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Article ; Online: “Beef Jerky in a Ball Gown”

Dexl Carmen / Horn Katrin

Open Cultural Studies, Vol 1, Iss 1, Pp 442-

The Camp Excesses of Titus Andromedon in Unbreakable Kimmy Schmidt

2017 Volume 453

Abstract: In this essay, we look at Titus Andromedon from the Netflix-sitcom Unbreakable Kimmy Schmidt (2014-) as a singular phenomenon in contemporary TV: a black queen whose use of camp distances him from stereotypes, but connects him with audiences. Titus thus ... ...

Abstract	In this essay, we look at Titus Andromedon from the Netflix-sitcom Unbreakable Kimmy Schmidt (2014-) as a singular phenomenon in contemporary TV: a black queen whose use of camp distances him from stereotypes, but connects him with audiences. Titus thus not only adds to a more diverse representation of black experience on TV but also interrogates prevailing TV tropes. Titus thus presents a crucial (and critical) addition to the contemporary TV landscape, to which several TV critics in leading media outlets have recently attested a turning point in the representation-both in quantity and quality-of black characters on big and small screens. Titus breaks with historical traditions of African American representation in the sitcom, both in so-called “black sitcoms” with a majority of African American characters and in white sitcoms which have featured people of color as sidekicks. In addition, Titus picks up on gay sidekicks and their relation to female lead characters, whose dynamics are interrogated through Titus’s growing agency as a character in his own right. Titus expands on these novelties in meaningful ways, as he wholeheartedly embraces his queer identity and furthermore offers a running commentary on other characters’ “white nonsense,” thereby clearly refusing the assimilationist tendencies typical for much of “Post-Cosby”-sitcom black representation. This article therefore claims that Titus’ character relies on camp in his balancing act between comic relief, affective centering, and critical distance, and illustrates this by analyzing the specific techniques of Titus’ critical engagement with stereotypical representation of gay and black TV characters.
Keywords	unbreakable kimmy schmidt ; camp ; sitcom ; queer ; black ; representation ; Social sciences (General) ; H1-99
Subject code	820
Language	English
Publishing date	2017-12-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: First genome-wide association study of 99 body measures derived from 3-dimensional body scans.

Kühnapfel, Andreas / Ahnert, Peter / Horn, Katrin / Kirsten, Holger / Loeffler, Markus / Scholz, Markus

Genes & diseases

2021 Volume 9, Issue 3, Page(s) 777–788

Abstract: Body height, body mass index, hip and waist circumference are important risk factors or outcome variables in clinical and epidemiological research with complex underlying genetics. However, these classical anthropometric traits represent only a very ... ...

Abstract	Body height, body mass index, hip and waist circumference are important risk factors or outcome variables in clinical and epidemiological research with complex underlying genetics. However, these classical anthropometric traits represent only a very limited view on the human body and other traits with potentially higher functional specificity are not yet studied to a larger extent. Participants of LIFE-Adult were assessed by three-dimensional body scanner VITUS XXL determining 99 high-quality anthropometric traits in parallel. Genotyping was performed by Axiom Genome-Wide CEU 1 Array Plate microarray technology and imputation was done using 1000 Genomes phase 3 reference panel. Combined phenotype and genetic information are available for a total of 7,562 participants. Largest heritabilities were estimated for height traits (maximum heritability with h
Language	English
Publishing date	2021-02-16
Publishing country	China
Document type	Journal Article
ZDB-ID	2821806-1
ISSN	2352-3042 ; 2352-3042
ISSN (online)	2352-3042
ISSN	2352-3042
DOI	10.1016/j.gendis.2021.02.003
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Article ; Online: Genetic Regulation of Cytokine Response in Patients with Acute Community-Acquired Pneumonia.

Kühnapfel, Andreas / Horn, Katrin / Klotz, Ulrike / Kiehntopf, Michael / Rosolowski, Maciej / Loeffler, Markus / Ahnert, Peter / Suttorp, Norbert / Witzenrath, Martin / Scholz, Markus

Genes

2022 Volume 13, Issue 1

Abstract: Background: Community-acquired pneumonia (CAP) is an acute disease condition with a high risk of rapid deteriorations. We analysed the influence of genetics on cytokine regulation to obtain a better understanding of patient's heterogeneity.: Methods: ...

