinitis with asthma, and the prevention of exercise-induced asthma episodes. The psychiatric side effects of montelukast have been known for the last 10 years; in the case of such symptoms benefits and risks should be considered. Due to potential life-threatening psychiatric adverse events, particularly suicide, a black box warning was issued. In this statement the Austrian working group of pediatric pulmonology and allergology advises that treatment with montelukast should be started only after critical evaluation. Treatment should be stopped on the occurrence of any neuropsychiatric side effects.
    MeSH term(s) Acetates/adverse effects ; Anti-Asthmatic Agents/adverse effects ; Austria ; Child ; Cyclopropanes ; Humans ; Infant ; Pulmonary Medicine ; Quinolines/adverse effects ; Sulfides
    Chemical Substances Acetates ; Anti-Asthmatic Agents ; Cyclopropanes ; Quinolines ; Sulfides ; montelukast (MHM278SD3E)
    Language English
    Publishing date 2021-12-13
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 200462-8
    ISSN 1613-7671 ; 0043-5325 ; 0300-5178
    ISSN (online) 1613-7671
    ISSN 0043-5325 ; 0300-5178
    DOI 10.1007/s00508-021-01981-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Answers to burning questions for clinical allergologists related to the new COVID-19 vaccines.

    Altrichter, Sabine / Wöhrl, Stefan / Horak, Fritz / Idzko, Marco / Jordakieva, Galateja / Untersmayr, Eva / Szepfalusi, Zsolt / Zieglmayer, Petra / Jensen-Jarolim, Erika / Wiedermann, Ursula / Rosenkranz, Alexander / Hötzenecker, Wolfram

    Allergo journal international

    2021  Volume 30, Issue 5, Page(s) 169–175

    Abstract: Background: Along with the newly approved vaccines against coronavirus disease 2019 (COVID-19), first reports of allergic or intolerance reactions were published. Subsequently, questions arose whether these vaccines pose an increased risk for ... ...

    Abstract Background: Along with the newly approved vaccines against coronavirus disease 2019 (COVID-19), first reports of allergic or intolerance reactions were published. Subsequently, questions arose whether these vaccines pose an increased risk for intolerance reactions and whether allergic patients may be at higher risk for this.
    Results: Allergic reactions following COVID-19 vaccinations have been reported, but mostly of mild severity and at normal (Moderna®) or only slightly increased frequency (BioNTech/Pfizer®) compared to established conventional vaccines. The risk of allergic reaction to the newly licensed vector vaccines (AstraZeneca®, Johnson&Johnson®) cannot be conclusively assessed yet, but also appears to be low. There is currently no evidence that patients with allergic diseases (atopic patients) react more frequently or more severely to these vaccines. It is currently assumed that intolerance reactions of the immediate-type are either type I allergic (IgE-mediated) reactions or occur via complement activation (CARPA, "complement activation-related pseudoallergy"). Polyethylene glycol (PEG) or polysorbate, which are present as stabilizers in the vaccines, are suspected as triggers for this.
    Conclusion: The data available so far do not show a significantly increased risk of immediate-type allergic reactions in atopic persons. In almost all cases, atopic patients can be vaccinated without problems. Standardized follow-up tests after suspected allergic reactions or CARPA-mediated reactions are currently limited.
    Language English
    Publishing date 2021-07-14
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 2197-0378
    ISSN 2197-0378
    DOI 10.1007/s40629-021-00177-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: IgE-cross-blocking antibodies to Fagales following sublingual immunotherapy with recombinant Bet v 1.

    Grilo, João Rodrigues / Kitzmüller, Claudia / Aglas, Lorenz / Sánchez Acosta, Gabriela / Vollmann, Ute / Ebner, Christof / Horak, Fritz / Kinaciyan, Tamar / Radauer, Christian / Ferreira, Fatima / Jahn-Schmid, Beatrice / Bohle, Barbara

    Allergy

    2021  Volume 76, Issue 8, Page(s) 2555–2564

    Abstract: Background: Evidence has accumulated that birch pollen immunotherapy reduces rhinoconjunctivitis to pollen of birch homologous trees. Therapeutic efficacy has been associated with IgE-blocking IgG antibodies. We have recently shown that sera collected ... ...

