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  1. AU="Horná, Simona"
  2. AU="Sciacca, Chiara"
  3. AU=Magee L A
  4. AU="Mansour, Heba Mohamed"
  5. AU="Iglesias-Gutiérrez, Eduardo"
  6. AU="He, Yudou"
  7. AU="Dadas, Osman"
  8. AU="Chen, Fiona"
  9. AU=Itoh Nobuyuki
  10. AU="Adorjan, Kristina"
  11. AU="Humaid Al-Shamsi, Mohammed"
  12. AU="TATIANA B. FANTAZZINI"
  13. AU="Yonan, Charles"
  14. AU="Denic, Milica"
  15. AU="Pértega-Díaz, Sonia"
  16. AU=Passos Maria do Carmo Friche
  17. AU=Lumb Bridget M
  18. AU="Drabo, Emmanuel F"
  19. AU="Raux, M"
  20. AU="Kubba, Haytham"
  21. AU="Hence, Deanna"
  22. AU="Swiger, James"
  23. AU="Loftus Jr, E. V."
  24. AU="Pozzi Mucelli, Roberto"
  25. AU="Subedi, Prajan"
  26. AU=Xiao Xizhu
  27. AU="Franzén, Anna"
  28. AU=Klonoff David C
  29. AU="DeCobelli, Francesco"
  30. AU="Zhang, KaiDong"

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  1. Artikel ; Online: Gastrointestinal Complications of Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS) Syndrome Managed By Parenteral Nutrition.

    Horná, Simona / Péč, Martin Jozef / Krivuš, Juraj / Michalová, Renáta / Sivák, Štefan / Galajda, Peter / Mokáň, Marián

    European journal of case reports in internal medicine

    2024  Band 11, Heft 2, Seite(n) 4268

    Abstract: MELAS - an acronym for mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes - is a multiorgan disease caused by a mutation in mitochondrial DNA (mtDNA). Its clinical manifestations are highly variable; mainly stroke-like episodes, ... ...

    Abstract MELAS - an acronym for mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes - is a multiorgan disease caused by a mutation in mitochondrial DNA (mtDNA). Its clinical manifestations are highly variable; mainly stroke-like episodes, seizures, recurrent headaches, or muscle weakness. However, gastrointestinal complications such as chronic intestinal pseudo-obstruction (IPO), pancreatitis, gastroparesis and hepatopathy are also common. In this report we describe a young patient with gastrointestinal complication of MELAS which led to superior mesenteric artery syndrome (SMAS). It is rare but not surprising combination and should be considered in cases with significant weight loss and resistance to symptomatic treatment. The optimal energy support is the main pillar of the treatment.
    Learning points: Gastrointestinal complications of MELAS such as chronic intestinal pseudo-obstruction, pancreatitis and gastroparesis can lead to undernutrition.Superior mesenteric artery syndrome is a rare condition but should be considered in cases with significant weight loss and resistance to symptomatic treatment.Optimal caloric intake and energy support can improve the condition of patients with MELAS.
    Sprache Englisch
    Erscheinungsdatum 2024-01-22
    Erscheinungsland Italy
    Dokumenttyp Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2024_004268
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: A Rare Early-Onset Fatal Complication after Transarterial Chemoembolization: A Case Report and Review of the Literature.

    Péčová, Monika / Benko, Jakub / Péč, Martin Jozef / Jurica, Jakub / Horná, Simona / Bolek, Tomáš / Hurtová, Tatiana / Sýkora, Ján / Zeleňák, Kamil / Samoš, Matej / Sokol, Juraj

    Current oncology (Toronto, Ont.)

    2024  Band 31, Heft 4, Seite(n) 1961–1970

    Abstract: Transarterial chemoembolization (TACE) is a minimally invasive treatment for liver cancer, often employed as a bridging therapy or destination treatment for non-operable cases. This case report discusses an 82-year-old woman with a large hepatocellular ... ...

    Abstract Transarterial chemoembolization (TACE) is a minimally invasive treatment for liver cancer, often employed as a bridging therapy or destination treatment for non-operable cases. This case report discusses an 82-year-old woman with a large hepatocellular carcinoma (HCC) who underwent elective TACE due to the high surgical risk associated with her tumor size. Unexpectedly, the patient experienced liver rupture 20 h post-procedure, leading to acute surgical intervention. Despite successful hemostasis during surgery, the patient succumbed to progressive multi-organ failure. We aimed to search the PubMed database for documented cases of ruptured HCC after TACE. This study highlights risk factors for spontaneous HCC rupture and specific factors associated with TACE-induced rupture. Transarterial embolization (TAE) is currently favored as the treatment method for spontaneous ruptures, while the optimal therapy for TACE-induced ruptures remains unclear. In conclusion, this case underscores the importance of recognizing the rare complication of HCC rupture post-TACE and the need for personalized risk assessment. While TAE emerges as a primary treatment choice, the lack of consensus necessitates further studies to establish evidence-based approaches for managing this uncommon yet life-threatening complication.
    Mesh-Begriff(e) Humans ; Female ; Chemoembolization, Therapeutic/adverse effects ; Chemoembolization, Therapeutic/methods ; Liver Neoplasms/therapy ; Aged, 80 and over ; Carcinoma, Hepatocellular/therapy ; Fatal Outcome
    Sprache Englisch
    Erscheinungsdatum 2024-04-03
    Erscheinungsland Switzerland
    Dokumenttyp Case Reports ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol31040147
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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