Abstract	Background: Community-acquired pneumonia (CAP) is an acute disease condition with a high risk of rapid deteriorations. We analysed the influence of genetics on cytokine regulation to obtain a better understanding of patient's heterogeneity. Methods: For up to Results: 102 SNPs from 14 loci showed genome-wide significant associations with five of the cytokines. The most interesting associations were found at 6p21.1 for VEGF ( Conclusion: This is the first context-specific genetic association study of blood cytokine concentrations in CAP patients revealing numerous biologically plausible candidate genes. Two of the loci were also associated with atherosclerosis with probable common or consecutive pathomechanisms.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers/metabolism ; Case-Control Studies ; Community-Acquired Infections/etiology ; Community-Acquired Infections/metabolism ; Community-Acquired Infections/pathology ; Cytokines/genetics ; Cytokines/metabolism ; Female ; Follow-Up Studies ; Gene Expression Regulation ; Genome-Wide Association Study ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Pneumonia/etiology ; Pneumonia/metabolism ; Pneumonia/pathology ; Prognosis ; Prospective Studies ; Young Adult
Chemical Substances	Biomarkers ; Cytokines
Language	English
Publishing date	2022-01-06
Publishing country	Switzerland
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes13010111
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Article: Genetic Regulation of Cytokine Response in Patients with Acute Community-Acquired Pneumonia

Kühnapfel, Andreas / Horn, Katrin / Klotz, Ulrike / Kiehntopf, Michael / Rosolowski, Maciej / Loeffler, Markus / Ahnert, Peter / Suttorp, Norbert / Witzenrath, Martin / Scholz, Markus

Genes. 2022 Jan. 06, v. 13, no. 1

2022

Abstract	Background: Community-acquired pneumonia (CAP) is an acute disease condition with a high risk of rapid deteriorations. We analysed the influence of genetics on cytokine regulation to obtain a better understanding of patient’s heterogeneity. Methods: For up to N = 389 genotyped participants of the PROGRESS study of hospitalised CAP patients, we performed a genome-wide association study of ten cytokines IL-1β, IL-6, IL-8, IL-10, IL-12, MCP-1 (MCAF), MIP-1α (CCL3), VEGF, VCAM-1, and ICAM-1. Consecutive secondary analyses were performed to identify independent hits and corresponding causal variants. Results: 102 SNPs from 14 loci showed genome-wide significant associations with five of the cytokines. The most interesting associations were found at 6p21.1 for VEGF (p = 1.58 × 10⁻²⁰), at 17q21.32 (p = 1.51 × 10⁻⁹) and at 10p12.1 (p = 2.76 × 10⁻⁹) for IL-1β, at 10p13 for MIP-1α (CCL3) (p = 2.28 × 10⁻⁹), and at 9q34.12 for IL-10 (p = 4.52 × 10⁻⁸). Functionally plausible genes could be assigned to the majority of loci including genes involved in cytokine secretion, granulocyte function, and cilial kinetics. Conclusion: This is the first context-specific genetic association study of blood cytokine concentrations in CAP patients revealing numerous biologically plausible candidate genes. Two of the loci were also associated with atherosclerosis with probable common or consecutive pathomechanisms.
Keywords	acute course ; atherosclerosis ; blood ; genome-wide association study ; genotyping ; intercellular adhesion molecule-1 ; interleukin-10 ; interleukin-12 ; interleukin-6 ; interleukin-8 ; patients ; pneumonia ; risk ; secretion ; vascular cell adhesion molecules
Language	English
Dates of publication	2022-0106
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2527218-4
ISSN	2073-4425
ISSN	2073-4425
DOI	10.3390/genes13010111
Database	NAL-Catalogue (AGRICOLA)

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Article: Automated detection of genetic relatedness from fundus photographs using Siamese Neural Networks.

