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  1. Article ; Online: A profile of research on the parasitic trypanosomatids and the diseases they cause.

    Horn, David

    PLoS neglected tropical diseases

    2022  Volume 16, Issue 1, Page(s) e0010040

    Abstract: The parasitic trypanosomatids cause lethal and debilitating diseases, the leishmaniases, Chagas disease, and the African trypanosomiases, with major impacts on human and animal health. Sustained research has borne fruit by assisting efforts to reduce the ...

    Abstract The parasitic trypanosomatids cause lethal and debilitating diseases, the leishmaniases, Chagas disease, and the African trypanosomiases, with major impacts on human and animal health. Sustained research has borne fruit by assisting efforts to reduce the burden of disease and by improving our understanding of fundamental molecular and cell biology. But where has the research primarily been conducted, and which research areas have received the most attention? These questions are addressed below using publication and citation data from the past few decades.
    MeSH term(s) Animals ; Euglenozoa Infections/epidemiology ; Euglenozoa Infections/parasitology ; Global Health ; Humans ; Research ; Trypanosomatina
    Language English
    Publishing date 2022-01-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2735
    ISSN (online) 1935-2735
    ISSN 1935-2735
    DOI 10.1371/journal.pntd.0010040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Thesis: Verbessertes Therapieansprechen des Plattenepithelkarzinoms der Kopf- und Halsregion auf Bestrahlung nach Inhibition des PI3K/AKT-Signalwegs in der ex vivo Gewebekultur

    Horn, Dominik

    2015  

    Author's details vorgelegt von Dominik Andreas Horn
    Language German
    Size 94 S. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2015
    HBZ-ID HT018827227
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 E 2015 order for loan Magazin

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  3. Article ; Online: Genome-scale RNAi screens in African trypanosomes.

    Horn, David

    Trends in parasitology

    2021  Volume 38, Issue 2, Page(s) 160–173

    Abstract: Genome-scale genetic screens allow researchers to rapidly identify the genes and proteins that impact a particular phenotype of interest. In African trypanosomes, RNA interference (RNAi) knockdown screens have revealed mechanisms underpinning drug ... ...

    Abstract Genome-scale genetic screens allow researchers to rapidly identify the genes and proteins that impact a particular phenotype of interest. In African trypanosomes, RNA interference (RNAi) knockdown screens have revealed mechanisms underpinning drug resistance, drug transport, prodrug metabolism, quorum sensing, genome replication, and gene expression control. RNAi screening has also been remarkably effective at highlighting promising potential antitrypanosomal drug targets. The first ever RNAi library screen was implemented in African trypanosomes, and genome-scale RNAi screens and other related approaches continue to have a major impact on trypanosomatid research. Here, I review those impacts in terms of both discovery and translation.
    MeSH term(s) Animals ; Antiprotozoal Agents/pharmacology ; Genome ; RNA Interference ; Trypanosoma/genetics ; Trypanosoma brucei brucei/genetics ; Trypanosoma brucei brucei/metabolism ; Trypanosomiasis, African/drug therapy
    Chemical Substances Antiprotozoal Agents
    Language English
    Publishing date 2021-09-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2021.09.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2898: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 16: Show issues
    Zs.MO 251: Show issues

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  4. Article: Forschung und Entwicklung. Die neuen Leitsätze für Fleisch und Fleischerzeugnisse - Rechtliche Anpassungen, überarbeitete Leitsatzziffer-Struktur und neu vergebene Leitsatznummern. The new version of the Guidelines for Meat and Meat Products - Legal adjustments, revised guideline numbering structure and newly assigned guideline numbers

    Horn, Detlef

    Fleischwirtschaft

    2022  Volume 102, Issue 9, Page(s) 74

    Language German
    Document type Article
    ZDB-ID 41203-X
    ISSN 0015-363X
    Database Current Contents Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

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  5. Article: Genome-scale RNAi screens in African trypanosomes

    Horn, David

    Trends in parasitology. 2022 Feb., v. 38, no. 2

    2022  

    Abstract: Genome-scale genetic screens allow researchers to rapidly identify the genes and proteins that impact a particular phenotype of interest. In African trypanosomes, RNA interference (RNAi) knockdown screens have revealed mechanisms underpinning drug ... ...

    Abstract Genome-scale genetic screens allow researchers to rapidly identify the genes and proteins that impact a particular phenotype of interest. In African trypanosomes, RNA interference (RNAi) knockdown screens have revealed mechanisms underpinning drug resistance, drug transport, prodrug metabolism, quorum sensing, genome replication, and gene expression control. RNAi screening has also been remarkably effective at highlighting promising potential antitrypanosomal drug targets. The first ever RNAi library screen was implemented in African trypanosomes, and genome-scale RNAi screens and other related approaches continue to have a major impact on trypanosomatid research. Here, I review those impacts in terms of both discovery and translation.
    Keywords RNA interference ; Trypanosoma ; drug resistance ; drugs ; gene expression ; metabolism ; parasitology ; phenotype
    Language English
    Dates of publication 2022-02
    Size p. 160-173.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2021.09.002
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2898: Show issues Location:
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    Zs.MO 251: Show issues

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  6. Book ; Thesis: Immunsuppressiver Effekt Mesenchymaler Stammzellen aus Fettgewebe im Rattenmodell

    Horn, Dominik

    2012  

    Author's details vorgelegt von Dominik Andreas Horn
    Language German
    Size 78 Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2013
    HBZ-ID HT018093216
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 E 1162 order for loan Magazin

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  7. Article ; Online: Liver Laceration Secondary to Resuscitation.

