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  1. AU="Horbay, Rostyslav"
  2. AU="Akdemir, Selim E"
  3. AU="Riviello, James J"
  4. AU="S, Bahja"
  5. AU="Quiñonez, C"
  6. AU=Chen Nancy
  7. AU="Behl, Gautam"
  8. AU="Zhang, Honghe"
  9. AU="Rian Roelofs"
  10. AU=Kellum John A.
  11. AU="César I. A. Vela"
  12. AU="van Riel, Annick"
  13. AU="Ting Shu"
  14. AU="Doria, Margaux"
  15. AU="Heinz Flessa"
  16. AU="R.Mittleman, "
  17. AU="F.Baldaccini, "
  18. AU="Butler, W R"

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Treffer 1 - 6 von insgesamt 6

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  1. Artikel ; Online: Role of Ceramides and Lysosomes in Extracellular Vesicle Biogenesis, Cargo Sorting and Release.

    Horbay, Rostyslav / Hamraghani, Ali / Ermini, Leonardo / Holcik, Sophie / Beug, Shawn T / Yeganeh, Behzad

    International journal of molecular sciences

    2022  Band 23, Heft 23

    Abstract: Cells have the ability to communicate with their immediate and distant neighbors through the release of extracellular vesicles (EVs). EVs facilitate intercellular signaling through the packaging of specific cargo in all type of cells, and perturbations ... ...

    Abstract Cells have the ability to communicate with their immediate and distant neighbors through the release of extracellular vesicles (EVs). EVs facilitate intercellular signaling through the packaging of specific cargo in all type of cells, and perturbations of EV biogenesis, sorting, release and uptake is the basis of a number of disorders. In this review, we summarize recent advances of the complex roles of the sphingolipid ceramide and lysosomes in the journey of EV biogenesis to uptake.
    Sprache Englisch
    Erscheinungsdatum 2022-12-05
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232315317
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Mitochondrial dynamics during cell cycling.

    Horbay, Rostyslav / Bilyy, Rostyslav

    Apoptosis : an international journal on programmed cell death

    2016  Band 21, Heft 12, Seite(n) 1327–1335

    Abstract: Mitochondria are the cell's power plant that must be in a proper functional state in order to produce the energy necessary for basic cellular functions, such as proliferation. Mitochondria are 'dynamic' in that they are constantly undergoing fission and ... ...

    Abstract Mitochondria are the cell's power plant that must be in a proper functional state in order to produce the energy necessary for basic cellular functions, such as proliferation. Mitochondria are 'dynamic' in that they are constantly undergoing fission and fusion to remain in a functional state throughout the cell cycle, as well as during other vital processes such as energy supply, cellular respiration and programmed cell death. The mitochondrial fission/fusion machinery is involved in generating young mitochondria, while eliminating old, damaged and non-repairable ones. As a result, the organelles change in shape, size and number throughout the cell cycle. Such precise and accurate balance is maintained by the cytoskeletal transporting system via microtubules, which deliver the mitochondrion from one location to another. During the gap phases G
    Sprache Englisch
    Erscheinungsdatum 2016-12
    Erscheinungsland Netherlands
    Dokumenttyp Review ; Journal Article
    ZDB-ID 1452360-7
    ISSN 1573-675X ; 1360-8185
    ISSN (online) 1573-675X
    ISSN 1360-8185
    DOI 10.1007/s10495-016-1295-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Giant cell formation

    Horbay Rostyslav / Stoika Rostyslav

    Open Life Sciences, Vol 6, Iss 5, Pp 675-

    the way to cell death or cell survival?

    2011  Band 684

    Schlagwörter nk/ly lymphoma ; giant cells ; mitotic catastrophe ; apoptosis ; neosis ; vinblastine ; paclitaxel ; β-tubulin ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2011-10-01T00:00:00Z
    Verlag De Gruyter
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel: Giant cell formation: the way to cell death or cell survival?

    Horbay, Rostyslav / Rostyslav Stoika

    Open life sciences. 2011 Sept. 2, v. 6, no. 5

    2011  

    Abstract: The study of giant cells in populations of different tumor cells and evaluation of their role in cancer development is an expanding field. The formation of giant cells has been shown to be followed by mitotic catastrophe, apoptosis, necrosis, and other ... ...