Bhandari, Sakshi Manoj / Singh, Praveer / Arun, Nishanth / Sekimitsu, Sayuri / Raghu, Vineet / Rauscher, Franziska G / Elze, Tobias / Horn, Katrin / Kirsten, Toralf / Scholz, Markus / Segrè, Ayellet V / Wiggs, Janey L / Kalpathy-Cramer, Jayashree / Zebardast, Nazlee

medRxiv : the preprint server for health sciences

2023

Abstract: Heritability of common eye diseases and ocular traits are relatively high. Here, we develop an automated algorithm to detect genetic relatedness from color fundus photographs (FPs). We estimated the degree of shared ancestry amongst individuals in the UK ...

Abstract	Heritability of common eye diseases and ocular traits are relatively high. Here, we develop an automated algorithm to detect genetic relatedness from color fundus photographs (FPs). We estimated the degree of shared ancestry amongst individuals in the UK Biobank using KING software. A convolutional Siamese neural network-based algorithm was trained to output a measure of genetic relatedness using 7224 pairs (3612 related and 3612 unrelated) of FPs. The model achieved high performance for prediction of genetic relatedness; when computed Euclidean distances were used to determine probability of relatedness, the area under the receiver operating characteristic curve (AUROC) for identifying related FPs reached 0.926. We performed external validation of our model using FPs from the LIFE-Adult study and achieved an AUROC of 0.69. An occlusion map indicates that the optic nerve and its surrounding area may be the most predictive of genetic relatedness. We demonstrate that genetic relatedness can be captured from FP features. This approach may be used to uncover novel biomarkers for common ocular diseases.
Language	English
Publishing date	2023-08-23
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.08.16.23294183
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Article: Sex-Specific Causal Relations between Steroid Hormones and Obesity-A Mendelian Randomization Study.

Pott, Janne / Horn, Katrin / Zeidler, Robert / Kirsten, Holger / Ahnert, Peter / Kratzsch, Jürgen / Loeffler, Markus / Isermann, Berend / Ceglarek, Uta / Scholz, Markus

Metabolites

2021 Volume 11, Issue 11

Abstract: Steroid hormones act as important regulators of physiological processes including gene expression. They provide possible mechanistic explanations of observed sex-dimorphisms in obesity and coronary artery disease (CAD). Here, we aim to unravel causal ... ...

Abstract	Steroid hormones act as important regulators of physiological processes including gene expression. They provide possible mechanistic explanations of observed sex-dimorphisms in obesity and coronary artery disease (CAD). Here, we aim to unravel causal relationships between steroid hormones, obesity, and CAD in a sex-specific manner. In genome-wide meta-analyses of four steroid hormone levels and one hormone ratio, we identified 17 genome-wide significant loci of which 11 were novel. Among loci, seven were female-specific, four male-specific, and one was sex-related (stronger effects in females). As one of the loci was the human leukocyte antigen (HLA) region, we analyzed HLA allele counts and found four HLA subtypes linked to 17-OH-progesterone (17-OHP), including HLA-B1402. Using Mendelian randomization approaches with four additional hormones as exposure, we detected causal effects of dehydroepiandrosterone sulfate (DHEA-S) and 17-OHP on body mass index (BMI) and waist-to-hip ratio (WHR). The DHEA-S effect was stronger in males. Additionally, we observed the causal effects of testosterone, estradiol, and their ratio on WHR. By mediation analysis, we found a direct sex-unspecific effect of 17-OHP on CAD while the other four hormone effects on CAD were mediated by BMI or WHR. In conclusion, we identified the sex-specific causal networks of steroid hormones, obesity-related traits, and CAD.
Language	English
Publishing date	2021-10-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo11110738
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Article ; Online: Genome-wide association and transcriptome analysis suggests total serum ghrelin to be linked with GFRAL.

Wittekind, Dirk Alexander / Scholz, Markus / Kratzsch, Jürgen / Löffler, Markus / Horn, Katrin / Kirsten, Holger / Witte, Veronica / Villringer, Arno / Kluge, Michael

European journal of endocrinology

2021 Volume 184, Issue 6, Page(s) 847–856

Abstract: Objective: Ghrelin is an orexigenic peptide hormone involved in the regulation of energy homeostasis, food intake and glucose metabolism. Serum levels increase anticipating a meal and fall afterwards. Underlying genetic mechanisms of the ghrelin ... ...

