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  1. Book: Gynecologic oncology for the generalist

    Horowitz, Ira R.

    (Obstetrics and gynecology clinics of North America ; 28,4)

    2001  

    Author's details Ira R. Horowitz, guest ed
    Series title Obstetrics and gynecology clinics of North America ; 28,4
    Collection
    Language English
    Size XIV S., S. 637 - 887 : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT013223794
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 255 -28,4- verfügbar in Königswinter Königswinter

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  2. Book: Obstetrics & gynecology on call

    Horowitz, Ira R.

    1993  

    Title variant Obstretics and gynecology on call
    Author's details ed. by Ira R. Horowitz
    Keywords Pregnancy Complications / diagnosis / handbooks ; Pregnancy Complications / therapy / handbooks ; Genital Diseases, Female / diagnosis / handbooks ; Genital Diseases, Female / therapy / handbooks
    Size XV, 640 S. : Ill., graph. Darst.
    Edition 1. ed., 1. [Dr.], Internat. ed.
    Publisher Prentice-Hall International Inc
    Publishing place London u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT004504727
    ISBN 0-8385-7212-X ; 978-0-8385-7212-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1993 B 476 order for loan Magazin

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  3. Book: Clinical gynecology

    Bieber, Eric J. / Sanfilippo, Joseph S. / Horowitz, Ira R.

    2006  

    Author's details Eric J. Bieber ; Joseph S. Sanfilippo ; Ira R. Horowitz
    Keywords Genital Diseases, Female ; Gynecologic Surgical Procedures / methods ; Gynecology / methods ; Gynecology ; Clinical medicine ; Generative organs, Female/Diseases
    Subject code 618.1
    Language English
    Size XVII, 1003 S. : Ill., graph. Darst.
    Publisher Churchill Livingstone Elsevier
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book
    HBZ-ID HT014773190
    ISBN 0-443-06691-4 ; 978-0-443-06691-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2006 A 5447 order for loan Magazin

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  4. Article ; Online: Folate Receptor Alpha Is Preferentially Expressed in the Carcinoma Component of Endometrial Carcinosarcomas: A Potential Target for Adjuvant Therapy.

    Hanley, Krisztina Z / Horowitz, Ira R / Gordon, Alan / Meisel, Jane / Khanna, Namita

    International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists

    2021  Volume 40, Issue 5, Page(s) 501–509

    Abstract: Carcinosarcomas (CSs) of the endometrium are biphasic malignancies, composed of high-grade carcinomatous and sarcomatous components. Surgical stage and pathologic characteristics are the most important prognostic findings, with a 5-yr survival of 15% to ... ...

    Abstract Carcinosarcomas (CSs) of the endometrium are biphasic malignancies, composed of high-grade carcinomatous and sarcomatous components. Surgical stage and pathologic characteristics are the most important prognostic findings, with a 5-yr survival of 15% to 30% in advance stage disease. Folate receptor alpha (FRA) overexpression has been observed in endometrial carcinomas and not yet studied in CSs. This study evaluates semiquantitative expression of FRA in both carcinomatous and sarcomatous components of CSs on whole tissue sections. Immunohistochemistry for FRA expression was performed and extent and intensity of staining were recorded for each case for both histologic components. A total of 46 cases were stained for FRA. The majority of these (40/46, 87%) showed FRA staining at variable intensity in the carcinomatous component, stronger in serous carcinomas and high-grade endometrioid, while only a small subset of tumors demonstrated weak staining in the sarcomatous component (2/46, 4.35%). CS is known to be associated with poor prognosis and adjuvant therapy is recommended even in low stage disease. Serous and high-grade endometrioid carcinomas are the most common carcinomatous components of CSs and are known to show consistently high FRA expression. Folate plays a role in tumor cell migration and loss of cellular adhesion, which are key steps in epithelial-mesenchymal transition, the process by which CS develops from carcinoma cells. Our study shows expression of FRA in the carcinomatous component of almost all CS cases (87%), further favoring FRA as a target for adjuvant treatment. While expression of FRA in the sarcomatous component was rarely observed, the carcinomatous component being associated with metastatic potential underscores the importance of anti-FRA therapy for systemic disease control.
    MeSH term(s) Biomarkers, Tumor/metabolism ; Carcinosarcoma/diagnosis ; Carcinosarcoma/drug therapy ; Carcinosarcoma/pathology ; Cystadenocarcinoma, Serous/diagnosis ; Cystadenocarcinoma, Serous/pathology ; Endometrial Neoplasms/diagnostic imaging ; Endometrial Neoplasms/pathology ; Epithelial-Mesenchymal Transition ; Female ; Folate Receptor 1/genetics ; Humans ; Immunohistochemistry ; Middle Aged ; Prognosis ; Sensitivity and Specificity
    Chemical Substances Biomarkers, Tumor ; FOLR1 protein, human ; Folate Receptor 1
    Language English
    Publishing date 2021-01-12
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 604859-6
    ISSN 1538-7151 ; 0277-1691
    ISSN (online) 1538-7151
    ISSN 0277-1691
    DOI 10.1097/PGP.0000000000000736
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1814: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Controversies in the management of advanced ovarian cancer.