    Abstract Background: Evidence has accumulated that birch pollen immunotherapy reduces rhinoconjunctivitis to pollen of birch homologous trees. Therapeutic efficacy has been associated with IgE-blocking IgG antibodies. We have recently shown that sera collected after 16 weeks of sublingual immunotherapy with recombinant Bet v 1 (rBet v 1-SLIT) display strong IgE-blocking bioactivity for Bet v 1. Here, we assessed whether rBet v 1-SLIT-induced IgG antibodies display cross-blocking activity to related allergens in Fagales pollen.
    Methods: IgE, IgG1 and IgG4 reactivity to recombinant Bet v 1, Aln g 1, Car b 1, Ost c 1, Cor a 1, Fag s 1, Cas s 1 and Que a 1 were assessed in pre- and post-SLIT samples of 17 individuals by ELISA. A basophil inhibition assay using stripped basophils re-sensitized with a serum pool containing high Bet v 1-specific IgE levels was established and used to assess CD63 expression in response to allergens after incubation with pre-SLIT or post-SLIT samples. IgG1 and IgG4 were depleted from post-SLIT samples to assess its contribution to IgE-cross-blocking.
    Results: Sublingual immunotherapy with recombinant Bet v 1 boosted cross-reactive IgE antibodies and induced IgG1 and IgG4 antibodies with inter- and intra-individually differing reactivity to the homologs. Highly variable cross-blocking activities of post-SLIT samples to the different allergens were found. IgG1 and IgG4 antibodies displayed cross-blocking activity with individual variance.
    Conclusions: Our mechanistic approach suggested that immunotherapy with the reference allergen Bet v 1 induces individual repertoires of cross-reactive IgG1 and IgG4 antibodies. The cross-blocking bioactivity of these antibodies was also highly variable and neither predictable from protein homology nor IgE-cross-reactivity.
    MeSH term(s) Allergens ; Antibodies, Blocking ; Antigens, Plant/immunology ; Antigens, Plant/therapeutic use ; Fagales ; Humans ; Immunoglobulin E ; Plant Proteins ; Recombinant Proteins ; Sublingual Immunotherapy
    Chemical Substances Allergens ; Antibodies, Blocking ; Antigens, Plant ; Plant Proteins ; Recombinant Proteins ; Bet v 1 allergen, Betula (126161-14-6) ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2021-05-06
    Publishing country Denmark
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.14817
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Therapie mit inhalativen Glukokortikoiden bei COVID-19.

    Idzko, Marco / Lommatzsch, Marek / Taube, Christian / Eber, Ernst / Lamprecht, Bernd / Horak, Fritz / Pohl, Wolfgang / Rabe, Klaus F / Virchow, Johann Christian / Hamelmann, Eckard / Pfeifer, Michael / Bauer, Torsten / Buhl, Roland

    Pneumologie (Stuttgart, Germany)

    2021  Volume 75, Issue 6, Page(s) 418–420

    Title translation Treatment of COVID-19 with Inhaled Glucocorticoids - Statement of the German Respiratory Society (DGP), the Austrian Society of Pneumology (ÖGP) and the German Society of Allergology and Clinical Immunology (DGAKI).
    MeSH term(s) Austria ; Budesonide ; COVID-19 ; Glucocorticoids ; Humans ; Pulmonary Medicine ; SARS-CoV-2
    Chemical Substances Glucocorticoids ; Budesonide (51333-22-3)
    Language German
    Publishing date 2021-05-17
    Publishing country Germany
    Document type Journal Article ; Comment
    ZDB-ID 607630-0
    ISSN 1438-8790 ; 0934-8387
    ISSN (online) 1438-8790
    ISSN 0934-8387
    DOI 10.1055/a-1488-5373
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [No title information]

    Altrichter, Sabine / Wöhrl, Stefan / Horak, Fritz / Idzko, Marco / Jordakieva, Galateja / Untersmayr, Eva / Szepfalusi, Zsolt / Zieglmayer, Petra / Jensen-Jarolim, Erika / Wiedermann, Ursula / Rosenkranz, Alexander / Hötzenecker, Wolfram

    Allergo Journal : interdisziplinare Zeitschrift fur Allergologie und Umweltmedizin : Organ der Deutschen Gesellschaft fur Allergie- und Immunitatsforschung

    2021  Volume 30, Issue 5, Page(s) 48–54

    Title translation Antworten auf brennende Fragen an klinische Allergolog*innen im Zusammenhang mit den neuen COVID-19-Impfstoffen.
    Language German
    Publishing date 2021-08-13
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1136943-7
    ISSN 0941-8849
    ISSN 0941-8849
    DOI 10.1007/s15007-021-4847-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Erratum: S2k-Leitlinie zur fachärztlichen Diagnostik und Therapie von Asthma 2023.