    Abstract The study of giant cells in populations of different tumor cells and evaluation of their role in cancer development is an expanding field. The formation of giant cells has been shown to be followed by mitotic catastrophe, apoptosis, necrosis, and other types of cell elimination. Reports also demonstrate that giant cells can escape cell death and give rise to new cancer cells. However, it is not known if the programmed cell death is involved in this type of cell cycle disorders. Here we describe principal events that are observed during giant cell formation. We also consider the role of giant cells in cancer development, taking into account both published work and our own recent data in this field.
    Schlagwörter apoptosis ; carcinogenesis ; cell viability ; giant cells ; mitosis ; necrosis ; neoplasm cells ; neoplasms
    Sprache Englisch
    Erscheinungsverlauf 2011-0902
    Umfang p. 675-684.
    Erscheinungsort Versita
    Dokumenttyp Artikel
    ZDB-ID 2817958-4
    ISSN 2391-5412
    ISSN 2391-5412
    DOI 10.2478/s11535-011-0058-0
    Datenquelle NAL Katalog (AGRICOLA)

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  5. Artikel ; Online: Respiration characteristics of mitochondria in parental and giant transformed cells of the murine Nemeth-Kellner lymphoma.

    Horbay, Rostyslav O / Manko, Bohdan O / Manko, Volodymyr V / Lootsik, Maxim D / Stoika, Rostyslav S

    Cell biology international

    2012  Band 36, Heft 1, Seite(n) 71–77

    Abstract: Respiration characteristics of mitochondria of the parental and giant cells of murine NK/Ly (Nemeth-Kellner lymphoma) were studied. The giant cell-enriched ascites were obtained by serial intraperitoneal injections of vinblastine in tumour-bearing mice. ... ...

    Abstract Respiration characteristics of mitochondria of the parental and giant cells of murine NK/Ly (Nemeth-Kellner lymphoma) were studied. The giant cell-enriched ascites were obtained by serial intraperitoneal injections of vinblastine in tumour-bearing mice. Ascites containing >70% giant cells were used. Their diameter of was over 17 μm (~2800 μm(3)), while the diameter of the parental cells was 12.7 μm (1100 μm(3)). The respiration rate of mitochondria in situ was measured by oxygen consumption in intact and digitonin-permeabilized NK/Ly cells. Endogenous respiration of intact giant NK/Ly cells was three times higher compared to the parental ones, roughly in agreement with the volume change. The giant NK/Ly cells were far more resistant to permeabilization with digitonin than the parental cells, as shown by Trypan Blue and LDH (lactate dehydrogenase) release tests. After digitonin permeabilization, oxygen consumption was reduced to a minimal level (0.06 ng atom O/(s × 106 cells) in both types of cells. Addition of α-ketoglutarate or succinate to the incubation medium increased oxygen consumption in the parental cells by 46 and 164% respectively. In the giant NK/Ly cells, the corresponding increases were 164 and 276%. Addition of ADP to α-ketoglutarate- or succinate-supplemented medium further stimulated oxygen consumption of the permeabilized NK/Ly cells; however, the effect of ADP was more pronounced in the giant cells. In addition, indices of respiratory control were significantly higher in the giant cells. Oligomycin suppressed considerably the respiration of the intact giant cells but had a much weaker effect on parental cells. Thus, giant NK/Ly cells possess much higher respiration rates and show tighter coupling between the respiration and oxidative phosphorylation compared with parental cells.
    Mesh-Begriff(e) Adenosine Diphosphate/pharmacology ; Animals ; Cell Line, Tumor ; Cell Membrane Permeability ; Cell Size ; Digitonin/pharmacology ; Giant Cells/drug effects ; Giant Cells/metabolism ; Ketoglutaric Acids/pharmacology ; L-Lactate Dehydrogenase/metabolism ; Lymphoma/metabolism ; Lymphoma/pathology ; Mice ; Mice, Inbred C57BL ; Mitochondria/drug effects ; Mitochondria/metabolism ; Oligomycins/pharmacology ; Oxidative Phosphorylation ; Oxygen Consumption/drug effects ; Respiration/drug effects ; Vinblastine/pharmacology
    Chemische Substanzen Ketoglutaric Acids ; Oligomycins ; Vinblastine (5V9KLZ54CY) ; Adenosine Diphosphate (61D2G4IYVH) ; alpha-ketoglutaric acid (8ID597Z82X) ; L-Lactate Dehydrogenase (EC 1.1.1.27) ; Digitonin (KOO5CM684H)
    Sprache Englisch
    Erscheinungsdatum 2012-01
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1143453-3
    ISSN 1095-8355 ; 1065-6995
    ISSN (online) 1095-8355
    ISSN 1065-6995
    DOI 10.1042/CBI20110017
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1451: Hefte anzeigen Standort:
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  6. Artikel ; Online: Visualization of melanoma tumor with lectin-conjugated rare-earth doped fluoride nanocrystals.