    Khanna, Namita / Horowitz, Ira R

    Oncology (Williston Park, N.Y.)

    2011  Volume 25, Issue 10, Page(s) 934, 937

    MeSH term(s) Female ; Humans ; Ovarian Neoplasms/surgery
    Language English
    Publishing date 2011-09
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 1067950-9
    ISSN 0890-9091
    ISSN 0890-9091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3168: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 372: Show issues

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  6. Article: What's new in gynecology and obstetrics.

    Horowitz, Ira R

    Journal of the American College of Surgeons

    2003  Volume 197, Issue 4, Page(s) 612–619

    MeSH term(s) Adult ; Embolization, Therapeutic ; Endometriosis/diagnosis ; Endometriosis/surgery ; Female ; Genital Diseases, Female/surgery ; Genital Diseases, Female/therapy ; Gynecologic Surgical Procedures ; Humans ; Hysterectomy ; Hysteroscopy ; Laparoscopy ; Leiomyoma/therapy ; Middle Aged ; Urinary Bladder Diseases/surgery ; Urinary Incontinence, Stress/surgery ; Urologic Surgical Procedures ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/surgery ; Uterine Hemorrhage/diagnosis ; Uterine Hemorrhage/therapy ; Uterine Neoplasms/therapy
    Language English
    Publishing date 2003-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1181115-8
    ISSN 1879-1190 ; 1072-7515
    ISSN (online) 1879-1190
    ISSN 1072-7515
    DOI 10.1016/S1072-7515(03)00722-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.61: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Margins for cervical and vulvar cancer.

    Khanna, Namita / Rauh, Lisa A / Lachiewicz, Mark P / Horowitz, Ira R

    Journal of surgical oncology

    2016  Volume 113, Issue 3, Page(s) 304–309

    Abstract: Surgery is the primary treatment for vulvar cancer as well as early-stage carcinoma of the cervix. This article reviews the significance of margin status after surgery on overall survival, need for further surgical intervention, and role for possible ... ...

    Abstract Surgery is the primary treatment for vulvar cancer as well as early-stage carcinoma of the cervix. This article reviews the significance of margin status after surgery on overall survival, need for further surgical intervention, and role for possible adjuvant therapy. It summarizes the abundant literature on margin status in vulvar cancer and highlights the need for further investigation on the prognostic significance of margins in cervical cancer. In addition, it reviews other important operative considerations.
    MeSH term(s) Chemotherapy, Adjuvant ; Disease-Free Survival ; Electrosurgery ; Female ; Fertility Preservation ; Frozen Sections ; Humans ; Hysterectomy/methods ; Hysterectomy/standards ; Intraoperative Period ; Neoplasm Recurrence, Local/prevention & control ; Neoplasm Staging ; Neoplasm, Residual/prevention & control ; Organ Sparing Treatments/methods ; Organ Sparing Treatments/standards ; Predictive Value of Tests ; Prognosis ; Radiotherapy, Adjuvant ; Survival Rate ; Trachelectomy/standards ; United States/epidemiology ; Uterine Cervical Neoplasms/epidemiology ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/prevention & control ; Uterine Cervical Neoplasms/surgery ; Vulvar Neoplasms/epidemiology ; Vulvar Neoplasms/pathology ; Vulvar Neoplasms/prevention & control ; Vulvar Neoplasms/surgery
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 82063-5
    ISSN 1096-9098 ; 0022-4790
    ISSN (online) 1096-9098
    ISSN 0022-4790
    DOI 10.1002/jso.24108
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 706: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Folate Receptor Alpha Expression in Platinum Resistant/Refractory Ovarian Carcinomas and Primary Endocervical Adenocarcinomas.

    Rubinsak, Lisa A / Cohen, Cynthia / Khanna, Namita / Horowitz, Ira R / Hanley, Krisztina Z

    Applied immunohistochemistry & molecular morphology : AIMM

    2016  Volume 26, Issue 8, Page(s) 567–572

    Abstract: Introduction: Treatment of advanced stage ovarian carcinoma is challenging, and despite surgical treatment and chemotherapy, the 5-year survival rate is estimated around 30%. Early recurrence and resistance to platinum-based chemotherapy are associated ... ...