    Lommatzsch, Marek / Criée, Carl-Peter / de Jong, Carmen C M / Gappa, Monika / Geßner, Christian / Gerstlauer, Michael / Hämäläinen, Nina / Haidl, Peter / Hamelmann, Eckard / Horak, Fritz / Idzko, Marco / Ignatov, Atanas / Koczulla, Andreas Rembert / Korn, Stephanie / Köhler, Michael / Lex, Christiane / Meister, Jochen / Milger-Kneidinger, Katrin / Nowak, Dennis /
    Nothacker, Monika / Pfaar, Oliver / Pohl, Wolfgang / Preisser, Alexandra M / Rabe, Klaus F / Riedler, Josef / Schmidt, Olaf / Schreiber, Jens / Schuster, Antje / Schuhmann, Maren / Spindler, Thomas / Taube, Christian / Christian Virchow, Johann / Vogelberg, Christian / Vogelmeier, Claus Franz / Wantke, Felix / Windisch, Wolfram / Worth, Heinrich / Zacharasiewicz, Angela / Buhl, Roland

    Pneumologie (Stuttgart, Germany)

    2024  Volume 77, Issue 8, Page(s) e3

    Title translation Diagnosis and treatment of asthma: a guideline for respiratory specialists 2023 - published by the German Respiratory Society (DGP) e. V.
    Language German
    Publishing date 2024-03-21
    Publishing country Germany
    Document type Journal Article ; Published Erratum
    ZDB-ID 607630-0
    ISSN 1438-8790 ; 0934-8387
    ISSN (online) 1438-8790
    ISSN 0934-8387
    DOI 10.1055/a-2284-8593
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Therapie mit inhalativen Glukokortikoiden bei COVID-19

    Idzko, Marco / Lommatzsch, Marek / Taube, Christian / Eber, Ernst / Lamprecht, Bernd / Horak, Fritz / Pohl, Wolfgang / Rabe, Klaus F. / Virchow, Johann Christian / Hamelmann, Eckard / Pfeifer, Michael / Bauer, Torsten / Buhl, Roland

    Pneumologie

    2021  Volume 75, Issue 06, Page(s) 418–420

    Language German
    Publishing date 2021-05-17
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 607630-0
    ISSN 1438-8790 ; 0934-8387
    ISSN (online) 1438-8790
    ISSN 0934-8387
    DOI 10.1055/a-1488-5373
    Database Thieme publisher's database

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  10. Article ; Online: Diagnosis and management of asthma - Statement on the 2015 GINA Guidelines.

    Horak, Fritz / Doberer, Daniel / Eber, Ernst / Horak, Elisabeth / Pohl, Wolfgang / Riedler, Josef / Szépfalusi, Zsolt / Wantke, Felix / Zacharasiewicz, Angela / Studnicka, Michael

    Wiener klinische Wochenschrift

    2016  Volume 128, Issue 15-16, Page(s) 541–554

    Abstract: This statement was written by a group of pulmonologists and pediatric pulmonologists belonging to the corresponding professional associations ÖGP (Austrian Society for Pulmonology) and ÖGKJ (Austrian Society for pediatric and adolescent medicine) to ... ...

    Abstract This statement was written by a group of pulmonologists and pediatric pulmonologists belonging to the corresponding professional associations ÖGP (Austrian Society for Pulmonology) and ÖGKJ (Austrian Society for pediatric and adolescent medicine) to provide a concise overview of the latest updates in the 2015 GINA Guidelines and to include aspects that are specific to Austria.
    MeSH term(s) Anti-Asthmatic Agents/administration & dosage ; Asthma/diagnosis ; Asthma/therapy ; Austria ; Child, Preschool ; Combined Modality Therapy/standards ; Drug Monitoring/standards ; Evidence-Based Medicine/standards ; Female ; Humans ; Immunotherapy/standards ; Infant ; Infant, Newborn ; Male ; Medical History Taking/standards ; Pediatrics/standards ; Practice Guidelines as Topic ; Pulmonary Medicine/standards ; Respiratory Function Tests/standards
    Chemical Substances Anti-Asthmatic Agents
    Language English
    Publishing date 2016-08
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 200462-8
    ISSN 1613-7671 ; 0043-5325 ; 0300-5178
    ISSN (online) 1613-7671
    ISSN 0043-5325 ; 0300-5178
    DOI 10.1007/s00508-016-1019-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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