    Zensen, Sebastian / Horn, Detlef

    Deutsches Arzteblatt international

    2022  Volume 119, Issue 24, Page(s) 417

    MeSH term(s) Humans ; Lacerations/etiology ; Liver/diagnostic imaging ; Liver/injuries ; Resuscitation
    Language English
    Publishing date 2022-09-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.m2022.0018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Parallel Activation of Memories in an Oscillatory Neural Network.

    Horn, D / Usher, M

    Neural computation

    2019  Volume 3, Issue 1, Page(s) 31–43

    Abstract: We describe a feedback neural network whose elements possess dynamic thresholds. This network has an oscillatory mode that we investigate by measuring the activities of memory patterns as functions of time. We observe spontaneous and induced transitions ... ...

    Abstract We describe a feedback neural network whose elements possess dynamic thresholds. This network has an oscillatory mode that we investigate by measuring the activities of memory patterns as functions of time. We observe spontaneous and induced transitions between the different oscillating memories. Moreover, the network exhibits pattern segmentation, by oscillating between different memories that are included as a mixture in a constant input. The efficiency of pattern segmentation decreases strongly as the number of the input memories is increased. Using oscillatory inputs we observe resonance behavior.
    Language English
    Publishing date 2019-05-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1025692-1
    ISSN 1530-888X ; 0899-7667
    ISSN (online) 1530-888X
    ISSN 0899-7667
    DOI 10.1162/neco.1991.3.1.31
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2914: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article ; Online: Genome-wide screens connect HD82 loss-of-function to purine analog resistance in African trypanosomes.

    Trenaman, Anna / Tinti, Michele / Atrih, Abdelmadjid / Horn, David

    mSphere

    2023  Volume 9, Issue 1, Page(s) e0036323

    Abstract: Nucleoside analogs have been used extensively as anti-infective agents, particularly against viral infections, and have long been considered promising anti-parasitic agents. These pro-drugs are metabolized by host-cell, viral, or parasite enzymes prior ... ...

    Abstract Nucleoside analogs have been used extensively as anti-infective agents, particularly against viral infections, and have long been considered promising anti-parasitic agents. These pro-drugs are metabolized by host-cell, viral, or parasite enzymes prior to incorporation into DNA, thereby inhibiting DNA replication. Here, we report genes that sensitize African trypanosomes to nucleoside analogs, including the guanosine analog, ganciclovir. We applied ganciclovir selective pressure to a trypanosome genome-wide knockdown library, which yielded nucleoside mono- and diphosphate kinases as hits, validating the approach. The two most dominant hits to emerge, however, were Tb927.6.2800 and Tb927.6.2900, which both encode nuclear proteins; the latter of which is HD82, a SAMHD1-related protein and a putative dNTP triphosphohydrolase. We independently confirmed that HD82, which is conserved among the trypanosomatids, can sensitize
    MeSH term(s) Animals ; Nucleosides/metabolism ; SAM Domain and HD Domain-Containing Protein 1 ; Trypanosoma/metabolism ; Purines/metabolism ; Nucleotides/metabolism ; Ganciclovir/metabolism ; Mammals
    Chemical Substances Nucleosides ; SAM Domain and HD Domain-Containing Protein 1 (EC 3.1.5.-) ; Purines ; Nucleotides ; Ganciclovir (P9G3CKZ4P5)
    Language English
    Publishing date 2023-12-21
    Publishing country United States
    Document type Journal Article
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/msphere.00363-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Mild to Moderate Intellectual Disability and Significant Speech and Language Deficits in Patients with FOXP1 Deletions and Mutations.

    Horn, D

    Molecular syndromology

    2011  Volume 2, Issue 3-5, Page(s) 213–216

    Abstract: Very recently, FOXP1 deficiency was shown to result in a phenotype of intellectual disability with significant speech and language impairment. Behavioral abnormalities should be considered as part of the clinical spectrum. Mild craniofacial abnormalities ...

    Abstract Very recently, FOXP1 deficiency was shown to result in a phenotype of intellectual disability with significant speech and language impairment. Behavioral abnormalities should be considered as part of the clinical spectrum. Mild craniofacial abnormalities found in half of the described patients expand the clinical spectrum associated with FOXP1 mutations.
    Language English
    Publishing date 2011-08-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2546218-0
    ISSN 1661-8777 ; 1661-8769
    ISSN (online) 1661-8777
    ISSN 1661-8769
    DOI 10.1159/000330916
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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