    Abstract Introduction: Treatment of advanced stage ovarian carcinoma is challenging, and despite surgical treatment and chemotherapy, the 5-year survival rate is estimated around 30%. Early recurrence and resistance to platinum-based chemotherapy are associated with poor prognosis and limited response to available second-line chemotherapy. The relative incidence of endocervical adenocarcinoma (EAC) compared with squamous cell carcinoma is increasing. Although the first-line treatment modality for early stage EAC is surgical resection, for locally advanced disease chemoradiation or neoadjuvant chemotherapy is used. Recently, folate along with its receptor alpha (FRA) has been studied as a potential target in gynecologic malignancy. The objective of this study was to elucidate FRA expression in chemotherapy resistant ovarian cancer and primary EAC.
    Methods: FRA expression was evaluated in tissue samples in an epithelial ovarian tumor microarray and 2 study groups: platinum resistant ovarian cancer and primary EAC. Staining intensity was analyzed with a semiquantitative staining algorithm.
    Results: FRA expression was positive in 32 of 40 (80%) ovarian tumors in the control group. In the platinum resistant ovarian cancer group, FRA was expressed in all 30 samples with moderate to strong staining. None of the EAC samples stained positive for FRA expression.
    Conclusions: FRA expression occurs frequently in epithelial ovarian cancer. Our data supports that FRA expressions are maintained after chemotherapy treatment. Folate targeted therapies may be most useful in patients with chemotherapy resistant disease based on high levels of FRA expression in these tumors. There is likely no benefit to folate therapy as an adjuvant treatment in EAC.
    MeSH term(s) Adenocarcinoma/drug therapy ; Adenocarcinoma/metabolism ; Adenocarcinoma/pathology ; Adolescent ; Adult ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/pathology ; Drug Resistance, Neoplasm ; Female ; Folate Receptor 1/biosynthesis ; Gene Expression Regulation, Neoplastic ; Humans ; Neoplasm Proteins/biosynthesis ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/pathology ; Platinum ; Uterine Cervical Neoplasms/drug therapy ; Uterine Cervical Neoplasms/metabolism ; Uterine Cervical Neoplasms/pathology
    Chemical Substances FOLR1 protein, human ; Folate Receptor 1 ; Neoplasm Proteins ; Platinum (49DFR088MY)
    Language English
    Publishing date 2016-12-06
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 1473273-7
    ISSN 1533-4058 ; 1062-3345 ; 1541-2016
    ISSN (online) 1533-4058
    ISSN 1062-3345 ; 1541-2016
    DOI 10.1097/PAI.0000000000000476
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3783: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Book: Clinical gynecology

    Bieber, Eric J / Sanfilippo, J. S / Horowitz, Ira R / Shafi, Mahmood

    (Cambridge medicine)

    2015  

    Abstract: Written with the busy practice in mind this book delivers clinically focused, evidence-based gynecology guidance in a quick-reference format. It explores etiology, screening, tests, diagnosis, and treatment for a full range of gynecologic health issues. ...

    Author's details edited by Eric J. Bieber, Joseph S. Sanfilippo, Ira R. Horowitz, Mahmood I. Shafi
    Series title Cambridge medicine
    Abstract "Written with the busy practice in mind this book delivers clinically focused, evidence-based gynecology guidance in a quick-reference format. It explores etiology, screening, tests, diagnosis, and treatment for a full range of gynecologic health issues. The coverage includes the full range of gynecologic malignancies, reproductive endocrinology and infertility, infectious diseases, urogynecologic problems, gynecologic concerns in children and adolescents, and surgical interventions including minimally invasive surgical procedures. Information is easy to find and absorb owing to the extensive use of full-color diagrams, algorithms, and illustrations. The new edition has been expanded to include aspects of gynecology important in international and resource-poor settings"--Provided by publisher.
    MeSH term(s) Genital Diseases, Female ; Gynecologic Surgical Procedures/methods ; Gynecology/methods
    Language English
    Size xxiii, 1102 pages :, illustrations.
    Edition Second edition.
    Document type Book
    ISBN 9781107040397 ; 1107040396
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Book: Clinical gynecology

    Bieber, Eric J / Horowitz, Ira R

    2006  

    Author's details [edited by] Eric J. Bieber, Joseph S. Sanfilippo, Ira R. Horowitz
    MeSH term(s) Genital Diseases, Female ; Gynecologic Surgical Procedures/methods ; Gynecology/methods
    Language English
    Size xvii, 1003 p. :, ill.
    Publisher Churchill Livingstone Elsevier
    Publishing place Philadelphia
    Document type Book
    ISBN 9780443066917 ; 0443066914
    Database Catalogue of the US National Library of Medicine (NLM)

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