Abstract	Objective: Ghrelin is an orexigenic peptide hormone involved in the regulation of energy homeostasis, food intake and glucose metabolism. Serum levels increase anticipating a meal and fall afterwards. Underlying genetic mechanisms of the ghrelin secretion are unknown. Methods: Total serum ghrelin was measured in 1501 subjects selected from the population-based LIFE-ADULT-sample after an overnight fast. A genome-wide association study (GWAS) was performed. Gene-based expression association analyses (transcriptome-wide association study (TWAS)) are statistical tests associating genetically predicted expression to a certain trait and were done using MetaXcan. Results: In the GWAS, three loci reached genome-wide significance: the WW-domain containing the oxidoreductase-gene (WWOX; P = 1.80E-10) on chromosome 16q23.3-24.1 (SNP: rs76823993); the contactin-associated protein-like 2 gene (CNTNAP2; P = 9.0E-9) on chromosome 7q35-q36 (SNP: rs192092592) and the ghrelin And obestatin prepropeptide gene (GHRL; P = 2.72E-8) on chromosome 3p25.3 (SNP: rs143729751). In the TWAS, the three genes where the expression was strongest associated with serum ghrelin levels was the ribosomal protein L36 (RPL36; P = 1.3E-06, FDR = 0.011, positively correlated), AP1B1 (P = 1.1E-5, FDR = 0.048, negatively correlated) and the GDNF family receptor alpha like (GFRAL), receptor of the anorexigenic growth differentiation factor-15 (GDF15), (P = 1.8E-05, FDR = 0.15, also negatively correlated). Conclusions: The three genome-wide significant genetic loci from the GWA and the genes identified in the TWA are functionally plausible and should initiate further research.
MeSH term(s)	Adolescent ; Adult ; Female ; Gene Expression Profiling ; Genome-Wide Association Study ; Ghrelin/blood ; Glial Cell Line-Derived Neurotrophic Factor Receptors/genetics ; Humans ; Male ; Membrane Proteins/genetics ; Nerve Tissue Proteins/genetics ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci ; Transcriptome ; WW Domain-Containing Oxidoreductase/genetics ; Young Adult
Chemical Substances	CNTNAP2 protein, human ; Ghrelin ; Glial Cell Line-Derived Neurotrophic Factor Receptors ; Membrane Proteins ; Nerve Tissue Proteins ; WW Domain-Containing Oxidoreductase (EC 1.1.1.-)
Language	English
Publishing date	2021-05-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1183856-5
ISSN	1479-683X ; 0804-4643
ISSN (online)	1479-683X
ISSN	0804-4643
DOI	10.1530/EJE-20-1220
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Article ; Online: Phenome- and genome-wide analyses of retinal optical coherence tomography images identify links between ocular and systemic health.

Zekavat, Seyedeh Maryam / Jorshery, Saman Doroodgar / Rauscher, Franziska G / Horn, Katrin / Sekimitsu, Sayuri / Koyama, Satoshi / Nguyen, Trang T / Costanzo, Maria C / Jang, Dongkeun / Burtt, Noël P / Kühnapfel, Andreas / Shweikh, Yusrah / Ye, Yixuan / Raghu, Vineet / Zhao, Hongyu / Ghassemi, Marzyeh / Elze, Tobias / Segrè, Ayellet V / Wiggs, Janey L /

Del Priore, Lucian / Scholz, Markus / Wang, Jay C / Natarajan, Pradeep / Zebardast, Nazlee

Science translational medicine

2024 Volume 16, Issue 731, Page(s) eadg4517

Abstract: The human retina is a multilayered tissue that offers a unique window into systemic health. Optical coherence tomography (OCT) is widely used in eye care and allows the noninvasive, rapid capture of retinal anatomy in exquisite detail. We conducted ... ...