    Dumych, Tetiana / Lutsyk, Maxym / Banski, Mateusz / Yashchenko, Antonina / Sojka, Bartlomiej / Horbay, Rostyslav / Lutsyk, Alexander / Stoika, Rostyslav / Misiewicz, Jan / Podhorodecki, Artur / Bilyy, Rostyslav

    Croatian medical journal

    2014  Band 55, Heft 3, Seite(n) 186–194

    Abstract: Aim: To develop specific fluorescent markers for melanoma tumor visualization, which would provide high selectivity and reversible binding pattern, by the use of carbohydrate-recognizing proteins, lectins, combined with the physical ability for imaging ... ...

    Abstract Aim: To develop specific fluorescent markers for melanoma tumor visualization, which would provide high selectivity and reversible binding pattern, by the use of carbohydrate-recognizing proteins, lectins, combined with the physical ability for imaging deep in the living tissues by utilizing red and near infrared fluorescent properties of specific rare-earth doped nanocrystals (NC).
    Methods: B10F16 melanoma cells were inoculated to C57BL/6 mice for inducing experimental melanoma tumor. Tumors were removed and analyzed by lectin-histochemistry using LABA, PFA, PNA, HPA, SNA, GNA, and NPL lectins and stained with hematoxylin and eosin. NPL lectin was conjugated to fluorescent NaGdF4:Eu(3+)-COOH nanoparticles (5 nm) via zero length cross-linking reaction, and the conjugates were purified from unbound substances and then used for further visualization of histological samples. Fluorescent microscopy was used to visualize NPL-NaGdF4:Eu(3+) with the fluorescent emission at 600-720 nm range.
    Results: NPL lectin selectively recognized regions of undifferentiated melanoblasts surrounding neoangiogenic foci inside melanoma tumor, PNA lectin recognized differentiated melanoblasts, and LCA and WGA were bound to tumor stroma regions. NPL-NaGdF4:Eu(3+) conjugated NC were efficiently detecting newly formed regions of melanoma tumor, confirmed by fluorescent microscopy in visible and near infrared mode. These conjugates possessed high photostability and were compatible with convenient xylene-based mounting systems and preserved intensive fluorescent signal at samples storage for at least 6 months.
    Conclusion: NPL lectin-NaGdF4:Eu(3+) conjugated NC permitted distinct identification of contours of the melanoma tissue on histological sections using red excitation at 590-610 nm and near infrared emission of 700-720 nm. These data are of potential practical significance for development of glycans-conjugated nanoparticles to be used for in vivo visualization of melanoma tumor.
    Mesh-Begriff(e) Animals ; Antigens, Neoplasm/metabolism ; Antigens, Tumor-Associated, Carbohydrate/metabolism ; Fluorescent Dyes ; Histocytochemistry ; Humans ; Lectins/metabolism ; Melanoma, Experimental/metabolism ; Melanoma, Experimental/pathology ; Metals, Rare Earth ; Mice ; Mice, Inbred C57BL ; Microscopy, Fluorescence/methods ; Nanoparticles ; Neoplasm Proteins/metabolism ; Skin Neoplasms/metabolism ; Skin Neoplasms/pathology
    Chemische Substanzen Antigens, Neoplasm ; Antigens, Tumor-Associated, Carbohydrate ; Fluorescent Dyes ; Lectins ; Metals, Rare Earth ; Neoplasm Proteins
    Sprache Englisch
    Erscheinungsdatum 2014-06-02
    Erscheinungsland Croatia
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1157623-6
    ISSN 1332-8166 ; 0353-9504
    ISSN (online) 1332-8166
    ISSN 0353-9504
    DOI 10.3325/cmj.2014.55.186
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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