Abstract	The human retina is a multilayered tissue that offers a unique window into systemic health. Optical coherence tomography (OCT) is widely used in eye care and allows the noninvasive, rapid capture of retinal anatomy in exquisite detail. We conducted genotypic and phenotypic analyses of retinal layer thicknesses using macular OCT images from 44,823 UK Biobank participants. We performed OCT layer cross-phenotype association analyses (OCT-XWAS), associating retinal thicknesses with 1866 incident conditions (median 10-year follow-up) and 88 quantitative traits and blood biomarkers. We performed genome-wide association studies (GWASs), identifying inherited genetic markers that influence retinal layer thicknesses and replicated our associations among the LIFE-Adult Study (
MeSH term(s)	Adult ; Humans ; Genome-Wide Association Study ; Tomography, Optical Coherence ; Face ; Retina/diagnostic imaging ; Cardiovascular Diseases
Language	English
Publishing date	2024-01-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2518854-9
ISSN	1946-6242 ; 1946-6234
ISSN (online)	1946-6242
ISSN	1946-6234
DOI	10.1126/scitranslmed.adg4517
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Conference proceedings: Erste genomweite Assoziationsstudie von 99 Körpermaßen aus 3D-Körper-Scans

Kühnapfel, Andreas / Ahnert, Peter / Horn, Katrin / Kirsten, Holger / Löffler, Markus / Scholz, Markus

2021 , Page(s) Abstr. 104

Event/congress	66. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e. V. (GMDS), 12. Jahreskongress der Technologie- und Methodenplattform für die vernetzte medizinische Forschung e.V. (TMF); sine loco [digital]; Deutsche Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie; 2021
Keywords	Medizin, Gesundheit ; GWAS ; Bodyscanner ; Heritabilität ; Genetische Korrelation
Publishing date	2021-09-24
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/21gmds113
Database	German Medical Science

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Article: Insights into human health from phenome- and genome-wide analyses of UK Biobank retinal optical coherence tomography phenotypes.

Zekavat, Seyedeh Maryam / Jorshery, Saman Doroodgar / Shweikh, Yusrah / Horn, Katrin / Rauscher, Franziska G / Sekimitsu, Sayuri / Kayoma, Satoshi / Ye, Yixuan / Raghu, Vineet / Zhao, Hongyu / Ghassemi, Marzyeh / Elze, Tobias / Segrè, Ayellet V / Wiggs, Janey L / Scholz, Markus / Priore, Lucian Del / Wang, Jay C / Natarajan, Pradeep / Zebardast, Nazlee

medRxiv : the preprint server for health sciences

2023

Abstract: The human retina is a complex multi-layered tissue which offers a unique window into systemic health and disease. Optical coherence tomography (OCT) is widely used in eye care and allows the non-invasive, rapid capture of retinal measurements in ... ...

Abstract	The human retina is a complex multi-layered tissue which offers a unique window into systemic health and disease. Optical coherence tomography (OCT) is widely used in eye care and allows the non-invasive, rapid capture of retinal measurements in exquisite detail. We conducted genome- and phenome-wide analyses of retinal layer thicknesses using macular OCT images from 44,823 UK Biobank participants. We performed phenome-wide association analyses, associating retinal thicknesses with 1,866 incident ICD-based conditions (median 10-year follow-up) and 88 quantitative traits and blood biomarkers. We performed genome-wide association analyses, identifying inherited genetic markers which influence the retina, and replicated our associations among 6,313 individuals from the LIFE-Adult Study. And lastly, we performed comparative association of phenome- and genome- wide associations to identify putative causal links between systemic conditions, retinal layer thicknesses, and ocular disease. Independent associations with incident mortality were detected for photoreceptor thinning and ganglion cell complex thinning. Significant phenotypic associations were detected between retinal layer thinning and ocular, neuropsychiatric, cardiometabolic and pulmonary conditions. Genome-wide association of retinal layer thicknesses yielded 259 loci. Consistency between epidemiologic and genetic associations suggested putative causal links between thinning of the retinal nerve fiber layer with glaucoma, photoreceptor segment with AMD, as well as poor cardiometabolic and pulmonary function with PS thinning, among other findings. In conclusion, retinal layer thinning predicts risk of future ocular and systemic disease. Furthermore, systemic cardio-metabolic-pulmonary conditions promote retinal thinning. Retinal imaging biomarkers, integrated into electronic health records, may inform risk prediction and potential therapeutic strategies.
Language	English
Publishing date	2023-05-17
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.05.16.23290063
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